LOCUS       NM_001108168            3708 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus bone morphogenetic protein 5 (Bmp5), mRNA.
ACCESSION   NM_001108168 XM_001059589 XM_236415
VERSION     NM_001108168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3708)
  AUTHORS   Palmer K, Fairfield H, Borgeia S, Curtain M, Hassan MG, Dionne L,
            Yong Karst S, Coombs H, Bronson RT, Reinholdt LG, Bergstrom DE,
            Donahue LR, Cox TC and Murray SA.
  TITLE     Discovery and characterization of spontaneous mouse models of
            craniofacial dysmorphology
  JOURNAL   Dev Biol 415 (2), 216-227 (2016)
   PUBMED   26234751
REFERENCE   2  (bases 1 to 3708)
  AUTHORS   Kusakawa Y, Mikawa S and Sato K.
  TITLE     BMP5 expression in the adult rat brain
  JOURNAL   Neuroscience 284, 972-987 (2015)
   PUBMED   25110111
  REMARK    GeneRIF: Results suggest that BMP5 is widely expressed throughout
            the adult CNS, and this abundant expression in the adult brain
            strongly supports the idea that BMP5 plays important roles not only
            in the developing brain but also in the adult brain
REFERENCE   3  (bases 1 to 3708)
  AUTHORS   Johnsen IK, Kappler R, Auernhammer CJ and Beuschlein F.
  TITLE     Bone morphogenetic proteins 2 and 5 are down-regulated in
            adrenocortical carcinoma and modulate adrenal cell proliferation
            and steroidogenesis
  JOURNAL   Cancer Res 69 (14), 5784-5792 (2009)
   PUBMED   19584291
REFERENCE   4  (bases 1 to 3708)
  AUTHORS   Mailhot G, Yang M, Mason-Savas A, Mackay CA, Leav I and Odgren PR.
  TITLE     BMP-5 expression increases during chondrocyte differentiation in
            vivo and in vitro and promotes proliferation and cartilage matrix
            synthesis in primary chondrocyte cultures
  JOURNAL   J Cell Physiol 214 (1), 56-64 (2008)
   PUBMED   17541940
  REMARK    GeneRIF: Bmp5 expression increases during chondrocyte
            differentiation in vivo and in vitro and promotes cartilage matrix
            synthesis in primary chondrocyte cultures.
REFERENCE   5  (bases 1 to 3708)
  AUTHORS   Nahar NN, Missana LR, Garimella R, Tague SE and Anderson HC.
  TITLE     Matrix vesicles are carriers of bone morphogenetic proteins (BMPs),
            vascular endothelial growth factor (VEGF), and noncollagenous
            matrix proteins
  JOURNAL   J Bone Miner Metab 26 (5), 514-519 (2008)
   PUBMED   18758911
REFERENCE   6  (bases 1 to 3708)
  AUTHORS   Beck HN, Drahushuk K, Jacoby DB, Higgins D and Lein PJ.
  TITLE     Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in
            cultured sympathetic neurons
  JOURNAL   BMC Neurosci 2, 12 (2001)
   PUBMED   11580864
REFERENCE   7  (bases 1 to 3708)
  AUTHORS   Solloway MJ and Robertson EJ.
  TITLE     Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests
            functional redundancy within the 60A subgroup
  JOURNAL   Development 126 (8), 1753-1768 (1999)
   PUBMED   10079236
REFERENCE   8  (bases 1 to 3708)
  AUTHORS   Solloway MJ, Dudley AT, Bikoff EK, Lyons KM, Hogan BL and Robertson
            EJ.
  TITLE     Mice lacking Bmp6 function
  JOURNAL   Dev Genet 22 (4), 321-339 (1998)
   PUBMED   9664685
REFERENCE   9  (bases 1 to 3708)
  AUTHORS   Yamaji N, Celeste AJ, Thies RS, Song JJ, Bernier SM, Goltzman D,
            Lyons KM, Nove J, Rosen V and Wozney JM.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   10 (bases 1 to 3708)
  AUTHORS   Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland
            NG and Jenkins NA.
  TITLE     The mouse short ear skeletal morphogenesis locus is associated with
            defects in a bone morphogenetic member of the TGF beta superfamily
  JOURNAL   Cell 71 (3), 399-410 (1992)
   PUBMED   1339316
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236415.4, XM_001059589.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3708
                     /gene="Bmp5"
                     /note="bone morphogenetic protein 5"
                     /db_xref="GeneID:315824"
                     /db_xref="RGD:1305979"
     exon            1..510
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1385
                     /gene="Bmp5"
                     /codon_start=1
                     /product="bone morphogenetic protein 5 precursor"
                     /protein_id="NP_001101638.1"
                     /db_xref="GeneID:315824"
                     /db_xref="RGD:1305979"
                     /translation="MHWTVFLLRGIVGFLWSSWVQVGYAKGGLGDNHVHSSFIYRRLR
                     NHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEENPEESEYLVR
                     VSLAGEAKETRKGYPASPNGYAHRLHLPPRIPLTTQSPPLASLHDTNFLNDADMVMSF
                     VNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDKSNHRFENETIKISI
                     YQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETG
                     DGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNKSSSHQD
                     PSRIPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNA
                     HMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS
                     CGCH"
     exon            511..703
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            704..852
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1047
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1124
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1235
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..3708
                     /gene="Bmp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtttgcct ttgtacaaaa atgcattgga ctgtattttt acttaggggt attgtgggct
       61 tcctctggag cagctgggtt caagtgggtt atgccaaagg aggcttggga gacaatcatg
      121 ttcactccag ttttatttat agaagactac ggaaccacga aagacgggaa atacagaggg
      181 aaattctctc tattctgggt ttgcctcaca gacccaggcc cttttcaccg gggaagcaag
      241 catcttctgc acccctcttt atgctggatc tgtacaacgc catggccagc gaagaaaacc
      301 ctgaggagtc agaatattta gtgagggtat ccctggctgg agaggctaaa gagacaagaa
      361 agggataccc agcctctccc aatgggtatg cacatcgtct gcacttacct ccaaggattc
      421 ctctgactac ccagagccca cctcttgcca gtctacacga taccaatttt ctgaatgatg
      481 ctgacatggt catgagtttt gtcaacctag ttgaaagaga caaagacttt tctcatcaga
      541 gaaggcatta caaagaattt cggtttgatc tgacccaaat tccacatgga gaagcagtga
      601 cggcagctga attccggatt tataaggaca aaagcaacca tcggtttgaa aatgaaacaa
      661 ttaagattag catatatcag atcatcaagg aatacacaaa tagggacgca gatctttttc
      721 tgctagatac aaggaaggca caagctttag atgtgggttg gcttgtcttt gatatcaccg
      781 tgaccagcaa tcattgggtg attaatccac agaacaattt gggcttacag ctctgcgcag
      841 agacggggga tggacgcagc atcaatgtaa aatctgccgg tctcgtggga agacacgggc
      901 ctcagtcaaa gcagccgttc atggtggcct tcttcaaggc aagtgaggtt cttcttcgat
      961 ctgtgagagc agccagcaaa cggaaaaacc aaaaccgcaa taaatccagc tctcatcagg
     1021 acccctccag gattcccagt gctggagatt ataataccag tgaacagaaa caagcttgca
     1081 agaagcacga gctctatgtg agtttccgcg atctgggatg gcaggactgg atcatagcac
     1141 cagaaggata tgccgcattt tattgcgatg gagaatgttc ttttccactt aacgcccaca
     1201 tgaatgccac taaccatgcc atagtccaga ctctggtaca cctgatgttt cctgaccatg
     1261 ttcccaagcc ctgttgtgct ccaaccaaac taaatgccat ctcggtcctg tactttgatg
     1321 acagctccaa tgtaattttg aaaaagtaca gaaatatggt agtccgttca tgtggctgcc
     1381 actagctgga cgttctagtg ataacaatga aacagatctg tgttatgttt atgaccgcaa
     1441 taaaaagcag ggaaatgggg aatttcctaa aatcgatctg ggtcatttca tctctatgta
     1501 tgataatcat gtatatacac ttcttattta tttaaaatga tatattctct ttcggatgcc
     1561 ttaccagtaa aatctgttaa agatccccat attatataat agattcctat tctagctttc
     1621 gttggggtgt gatgagtcca gtttaattct atgccaacat ttttctcaat gctaatataa
     1681 atgattttct gatattaagt agagctcctc tgagagttta atgttgaagg gaaatgaatg
     1741 catttgacat gttgcactaa ctcaaactaa aatggaatat ctagaaagaa agttgctaac
     1801 agccaaaatt ataaaaacca cattgtttac catttgtgct tctttggtaa aggtaaaatg
     1861 ttgaactgga tttgaattag tgaacggtag gctggggaca gaggttggaa gactgcgtaa
     1921 ttcttttaac tcttcccttt gatggcgttg gtgggactct cgcagcgtgc tgctccttgc
     1981 ttctgaccgg cagattttgt tatgtttttg caagaagtcg gaagcttcag gcttgggtct
     2041 aggtccacct ggttccaaac cgacactcca aagtacaata caaccttacc tcaatgaacc
     2101 gtctgaccat tgtctacacc actaccacaa cagtgggttt ctttcttgtt tcaaacgtaa
     2161 gccaaagtta aagagataat cgcatgtgct ccacttcact ccctacagac aagagtcact
     2221 tcatgcataa aatgtgctgg gactcgtcac gccaacacag tctcttgctg tcctttataa
     2281 tggacgttac cagttgatgt gctataaggg actgtattct gggtgagagc gttgacatta
     2341 agctgaaaga aaaaaaatca ccaaatggct ttgacagaac catcatttta aaacagctaa
     2401 atgccatttc tccatgtttt ttgagaagaa gctcagtgaa aaacccaatt ttacaaaggg
     2461 attttggaaa ccttcctcct agcatgaata agtacgatag ggacagttct ggggtggtat
     2521 aaaagagaga gagagagaga gagagagagt gtgtgtgtgt gtgtgtgtgt gtgtgaatat
     2581 gtgtgtctgt gcatgtgtgc atgtgtgtgt gtatgtgtga atgtgtgtga atatgtatgt
     2641 ctgtgcatgt atgtatatgt gtgtgtgaat gtgtgcaagt gtgtgtgtat gtatgtgtat
     2701 gtgtgaatgt gtgtgtgtga atatgtgtgt ctgtgcacgt gtgcatatgt gcatgtgtgt
     2761 gtatgtgtga atgtgtgtgt gaatatgtat gtctatgcat gtatgtatat gtgtgtgtga
     2821 atgtgtgtgt atgtgtgcat gtgtgtgtat gtgtgaatgt gtgtgtgaat atgtatgtct
     2881 atgcatgtat gtatatgtgt gtgtgaatgt gtgtgtatgt gtgcatgtgt gtgtatatgt
     2941 gtgaatgtgt gtgtgaatgt gtgcatgtgt ttgtgtgtga atgtgtgtgt atgtgtgtgt
     3001 atgtgcgtgt gtgtgtgtgt gtgtgtgtgt gcacatgccc atgcttttct ctctgatgtt
     3061 tatttatttt atctctattg gaatggtgac tggctactaa ggtctttctc cagcccacac
     3121 tgactttctg aggagtgggt ctctagttaa tcatttacta ctgtttgtaa gttccatggt
     3181 aaggcttgta gtagtcgact gaaaatgtcc accacgaagc accatttcca gtatatcgtt
     3241 tatagctttc aagtgaggac ccattgttaa taatctccaa acattgtggc ttgtttgtaa
     3301 ttcagatatt ttacaatgtt gttttaaaac agtttacagt atagaaactg tggtattaat
     3361 gatattgggg gatgtgttaa gtaatatatt tttagttaat aagttaatag tgtaccaatg
     3421 aggataagac tagagattaa gaaatagaat tctattatat tattctttaa atgtactact
     3481 tgaatatatg tttacattta aaatatatta aactcatgat gccaaactct gttgcggttt
     3541 gtgtgtgtgt atgtgtgtgg catagttctt tattaaaaaa tgtaaatgca tcctagacta
     3601 aaatatttat cagatacaaa atacttttaa ttacataggt cattaaatgc tttcagttga
     3661 tgatgctctt ttgtacttct cataattaac tcactaataa gtgcacaa
//
