LOCUS       NM_012827               1559 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 4 (Bmp4), mRNA.
ACCESSION   NM_012827
VERSION     NM_012827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Shen,S., Nan,W., Zhang,W., Wu,H. and Zhang,Y.
  TITLE     Bone morphogenetic protein 4 inhibits corneal neovascularization by
            blocking NETs-induced disruption to corneal epithelial barrier
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113023 (2024)
   PUBMED   39217886
  REMARK    GeneRIF: Bone morphogenetic protein 4 inhibits corneal
            neovascularization by blocking NETs-induced disruption to corneal
            epithelial barrier.
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Li,Q., Li,Z., Li,J., Qin,X., Wu,F. and Chen,C.
  TITLE     Bone Morphogenetic Protein-4 Promotes Phenotypic Modulation via
            SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells
  JOURNAL   J Vasc Res 61 (3), 99-108 (2024)
   PUBMED   38151007
  REMARK    GeneRIF: Bone Morphogenetic Protein-4 Promotes Phenotypic
            Modulation via SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells.
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Zhou,Y., Yang,Y., Dong,R. and Huang,Y.
  TITLE     Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in
            Rectal Nervous System Development of Fetal Rats with Anorectal
            Malformation
  JOURNAL   J Pediatr Surg 58 (7), 1317-1321 (2023)
   PUBMED   36906487
  REMARK    GeneRIF: Regulation of Shh/Bmp4 Signaling Pathway by DNA
            Methylation in Rectal Nervous System Development of Fetal Rats with
            Anorectal Malformation.
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Gao,L.T., Yuan,J.Q., Zhang,Z.Y., Zhao,H.M. and Gao,L.
  TITLE     Hypermethylation of the Bmp4 promoter dampens binding of HIF-1alpha
            and impairs its cardiac protective effects from oxidative stress in
            prenatally GC-exposed offspring
  JOURNAL   Cell Mol Life Sci 80 (3), 58 (2023)
   PUBMED   36746787
  REMARK    GeneRIF: Hypermethylation of the Bmp4 promoter dampens binding of
            HIF-1alpha and impairs its cardiac protective effects from
            oxidative stress in prenatally GC-exposed offspring.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Li,Q., Kou,X., Qin,X., Li,Z., Li,J. and Chen,C.
  TITLE     BMP-4 impedes endothelial cell migration in neointimal hyperplasia
            via FoXO-3 specific modulation of reactive oxygen species
  JOURNAL   Atherosclerosis 351, 9-17 (2022)
   PUBMED   35605369
  REMARK    GeneRIF: BMP-4 impedes endothelial cell migration in neointimal
            hyperplasia via FoXO-3 specific modulation of reactive oxygen
            species.
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Winnier,G., Blessing,M., Labosky,P.A. and Hogan,B.L.
  TITLE     Bone morphogenetic protein-4 is required for mesoderm formation and
            patterning in the mouse
  JOURNAL   Genes Dev 9 (17), 2105-2116 (1995)
   PUBMED   7657163
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Johansson,B.M. and Wiles,M.V.
  TITLE     Evidence for involvement of activin A and bone morphogenetic
            protein 4 in mammalian mesoderm and hematopoietic development
  JOURNAL   Mol Cell Biol 15 (1), 141-151 (1995)
   PUBMED   7799920
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Phelan,J.P.
  TITLE     Genetic variability and rodent models of human aging
  JOURNAL   Exp Gerontol 27 (2), 147-159 (1992)
   PUBMED   1521591
  REMARK    Review article
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Wozney,J.M., Rosen,V., Celeste,A.J., Mitsock,L.M., Whitters,M.J.,
            Kriz,R.W., Hewick,R.M. and Wang,E.A.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078901.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078901.1, CK478915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1559
                     /gene="Bmp4"
                     /gene_synonym="BOMPR4A"
                     /note="bone morphogenetic protein 4"
                     /db_xref="GeneID:25296"
                     /db_xref="RGD:2213"
     exon            1..131
                     /gene="Bmp4"
                     /gene_synonym="BOMPR4A"
                     /inference="alignment:Splign:2.1.0"
     exon            132..511
                     /gene="Bmp4"
                     /gene_synonym="BOMPR4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1365
                     /gene="Bmp4"
                     /gene_synonym="BOMPR4A"
                     /note="BMP-4; BMP-2B; bone morphogenetic protein 2B"
                     /codon_start=1
                     /product="bone morphogenetic protein 4 precursor"
                     /protein_id="NP_036959.2"
                     /db_xref="GeneID:25296"
                     /db_xref="RGD:2213"
                     /translation="MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGG
                     RRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQG
                     TGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFFFNLSSIPENEVISSAELR
                     LFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVHHNVTRWETFDV
                     SPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTF
                     GHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQA
                     FYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKV
                     VLKNYQEMVVEGCGCR"
     exon            512..1535
                     /gene="Bmp4"
                     /gene_synonym="BOMPR4A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttaggagc cattccgtag tgccattccg agcgacgcac tgccgcagct tctctgagcc
       61 tttccagcaa gtttgttcaa gattggctcc caagaatcat ggactgttat tatatgcctt
      121 gttttctgtc aagacaccat gattcctggt aaccgaatgc tgatggtcgt tttattatgc
      181 caagtcctgc taggaggcgc gagccatgct agtttgatac ctgagaccgg gaagaaaaaa
      241 gtcgccgaga ttcagggcca cgcgggagga cgccgctcag ggcagagcca tgagctcctg
      301 cgggacttcg aggcgacact tctgcagatg tttgggctgc gccgccgtcc gcagccgagc
      361 aagagcgccg tcatcccgga ttacatgagg gatctttacc ggctccagtc tggggaggag
      421 gaggaagaag agcagagcca gggaaccggg cttgagtacc ctgagcgtcc tgccagcaga
      481 gccaacactg tgaggagttt ccatcacgaa gaacatctgg agaacatccc agggaccagt
      541 gagagctctg cttttcgttt cttctttaac ctcagcagca tcccagagaa tgaggtgatc
      601 tcctctgcag agctccggct atttcgggag caggtggacc agggccctga ctgggaacag
      661 ggcttccacc gtataaacat ttatgaggtt atgaagcccc cagcagaaat ggtgcctgga
      721 cacctcatca cacgactact ggacaccaga ctagtccatc acaatgtgac acggtgggaa
      781 actttcgatg tgagccctgc agtccttcga tggacccggg aaaagcaacc caactatggg
      841 ctggccattg aggtgactca cctccaccag acacggaccc accagggcca acatgtcagg
      901 attagccgat cgttacctca agggagtgga aattgggccc aactccggcc cctcctggtc
      961 acttttggcc acgatggccg gggtcatacc ttgacccgcc ggagggccaa gcgtagtccc
     1021 aagcatcacc cacagcgctc caggaagaag aataagaact gccgtcgcca ttcgctctac
     1081 gtggacttca gtgacgtggg ctggaatgat tggatcgtgg ccccaccggg ctaccaggcc
     1141 ttctactgcc acggggactg tccctttcca ctggcggacc acctcaactc aaccaatcat
     1201 gccattgtgc agaccctggt caactccgtt aattctagca tccctaaggc ctgctgtgtc
     1261 cccaccgaac tgagcgccat ttccatgttg tatctggacg agtacgacaa ggtggtgttg
     1321 aaaaattatc aggagatggt ggtggagggg tgcggatgcc gctgaaatca ggcagtccgg
     1381 aggacggatg cacacacaca cacacacaca cacacacaca cacacacaca cacaaagccc
     1441 atccgaccac ccacacatac cacacaaact gcttccctat agctggactt ttatcttaaa
     1501 aaaaagaaaa aaagaaagaa agaaaaagaa agacaaaaaa aaaaaaaaaa aaaaaaaaa
//
