LOCUS       NM_017105               2158 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 3 (Bmp3), mRNA.
ACCESSION   NM_017105
VERSION     NM_017105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Song,B., Li,X., Xu,Q., Yin,S., Wu,S., Meng,X., Huang,C. and Li,J.
  TITLE     Inhibition of BMP3 increases the inflammatory response of
            fibroblast-like synoviocytes in rheumatoid arthritis
  JOURNAL   Aging (Albany NY) 12 (12), 12305-12323 (2020)
   PUBMED   32568738
  REMARK    GeneRIF: Inhibition of BMP3 increases the inflammatory response of
            fibroblast-like synoviocytes in rheumatoid arthritis.
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Yamashita,K., Mikawa,S. and Sato,K.
  TITLE     BMP3 expression in the adult rat CNS
  JOURNAL   Brain Res 1643, 35-50 (2016)
   PUBMED   27130896
  REMARK    GeneRIF: Data indicate that bone morphogenetic protein-3 (BMP3) is
            widely expressed throughout the adult central nervous system, and
            its abundant expression in the adult brain strongly supports the
            idea that BMP3 plays important roles in the adult brain.
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Grgurevic,L., Macek,B., Healy,D.R., Brault,A.L., Erjavec,I.,
            Cipcic,A., Grgurevic,I., Rogic,D., Galesic,K., Brkljacic,J.,
            Stern-Padovan,R., Paralkar,V.M. and Vukicevic,S.
  TITLE     Circulating bone morphogenetic protein 1-3 isoform increases renal
            fibrosis
  JOURNAL   J Am Soc Nephrol 22 (4), 681-692 (2011)
   PUBMED   21415150
  REMARK    GeneRIF: Circulating bone morphogenetic protein 1-3 isoform
            increases renal fibrosis.
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Nahar,N.N., Missana,L.R., Garimella,R., Tague,S.E. and
            Anderson,H.C.
  TITLE     Matrix vesicles are carriers of bone morphogenetic proteins (BMPs),
            vascular endothelial growth factor (VEGF), and noncollagenous
            matrix proteins
  JOURNAL   J Bone Miner Metab 26 (5), 514-519 (2008)
   PUBMED   18758911
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Takahashi,H. and Ikeda,T.
  TITLE     Transcripts for two members of the transforming growth factor-beta
            superfamily BMP-3 and BMP-7 are expressed in developing rat embryos
  JOURNAL   Dev Dyn 207 (4), 439-449 (1996)
   PUBMED   8950518
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Takao,M., Hino,J., Takeshita,N., Konno,Y., Nishizawa,T., Matsuo,H.
            and Kangawa,K.
  TITLE     Identification of rat bone morphogenetic protein-3b (BMP-3b), a new
            member of BMP-3
  JOURNAL   Biochem Biophys Res Commun 219 (2), 656-662 (1996)
   PUBMED   8605043
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Chen,D., Feng,J.Q., Feng,M., Harris,M.A., Mahy,P., Mundy,G.R. and
            Harris,S.E.
  TITLE     Sequence and expression of bone morphogenetic protein 3 mRNA in
            prolonged cultures of fetal rat calvarial osteoblasts and in rat
            prostate adenocarcinoma PA III cells
  JOURNAL   DNA Cell Biol 14 (3), 235-239 (1995)
   PUBMED   7880444
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Ohta,S., Hiraki,Y., Shigeno,C., Suzuki,F., Kasai,R., Ikeda,T.,
            Kohno,H., Lee,K., Kikuchi,H., Konishi,J. et al.
  TITLE     Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase
            expression of the proto-oncogene c-fos in murine osteoblastic
            MC3T3-E1 cells
  JOURNAL   FEBS Lett 314 (3), 356-360 (1992)
   PUBMED   1468569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D63860.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2158
                     /gene="Bmp3"
                     /gene_synonym="PBMP3"
                     /note="bone morphogenetic protein 3"
                     /db_xref="GeneID:25667"
                     /db_xref="RGD:2212"
     exon            1..914
                     /gene="Bmp3"
                     /gene_synonym="PBMP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2011
                     /gene="Bmp3"
                     /gene_synonym="PBMP3"
                     /note="BMP-3"
                     /codon_start=1
                     /product="bone morphogenetic protein 3 precursor"
                     /protein_id="NP_058801.1"
                     /db_xref="GeneID:25667"
                     /db_xref="RGD:2212"
                     /translation="MAGARGLLCLWLGCFCLNLAQGQRPNLHLPGLRGTESSDRMTGG
                     GPSPDLRPHDKVSEHMLWLYDRYSGSNRAQATRTPGSQLPGPQPLRGGNTVRSFRAAA
                     AGTLQRKGLHTFNLTSLTKSENILSATLYFYIGELVNTSVNCPESQGCSHDSQRQHIQ
                     IDLSAWTLQSNQSQLLGHLSVDTAKPYRDSMSWLSKDITQLLRKAKQDEEFLIGFNIT
                     SRAHELPKRMLLFPEPYILVYANDAAICEPESVVSSLQRHRDFTAGTVPRLDSHVREA
                     LSVERRKKRSTGILLPLQNNELPGAEYQYKEAGVWEERKPYKSLQTQPPEKSRSKKKQ
                     RKGPHQKGQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDA
                     YYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENK
                     NVVLKVYPNMTVDSCACR"
     exon            915..1819
                     /gene="Bmp3"
                     /gene_synonym="PBMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2158
                     /gene="Bmp3"
                     /gene_synonym="PBMP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgagctag aggctagagg gagaacttgg ccacaggcgg accagacaga tcagatcagg
       61 gcaagaagga acagaaccag tctgtctctc tgtctctgtc tctctgtctc tgtgtgtgtg
      121 tgtgtctctc tctgtctctc tgtgtctcta cacacacaca cacacacaca cacacacaca
      181 cacacacaca cacacacaca cacacacacc acgtcctctg agaactcagc tggctgcgac
      241 cgcgcacacc ccgcccgggc gcgcgtccca ggctggtgga gcgcagatcc agatccccat
      301 agcggccggg tgttcccgag tctcaggtgg cgcggaaggg agaacccgcg cttgacaact
      361 cgtctgcgct cgcccagacc ttccgccctc ggaccggccg gtgagcggag ctgagcgggt
      421 gcggctgcca cccagagccc acctgccgac cctcgcgtcg cggccccgcg ccagctgtgc
      481 cgggctcccg gcgcccgctc cgcagctgga gcgccacccc ggctctacta cagtcccttc
      541 cgtctccaga gtgtcccgga cgacggcgac ccgaagtagc gcggcacgac agcgggactt
      601 gactatggct ggggctcgcg ggctgctgtg tctgtggcta ggttgtttct gcctgaacct
      661 ggcacaggga cagagaccaa atttgcacct cccgggactc cgcgggactg agtcaagcga
      721 ccgcatgaca ggtggtggcc cgagcccgga cctgaggcct cacgacaagg tgtcagagca
      781 tatgctgtgg ctctatgaca ggtacagcgg cagcaacaga gcccaggcta cccggacacc
      841 gggctcgcag ctcccgggtc cccaacccct gcgtggcggt aacacggttc gtagcttcag
      901 agccgcagcc gcaggaactc ttcaaagaaa gggcttgcac acttttaatc tgacttctct
      961 aaccaagtct gagaacattt tgtcagccac actgtatttc tacattggag aattggtgaa
     1021 caccagtgtg aactgtccag aatcccaagg ttgttcccat gacagccaga gacaacacat
     1081 ccagatagac ctctctgcat ggaccctcca atccaaccaa agccagctct tgggtcatct
     1141 gtcagtagat acggccaaac cttatagaga cagcatgtct tggctgtcaa aagacatcac
     1201 tcagctctta cggaaggcca agcaagacga ggagtttctc ataggattta acattacctc
     1261 cagagcacac gagcttccca agaggatgct gcttttcccg gaaccttata tcttggtgta
     1321 tgccaacgat gccgccattt gtgagcctga aagcgtggta tctagcctac agagacaccg
     1381 cgatttcaca gcaggaactg tgcccagact ggatagccac gtcagagaag ccctctctgt
     1441 tgagaggagg aagaagcgct ctactgggat cttgttgcca ttgcagaaca acgagctccc
     1501 tggggccgag tatcagtaca aggaggctgg agtgtgggag gagagaaagc cttacaagag
     1561 ccttcagact cagcctcctg aaaagagccg gagcaaaaag aaacagagga aagggcctca
     1621 tcaaaaggga cagacactgc agtttgatga gcagacactg aagaaggcga ggcgaaagca
     1681 gtggatcgag cctcggaact gtgcccgcag gtaccttaaa gtggactttg ccgatattgg
     1741 ctggagcgaa tggattatct cccccaagtc atttgatgcc tactattgct ccggagcctg
     1801 ccagttcccc atgccaaagt ctttgaagcc atcaaatcac gccaccatcc agagcatagt
     1861 gagagccgtg ggggtcgtct ctgggattcc tgagccctgc tgtgttccgg agaagatgtc
     1921 ctcgctcagc atcttgttct ttgacgagaa caagaatgtg gtcctcaaag tctatcctaa
     1981 catgacagta gactcttgtg cttgtagata acctagcaga gaacacactc aaacgctcca
     2041 ttcaatcatt aattgggttt tatggacttt tatttttgtc ttttgcactg ccaatgcatt
     2101 ttgtcccaaa agatgtttta tagcagaaag aaaatgaaca aagagatcga agatttcc
//
