LOCUS       NM_001419798            7277 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus BMP-2 inducible kinase (Bmp2k), mRNA.
ACCESSION   NM_001419798 XM_039092659
VERSION     NM_001419798.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7277)
  AUTHORS   Kearns,A.E., Donohue,M.M., Sanyal,B. and Demay,M.B.
  TITLE     Cloning and characterization of a novel protein kinase that impairs
            osteoblast differentiation in vitro
  JOURNAL   J Biol Chem 276 (45), 42213-42218 (2001)
   PUBMED   11500515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Apr 19, 2023 this sequence version replaced XM_039092659.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.46145.1,
                                           SRR26643299.53986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000014.1  12882275-12882657   c
            384-502             JAXUCZ010000014.1  12851683-12851801   c
            503-608             JAXUCZ010000014.1  12848702-12848807   c
            609-751             JAXUCZ010000014.1  12842710-12842852   c
            752-873             JAXUCZ010000014.1  12841190-12841311   c
            874-955             JAXUCZ010000014.1  12838877-12838958   c
            956-1088            JAXUCZ010000014.1  12834540-12834672   c
            1089-1192           JAXUCZ010000014.1  12825811-12825914   c
            1193-1272           JAXUCZ010000014.1  12824214-12824293   c
            1273-1433           JAXUCZ010000014.1  12822093-12822253   c
            1434-1666           JAXUCZ010000014.1  12818460-12818692   c
            1667-1765           JAXUCZ010000014.1  12816798-12816896   c
            1766-1950           JAXUCZ010000014.1  12815540-12815724   c
            1951-2108           JAXUCZ010000014.1  12811889-12812046   c
            2109-2219           JAXUCZ010000014.1  12805787-12805897   c
            2220-7277           JAXUCZ010000014.1  12785169-12790226   c
FEATURES             Location/Qualifiers
     source          1..7277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..7277
                     /gene="Bmp2k"
                     /note="BMP-2 inducible kinase"
                     /db_xref="GeneID:498333"
                     /db_xref="RGD:1564828"
     exon            1..383
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3580
                     /gene="Bmp2k"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="BMP-2-inducible protein kinase"
                     /protein_id="NP_001406727.1"
                     /db_xref="GeneID:498333"
                     /db_xref="RGD:1564828"
                     /translation="MKKFSRMPKSEGSGGGAAAGGAAGSGLGGGFGSSSMGVRVFAVG
                     RYQVTLEESLAEGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKELSGH
                     KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTESEVLQIFCDTC
                     EAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEI
                     KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFALPFGESQVAICDGSFT
                     IPDNSRYSHNVHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSILPSTL
                     PEPMTATEAAARKSQMKARITDTIGPTETSIAPRQRPKANSTAAISSVLTIQSSATPV
                     KVPAPGEFSNHKPKGALRPGNGSDILMVQGPTQQPPQQHRVLQQLQQGDWRLQQLHLH
                     RHPQQQQQQQQQQQQQQQQQQQQQQLLQNAYLQQYQHAMHQQQILQQQFLMHSVYQPQ
                     PLASQYPTMMQQYQQALLQQQMLAHHQQPAQQVSPEYLTSPQEFSPALAPYGSSLPAQ
                     VGTIVDSSYGATRSVAEKEAVANFTNQKTISHPPDMSGWNPFGEDNFSKLTEEELLDR
                     EFDLLRSNRLGESTPSDKNVDPPPAPHSRPPEEPFASVPFISHSGSPEKKTEHSPNQK
                     NITAHPTKNGSSSPICKAGQKTSENPVVRGHAQKGNDESESEFESDPPSPKSSEEEQE
                     DEDAQGEHGDFNDEDTEPENLGHRPLLMDSEDEEEDDKHSSDSECEQAKAKGGESSSL
                     RRNKPGGAPEPASSPALTPSQEFDVFGAVPFFAVPAPELQHRGSGKSVSQQMFPEQEE
                     YDVFTKAPFSKKVTVQDWPAVRPDTRPLPARPRSVDIFGSTPFQPFSTAASKSESKED
                     VFGLVPFEEITGSQQQQQKVKQRSLQKLSSRQRRTKQDVSKSNGKRHHGTPTSAKKPL
                     KPPYRTPERARRHKRVGRRDSQSSNEFLTISDSKENISVALTDGKDRASVLPPDESLL
                     DPFGAKPFHPPDLWHQTHQGLSDICVDHTAILPGRPRQNSVHGSFHSADALRMDDFGA
                     VPFTELVVQSVSPQQSQPVELDPFGAAPFPSKQ"
     exon            384..502
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            503..608
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            609..751
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            752..873
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            874..955
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1088
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1192
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1272
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1433
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1666
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1765
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1950
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2108
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2219
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..7277
                     /gene="Bmp2k"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgcagcg ggcggccggg gctgcgcgct cgggacgcgc ggaatgtgag gcgcggcgag
       61 ccgctgcgca ccgacgctcg cgcgcgcgaa gggcggcgac ccctcacaga cggtcggccg
      121 cgccccgcgc tccgctgcgc gccgcgcggg tcgggctctc gcccctcgcg cgccctcgtg
      181 ccctcctggt gccctccagc gcgccggcgg gaccatgaag aagttctctc ggatgcccaa
      241 gtcggagggc agcggcggcg gggcggcggc tggaggggcc gcgggctccg ggctcggcgg
      301 cggcttcgga agctcgtcca tgggggtccg ggtgttcgcc gtcggccgct atcaggtcac
      361 cctggaggag tcgctggccg aaggcggctt ctccactgtt ttcctggtgc ggactcacag
      421 tgggatccga tgcgcactga agcgaatgta cgtcaataac acacctgacc tcaacatctg
      481 taaaagggaa atcacaatta tgaaagagct atctggccac aaaaatattg ttggttattt
      541 ggactgtgct gtcaattcaa ttagtgataa tgtatgggaa gtgctcatcc taatggaata
      601 ttgtcgagct gggcaggtcg tgaaccagat gaataagaag ctgcagacag gctttaccga
      661 gtctgaagtc ctacagatct tctgtgacac ctgtgaagca gtcgcacggt tgcatcaatg
      721 taagactccc ataatccacc gggatctgaa ggtagaaaat attttgttaa atgatgctgg
      781 gaattacgtg ctttgtgact ttggcagtgc cactaataaa tttctcaatc ctcaaaaaga
      841 tggagttaat gtagtagaag aagaaattaa aaaatacacg actctgtcat atagagcccc
      901 agaaatgatc aacctttatg gagggaaacc gatcaccacc aaggctgata tctgggccct
      961 gggatgtttg ctgtataaac tttgtttctt cgctcttcct tttggtgaga gtcaggttgc
     1021 tatctgtgac ggcagcttca ccatcccaga taattctcgc tactcccata acgttcattg
     1081 tttgattagg ttcatgcttg aaccagaccc cgagcacaga cctgacatat ttcaagtctc
     1141 ctactttgca tttaaatttg ccaaaaagga ttgtccggtc tccaacatca ataattccat
     1201 tcttccatca actcttccag aaccgatgac tgctaccgaa gccgctgcta ggaaaagcca
     1261 gatgaaagcc agaataacag ataccattgg accaacagaa acctcaattg caccaagaca
     1321 aagaccaaag gccaattcca ccgctgccat ttccagtgtg ctgaccattc agagttcagc
     1381 aacgccggtt aaagtccctg ctcctgggga attcagtaac cacaaaccca aaggagcact
     1441 gagacctgga aatgggtctg acatcttaat ggttcaggga cccactcagc agccaccaca
     1501 gcagcataga gttctccagc aattacagca gggagattgg agattacagc agcttcattt
     1561 gcatcgtcat ccccagcagc agcagcagca gcagcagcag cagcagcagc agcaacagca
     1621 gcaacagcag cagcagcaac tacttcaaaa cgcttatttg cagcagtatc aacatgcaat
     1681 gcaccagcaa caaatacttc aacaacagtt tttaatgcac tcagtgtatc agccacaacc
     1741 tcttgcatct cagtatccga ccatgatgca gcagtatcag caggctctct tgcagcagca
     1801 gatgctagct caccatcagc agccagcgca gcaggtgtca cctgagtatc ttacctctcc
     1861 tcaagagttc tcaccagcct tagctcccta cggctcttca cttccagctc aggttggaac
     1921 catagtggac tcctcttatg gtgccaccag gtcagtcgct gagaaagagg cagttgcaaa
     1981 tttcacaaat cagaagacca tcagtcaccc ccctgacatg tcagggtgga atccttttgg
     2041 agaagacaat ttttccaagt taacagaaga ggaactgttg gacagagaat ttgacctcct
     2101 aagatcaaac aggctcgggg agagcacacc ctcagataag aatgtagacc cgccccctgc
     2161 tccacatagc cgtcctccgg aggagccttt tgcttccgtc cctttcattt ctcactcagg
     2221 ttctcctgaa aagaaaacgg aacattctcc aaaccagaaa aatatcactg cacacccaac
     2281 caaaaatgga agctcaagtc cgatatgtaa agctggacag aaaacctcag agaatcctgt
     2341 agttaggggt cacgcacaga agggaaatga cgagtctgaa agtgaatttg aatcagaccc
     2401 cccttctccc aagagcagtg aagaagaaca agaggatgaa gacgcacagg gagaacacgg
     2461 ggactttaat gatgaggaca ctgagccaga gaacctgggt cacaggcctc tgctcatgga
     2521 ctccgaagat gaggaggagg acgacaaaca cagctctgac tcggagtgtg aacaggcaaa
     2581 agccaaggga ggagaatcga gctccttgcg cagaaacaaa cctggtggtg ccccggagcc
     2641 tgccagttca cccgcgctga ctcccagtca ggagttcgat gtgttcggtg ctgttccctt
     2701 ctttgcagtg cctgctccag agctgcagca cagagggagt gggaagagcg tctcccagca
     2761 gatgtttcca gagcaggagg aatatgacgt gttcacaaag gcacccttca gcaagaaggt
     2821 caccgtacag gactggcccg ccgtgcggcc agacactcgc cccctgcctg cacgacccag
     2881 aagtgtagac atatttggct ccactccctt tcagccattt tccacagcag ccagtaaaag
     2941 tgaaagcaag gaggatgttt ttgggctcgt gccctttgag gaaataaccg ggagtcagca
     3001 gcagcagcaa aaagtcaagc agcgtagctt gcagaaactg tcctctcgcc agaggcgcac
     3061 gaagcaggat gtgtcgaaaa gcaacgggaa gcggcatcac ggcacaccca ccagcgccaa
     3121 gaagcccctg aagcctccct accgcacacc cgagagggcc cgcaggcaca agagggtggg
     3181 ccgcagagac tcacaaagca gcaatgagtt cttaacaatt tcggactcca aggagaacat
     3241 cagcgtcgcg ctgaccgatg gcaaagacag ggccagcgtc ctgccacccg atgagagtct
     3301 gctggaccct tttggtgcca agccttttca tcctccagac ttgtggcacc agacccatca
     3361 gggcctaagc gacatctgtg tggatcacac cgccattctg cctgggagac cacgacagaa
     3421 ttcagtacat gggtcattcc acagcgcaga cgcattgaga atggatgact ttggtgccgt
     3481 gccctttaca gaactcgtgg tgcagagcgt ctctccgcag cagtcccagc cggtggaatt
     3541 agaccccttc ggtgctgctc cattcccttc taaacagtag acacttcagg tggactcagc
     3601 gatactcctg ttcaaaaaag tatgaatagt tttatgaatc tggaagaaat gtatttgtat
     3661 agttgtttat atcattcact cactctcaca ggttaatcag gataggtgat ttttaaataa
     3721 accaaatgga attatttgta cagggtagta agttgatgcc ttcttcaagc aggagaaggc
     3781 ctaaatcgaa agccaagggc ttttgctact gacagctcag aggttcaccc gtggggcttc
     3841 ctgggaaagc tggtgtgtac cgctagggac aggagagcca tcacttcgga tatcaagatg
     3901 tcacgtaggg gcacacccta gatccagcat ttgaagccag gcaggctgac tgtttccacc
     3961 cacgagggaa gagtctagag tgtgctctcc atacacttct ctgtaaggta gagccacaag
     4021 aaactgacta ttgtgcctaa aaaactgttg cattaaaaac aaaaaaccaa gtgccattaa
     4081 caatggactc tgtgatgata aggatatgaa atgatgtata tattagctca gtctagccct
     4141 tctacggtgt atagagcaag acattacatg gtaatatata tgcggttttt aatctgtcaa
     4201 gaaaaaattt ttacaatgtg gaatgcttaa tagaagccta gaacaaaaat ataaagagaa
     4261 atatctggca tttgaaaaaa aaatgtaaaa gaatgacaca tcaaaaagaa aagcaccatc
     4321 tggtacttga gaaatacttt gtctttgagt gggtatttgc caaaaccttt atcatcatgt
     4381 ccctactgaa gtaccttcat agaaagggga ggggcagggt atatagaaat ttaatttcag
     4441 aaacaatgta gctgaaactt taatttttta aagaagttta caatgtaaaa tcatgttgca
     4501 tttactgaca cactttatga cagcacttcc ctcctccagc agggcagagt cctgggctgc
     4561 agttccttcc ttcagggtga gagggggcag ttctactaca gtgctccagc agtgccaccc
     4621 agtccctcag cactgacagc cagaccctca gtgggtggaa gaactagatg gtgggactag
     4681 gagcttaatt ctgctacccg attgcattga tagtgaaaag aactaaacta ccaaattgcc
     4741 tttaaaatac atcaccagtc ctaatgagaa acttgaaatt ttgtagttgt ggtcagtggt
     4801 aatagttata catcagttaa tgtgaatgta ctgtccgtgc ttcctctgtc tgtcctaagt
     4861 tatgattaga tgtctttaca gatgagcatt cgaagtttct agatcaacag ctattgctat
     4921 tggtagctgt gttttaactt tgccccagtt agtgtccctt aataagtaat cttcttaaaa
     4981 ccttaacttt agtgcccaca gaggacacat catttgccta ctctcagagt tcagaacctg
     5041 gaaagaagtg aaacacaaaa ccaagccgag gtcccttttt atggttgtct cctcctctgc
     5101 cagctcagcc agggtagtgt ggacaggaca ggtcacgtca caccgccacc cagaacaggg
     5161 ctgcaccact taatgtcctt gtgccaaagg cagaggctgt gtttgcacct ttctgtctgg
     5221 ttctcaggtt gattattctc actaatgcaa atggcagtag gccctctacg ctaccgaaca
     5281 gaaatgcttt cctcctaaag taatgagttg tgactatgaa gtcagagttc cactcgcctt
     5341 tcactgcact gaatacttag aagtgattca ctcgcagccc ctccggctaa tgctggacaa
     5401 atccttagga aacagctgtg ccacagccta aaatgtttac attgcctcca acagcccagc
     5461 gggtgacgcg cctctcgaga ccatctcatt ggacagactg tttcactgga ggtccaaggg
     5521 gcggctcctt tgcgttacat tttctcttgc acaagagagc acttagcacc cagcacccag
     5581 cacccagcac ccagcactca ctgaaaggct ggctctgtta tgggacggcc cagttctggt
     5641 ttaaagaatg tcatttgggt gtgccttgtg cttcccagtg tgcaaagcag ttctaactaa
     5701 acctgttaga cttgaacatc gaagggaagt cacgttagga acccagctcg aaagtctgag
     5761 gccaaaggtg tcacctagaa gctttaactg tgctcattaa cttggaatct tttcttaaaa
     5821 agtggactac ttgctttact ttgatcacgt cagcaaaacg ctagtattac cagaggatct
     5881 ttcagggcac ttaagaaatg gatctactaa ggcacagacg ttctcggtat gtagttggag
     5941 aaaaggacta ctccaagttg ggtgagaatg gaaccgacca gaattttaag cactgagtgc
     6001 ccctcccctg agctgtgtac cctgggcatt tatgaagtca cgtggctctc ggatctgcgc
     6061 accttgcgat cagtcctacc ctgtttaaca gggactgact actctcctct tcctgacgga
     6121 aaatacgaag gtggagccag tcttgggtgt gcctcccttg ggttatccag atttgggcac
     6181 ttcactaaag cactgtcaga aggcgcacat gtattaatgt cactacctgt ggggagttag
     6241 gtattatctg tttaatacat gtagaatgcg cagtgaactc tgtcattctt tttcttttat
     6301 ttctaagcaa aactagtcat caatttacat tcagttactg agttgacagt ctactgagtc
     6361 tactgagaga acaacagatg actgttggaa aaaatttaca ctcggtggtg ttctctacta
     6421 agataaaaag acacaggcac atcgaggctc tccactacgg aattaatgtg aatttaaaaa
     6481 ggcaatcgtt tctcttaaga gcattcactc ctagtgacga agtttacaaa agccactaaa
     6541 aggaagaagt agatgaaaat acagagggct gggtctggtt taggttattt ttttttaatt
     6601 aaagttcaca gtgctacagg aagactgatt ttattactat gttctttttg tgactgagag
     6661 atcatcctat actagaagga gtaattgcca cttgttcttt cttttgcggt gctgggaact
     6721 gaacccaggg ccttgcacat gctgggcaag cgctttaggg ctgagccaca cctccagcct
     6781 ggaagagccc tttaattgct ggcaaacggc tttaagtgca ctttctttga ttacacttcc
     6841 tttttttttt tttttttgtt aaacttgaat tttctgaagc cttttatgta ccactaagca
     6901 aataacttta atttttaaat aaactgggtt tatatcctta gttatatttc taattgttat
     6961 aagacatact tgctaaagta acttaagccc tcaaatgtag ccgggaagag tttgagatag
     7021 acttcagtta ctttccctgt acccagtaaa gcactaattt tgttacctta ttgcctttac
     7081 attgcttagt cttgaattct gttcactgtt ttgtttgaga tttaaagtta ttttcttact
     7141 gtatttatca tacctactgt tttaataatc tgccgtcttt aaatgcaata aatcccaaac
     7201 ggatcgctta ttcttcatag ccaatgcctt tggagtttta ttattactat ttgtatcatt
     7261 aaaagtttca tcacaaa
//
