LOCUS       NM_017178               1451 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 2 (Bmp2), mRNA.
ACCESSION   NM_017178
VERSION     NM_017178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Zheng,Z., Wang,D., Zhang,W., Yu,H., Zhang,Y., Feng,T. and Zhong,X.
  TITLE     MiR-20 promotes cartilage repair in knee osteoarthritis rats via
            BMP2/Smad1 signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 256-261 (2023)
   PUBMED   38063098
  REMARK    GeneRIF: MiR-20 promotes cartilage repair in knee osteoarthritis
            rats via BMP2/Smad1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Deng,J., Zhao,H.J., Zhong,Y., Hu,C., Meng,J., Wang,C., Lan,X.,
            Wang,X., Chen,Z.J., Yan,J., Wang,W. and Li,Y.
  TITLE     H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement
            compensates for shallow trophoblast invasion in preeclampsia
  JOURNAL   EBioMedicine 93, 104664 (2023)
   PUBMED   37331163
  REMARK    GeneRIF: H3K27me3-modulated Hofbauer cell BMP2 signalling
            enhancement compensates for shallow trophoblast invasion in
            preeclampsia.
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Wang,M., Qiu,Y., Gao,L., Qi,F. and Bi,L.
  TITLE     The impact of IGF-1 on alveolar bone remodeling and BMP-2
            expression in orthodontic tooth movement in diabetic rats
  JOURNAL   Adv Clin Exp Med 32 (3), 349-356 (2023)
   PUBMED   36421043
  REMARK    GeneRIF: The impact of IGF-1 on alveolar bone remodeling and BMP-2
            expression in orthodontic tooth movement in diabetic rats.
REFERENCE   4  (bases 1 to 1451)
  AUTHORS   Manzano-Lista,F.J., Sanz-Gomez,M., Gonzalez-Moreno,D.,
            Vega-Martin,E., Gil-Ortega,M., Schulz,A., Rubio,M.A.,
            Ruiz-Hurtado,G., Ruilope,L.M., Aranguez,I., Kreutz,R. and
            Fernandez-Alfonso,M.S.
  TITLE     Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with
            Renal and Cardiovascular Damage in Chronic Kidney Disease
  JOURNAL   Int J Mol Sci 24 (1), 40 (2022)
   PUBMED   36613483
  REMARK    GeneRIF: Imbalance in Bone Morphogenic Proteins 2 and 7 Is
            Associated with Renal and Cardiovascular Damage in Chronic Kidney
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1451)
  AUTHORS   Howard,M.T., Wang,S., Berger,A.G., Martin,J.R.,
            Jalili-Firoozinezhad,S., Padera,R.F. and Hammond,P.T.
  TITLE     Sustained release of BMP-2 using self-assembled layer-by-layer
            film-coated implants enhances bone regeneration over burst release
  JOURNAL   Biomaterials 288, 121721 (2022)
   PUBMED   35981926
  REMARK    GeneRIF: Sustained release of BMP-2 using self-assembled
            layer-by-layer film-coated implants enhances bone regeneration over
            burst release.
REFERENCE   6  (bases 1 to 1451)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   7  (bases 1 to 1451)
  AUTHORS   Begue-Kirn,C., Smith,A.J., Loriot,M., Kupferle,C., Ruch,J.V. and
            Lesot,H.
  TITLE     Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin,
            osteonectin and bone sialoprotein gene expression during normal and
            in vitro-induced odontoblast differentiation
  JOURNAL   Int J Dev Biol 38 (3), 405-420 (1994)
   PUBMED   7848824
REFERENCE   8  (bases 1 to 1451)
  AUTHORS   Ohta,S., Hiraki,Y., Shigeno,C., Suzuki,F., Kasai,R., Ikeda,T.,
            Kohno,H., Lee,K., Kikuchi,H., Konishi,J. et al.
  TITLE     Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase
            expression of the proto-oncogene c-fos in murine osteoblastic
            MC3T3-E1 cells
  JOURNAL   FEBS Lett 314 (3), 356-360 (1992)
   PUBMED   1468569
REFERENCE   9  (bases 1 to 1451)
  AUTHORS   Kaplan,F.S., Tabas,J.A. and Zasloff,M.A.
  TITLE     Fibrodysplasia ossificans progressiva: a clue from the fly?
  JOURNAL   Calcif Tissue Int 47 (2), 117-125 (1990)
   PUBMED   2117991
  REMARK    Review article
REFERENCE   10 (bases 1 to 1451)
  AUTHORS   Wozney,J.M., Rosen,V., Celeste,A.J., Mitsock,L.M., Whitters,M.J.,
            Kriz,R.W., Hewick,R.M. and Wang,E.A.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_017178.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z25868.1, L20678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000003.1  141265524-141265767
            245-594             JAXUCZ010000003.1  141266820-141267169
            595-1451            JAXUCZ010000003.1  141273381-141274237
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1451
                     /gene="Bmp2"
                     /note="bone morphogenetic protein 2"
                     /db_xref="GeneID:29373"
                     /db_xref="RGD:2211"
     exon            1..244
                     /gene="Bmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..594
                     /gene="Bmp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1436
                     /gene="Bmp2"
                     /note="BMP-2; BMP-2A; bone morphogenetic protein 2A"
                     /codon_start=1
                     /product="bone morphogenetic protein 2 precursor"
                     /protein_id="NP_058874.2"
                     /db_xref="GeneID:29373"
                     /db_xref="RGD:2211"
                     /translation="MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAGASGRPLSRP
                     SDDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGAPAPDHRLERAA
                     SRANTVRSFHHEEAIEELPEMSGKTSRRFFFNLSSVPTDEFLTSAELQIFREQMQEAL
                     GNSSFQHRINIYEIIKPATASSKFPVTRLLDTRLVTQNTSQWESFDVTPAVMRWTAQG
                     HTNHGFVVEVAHLEEKPGVSKRHVRISRSLHQDEHSWSQVRPLLVTFGHDGKGHPLHK
                     REKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADH
                     LNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCG
                     CR"
     exon            595..1451
                     /gene="Bmp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcccggcg gatccagtct tgccgccgcc tccagcccgg tcacctctct gttccttggc
       61 cggctgggcc caccccaaga cacggttccc ttcggggaga acacccggag aaggaggagg
      121 tgaagaaagg caacagaagc ccagtcgctg ctccaggtcc ctcggacaga gctttttcca
      181 tgtggagact ctctcaatgg acgtgccccc tagtgcttct tagacggact gcggtctcct
      241 aaaggtcgac catggtggcc gggacccgct gtcttctagt gttgctgctt ccccaggtcc
      301 tcctgggcgg cgcggccggc ctcattccgg agctgggccg caagaagttc gccggggcat
      361 ccggccgccc cttgtcccgg ccttcggacg acgtcctcag cgagtttgag ttgaggctgc
      421 tcagcatgtt tggcctgaag cagagaccca cccccagcaa ggacgtcgtg gtgcccccct
      481 atatgctcga cctgtaccgc cggcactcgg gccagccagg agcgcccgcc ccagaccacc
      541 ggctggagag ggcagccagc cgcgccaaca ccgtgcgcag cttccatcac gaagaagcca
      601 tcgaggaact tccagaaatg agtgggaaaa cgtcccgacg cttcttcttc aatttaagtt
      661 ctgtccctac tgatgagttt ctcacatctg cggagctcca gatttttcgg gaacaaatgc
      721 aggaagcttt gggaaatagt agtttccagc accgaattaa tatttatgaa attataaagc
      781 ctgccacagc cagctcaaaa tttcctgtga ccagactatt ggacaccagg ttagtgactc
      841 agaacacaag tcagtgggag agctttgatg tcaccccggc tgtgatgcga tggacagcac
      901 agggacacac caaccatggg tttgtggtgg aagtggccca cttagaggag aagccaggtg
      961 tctccaagag acatgtgagg attagcaggt ctttgcacca agatgaacac agctggtctc
     1021 aggtaagacc actgctagtg acttttggcc acgacggaaa aggacatcca ctccacaaac
     1081 gagaaaagcg tcaagccaaa cacaaacagc ggaagcgtct taagtccagc tgcaaaaggc
     1141 accctttgta tgtggacttc agtgatgtgg ggtggaatga ctggatcgtg gcccctccag
     1201 gctatcatgc cttttactgc catggggaat gtccttttcc cctggctgat cacctgaact
     1261 ccaccaacca tgccatagtg cagactctgg taaactctgt gaattccaaa atccctaagg
     1321 catgctgtgt ccccactgag cttagcgcaa tctccatgtt gtacctagat gaaaacgaaa
     1381 aggttgtgct aaaaaactat caggacatgg ttgtggaggg ttgcgggtgt cgctagcaca
     1441 gcaagaacaa a
//
