LOCUS       NM_001031824            1266 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 10 (Bmp10), mRNA.
ACCESSION   NM_001031824 XM_575595
VERSION     NM_001031824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Hirono,K., Saito,K., Munkhsaikhan,U., Xu,F., Wang,C., Lu,L.,
            Ichida,F., Towbin,J.A. and Purevjav,E.
  TITLE     Familial Left Ventricular Non-Compaction Is Associated With a Rare
            p.V407I Variant in Bone Morphogenetic Protein 10
  JOURNAL   Circ J 83 (8), 1737-1746 (2019)
   PUBMED   31243186
  REMARK    GeneRIF: W143*-NRG1and V470I-BMP10 variants are associated with
            left ventricular non-compaction.
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Sun,L., Yu,J., Qi,S., Hao,Y., Liu,Y. and Li,Z.
  TITLE     Bone morphogenetic protein-10 induces cardiomyocyte proliferation
            and improves cardiac function after myocardial infarction
  JOURNAL   J Cell Biochem 115 (11), 1868-1876 (2014)
   PUBMED   24906204
  REMARK    GeneRIF: These data indicated that BMP10 stimulated cardiomyocyte
            proliferation and repaired cardiac function after heart injury.
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Yan,Y., Gong,P., Jin,W., Xu,J., Wu,X., Xu,T., Hang,Q., Fu,H.,
            Kei,K. and Gao,Y.
  TITLE     The cell-specific upregulation of bone morphogenetic protein-10
            (BMP-10) in a model of rat cortical brain injury
  JOURNAL   J Mol Histol 43 (5), 543-552 (2012)
   PUBMED   22797972
  REMARK    GeneRIF: the present data suggested that BMP-10 may be implicated
            in CNS pathophysiology after traumatic brain injury
REFERENCE   4  (bases 1 to 1266)
  AUTHORS   Somekawa,S., Imagawa,K., Hayashi,H., Sakabe,M., Ioka,T., Sato,G.E.,
            Inada,K., Iwamoto,T., Mori,T., Uemura,S., Nakagawa,O. and Saito,Y.
  TITLE     Tmem100, an ALK1 receptor signaling-dependent gene essential for
            arterial endothelium differentiation and vascular morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12064-12069 (2012)
   PUBMED   22783020
REFERENCE   5  (bases 1 to 1266)
  AUTHORS   Seemann,P., Brehm,A., Konig,J., Reissner,C., Stricker,S., Kuss,P.,
            Haupt,J., Renninger,S., Nickel,J., Sebald,W., Groppe,J.C.,
            Ploger,F., Pohl,J., Schmidt-von Kegler,M., Walther,M., Gassner,I.,
            Rusu,C., Janecke,A.R., Dathe,K. and Mundlos,S.
  TITLE     Mutations in GDF5 reveal a key residue mediating BMP inhibition by
            NOGGIN
  JOURNAL   PLoS Genet 5 (11), e1000747 (2009)
   PUBMED   19956691
REFERENCE   6  (bases 1 to 1266)
  AUTHORS   Chen,H., Yong,W., Ren,S., Shen,W., He,Y., Cox,K.A., Zhu,W., Li,W.,
            Soonpaa,M., Payne,R.M., Franco,D., Field,L.J., Rosen,V., Wang,Y.
            and Shou,W.
  TITLE     Overexpression of bone morphogenetic protein 10 in myocardium
            disrupts cardiac postnatal hypertrophic growth
  JOURNAL   J Biol Chem 281 (37), 27481-27491 (2006)
   PUBMED   16798733
REFERENCE   7  (bases 1 to 1266)
  AUTHORS   Mazerbourg,S., Sangkuhl,K., Luo,C.W., Sudo,S., Klein,C. and
            Hsueh,A.J.
  TITLE     Identification of receptors and signaling pathways for orphan bone
            morphogenetic protein/growth differentiation factor ligands based
            on genomic analyses
  JOURNAL   J Biol Chem 280 (37), 32122-32132 (2005)
   PUBMED   16049014
REFERENCE   8  (bases 1 to 1266)
  AUTHORS   Tsuji,A.B., Sugyo,A., Ogiu,T., Sagara,M., Kimura,T., Ishikawa,A.,
            Sudo,H., Ohtsuki,M., Aburatani,H., Imai,T. and Harada,Y.N.
  TITLE     Fine mapping of radiation susceptibility and gene expression
            analysis of LEC congenic rat lines
  JOURNAL   Genomics 86 (3), 271-279 (2005)
   PUBMED   15978772
REFERENCE   9  (bases 1 to 1266)
  AUTHORS   Chen,H., Shi,S., Acosta,L., Li,W., Lu,J., Bao,S., Chen,Z., Yang,Z.,
            Schneider,M.D., Chien,K.R., Conway,S.J., Yoder,M.C., Haneline,L.S.,
            Franco,D. and Shou,W.
  TITLE     BMP10 is essential for maintaining cardiac growth during murine
            cardiogenesis
  JOURNAL   Development 131 (9), 2219-2231 (2004)
   PUBMED   15073151
REFERENCE   10 (bases 1 to 1266)
  AUTHORS   Neuhaus,H., Rosen,V. and Thies,R.S.
  TITLE     Heart specific expression of mouse BMP-10 a novel member of the
            TGF-beta superfamily
  JOURNAL   Mech Dev 80 (2), 181-184 (1999)
   PUBMED   10072785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB158417.1.
            
            On Aug 19, 2005 this sequence version replaced XM_575595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB158417.1, AB158418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344/DuCrj"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1266
                     /gene="Bmp10"
                     /note="bone morphogenetic protein 10"
                     /db_xref="GeneID:500245"
                     /db_xref="RGD:1562986"
     CDS             1..1266
                     /gene="Bmp10"
                     /note="BMP-10"
                     /codon_start=1
                     /product="bone morphogenetic protein 10 precursor"
                     /protein_id="NP_001026994.1"
                     /db_xref="GeneID:500245"
                     /db_xref="RGD:1562986"
                     /translation="MGSLVLPLSAVFCLVARLASGSPIMGLEQSPLEEDMPFFDDIFT
                     EQDGIDFNTLLQSMKDEFLKTLNLSDIPPQDTGRVDPPEYMLELYNKFATDRTSMPSA
                     NIIRSFKNEDLFSQPVSFNGIRKYPLLFNVSIPHHEEVVMAELRLYTLVQRDRLMYDG
                     VDRKIIIFEVLESADGSEDERSMLVLVSTEIYGTNSEWETFDITDATRRWQKSGPSTH
                     QLEIHIESRQNQAEDTGRGQLEIDMSAQNKHDPLLVVFSDDQSGDKEQKEELNELISH
                     EQDLDLGTDGFFGGPDEEALLQMRSNMIDDSTARIRRNAKGNYCKKTPLYIDFKEIGW
                     DSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLD
                     PISILYLDKGVVTYKFKYEGMAVSECGCR"
     exon            1..334
                     /gene="Bmp10"
                     /inference="alignment:Splign:2.1.0"
     exon            335..1266
                     /gene="Bmp10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggttctc tggttctgcc gctgagcgcc gtcttctgcc tggtggctcg tctggcttct
       61 ggcagcccca tcatgggcct tgagcagtcg cccctggaag aagacatgcc cttctttgat
      121 gatatcttca cagaacaaga tggtattgac ttcaacacac tgctgcagag catgaaggac
      181 gagtttctca agacgttgaa tctgtcagac attcccccac aggacacagg cagagtggat
      241 ccgccggagt acatgctgga gctctacaac aaattcgcca cggaccggac ctccatgcca
      301 tctgctaaca tcatccggag cttcaagaat gaagatctgt tttctcaacc agtcagtttc
      361 aatgggatcc ggaagtatcc tctcctcttc aacgtgtcca tccctcacca cgaagaggtc
      421 gtcatggctg aactgaggtt gtacacgctg gtgcagagag atcgtttgat gtatgatggt
      481 gtggaccgta aaataatcat ctttgaggtt ctagagagtg ccgatggtag cgaggatgag
      541 aggagcatgc tggtcttggt atcaacggag atctacggaa ccaacagtga gtgggagaca
      601 tttgacatca cggatgccac cagacgttgg caaaagtcag gcccatcaac ccaccagctg
      661 gagatccaca tcgaaagcag acaaaaccaa gctgaggaca ccggaagggg acaactggaa
      721 atagatatga gtgctcagaa taagcacgac cctttgcttg ttgtgttttc tgatgaccaa
      781 agcggtgaca aggagcagaa agaagagctg aatgaactga tctcccacga gcaggatctg
      841 gacctgggca ccgatggttt ctttggtggg cctgatgaag aggctctcct gcagatgagg
      901 tcaaacatga tcgatgactc taccgctcgg atcaggagga acgccaaggg gaactactgc
      961 aagaagactc cactgtacat cgacttcaag gagatcggct gggactcctg gatcatcgcg
     1021 cctcctggtt acgaggccta tgagtgccgc ggtgtgtgca actaccctct ggcggagcac
     1081 ctcacaccta cgaaacacgc aattatccag gccttggtcc acctcaagaa ttcccagaaa
     1141 gcctccaaag cctgctgcgt gcccacgaag ctggatccca tctccatcct ctatttagat
     1201 aaaggtgttg tcacctataa gtttaaatac gaaggaatgg ccgtgtctga atgtggctgt
     1261 agatag
//
