LOCUS       NM_031323               3647 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 1 (Bmp1), mRNA.
ACCESSION   NM_031323 XM_001070483 XM_001070524 XM_001075543 XM_573814
VERSION     NM_031323.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3647)
  AUTHORS   Hasegawa,T., Kamada,Y., Hosoya,T., Fujita,S., Nishiyama,Y.,
            Iwata,N., Hiramatsu,Y. and Otsuka,F.
  TITLE     A regulatory role of androgen in ovarian steroidogenesis by rat
            granulosa cells
  JOURNAL   J Steroid Biochem Mol Biol 172, 160-165 (2017)
   PUBMED   28684382
  REMARK    GeneRIF: Collectively, the results indicate that androgen and IGF-I
            mutually interact and accelerate progesterone production, at least
            in part, by regulating endogenous BMP signaling in rat granulosa
            cells.
REFERENCE   2  (bases 1 to 3647)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 3647)
  AUTHORS   Sautter,N.B., Delaney,K.L., Hausman,F.A. and Trune,D.R.
  TITLE     Tissue remodeling in the acute otitis media mouse model
  JOURNAL   Int J Pediatr Otorhinolaryngol 75 (11), 1368-1371 (2011)
   PUBMED   21889218
REFERENCE   4  (bases 1 to 3647)
  AUTHORS   Grgurevic,L., Macek,B., Healy,D.R., Brault,A.L., Erjavec,I.,
            Cipcic,A., Grgurevic,I., Rogic,D., Galesic,K., Brkljacic,J.,
            Stern-Padovan,R., Paralkar,V.M. and Vukicevic,S.
  TITLE     Circulating bone morphogenetic protein 1-3 isoform increases renal
            fibrosis
  JOURNAL   J Am Soc Nephrol 22 (4), 681-692 (2011)
   PUBMED   21415150
  REMARK    GeneRIF: Circulating bone morphogenetic protein 1-3 isoform
            increases renal fibrosis.
REFERENCE   5  (bases 1 to 3647)
  AUTHORS   Berry,R., Jowitt,T.A., Ferrand,J., Roessle,M., Grossmann,J.G.,
            Canty-Laird,E.G., Kammerer,R.A., Kadler,K.E. and Baldock,C.
  TITLE     Role of dimerization and substrate exclusion in the regulation of
            bone morphogenetic protein-1 and mammalian tolloid
  JOURNAL   Proc Natl Acad Sci U S A 106 (21), 8561-8566 (2009)
   PUBMED   19429706
REFERENCE   6  (bases 1 to 3647)
  AUTHORS   Nahar,N.N., Missana,L.R., Garimella,R., Tague,S.E. and
            Anderson,H.C.
  TITLE     Matrix vesicles are carriers of bone morphogenetic proteins (BMPs),
            vascular endothelial growth factor (VEGF), and noncollagenous
            matrix proteins
  JOURNAL   J Bone Miner Metab 26 (5), 514-519 (2008)
   PUBMED   18758911
REFERENCE   7  (bases 1 to 3647)
  AUTHORS   Zhang,Y., Ge,G. and Greenspan,D.S.
  TITLE     Inhibition of bone morphogenetic protein 1 by native and altered
            forms of alpha2-macroglobulin
  JOURNAL   J Biol Chem 281 (51), 39096-39104 (2006)
   PUBMED   17071617
  REMARK    GeneRIF: bone morphogenetic protein 1 is inhibited by native and
            altered forms of alpha2-macroglobulin
REFERENCE   8  (bases 1 to 3647)
  AUTHORS   Jasuja,R., Voss,N., Ge,G., Hoffman,G.G., Lyman-Gingerich,J.,
            Pelegri,F. and Greenspan,D.S.
  TITLE     bmp1 and mini fin are functionally redundant in regulating
            formation of the zebrafish dorsoventral axis
  JOURNAL   Mech Dev 123 (7), 548-558 (2006)
   PUBMED   16824737
REFERENCE   9  (bases 1 to 3647)
  AUTHORS   Steiglitz,B.M., Keene,D.R. and Greenspan,D.S.
  TITLE     PCOLCE2 encodes a functional procollagen C-proteinase enhancer
            (PCPE2) that is a collagen-binding protein differing in
            distribution of expression and post-translational modification from
            the previously described PCPE1
  JOURNAL   J Biol Chem 277 (51), 49820-49830 (2002)
   PUBMED   12393877
REFERENCE   10 (bases 1 to 3647)
  AUTHORS   Wozney,J.M., Rosen,V., Celeste,A.J., Mitsock,L.M., Whitters,M.J.,
            Kriz,R.W., Hewick,R.M. and Wang,E.A.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_573814.2, XM_001075543.1, XM_001070524.1, XM_001070483.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.49101.1,
                                           SRR26643290.46632.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               JAXUCZ010000015.1  52005201-52005485   c
            286-399             JAXUCZ010000015.1  51997075-51997188   c
            400-564             JAXUCZ010000015.1  51994075-51994239   c
            565-682             JAXUCZ010000015.1  51993785-51993902   c
            683-861             JAXUCZ010000015.1  51993331-51993509   c
            862-967             JAXUCZ010000015.1  51992809-51992914   c
            968-1092            JAXUCZ010000015.1  51990752-51990876   c
            1093-1208           JAXUCZ010000015.1  51990109-51990224   c
            1209-1311           JAXUCZ010000015.1  51981052-51981154   c
            1312-1428           JAXUCZ010000015.1  51978760-51978876   c
            1429-1574           JAXUCZ010000015.1  51978415-51978560   c
            1575-1770           JAXUCZ010000015.1  51978081-51978276   c
            1771-1896           JAXUCZ010000015.1  51977327-51977452   c
            1897-2057           JAXUCZ010000015.1  51976558-51976718   c
            2058-2238           JAXUCZ010000015.1  51976029-51976209   c
            2239-2364           JAXUCZ010000015.1  51972394-51972519   c
            2365-2492           JAXUCZ010000015.1  51966660-51966787   c
            2493-2706           JAXUCZ010000015.1  51966075-51966288   c
            2707-2957           JAXUCZ010000015.1  51964419-51964669   c
            2958-3647           JAXUCZ010000015.1  51961310-51961999   c
FEATURES             Location/Qualifiers
     source          1..3647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..3647
                     /gene="Bmp1"
                     /note="bone morphogenetic protein 1"
                     /db_xref="GeneID:83470"
                     /db_xref="RGD:620739"
     exon            1..285
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..3092
                     /gene="Bmp1"
                     /EC_number="3.4.24.19"
                     /note="procollagen C-proteinase"
                     /codon_start=1
                     /product="bone morphogenetic protein 1 precursor"
                     /protein_id="NP_112613.1"
                     /db_xref="GeneID:83470"
                     /db_xref="RGD:620739"
                     /translation="MPGVARPPLPLLSLPLLLLLLLPRAGRPLDLADYTYDLGEEDAP
                     ELLNYKDPCKAAAFLGDIALDEEDLRAFRVQQAAVLRQQTAQRSSIKAAGNSSALGRQ
                     STSGQPQRGSRGRWRSRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMR
                     HWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHE
                     LGHVIGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHY
                     ARNTFSRGIFLDTIVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDST
                     GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFWR
                     KAPLRGRFCGGKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDNGHI
                     QSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSN
                     LIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQR
                     CLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQ
                     LVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQY
                     NNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLH
                     DNKHDCKEAGCEHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFVEMDI
                     ESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGNRMFLRFYSDNSVQRKGF
                     QASHSTECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFE
                     VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTISKKG
                     FHLRYTSTKFQDTLHSRK"
     exon            286..399
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..564
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..682
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..861
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..967
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1092
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1208
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1311
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1428
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1574
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1770
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1896
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2057
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2238
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2364
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2492
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2706
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2957
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3647
                     /gene="Bmp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaacggga cgggaagagg tggcctcggg gggagagcgc ctccccttcg ccttcagcgc
       61 tcccttcccg gtcgccccgc tcccgcgtcc gggcgcgacc gccaccgctg cccgccagca
      121 tgcccggcgt ggcccgcccg ccgctgccgc tgctgtcgct gccactgctg ctactgctgc
      181 tgctcccgcg cgccggccgg ccgctggact tggccgacta cacctacgac ctgggcgagg
      241 aggacgcccc ggagctcctc aactacaaag acccctgcaa ggcggctgcc tttcttgggg
      301 acattgccct ggatgaggag gacttgaggg ccttccgggt gcagcaggct gcagttctca
      361 gacaacaaac agcccagagg tcgtccatca aagctgcagg gaactcttct gccctgggta
      421 gacagagcac gagtgggcag ccgcagaggg gaagcagagg cagatggaga agcaggcctc
      481 ggagcaggcg ggcagcgaca tccagaccag agcgagtgtg gcccgatggg gtcatcccat
      541 ttgtcatcgg agggaatttc actggcagcc agagggcagt cttccggcag gccatgagac
      601 actgggagaa gcatacctgt gtcaccttct tggagcgcac agatgaggac agctatattg
      661 tattcaccta ccgaccctgc gggtgctgct cctacgtggg tcgccgaggt gggggccccc
      721 aggccatctc catcggcaag aactgtgaca agtttggcat cgtggtccat gagctgggcc
      781 atgtcattgg cttctggcac gagcacacgc ggcccgaccg ggaccgccat gtctctattg
      841 tacgggagaa catacagcca gggcaggagt ataacttctt gaagatggaa gttcaggaag
      901 tcgagtcctt gggagagacc tatgactttg acagtatcat gcactatgcc cggaacacgt
      961 tctccagggg catcttcctg gacaccattg ttcccaagta tgaggtgaat ggggtgaagc
     1021 cttccattgg ccaaaggacc cgactcagca agggggacat cgctcaggcc cggaagctct
     1081 acaaatgccc agcctgtggt gagaccctcc aagacagcac tggcaacttc tcctcccctg
     1141 agtatcccaa tggctactct gcccacatgc actgtgtatg gcgtatctct gtcacaccgg
     1201 gggagaagat tattctgaac ttcacatcta tggacctgta ccgtagccgc ctgtgctggt
     1261 atgactatgt ggaggtgcgg gatggcttct ggagaaaggc gcccctccga ggccggttct
     1321 gtggggggaa actccccgag cccattgtct ccaccgacag ccgcctctgg gtggaattcc
     1381 gaagcagcag caattgggtt ggaaagggct tctttgctgt ctacgaagcc atttgcggtg
     1441 gtgacgtgaa aaaggataac ggtcacatcc agtcacccaa ttaccccgac gattaccggc
     1501 ccagcaaagt ctgcatctgg cggatccagg tgtctgaggg tttccacgtg ggcctcacgt
     1561 tccagtcctt tgagatcgag cgtcacgaca gttgtgccta cgactacctg gaggtccgag
     1621 atgggcacag tgagagcagc aacctcattg ggcgatattg tgggtatgag aagcctgatg
     1681 acatcaaaag cacatctagt cggctctggc tcaagttcgt ctccgatggg tccattaaca
     1741 aagctggctt tgcagtcaac tttttcaaag aggtagatga gtgttcaagg cccaaccgcg
     1801 ggggctgtga gcagcggtgc ctaaacaccc tgggcagcta caagtgcagc tgtgaccccg
     1861 gctatgagct ggccccagac aagcgtcggt gtgaagctgc ctgcggtgga ttcctcacca
     1921 agctcaatgg ctccatcacc agccccggtt ggcccaaaga gtaccctccc aacaaaaact
     1981 gcatctggca gttggtggcc cccacccagt accgtatctc cctgcaattt gacttcttcg
     2041 agactgaggg caatgatgtg tgcaagtatg atttcgtgga ggtgcgcagc ggactcacag
     2101 ccgactctaa actacatggc aagttctgtg gctccgagaa accagaggtc atcacttccc
     2161 agtacaacaa catgcgtgtg gagttcaagt ctgacaatac tgtgtccaaa aagggcttca
     2221 aggcccactt cttctcagac aaggatgaat gttccaagga caatggtggc tgccagcaag
     2281 actgcgtgaa cacatttggc agctacgagt gtcagtgtcg cagcggcttt gtccttcacg
     2341 acaacaaaca tgactgtaag gaagccggct gtgagcacaa agtgacatcc accagtggca
     2401 ccatcaccag ccccaactgg cctgacaagt accccagcaa gaaggagtgt acgtgggcta
     2461 tctccagcac ccctgggcac cgggtgaagc tgacttttgt ggagatggat attgagtctc
     2521 agcctgaatg cgcttatgac cacctggagg tgtttgatgg gcgtgatgcc aaggcgccag
     2581 tccttggccg attctgtggc agtaagaagc ctgagccagt cctggctacc ggcaaccgca
     2641 tgttcttgcg cttctactca gacaactcag tacagaggaa aggtttccag gcctcccact
     2701 ccacagagtg tgggggccaa gtgcgggcag atgtgaagac caaagacctt tattcccatg
     2761 cccagtttgg tgataacaac taccccggag gggtggactg cgagtgggtg attgtggcag
     2821 aggaaggcta tggcgtggag ttggtgttcc agaccttcga ggtagaggag gagaccgact
     2881 gtggctatga ctacatggag ctcttcgacg gctacgacag cacagctcct agactggggc
     2941 gctactgtgg ctctgggcct cctgaggaag tgtactcggc cggagactct gtcctggtga
     3001 agttccactc tgatgacacc atctccaaga aaggctttca cctgcggtac acaagcacca
     3061 agttccagga cacactccac agcaggaagt gaccatggct cccgctcagt agtgggaact
     3121 ggagtcctgc ttccctagat cacccagact ggacaacggg ggacgggggg tgacaggcag
     3181 atggtgatgc attgtccctc acccccaggc accaggacct actgggccag tgggccaggc
     3241 gtcgtcagga ggtaggagac ttggactcct taagccagtc tcccactgcc tcctgtcagt
     3301 gggccaggga accagagctt ccaccaagac acttgaagtg accattcctc cttggggccc
     3361 tgcctggggt aagacagtct ctatgcagga ccctgcggcc ttccctacac gctgtattgt
     3421 gtagagccgg tggccctaat cttcattgta atgtacattt cctgcccctt ctccagcctt
     3481 gatttgattt tattttgacc caccgcttcc atgctttctg ggtacccctc agagctgtgg
     3541 tggggagttg gagaagaggg agtggataag taagacaggg cttctcttag gctcactggc
     3601 cacaccaggg caccccaacc aataaacaga aagtgttaca gccaata
//
