LOCUS       NM_001107368            1222 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus BMI1 proto-oncogene, polycomb ring finger (Bmi1),
            mRNA.
ACCESSION   NM_001107368 XM_001073733 XM_225606
VERSION     NM_001107368.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1222)
  AUTHORS   Takebe,H., Irie,K. and Hosoya,A.
  TITLE     Localization of Bmi1 in osteoblast-lineage cells during
            endochondral ossification
  JOURNAL   Anat Rec (Hoboken) 305 (5), 1112-1118 (2022)
   PUBMED   34101367
  REMARK    GeneRIF: Localization of Bmi1 in osteoblast-lineage cells during
            endochondral ossification.
REFERENCE   2  (bases 1 to 1222)
  AUTHORS   Hu,Q., Wu,T., Chen,X., Li,H., Du,Z., Hao,Y., Peng,J., Tai,S.,
            Song,M. and Cheng,B.
  TITLE     The poor outcome of second primary oral squamous cell carcinoma is
            attributed to Bmi1 upregulation
  JOURNAL   Cancer Med 7 (4), 1056-1069 (2018)
   PUBMED   29479858
  REMARK    GeneRIF: In a rat model of radiotherapy-induced mucositis, Bmi1
            upregulation was observed 8 days after irradiation. Consistently,
            Bmi1 was upregulated in HaCaT cells 1 h after irradiation, and its
            upregulation was in accord with X-ray exposure duration. the
            prognosis of s-OSCC is poorer as compared to p-OSCC, which may be
            attributed to Bmi1 upregulation.
REFERENCE   3  (bases 1 to 1222)
  AUTHORS   Poon,V.Y., Gu,M., Ji,F., VanDongen,A.M. and Fivaz,M.
  TITLE     miR-27b shapes the presynaptic transcriptome and influences
            neurotransmission by silencing the polycomb group protein Bmi1
  JOURNAL   BMC Genomics 17 (1), 777 (2016)
   PUBMED   27716060
  REMARK    GeneRIF: We conclude that silencing of Bmi1 by miR-27b relieves
            repression of the presynaptic transcriptome and supports
            neurotransmission in cortical networks.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1222)
  AUTHORS   Wu,W.R., Sun,H., Zhang,R., Yu,X.H., Shi,X.D., Zhu,M.S., Zeng,H.,
            Yan,L.X., Xu,L.B. and Liu,C.
  TITLE     Methylation-associated silencing of miR-200b facilitates human
            hepatocellular carcinoma progression by directly targeting BMI1
  JOURNAL   Oncotarget 7 (14), 18684-18693 (2016)
   PUBMED   26919246
REFERENCE   5  (bases 1 to 1222)
  AUTHORS   Taherbhoy,A.M., Huang,O.W. and Cochran,A.G.
  TITLE     BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
  JOURNAL   Nat Commun 6, 7621 (2015)
   PUBMED   26151332
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1222)
  AUTHORS   Koga,H., Matsui,S., Hirota,T., Takebayashi,S., Okumura,K. and
            Saya,H.
  TITLE     A human homolog of Drosophila lethal(3)malignant brain tumor
            (l(3)mbt) protein associates with condensed mitotic chromosomes
  JOURNAL   Oncogene 18 (26), 3799-3809 (1999)
   PUBMED   10445843
REFERENCE   7  (bases 1 to 1222)
  AUTHORS   Alkema,M.J., Jacobs,J., Voncken,J.W., Jenkins,N.A., Copeland,N.G.,
            Satijn,D.P., Otte,A.P., Berns,A. and van Lohuizen,M.
  TITLE     MPc2, a new murine homolog of the Drosophila polycomb protein is a
            member of the mouse polycomb transcriptional repressor complex
  JOURNAL   J Mol Biol 273 (5), 993-1003 (1997)
   PUBMED   9367786
REFERENCE   8  (bases 1 to 1222)
  AUTHORS   Schoorlemmer,J., Marcos-Gutierrez,C., Were,F., Martinez,R.,
            Garcia,E., Satijn,D.P., Otte,A.P. and Vidal,M.
  TITLE     Ring1A is a transcriptional repressor that interacts with the
            Polycomb-M33 protein and is expressed at rhombomere boundaries in
            the mouse hindbrain
  JOURNAL   EMBO J 16 (19), 5930-5942 (1997)
   PUBMED   9312051
REFERENCE   9  (bases 1 to 1222)
  AUTHORS   van der Lugt,N.M., Alkema,M., Berns,A. and Deschamps,J.
  TITLE     The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene
            expression
  JOURNAL   Mech Dev 58 (1-2), 153-164 (1996)
   PUBMED   8887324
REFERENCE   10 (bases 1 to 1222)
  AUTHORS   van der Lugt,N.M., Domen,J., Linders,K., van Roon,M.,
            Robanus-Maandag,E., te Riele,H., van der Valk,M., Deschamps,J.,
            Sofroniew,M., van Lohuizen,M. et al.
  TITLE     Posterior transformation, neurological abnormalities, and severe
            hematopoietic defects in mice with a targeted deletion of the bmi-1
            proto-oncogene
  JOURNAL   Genes Dev 8 (7), 757-769 (1994)
   PUBMED   7926765
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168209.1.
            
            On Aug 10, 2008 this sequence version replaced NM_001107368.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1222
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /note="BMI1 proto-oncogene, polycomb ring finger"
                     /db_xref="GeneID:307151"
                     /db_xref="RGD:1307403"
     exon            1..67
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            68..198
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1061
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /note="polycomb group ring finger 4; B lymphoma Mo-MLV
                     insertion region 1; Bmi1 polycomb ring finger oncogene"
                     /codon_start=1
                     /product="polycomb complex protein BMI-1"
                     /protein_id="NP_001100838.1"
                     /db_xref="GeneID:307151"
                     /db_xref="RGD:1307403"
                     /translation="MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIV
                     RYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHP
                     SADAANGSNEDRGEVADEDRRVIADDEIISLSIEFFHPSRSDRKVTKEKPKEEVNDKR
                     YLRCPAALTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGP
                     LPLKYRVRPTCKRMKMSQQRDGLTAAGELESDSGSDKANSPAGGAPSTSSCLPSPSTP
                     VQSPHPQFPHISSTMNGTSNSPSGNHQSSFASRPRKSSVNGSSATSSG"
     exon            199..295
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            296..351
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            352..402
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            403..511
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            512..551
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            552..650
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            651..731
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1131
                     /gene="Bmi1"
                     /gene_synonym="Pcgf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcacgcccg cagaggctgg gctcggccag ctccgcgcag agttgcagcg gtggctggat
       61 gccaagtggt cttttatcaa gcagaaatgc atcgaacaac cagaatcaag atcactgagc
      121 taaatcccca cctaatgtgt gtcctgtgtg gagggtactt cattgatgcc actaccataa
      181 tagaatgtct acattccttc tgtaaaacat gtattgtgcg ttacttggag accagcaagt
      241 attgtcctat ttgtgatgtc caagttcaca aaactcgacc actactgaat ataaggtcag
      301 acaaaactct tcaagatatt gtatacaaat tagttccagg gcttttcaaa aatgagatga
      361 agaggagaag agacttctat gcagctcacc cttcagcaga tgctgccaat ggctccaatg
      421 aagacagagg agaagttgca gatgaggacc ggcgggtcat agctgacgat gagattataa
      481 gcttgtctat cgagttcttc cacccaagca ggtcggatcg gaaagtaact aaagagaagc
      541 caaaggagga ggtgaatgat aaaaggtact tgcgatgccc agcagcactg acggtgatgc
      601 acttgagaaa gttcctcagg agtaaaatgg acatacctaa tactttccag attgacgtta
      661 tgtatgaaga ggagccttta aaggactact acacgctcat ggacattgcc tacatttaca
      721 cctggagacg gaatggccca ctgcctttga aataccgagt tcggccaact tgcaaaagaa
      781 tgaagatgag tcagcagaga gatggactga ccgcggctgg agagctggag agtgactctg
      841 ggagcgacaa ggccaacagc ccagcgggag gtgctccctc cacctcttcc tgcttgccca
      901 gccccagcac tccagtgcag tctcctcacc cacagttccc tcacatttcc agtaccatga
      961 atggaaccag caacagcccc agcggtaatc accaatcttc ctttgccagt agacctcgga
     1021 aatcatcagt aaatgggtca tcagcaactt cgtctggtta agaactaagg ggaagattct
     1081 tcaccccgtt tgagatacct tcatccatta cagcttagag atgctaatac aaaaaaaaaa
     1141 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aa
//
