LOCUS       NM_139258               4665 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant
            1, mRNA.
ACCESSION   NM_139258
VERSION     NM_139258.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4665)
  AUTHORS   Qin,Z., Wang,X., Zhou,Y., Zheng,J., Li,H. and Li,L.
  TITLE     Upregulation of miR-29b-3p alleviates coronary
            microembolization-induced myocardial injury via regulating BMF and
            GSK-3beta
  JOURNAL   Apoptosis 28 (1-2), 210-221 (2023)
   PUBMED   36315357
  REMARK    GeneRIF: Upregulation of miR-29b-3p alleviates coronary
            microembolization-induced myocardial injury via regulating BMF and
            GSK-3beta.
REFERENCE   2  (bases 1 to 4665)
  AUTHORS   Jiang,D., Sun,X., Wang,S. and Man,H.
  TITLE     Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion
            injury by directly targeting BMF and BCL2L13
  JOURNAL   Biomed Pharmacother 117, 108941 (2019)
   PUBMED   31200256
  REMARK    GeneRIF: miR-874-3p attenuated ischemic injury by negatively
            regulating BMF and BCL2L13.
REFERENCE   3  (bases 1 to 4665)
  AUTHORS   Wang,R., Kang,Y., Lohr,C.V., Fischer,K.A., Bradford,C.S.,
            Johnson,G., Dashwood,W.M., Williams,D.E., Ho,E. and Dashwood,R.H.
  TITLE     Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes
            overexpression in colorectal cancer
  JOURNAL   Cancer Lett 381 (2), 341-348 (2016)
   PUBMED   27539959
  REMARK    GeneRIF: Reciprocal regulation of BMF and BIRC5 is linked to Eomes
            overexpression in colorectal cancer.
REFERENCE   4  (bases 1 to 4665)
  AUTHORS   Contreras,A.U., Mebratu,Y., Delgado,M., Montano,G., Hu,C.A.,
            Ryter,S.W., Choi,A.M., Lin,Y., Xiang,J., Chand,H. and Tesfaigzi,Y.
  TITLE     Deacetylation of p53 induces autophagy by suppressing Bmf
            expression
  JOURNAL   J Cell Biol 201 (3), 427-437 (2013)
   PUBMED   23629966
REFERENCE   5  (bases 1 to 4665)
  AUTHORS   Du,H., Wolf,J., Schafer,B., Moldoveanu,T., Chipuk,J.E. and
            Kuwana,T.
  TITLE     BH3 domains other than Bim and Bid can directly activate Bax/Bak
  JOURNAL   J Biol Chem 286 (1), 491-501 (2011)
   PUBMED   21041309
REFERENCE   6  (bases 1 to 4665)
  AUTHORS   Lomonosova,E. and Chinnadurai,G.
  TITLE     BH3-only proteins in apoptosis and beyond: an overview
  JOURNAL   Oncogene 27 Suppl 1 (Suppl 1), S2-S19 (2008)
   PUBMED   19641503
  REMARK    Review article
REFERENCE   7  (bases 1 to 4665)
  AUTHORS   Show,M.D., Hill,C.M., Anway,M.D., Wright,W.W. and Zirkin,B.R.
  TITLE     Phosphorylation of mitogen-activated protein kinase 8 (MAPK8) is
            associated with germ cell apoptosis and redistribution of the
            Bcl2-modifying factor (BMF)
  JOURNAL   J Androl 29 (3), 338-344 (2008)
   PUBMED   18222916
  REMARK    GeneRIF: Activation of MAPK8 and redistribution of BMF may be
            integrally involved in the mechanism by which specific germ cells
            undergo programmed cell death in response to their detachment from
            Sertoli cells.
REFERENCE   8  (bases 1 to 4665)
  AUTHORS   Show,M.D., Folmer,J.S., Anway,M.D. and Zirkin,B.R.
  TITLE     Testicular expression and distribution of the rat bcl2 modifying
            factor in response to reduced intratesticular testosterone
  JOURNAL   Biol Reprod 70 (4), 1153-1161 (2004)
   PUBMED   14668207
  REMARK    GeneRIF: Bmf may well be involved in germ cell apoptosis and/or
            anoikis in response to decreased intratesticular testosterone
            concentration.
REFERENCE   9  (bases 1 to 4665)
  AUTHORS   Itoh,T., Itoh,A. and Pleasure,D.
  TITLE     Bcl-2-related protein family gene expression during
            oligodendroglial differentiation
  JOURNAL   J Neurochem 85 (6), 1500-1512 (2003)
   PUBMED   12787069
REFERENCE   10 (bases 1 to 4665)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 25, 2022 this sequence version replaced NM_139258.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.4533.1,
                                           SRR26643287.8681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840110,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000003.1  125973929-125974064 c
            137-266             JAXUCZ010000003.1  125973429-125973558 c
            267-563             JAXUCZ010000003.1  125971143-125971439 c
            564-727             JAXUCZ010000003.1  125969452-125969615 c
            728-4665            JAXUCZ010000003.1  125953466-125957403 c
FEATURES             Location/Qualifiers
     source          1..4665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..4665
                     /gene="Bmf"
                     /note="Bcl2 modifying factor"
                     /db_xref="GeneID:246142"
                     /db_xref="RGD:628658"
     exon            1..136
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..829
                     /gene="Bmf"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bcl-2-modifying factor; Bcl-2 modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform 1"
                     /protein_id="NP_640351.2"
                     /db_xref="GeneID:246142"
                     /db_xref="RGD:628658"
                     /translation="MPGAGVFWKQYRAVRGGLLPRQLTPTAVAARARATTSHRSPLEF
                     VPFFPIECGRQVPRVFVTLDPGAEPWHHDSEAETLSWSHPGDMEPPQCVEELEDDVFQ
                     PEDGEPGTQPGSLLSADLFAQSQLDCPLSRLQLFPLTHCCGPGLRPVSQEDKATQTLS
                     PASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAGSALGEQPPEGQFLQHRAEV
                     QIARKLQCIADQFHRLHMQQHQQNRDRAWRQVFLFLQNLALNRRENREGVGPW"
     exon            137..266
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            267..563
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            564..727
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
     exon            728..4665
                     /gene="Bmf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgtttgc gggatgcccg gagcgggcgt attttggaaa caataccgcg cggtgcgcgg
       61 tggcctcctc ccgcgccagc tcacgcccac agcagtcgct gcccgagccc gcgccaccac
      121 ctcccaccgc agcccgctgg agtttgtccc cttcttccca atcgagtgtg ggcgccaagt
      181 cccccgagtg ttcgtcaccc tggaccctgg cgcagagccc tggcatcacg actcggaggc
      241 tgagacgctg tcctggagtc acccaggaga catggagcca cctcagtgtg tggaggaact
      301 agaagatgat gtgttccagc cagaggatgg ggagccaggg acacagcctg ggagcttgct
      361 ctctgctgac ctgtttgccc agagccagct ggattgtccc ctcagtcggc ttcagctctt
      421 cccgcttacc cactgctgtg gtcctgggct ccggcctgta agccaggaag acaaggccac
      481 ccagaccctc agcccagcct ccccaagcca gggtgtcatg ctgccttgtg gggtgacaga
      541 ggaaccccag agactctttt acggcaacgc tggctacagg cttcctctcc ctgccagttt
      601 ccccgcaggc tcagcccttg gggagcagcc ccctgaagga cagttccttc agcaccgagc
      661 agaggtacag atcgccagaa agcttcagtg cattgcagac cagttccatc ggcttcatat
      721 gcaacaacac cagcagaacc gagaccgagc atggcggcag gtcttcctct tccttcaaaa
      781 cctggccttg aacagacgag aaaacaggga aggggtgggt ccctggtgag actgggctgc
      841 tcttgtcgga tagatcgccc ggaatgcagt ctggaacaga cattctggga ggacagatac
      901 tgtcttgtca agttttgtca ttctgaattt tctttccatg tgtacatatt acatacccca
      961 gtgggatctt ttttccccgt tcagaacgtc tcctggggat gggggccttt gtcaaacact
     1021 gttgaaggag aggcagctgt gtctgctggt tgagttccta aggctctgaa gatgaccaac
     1081 tggcgatgtt ctccaggaag tgaactgagg cttgctactg gagctggtta agtcaggtga
     1141 ggctcccagt accatcagac gtgccagcct tgcctcgtgc gtgcctgacg gaatcatggc
     1201 tttaacccac caggatcttg cctgggagct ttctggctaa gaacagctgt gcctcggcta
     1261 gctagcttta catctgggtt cccacttggc acagccagtg cccaccgcat gggctcaggg
     1321 attcttactc agtcgctgtc aacctccaga agacctcagg gagggttgga cttcaccaag
     1381 aacccctcaa aggtgccaca aaaatgaatc aagcttgata ggcttcaagt ctgactcggt
     1441 cctacatgga gacccttgga ttggtcccaa gggtgcaaac tgctgccacc tttgctgcct
     1501 gggtgtcaac cacgtgggag ccaagtagtc agttaccacc atgctgttgt accagcggcc
     1561 cgtgactttg tcagctttgt tttcaaagac tctgccaatg actggactgg attggactgc
     1621 gtccagatca gcagcagcgc tccaagatgc ggtgggcttg ctgggggcgt gggagccaag
     1681 cagccatccc actgataaac cggtcccagg ggaatcctag acctcttggt ttccttggaa
     1741 acgtgtacct cctccccctc accccaattc cttttctgta cctagtggga tacgggaaga
     1801 agcgaggaca gtggctttgt cagctggaaa gcgactttgg aaggagcaga cgtgactatg
     1861 ggacctgccg actcgagagc tgacacatct cgaatcttct tccttcagct ttcagctagg
     1921 ccagaaggga gagttctaga aggatctcag ctgcctccga ccttcttcct tctctccctg
     1981 acgcagcgct cagggaggca acgataagca gctgatctta gaaatcaagt cctaactttt
     2041 atgtatgtaa ggaaagacat tggtgctaaa atgaagggga gccaaggctc aaataaaaga
     2101 tggcttccct gagcaaagaa gaccacgggg tcactcaagg aacttggagg agaaactcag
     2161 agtagactct cgaattgaac aagcccagtg actccagttt ctgcagagga gggtgggggc
     2221 ttcagtacca tagaagggca cctggtctcc tgggcgtaca cttgggcagg tttctcatgg
     2281 cacaaggctg cctacagagg gggctcatag aggctgaagt ccagcctgtg ctctgctctc
     2341 taggctgcac atcctgatgt gggctgggtc tgcccagagt tagggatggc ttcctgattt
     2401 gcacagaggt actgtgtgct ctcggtggtc ccgaggagga acttaaagca tgcgtacaag
     2461 cctttgtgct tttctgctca gatgacctgg agatattacc tcttcttggc cacagtcatt
     2521 ttctcagggt gtataccatg gttcgtctgc taagaaactg ggttcctgtt tgcaaggaga
     2581 ggggatccaa gaaatgaata tgaagactgg ttccgaggca cactaattat tgtgaagccc
     2641 agccttccta catcccactc cctctgccgt ttagatgtgt gtgggacata tgtggtctgc
     2701 ccctttcctg gatcaaggct aggacaggca ggcaggcagg caggcaggct tctggtatgt
     2761 tcttggtggt acatgtgtgc ccctccccat acagaacctt gtacatcagt cacctttaac
     2821 ctgatttagt agactttcca tctgagctaa ggcttagctg tcagcttcag caaccttgcc
     2881 aggtacaggc tgggtaccct gtggcctgag aactgagccc agagtttgac ctgaacattg
     2941 agcctgggac caggcagaag ctggtcagaa tgcactgtct tcactttggg ccgaactagg
     3001 accaacctca ctaacttggg caagccaggg tgaaacttaa accctctttt atcttccacc
     3061 aacctgaatc caggctggag ttgaagctca gagataaagg gcttgcctgt cagtcaagag
     3121 acccttggat agatcccagg actggaaaat ataaataaat aaaaatatgc tccctccccc
     3181 caccccaccc caccacccct agatctagga ggcagctgga agcccagctc aaggaggcaa
     3241 gaggttcccc ctggctggtt gctctaattg gccagtgatc tctgcctgtt gaattggctt
     3301 tagagtctcc caggacagcc cctccccttt gcctctcccc aactccagga gcctggctgt
     3361 ctctagtgaa gagtggagat tcagattcag agggagggaa ggtctgacct gtgtggtgac
     3421 ctgtaaccag ctgaaggcag cagggctttt gtggtgtgct gaggatgggg gtgggagagg
     3481 ggctgggaaa ctcagtgtcg aaatagccta gaggaacaga agccccatat tcaggggctg
     3541 aactgatctc ctaattcaca atccccaggg gcatttctaa aagccagtga acagatctgg
     3601 aggggaacgt ccccccagtc cagtcactga ctcccccggg gaggctgggg tggtacacag
     3661 gagggtgggg ggtgggcact gtgcctggcc ctgtctctct gtttcaaagt ttggctgtgc
     3721 tgttcagttg tccccagtgg ccttgtcttg cttaatcaga ggtggaaaaa gatcacctcc
     3781 cggtgacctc cttcaggccc caggggatgg gctgtgtcca gagctgtgtg gcagagcttg
     3841 tctccagggt ccagagaggc ccagctggcc tgccttgctg ccccagccac gaaacccaag
     3901 cccaacctca agcatggcag ggagtgggtg ttggggacag tctagccaag gcctctgtct
     3961 gccccaagct ttccaggaac taagtagtga agtcactgtg accgtcctgg tcagtgagga
     4021 gaatattctg gtgagagctt ccgtttctgg gaacttgaga gggagtgggt acgggtgcat
     4081 ggagtagcaa aagaccccag ccttcgtggc tctgcaggat gtgggggaat cagtactgtg
     4141 gccaccattc ccccagtgga gcaaactggc tctgtgaata taagacttgt ggaggcaggc
     4201 tatcctggcc tcataccctg gctggaccca gagggacaca gggtggagcc acaggcattt
     4261 aaactttctc tggctccctg tgggctgcag gcctagggga cagagcctca cgggaacagc
     4321 agaacaaagc tggtctcttc cataagtgcc cagctttggc caaggtgcta tgagatacgt
     4381 ggcccccagc ttgcactgcc cctctctcta cagctgtctg tctctacccc ttctctgggt
     4441 ccacagcaag tgacatgggg agacccagtg agatgtagca tttcctccat ccccagttca
     4501 gttggcatgg ggtctgggca tttctgcctt aaggaaagga atggggactg ttatgtttta
     4561 acctgtatat aatatttgac tgttttggtt ctttatttgt atacatgtgt aaataccctc
     4621 tcacccatca agtggtaccg tttttaataa aaccatttaa atcag
//
