LOCUS       NM_133391               1862 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus basic helix-loop-helix ARNT like 2 (Bmal2), mRNA.
ACCESSION   NM_133391 XM_001075231 XM_342787
VERSION     NM_133391.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Polidarova,L., Sladek,M., Novakova,M., Parkanova,D. and Sumova,A.
  TITLE     Increased sensitivity of the circadian system to temporal changes
            in the feeding regime of spontaneously hypertensive rats - a
            potential role for Bmal2 in the liver
  JOURNAL   PLoS One 8 (9), e75690 (2013)
   PUBMED   24086613
  REMARK    GeneRIF: The Bmal2 gene in the higher sensitivity of the hepatic
            clock.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Sladek,M., Polidarova,L., Novakova,M., Parkanova,D. and Sumova,A.
  TITLE     Early chronotype and tissue-specific alterations of circadian clock
            function in spontaneously hypertensive rats
  JOURNAL   PLoS One 7 (10), e46951 (2012)
   PUBMED   23056539
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Kovanen,L., Saarikoski,S.T., Haukka,J., Pirkola,S., Aromaa,A.,
            Lonnqvist,J. and Partonen,T.
  TITLE     Circadian clock gene polymorphisms in alcohol use disorders and
            alcohol consumption
  JOURNAL   Alcohol Alcohol 45 (4), 303-311 (2010)
   PUBMED   20554694
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Sasaki,M., Yoshitane,H., Du,N.H., Okano,T. and Fukada,Y.
  TITLE     Preferential inhibition of BMAL2-CLOCK activity by PER2
            reemphasizes its negative role and a positive role of BMAL2 in the
            circadian transcription
  JOURNAL   J Biol Chem 284 (37), 25149-25159 (2009)
   PUBMED   19605937
REFERENCE   5  (bases 1 to 1862)
  AUTHORS   Woon,P.Y., Kaisaki,P.J., Braganca,J., Bihoreau,M.T., Levy,J.C.,
            Farrall,M. and Gauguier,D.
  TITLE     Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is
            associated with susceptibility to hypertension and type 2 diabetes
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14412-14417 (2007)
   PUBMED   17728404
REFERENCE   6  (bases 1 to 1862)
  AUTHORS   Hamaguchi,H., Fujimoto,K., Kawamoto,T., Noshiro,M., Maemura,K.,
            Takeda,N., Nagai,R., Furukawa,M., Honma,S., Honma,K., Kurihara,H.
            and Kato,Y.
  TITLE     Expression of the gene for Dec2, a basic helix-loop-helix
            transcription factor, is regulated by a molecular clock system
  JOURNAL   Biochem J 382 (Pt 1), 43-50 (2004)
   PUBMED   15147242
REFERENCE   7  (bases 1 to 1862)
  AUTHORS   Schoenhard,J.A., Smith,L.H., Painter,C.A., Eren,M., Johnson,C.H.
            and Vaughan,D.E.
  TITLE     Regulation of the PAI-1 promoter by circadian clock components:
            differential activation by BMAL1 and BMAL2
  JOURNAL   J Mol Cell Cardiol 35 (5), 473-481 (2003)
   PUBMED   12738229
REFERENCE   8  (bases 1 to 1862)
  AUTHORS   Schoenhard,J.A., Eren,M., Johnson,C.H. and Vaughan,D.E.
  TITLE     Alternative splicing yields novel BMAL2 variants: tissue
            distribution and functional characterization
  JOURNAL   Am J Physiol Cell Physiol 283 (1), C103-C114 (2002)
   PUBMED   12055078
REFERENCE   9  (bases 1 to 1862)
  AUTHORS   Okano,T., Sasaki,M. and Fukada,Y.
  TITLE     Cloning of mouse BMAL2 and its daily expression profile in the
            suprachiasmatic nucleus: a remarkable acceleration of Bmal2
            sequence divergence after Bmal gene duplication
  JOURNAL   Neurosci Lett 300 (2), 111-114 (2001)
   PUBMED   11207387
REFERENCE   10 (bases 1 to 1862)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Moran,S.M., Shimomura,K., Radcliffe,L.A.,
            Takahashi,J.S. and Bradfield,C.A.
  TITLE     The basic helix-loop-helix-PAS protein MOP9 is a brain-specific
            heterodimeric partner of circadian and hypoxia factors
  JOURNAL   J Neurosci 20 (13), RC83 (2000)
   PUBMED   10864977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1 and AY014838.1.
            
            On Jul 2, 2018 this sequence version replaced NM_133391.1.
            
            Summary: This gene encodes a basic helix-loop-helix transcription
            factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS
            proteins play important roles in adaptation to low atmospheric and
            cellular oxygen levels, exposure to certain environmental
            pollutants, and diurnal oscillations in light and temperature. This
            protein forms a transcriptionally active heterodimer with the
            circadian Clock protein, the structurally related Mop4, and
            hypoxia-inducible factors, such as Hif1alpha. Consistent with its
            role as a biologically relevant partner of circadian and hypoxia
            factors, this protein is coexpressed in regions of the brain such
            as the thalamus, hypothalamus, and amygdala. [provided by RefSeq,
            Feb 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY014838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN16093046
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                JAXUCZ010000004.1  181437591-181437611
            22-1623             AY014838.1         1-1602
            1624-1862           JAXUCZ010000004.1  181477385-181477623
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1862
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /note="basic helix-loop-helix ARNT like 2"
                     /db_xref="GeneID:362464"
                     /db_xref="RGD:620230"
     CDS             1..1647
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /note="transcription factor BMAL2; aryl hydrocarbon
                     receptor nuclear translocator-like protein 2; aryl
                     hydrocarbon receptor nuclear translocator-like protein
                     2-like; aryl hydrocarbon receptor nuclear
                     translocator-like 2"
                     /codon_start=1
                     /product="basic helix-loop-helix ARNT-like protein 2"
                     /protein_id="NP_596882.2"
                     /db_xref="GeneID:362464"
                     /db_xref="RGD:620230"
                     /translation="MEFPRKRRRSDSELLQSEFRTDAMVENLPRSPFTSVLSTRTGVA
                     VPNGIREAHSQTEKRRRDKMNHLIWKLSSMIPPHIPTAHKLDKLSVLRRAVQYLRSQR
                     GMTEFYLGENAKPSFIQDKELSHLILKASLMGQNLFDFLHPKDVAKVKEQLSCDVSLR
                     EKPIGTKTSPQVHSHSHIGRSRVHSGSRRSFFFRMKSSCTVPVKEEQRCSSCSKKKDQ
                     RKFHTIHCTGYLRSWPPNVVGTEKEMGSGKDSGPLTCLVAMGRLQPYTVPPKNGKINV
                     RPAEFITRFAMNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHSNLSDKHKAVL
                     QSKEKILTDSYKFRVKDGSFVTLKSKWFSFTNPWTKKLEYIVSVNTLVLGRSETAVSV
                     PQCRSSQSSEDSFRQPCVSVPGISTGTLLGTGSIGTDIANEVLSLQRSHSSSPEDANP
                     SGVVRDKHSVNFGSAPVPVSTGELFALSPETEGLEAARQHQSSEPAHCHKPLLSDSTQ
                     LGFDALCDSDDTAMATFMNYLEAEGGLGDPGDFSDIQWTL"
     exon            1..47
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..149
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..307
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..387
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..502
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..649
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..890
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..997
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1148
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1207
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1316
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1404
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1510
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1862
                     /gene="Bmal2"
                     /gene_synonym="Arnt4; Arntl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtttc caaggaaacg tagaagaagt gattcagagc tgctccagtc agaattcagg
       61 acagatgcaa tggtggaaaa ccttccccgg agtcccttta cctctgttct ttcaacaaga
      121 acaggagtag cagtgcccaa tggcatcagg gaagctcaca gccagacaga aaagcgtcgg
      181 agagacaaga tgaaccatct gatttggaaa ctgtcatcta tgatccctcc acacatcccc
      241 acagcccaca aactggacaa actgagcgtc ctgaggaggg cagtgcagta cttgaggtct
      301 cagagaggca tgacagagtt ttatttagga gaaaatgcta aaccttcatt tattcaggat
      361 aaggaactca gccacttaat cctcaaggct agtttgatgg gacagaactt gtttgacttc
      421 ttacacccaa aagatgtcgc caaagtaaag gaacaacttt cttgtgatgt ttcactgaga
      481 gagaaaccca taggcaccaa aacctctcct caggttcaca gtcactccca tattgggcga
      541 tcacgcgtgc attctggctc cagacgatct ttcttcttta gaatgaagag cagctgtaca
      601 gtccccgtca aagaagagca acgatgctcg tcctgttcaa agaagaaaga ccagagaaaa
      661 ttccacacca tccattgcac tggatacttg agaagctggc caccgaatgt tgtgggcacg
      721 gagaaagaga tgggcagtgg gaaagacagt ggtcctctta cctgccttgt ggctatggga
      781 cggttacagc catatactgt ccccccgaag aatggcaaga tcaacgtgag accggctgag
      841 ttcataaccc gattcgcaat gaacgggaaa ttcgtctacg tcgaccaaag ggcaacagca
      901 attttaggat acctgcctca ggaacttttg ggaacttcgt gttatgaata ttttcatcag
      961 gatgaccaca gtaatttgag tgacaagcac aaagcagttc tgcagagtaa ggagaaaata
     1021 cttacagatt catacaaatt cagagtgaag gatggctcct ttgtgactct gaagagcaag
     1081 tggttcagct tcactaaccc ttggaccaaa aagctggagt acatcgtgtc tgtcaacacg
     1141 ctggttttgg ggcgcagtga gaccgcagta tccgtgcctc agtgccgcag cagccagtcc
     1201 tctgaagact catttagaca accctgcgtc agtgtgccgg gcatatccac agggacctta
     1261 cttggcactg ggagtattgg aacagatatt gcaaatgagg ttctgagttt acagaggtca
     1321 cactcttcat ccccagaaga cgcaaaccct tcaggagtag tgagagataa gcacagtgta
     1381 aacttcggga gcgcccctgt gcccgtgtcc actggggagc tctttgcact gagtcctgaa
     1441 acagagggcc tggaggctgc caggcaacac cagagttctg agcccgccca ctgtcacaaa
     1501 ccactcctca gtgacagtac ccagttgggt tttgatgccc tgtgtgacag cgacgacaca
     1561 gccatggcta cattcatgaa ttacctcgaa gcagagggtg gcctgggtga ccctggggac
     1621 ttcagtgaca tccagtggac actctagcat tttgactttg aactctaatg tgagaatcat
     1681 tttagagtgt tttttttatt ttttttcaga gctgggaacc aaacccaggg ccttgcgctt
     1741 gctaggcaag cgccctaaca ctgagctgat caaccccagg gtgtttcatt tacaaaatgc
     1801 tttactcttg agcactgtat tgattgatac tttgtatctc ttattaagag tctactgatt
     1861 tt
//
