LOCUS       NM_024362               2991 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus basic helix-loop-helix ARNT like 1 (Bmal1), mRNA.
ACCESSION   NM_024362
VERSION     NM_024362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Tang,W., Guo,R., Hu,C., Yang,Y., Yang,D., Chen,X. and Liu,Y.
  TITLE     BMAL1 alleviates myocardial damage in sepsis by activating SIRT1
            signaling and promoting mitochondrial autophagy
  JOURNAL   Int Immunopharmacol 133, 112111 (2024)
   PUBMED   38678672
  REMARK    GeneRIF: BMAL1 alleviates myocardial damage in sepsis by activating
            SIRT1 signaling and promoting mitochondrial autophagy.
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Ma,H., Li,Q., Shang,Y., Xin,X., Liu,X., Wu,Z. and Yu,W.
  TITLE     Impact of circadian clock protein Bmal1 on experimentally-induced
            periodontitis-associated renal injury
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 42 (2), 163-171 (2024)
   PUBMED   38597076
  REMARK    GeneRIF: Impact of circadian clock protein Bmal1 on
            experimentally-induced periodontitis-associated renal injury.
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Xing,C., Zhai,B., Zhang,Y., Fang,Y., Zhang,M., Zhang,C., Wang,W.,
            Ding,M., Huang,X., Shen,B., Wang,R. and Song,L.
  TITLE     Sleep deprivation reduced LPS-induced IgG2b production by
            up-regulating BMAL1 and CLOCK expression
  JOURNAL   Biochem Biophys Res Commun 691, 149326 (2024)
   PUBMED   38035406
  REMARK    GeneRIF: Sleep deprivation reduced LPS-induced IgG2b production by
            up-regulating BMAL1 and CLOCK expression.
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Zhang,N., Yu,H., Liu,T., Zhou,Z., Feng,B., Wang,Y., Qian,Z., Hou,X.
            and Zou,J.
  TITLE     Bmal1 downregulation leads to diabetic cardiomyopathy by promoting
            Bcl2/IP3R-mediated mitochondrial Ca2+ overload
  JOURNAL   Redox Biol 64, 102788 (2023)
   PUBMED   37356134
  REMARK    GeneRIF: Bmal1 downregulation leads to diabetic cardiomyopathy by
            promoting Bcl2/IP3R-mediated mitochondrial Ca[2+] overload.
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Huang,A., Xiao,G., Chen,Y., Hu,Z., Lee,P.H., Huang,Y., Zhuang,Z.,
            Zhang,Y., Qing,P. and Zhao,C.
  TITLE     Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and
            Melatonin in Insomnia Rats
  JOURNAL   J Acupunct Meridian Stud 16 (3), 109-118 (2023)
   PUBMED   37381033
  REMARK    GeneRIF: Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA
            and Melatonin in Insomnia Rats.
REFERENCE   6  (bases 1 to 2991)
  AUTHORS   Honma,S., Ikeda,M., Abe,H., Tanahashi,Y., Namihira,M., Honma,K. and
            Nomura,M.
  TITLE     Circadian oscillation of BMAL1, a partner of a mammalian clock gene
            Clock, in rat suprachiasmatic nucleus
  JOURNAL   Biochem Biophys Res Commun 250 (1), 83-87 (1998)
   PUBMED   9735336
REFERENCE   7  (bases 1 to 2991)
  AUTHORS   Takahata,S., Sogawa,K., Kobayashi,A., Ema,M., Mimura,J., Ozaki,N.
            and Fujii-Kuriyama,Y.
  TITLE     Transcriptionally active heterodimer formation of an Arnt-like PAS
            protein, Arnt3, with HIF-1a, HLF, and clock
  JOURNAL   Biochem Biophys Res Commun 248 (3), 789-794 (1998)
   PUBMED   9704006
REFERENCE   8  (bases 1 to 2991)
  AUTHORS   Wolting,C.D. and McGlade,C.J.
  TITLE     Cloning and chromosomal localization of a new member of the
            bHLH/PAS transcription factor family
  JOURNAL   Mamm Genome 9 (6), 463-468 (1998)
   PUBMED   9585435
REFERENCE   9  (bases 1 to 2991)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   10 (bases 1 to 2991)
  AUTHORS   Hogenesch,J.B., Chan,W.K., Jackiw,V.H., Brown,R.C., Gu,Y.Z.,
            Pray-Grant,M., Perdew,G.H. and Bradfield,C.A.
  TITLE     Characterization of a subset of the basic-helix-loop-helix-PAS
            superfamily that interacts with components of the dioxin signaling
            pathway
  JOURNAL   J Biol Chem 272 (13), 8581-8593 (1997)
   PUBMED   9079689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099833.1.
            
            On Aug 7, 2005 this sequence version replaced NM_024362.1.
            
            Summary: The protein encoded by this gene is a basic
            helix-loop-helix protein that forms a heterodimer with Clock. This
            heterodimer binds E-box enhancer elements upstream of Period (Per1,
            Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates
            transcription of these genes. Per and Cry proteins heterodimerize
            and repress their own transcription by interacting in a feedback
            loop with Clock/Arntl complexes. Defects in this gene have been
            linked to infertility, problems with gluconeogenesis and
            lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132305
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..2991
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /note="basic helix-loop-helix ARNT like 1"
                     /db_xref="GeneID:29657"
                     /db_xref="RGD:62003"
     exon            1..88
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            89..161
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            162..321
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            322..449
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            450..575
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            576..728
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     CDS             589..2469
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /note="aryl hydrocarbon receptor nuclear translocator-like
                     protein 1; tic; brain and muscle ARNT-like 1"
                     /codon_start=1
                     /product="basic helix-loop-helix ARNT-like protein 1"
                     /protein_id="NP_077338.2"
                     /db_xref="GeneID:29657"
                     /db_xref="RGD:62003"
                     /translation="MADQRMDISSTISDFMSPGPTDLLSGSLSTSGVDCNRKRKGSAT
                     DYQESMDTDKDDPHGRLEYAEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTC
                     NAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLF
                     VVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRER
                     LIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFASTCSKKKADR
                     KSFCTIHSTGYLKSWPPTKMGLDEDSEPDNEGCNLSCLVAIGRLHSHMVPQPVNGEIR
                     VKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQV
                     LQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGD
                     PTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHR
                     IRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSAGLLPGQAQETPGYPY
                     SDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPW
                     PL"
     exon            729..767
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            768..809
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            810..967
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1047
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1140
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1258
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1408
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1655
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1762
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1913
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2002
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2111
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2205
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2308
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2977
                     /gene="Bmal1"
                     /gene_synonym="Arntl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctgttt acccgcgccg gacttgccgc cgccgccgcc gcgggatccg agtgcgggtg
       61 cgggcgcggg cgctcgcggc gagtcacggt ggtgttggcc agagtgaatg cttttggaag
      121 caagcttaag gtttcaaatg tggaccccaa ggccttcact ggaatggtgc tataaaccaa
      181 gattttggga agagaggcag aaggaattac tacaaggttg aagtcagact ggcatatgta
      241 gcaagttcca ggccagtcag gcctacacag ctacaccctg cctaggacaa caggaacaag
      301 aaaatgactg tctaggtgga ggattttgga agaagttgac tgcctggaag aaagttacaa
      361 aacatgaaag tcgctttgag gtgaccagca agtacagtgg ccccttgcac ctcacacgct
      421 ggaccgaagc ttgagaactg taacttcaga tgtgggaatt tgggcccaga gggtgggagt
      481 gacagcccca gtcaaatcct gtggaccttg gagccctttg aggcccactg ggcaacccct
      541 cttcaccagg gtttgaagtt agagtccctt gcaagcaccg tccttccaat ggcggaccag
      601 agaatggaca tttcctccac aatcagtgac ttcatgtctc cgggccccac cgacctgctc
      661 tccggttccc tgagcaccag tggtgtggac tgcaaccgca agaggaaagg cagtgccact
      721 gactaccaag aaagtatgga cacagacaaa gatgaccctc atggaaggtt agaatatgca
      781 gaacaccaag gaaggatcaa aaatgcaagg gaggcccaca gtcagattga aaagaggcgt
      841 cgggacaaaa tgaacagttt tattgacgaa ttggcttctt tggtaccaac atgcaatgcg
      901 atgtcccgga agttagataa actcaccgtg ctcaggatgg ctgttcagca catgaaaaca
      961 ttgagaggtg ccaccaaccc atacacagaa gcaaactaca agccaacatt tctatccgat
     1021 gacgaactga aacacctaat tctcagggca gcagatggat ttttgtttgt cgtaggatgt
     1081 gaccgaggga agatcctctt tgtctccgaa tctgtcttca agatcctcaa ttatagccag
     1141 aatgacctta ttggccagag tttgttcgac tacctgcatc caaaagatat tgccaaagtt
     1201 aaggaacagc tatcttcctc ggacactgca cctcgggagc gactcatcga tgcgaagact
     1261 ggacttccgg ttaaaacgga tataacccct gggccctccc gattgtgctc tggagctcgg
     1321 cgctctttct tctgtaggat gaagtgcaac aggccttcag taaaggtgga agataaggac
     1381 ttcgcctcca cctgttcaaa gaaaaaagca gatcgaaaga gcttctgcac aatccacagc
     1441 acaggctact tgaaaagctg gccacccaca aagatggggc tggacgaaga cagtgaacca
     1501 gacaatgagg gctgcaatct gagctgcctc gttgcaatcg ggcgactgca ctcacacatg
     1561 gttccacagc cagtgaacgg ggaaatacgg gtgaagtcta tggagtatgt gtctcgacat
     1621 gcaatagatg ggaaatttgt ttttgtagat cagagggcga cggctatttt ggcatatcta
     1681 ccacaggaac ttctaggtac atcgtgttat gagtattttc atcaagatga tataggacac
     1741 cttgcggaat gtcacaggca agttttacag acaagagaaa agatcacgac taattgctat
     1801 aagtttaaga tcaaagatgg ttcctttatc acactacgaa gtcgatggtt cagtttcatg
     1861 aacccgtgga ccaaggaagt agaatacatt gtctcaacca acactgttgt tttagccaat
     1921 gtcctggaag gcggggaccc aaccttccca cagctcacag catcccccca cagcatggac
     1981 agcatgctgc cctctggaga aggtggccca aagaggactc atcccactgt tccaggcatt
     2041 ccagggggaa ccagagctgg agcaggaaaa ataggtcgaa tgattgccga ggaaatcatg
     2101 gaaatccaca ggataagagg gtcatcacct tccagctgtg gctccagccc actgaacatc
     2161 acaagtacgc ctccccctga tgcttcctct ccaggaggca agaagattct aaatggaggg
     2221 actccagaca ttccttccgc tggcctacta ccagggcagg ctcaggagac cccaggctat
     2281 ccctactctg atagttcgtc tattcttggt gagaaccccc acataggcat cgacatgata
     2341 gacaacgacc aaggatcaag cagccccagt aacgacgagg cagcaatggc tgtcatcatg
     2401 agcctcttgg aagcagatgc ggggctgggt ggtcccgttg actttagtga cttgccatgg
     2461 ccactgtaga cactacattt tgctctggca acagctacag tatcaaagtg cattactggt
     2521 gaagttttac agtctgtgaa gcttactgga tagggagaga acagctttta tgtactgact
     2581 ccataaaagc catctcagag ccattgagac aagtcaatct accatgtgta acttcagaca
     2641 aagtggaact aagcctgctc cagtgtttcc tcatcattga gtttgggcta gctgtggata
     2701 gcttgcatta attgtatatt ttggattttg gttgtgttga attttttaat cattgtgcac
     2761 agaagcatca ttggtagctt ttatatgcaa aatggtcatt tcagatgtat ggtgttttta
     2821 cactacaaag aagtccccca tgtggatatt tcttatacta attgtatcat aaagctgttt
     2881 attcttcctt gtaagaatcc tttactataa atatgggtta aagtataatg tattagacag
     2941 ttaaatattt ttaataaatg tttcccttgt tctataaaaa aaaaaaaaaa a
//
