LOCUS       NM_001106236             884 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus biliverdin reductase B (Blvrb), mRNA.
ACCESSION   NM_001106236 XM_001072142 XM_214823
VERSION     NM_001106236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 884)
  AUTHORS   Ding B, Gibbs PE, Brookes PS and Maines MD.
  TITLE     The coordinated increased expression of biliverdin reductase and
            heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based
            peptide counters beta-adrenergic receptor ligand-mediated cardiac
            dysfunction
  JOURNAL   FASEB J 25 (1), 301-313 (2011)
   PUBMED   20876213
  REMARK    GeneRIF: Data show that siRNA blockage of BVR protein expression in
            cardiomyocytes inhibits HO-2 protein induction but not vice versa.
REFERENCE   2  (bases 1 to 884)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 884)
  AUTHORS   Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham
            O, Darcy K, Mantle TJ and Coll M.
  TITLE     Structure of human biliverdin IXbeta reductase, an early fetal
            bilirubin IXbeta producing enzyme
  JOURNAL   Nat Struct Biol 8 (3), 215-220 (2001)
   PUBMED   11224564
REFERENCE   4  (bases 1 to 884)
  AUTHORS   Lysakowski A and Singer M.
  TITLE     Nitric oxide synthase localized in a subpopulation of vestibular
            efferents with NADPH diaphorase histochemistry and nitric oxide
            synthase immunohistochemistry
  JOURNAL   J Comp Neurol 427 (4), 508-521 (2000)
   PUBMED   11056461
REFERENCE   5  (bases 1 to 884)
  AUTHORS   Yamaguchi T, Komoda Y and Nakajima H.
  TITLE     Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from
            human liver. Purification and characterization
  JOURNAL   J Biol Chem 269 (39), 24343-24348 (1994)
   PUBMED   7929092
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001072142.1, XM_214823.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230737.1, FQ232598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..884
                     /gene="Blvrb"
                     /note="biliverdin reductase B"
                     /db_xref="GeneID:292737"
                     /db_xref="RGD:1306080"
     exon            1..222
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..764
                     /gene="Blvrb"
                     /EC_number="1.3.1.24"
                     /note="NADPH-dependent diaphorase"
                     /codon_start=1
                     /product="flavin reductase (NADPH)"
                     /protein_id="NP_001099706.1"
                     /db_xref="GeneID:292737"
                     /db_xref="RGD:1306080"
                     /translation="MAVKKIAIFGATGRTGLTTLAQAVQAGYEVTVLVRDSSRLPSEG
                     PQPAHVVVGDVLQAGDVDKTVAGQDAVIVLLGTGNDLSPTTVMSEGTRNIVAAMKAHG
                     VDKVVACTSAFLLWDPSKVPPRLQDVTDDHIRMHKILEESGLKYVAVMPPHIGDQPLT
                     GAYTVTLDGRGPSRVISKHDLGHFMLRCLTTHEYDGQKTYPSHQYD"
     exon            223..387
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     exon            388..477
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     exon            478..606
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
     exon            607..884
                     /gene="Blvrb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggagtcgg aggcgggaaa cgtcgtctgg ccccgccccc tccttctgtg tggaggagaa
       61 cgcgctgcgc gccccacctt gcagctactg ggttcccgcg cgtcctcgga gttctcagct
      121 tttcgggccc tggaccctgc aacatggctg tcaagaagat cgcgatcttc ggtgccaccg
      181 gaaggaccgg gctcaccaca ctggcgcagg cggtgcaagc aggttacgag gtgacggtgc
      241 tggttcgaga ttccagcagg ttaccgtcag aggggcccca gccagcccac gtggtggtgg
      301 gagatgttct gcaggcgggc gatgtggaca agactgtggc tggacaggat gccgtcatcg
      361 tgctactggg cactggcaac gacctcagtc ctactacagt aatgtccgag ggcacccgga
      421 acattgtggc agccatgaag gcacatggag tggacaaggt cgtggcctgc acctcggcct
      481 tcctactctg ggacccgagc aaggtgcccc ctcgcctaca ggacgtgacc gatgaccaca
      541 tccggatgca taagattctg gaggagtcag gactgaagta cgtggctgta atgcccccac
      601 acattgggga ccaaccacta accggggcct acacagtgac cctggatgga cgagggccct
      661 cgagggtcat atccaagcat gatctgggtc acttcatgct acggtgcctc accacccatg
      721 agtatgacgg acagaagacc tacccttccc accagtatga ctaggaccct ggccctggct
      781 gggagggtcc catcctgaga aatggcacac atggagggat caatacattt ttagccaaga
      841 acttcaaatt ctttcagaaa acctaatcct aattttcctc tgtc
//
