LOCUS       NM_053850               1083 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus biliverdin reductase A (Blvra), mRNA.
ACCESSION   NM_053850
VERSION     NM_053850.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Song,S., Wang,S., Ma,J., Yao,L., Xing,H., Zhang,L., Liao,L. and
            Zhu,D.
  TITLE     Biliverdin reductase/bilirubin mediates the anti-apoptotic effect
            of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2
            pathway
  JOURNAL   Exp Cell Res 319 (13), 1973-1987 (2013)
   PUBMED   23722043
  REMARK    GeneRIF: BVR contributes to the inhibitory process of hypoxia on
            pulmonary arterial smooth muscle cell apoptosis, which is mediated
            by bilirubin through ERK1/2 pathway.
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Ding,B., Gibbs,P.E., Brookes,P.S. and Maines,M.D.
  TITLE     The coordinated increased expression of biliverdin reductase and
            heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based
            peptide counters beta-adrenergic receptor ligand-mediated cardiac
            dysfunction
  JOURNAL   FASEB J 25 (1), 301-313 (2011)
   PUBMED   20876213
  REMARK    GeneRIF: Data show that siRNA blockage of BVR protein expression in
            cardiomyocytes inhibits HO-2 protein induction but not vice versa.
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Franklin,E., Browne,S., Hayes,J., Boland,C., Dunne,A., Elliot,G.
            and Mantle,T.J.
  TITLE     Activation of biliverdin-IXalpha reductase by inorganic phosphate
            and related anions
  JOURNAL   Biochem J 405 (1), 61-67 (2007)
   PUBMED   17402939
  REMARK    GeneRIF: Results describe the activation of biliverdin-IXalpha
            reductase by inorganic phosphate and related anions.
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Whitby,F.G., Phillips,J.D., Hill,C.P., McCoubrey,W. and Maines,M.D.
  TITLE     Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor
            complex
  JOURNAL   J Mol Biol 319 (5), 1199-1210 (2002)
   PUBMED   12079357
  REMARK    GeneRIF: X-ray crystal structures of apo rat BVR and its complex
            with NADH at 1.2 A and 1.5 A resolution, respectively
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Sun,D., Sato,M., Yoshida,T., Shimizu,H., Miyatake,H., Adachi,S.,
            Shiro,Y. and Kikuchi,A.
  TITLE     Crystallization and preliminary X-ray diffraction analysis of a rat
            biliverdin reductase
  JOURNAL   Acta Crystallogr D Biol Crystallogr 56 (Pt 9), 1180-1182 (2000)
   PUBMED   10957639
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Cunningham,O., Dunne,A., Sabido,P., Lightner,D. and Mantle,T.J.
  TITLE     Studies on the specificity of the tetrapyrrole substrate for human
            biliverdin-IXalpha reductase and biliverdin-IXbeta reductase.
            Structure-activity relationships define models for both active
            sites
  JOURNAL   J Biol Chem 275 (25), 19009-19017 (2000)
   PUBMED   10858451
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   McCoubrey,W.K. Jr. and Maines,M.D.
  TITLE     Site-directed mutagenesis of cysteine residues in biliverdin
            reductase. Roles in substrate and cofactor binding
  JOURNAL   Eur J Biochem 222 (2), 597-603 (1994)
   PUBMED   8020496
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Fakhrai,H. and Maines,M.D.
  TITLE     Expression and characterization of a cDNA for rat kidney biliverdin
            reductase. Evidence suggesting the liver and kidney enzymes are the
            same transcript product
  JOURNAL   J Biol Chem 267 (6), 4023-4029 (1992)
   PUBMED   1371282
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_053850.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053850.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81681.1, BC078766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000003.1  134802910-134803022
            114-232             JAXUCZ010000003.1  134804415-134804533
            233-352             JAXUCZ010000003.1  134808146-134808265
            353-450             JAXUCZ010000003.1  134808805-134808902
            451-558             JAXUCZ010000003.1  134814019-134814126
            559-730             JAXUCZ010000003.1  134817123-134817294
            731-1083            JAXUCZ010000003.1  134819013-134819365
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1083
                     /gene="Blvra"
                     /note="biliverdin reductase A"
                     /db_xref="GeneID:116599"
                     /db_xref="RGD:620721"
     exon            1..113
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..989
                     /gene="Blvra"
                     /EC_number="1.3.1.24"
                     /note="BVR A; biliverdin-IX alpha-reductase"
                     /codon_start=1
                     /product="biliverdin reductase A"
                     /protein_id="NP_446302.2"
                     /db_xref="GeneID:116599"
                     /db_xref="RGD:620721"
                     /translation="MDAEPKRKFGVVVVGVGRAGSVRLRDLKDPRSAAFLNLIGFVSR
                     RELGSLDEVRQISLEDALRSQEIDVAYICSESSSHEDYIRQFLQAGKHVLVEYPMTLS
                     FAAAQELWELAAQKGRVLHEEHVELLMEEFEFLRREVLGKELLKGSLRFTASPLEEER
                     FGFPAFSGISRLTWLVSLFGELSLISATLEERKEDQYMKMTVQLETQNKGLLSWIEEK
                     GPGLKRNRYVNFQFTSGSLEEVPSVGVNKNIFLKDQDIFVQKLLGQVSAEDLAAEKKR
                     IMHCLGLASDIQKLCHQKK"
     exon            114..232
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
     exon            233..352
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
     exon            353..450
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
     exon            451..558
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
     exon            559..730
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1083
                     /gene="Blvra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgaaagcta agtgaaagcc atatccatag agagtttgtg ccagtgcccc aagatcctga
       61 acctctgtct gtcttcacgg acactgactg aagagaccga gatggatgcc gagccaaaga
      121 ggaaatttgg agtggtagtg gttggtgttg gcagagctgg ctcggtgagg ctgagggact
      181 tgaaggatcc acgctctgca gcattcctga acctgattgg atttgtgtcc agacgagagc
      241 ttgggagcct tgatgaagta cggcagattt ctttggaaga tgctctccga agccaagaga
      301 ttgatgtcgc ctatatttgc agtgagagtt ccagccatga agactatata cggcagtttc
      361 tgcaggctgg caagcatgtc ctcgtggaat accccatgac actgtcattt gcggcggccc
      421 aggagctgtg ggagctggcc gcacagaaag ggagagtcct gcatgaggag cacgtggaac
      481 tcttgatgga ggaattcgaa ttcctgagaa gagaagtgtt ggggaaagag ctactgaaag
      541 ggtctcttcg cttcacagct agcccactgg aagaagagag atttggcttc cctgcgttca
      601 gcggcatttc tcgcctgacc tggctggtct ccctcttcgg ggagctttct cttatttctg
      661 ccaccttgga agagcgaaaa gaggatcagt atatgaaaat gaccgtgcag ctggagaccc
      721 agaacaaggg tctgctgtca tggattgaag agaaagggcc tggcttaaaa agaaacagat
      781 atgtaaactt ccagttcact tctgggtccc tggaggaagt gccaagtgta ggggtcaata
      841 agaacatttt cctgaaagat caggatatat ttgttcagaa gctcttaggc caggtctctg
      901 cagaggacct ggctgctgag aagaagcgca tcatgcattg cctggggctg gccagcgaca
      961 tccagaagct ttgccaccag aagaagtgaa gaggaagctt cagagacttc tgaagggggc
     1021 cagggtttgg tcctatcaac cgttcacctt tagctcttac aattaaacat gtcagataaa
     1081 cac
//
