LOCUS       NM_001025714            2119 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus biogenesis of lysosomal organelles complex 1
            subunit 6 (Bloc1s6), mRNA.
ACCESSION   NM_001025714 XM_229231
VERSION     NM_001025714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Gokhale,A., Hartwig,C., Freeman,A.H., Das,R., Zlatic,S.A.,
            Vistein,R., Burch,A., Carrot,G., Lewis,A.F., Nelms,S.,
            Dickman,D.K., Puthenveedu,M.A., Cox,D.N. and Faundez,V.
  TITLE     The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin
            Polymerization Complex to Function Downstream of the Schizophrenia
            Susceptibility Factor Dysbindin at the Synapse
  JOURNAL   J Neurosci 36 (49), 12393-12411 (2016)
   PUBMED   27927957
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Lee,H.H., Nemecek,D., Schindler,C., Smith,W.J., Ghirlando,R.,
            Steven,A.C., Bonifacino,J.S. and Hurley,J.H.
  TITLE     Assembly and architecture of biogenesis of lysosome-related
            organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 287 (8), 5882-5890 (2012)
   PUBMED   22203680
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Ghiani,C.A., Starcevic,M., Rodriguez-Fernandez,I.A., Nazarian,R.,
            Cheli,V.T., Chan,L.N., Malvar,J.S., de Vellis,J., Sabatti,C. and
            Dell'Angelica,E.C.
  TITLE     The dysbindin-containing complex (BLOC-1) in brain: developmental
            regulation, interaction with SNARE proteins and role in neurite
            outgrowth
  JOURNAL   Mol Psychiatry 15 (2), 115 (2010)
   PUBMED   19546860
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Setty,S.R., Tenza,D., Truschel,S.T., Chou,E., Sviderskaya,E.V.,
            Theos,A.C., Lamoreux,M.L., Di Pietro,S.M., Starcevic,M.,
            Bennett,D.C., Dell'Angelica,E.C., Raposo,G. and Marks,M.S.
  TITLE     BLOC-1 is required for cargo-specific sorting from vacuolar early
            endosomes toward lysosome-related organelles
  JOURNAL   Mol Biol Cell 18 (3), 768-780 (2007)
   PUBMED   17182842
  REMARK    Erratum:[Mol Biol Cell. 2017 Feb 1;28(3):500.. PMID: 28137951]
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Falcon-Perez,J.M., Starcevic,M., Gautam,R. and Dell'Angelica,E.C.
  TITLE     BLOC-1, a novel complex containing the pallidin and muted proteins
            involved in the biogenesis of melanosomes and platelet-dense
            granules
  JOURNAL   J Biol Chem 277 (31), 28191-28199 (2002)
   PUBMED   12019270
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Huang,L., Kuo,Y.M. and Gitschier,J.
  TITLE     The pallid gene encodes a novel, syntaxin 13-interacting protein
            involved in platelet storage pool deficiency
  JOURNAL   Nat Genet 23 (3), 329-332 (1999)
   PUBMED   10610180
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Orn,A., Hakansson,E.M., Gidlund,M., Ramstedt,U., Axberg,I.,
            Wigzell,H. and Lundin,L.G.
  TITLE     Pigment mutations in the mouse which also affect lysosomal
            functions lead to suppressed natural killer cell activity
  JOURNAL   Scand J Immunol 15 (3), 305-310 (1982)
   PUBMED   7089489
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097469.1.
            
            On Jul 22, 2005 this sequence version replaced XM_229231.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097469.1, EV779061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2119
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /note="biogenesis of lysosomal organelles complex 1
                     subunit 6"
                     /db_xref="GeneID:317630"
                     /db_xref="RGD:1310208"
     exon            1..171
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..608
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /note="pallidin homolog; BLOC-1 subunit 6; pallid protein
                     homolog; biogenesis of lysosomal organelles complex-1,
                     subunit 6, pallidin"
                     /codon_start=1
                     /product="biogenesis of lysosome-related organelles
                     complex 1 subunit 6"
                     /protein_id="NP_001020885.1"
                     /db_xref="GeneID:317630"
                     /db_xref="RGD:1310208"
                     /translation="MNVPVPPPPDGVLTGPSDSLEAGEPTPGLSDRSPDEGLIEDLAL
                     EDRAVEHLVGGLLSHYLPDLQRSKRALQELTQNQVVLLDTLEQEISKFKECHSMLDIN
                     ALFTEAKHYHAKLVTIRKEMLLLHEKTSKLKKRALKLQQQRQKEELEREQQREREFER
                     EKQLTAKPAKRT"
     exon            172..313
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /inference="alignment:Splign:2.1.0"
     exon            314..401
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /inference="alignment:Splign:2.1.0"
     exon            402..488
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /inference="alignment:Splign:2.1.0"
     exon            489..2088
                     /gene="Bloc1s6"
                     /gene_synonym="Pldn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgactagac gctcgaactt gttaggttcc tacgtcttgc ctttggcttc tccacaccac
       61 tcgcccaacg cagcgcccag tgcagggaca tgaatgttcc tgtgccaccg cccccggacg
      121 gggtccttac ggggccctcc gacagcctgg aggccggcga gcctacgccg ggcttaagcg
      181 acaggtctcc agatgaagga ctgatagagg atttggcttt ggaggacaga gctgtagagc
      241 acctggtggg aggcctgctg tcccactacc taccagatct gcagaggtcc aagcgagcac
      301 tccaggaact cacacagaac caagttgtgt tactagatac actggaacaa gagatttcaa
      361 aatttaaaga atgccactcc atgctggaca tcaatgcttt gttcacggaa gcgaagcact
      421 atcacgccaa gctggtgacc ataaggaaag agatgttgct gctccacgag aaaacatcca
      481 agctgaaaaa aagagcactg aagctgcagc agcagaggca gaaagaggag ctggagagag
      541 agcagcagcg agagagggag tttgaaagag agaagcagct gacagccaag ccagccaaga
      601 ggacgtgagg agcctgcttt ccagttcctg tcccatcctg ctttctggat gtccagtgct
      661 gcatacagag agcgaggcgt ggatggtgcc ttacgccctg gcatgccttg agtctttccc
      721 agggttgtat gtgtccaaga cttcactcaa gaagccttgt tgatacttat gttttcaact
      781 cttgcttaac tttaaaattt attattttga tcttaaatca cttgtaaact gaaaacactg
      841 gttattgtaa gagtctggat acagttcaaa atgaggcgaa ggtctgaccg tcttaagagt
      901 cagttttagt ttcagtttct ccttttctga ggacaggcct tccctgcaca gccacactga
      961 tttctggcaa ctccttttta ttgtttaaag agaaactcca attgtttgac cgtaattctc
     1021 ccagaaagag agctgccaag cttttatgaa gaacttgtga agtgtatgtc actggtgagg
     1081 ccagcacctg agacgtaggc tgggagtaga tacagacaga ctctccagcc gttctcctct
     1141 gttttccagt cttgctgctg atagagattt tgggtttagg gcaggattct attcattcct
     1201 caagctgtgc agcaatggtg ggcctgccag atactcaaag gtgtgtctgt gtctgtctgt
     1261 gtgtctgtgt ctgtctgtgt gtgtgtgttt gcatgtgcat gctaagtcat cactgtgtaa
     1321 caatgtctct gtgttttttc ttttcctctc tccttttttt ttctcctaga gacaggctct
     1381 ctataaagcc ctggctgtcc tggtactcac tgtggagacc aggctggcct caaacaatcc
     1441 acttgcctct ttccccagtg ctgggattaa aggtgtgcac tgccacacct tgtttgaagt
     1501 agaacagagt ctgctactgc tcacagcata tgtaaagaac acagaagagg cccgattgat
     1561 gcctttgctg ttttctagac ctttccctct cctgtgtagg aacttactct gtaggcaaga
     1621 tgaagtctcc ttgttggaaa tcaagagtgc agtagtttac tccccatttt agtgtttaat
     1681 aggaagctcg tttctagccc ctactttgag tgagcagcac caagctacaa aggtgtctga
     1741 ttagaatgag catcttttat aacccatggt acacttttag taggctggaa ttactacctc
     1801 tgatcacata ctgggcgatg tggagatcat taaagatgac cagtgctaag aactcgtcag
     1861 cttaaaggct gtttctttga aggagccctt tcctttttaa tgaatgaatt gtgatctcac
     1921 agtcattgac ttgacttctg ttcaagaata caaatgaggt tatttgaacg gctgttaccc
     1981 tttgtcactt actgtcactt ctagagcaaa agtcattagg acttgcagga caatgccatt
     2041 acattacaga atgtacttat tacaataaaa tatctgatat ctggcaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaa
//
