LOCUS       NM_001107347            1782 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus biogenesis of lysosomal organelles complex 1
            subunit 5 (Bloc1s5), mRNA.
ACCESSION   NM_001107347 XM_001063623 XM_225255
VERSION     NM_001107347.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Gokhale,A., Hartwig,C., Freeman,A.H., Das,R., Zlatic,S.A.,
            Vistein,R., Burch,A., Carrot,G., Lewis,A.F., Nelms,S.,
            Dickman,D.K., Puthenveedu,M.A., Cox,D.N. and Faundez,V.
  TITLE     The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin
            Polymerization Complex to Function Downstream of the Schizophrenia
            Susceptibility Factor Dysbindin at the Synapse
  JOURNAL   J Neurosci 36 (49), 12393-12411 (2016)
   PUBMED   27927957
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Lee,H.H., Nemecek,D., Schindler,C., Smith,W.J., Ghirlando,R.,
            Steven,A.C., Bonifacino,J.S. and Hurley,J.H.
  TITLE     Assembly and architecture of biogenesis of lysosome-related
            organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 287 (8), 5882-5890 (2012)
   PUBMED   22203680
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Setty,S.R., Tenza,D., Truschel,S.T., Chou,E., Sviderskaya,E.V.,
            Theos,A.C., Lamoreux,M.L., Di Pietro,S.M., Starcevic,M.,
            Bennett,D.C., Dell'Angelica,E.C., Raposo,G. and Marks,M.S.
  TITLE     BLOC-1 is required for cargo-specific sorting from vacuolar early
            endosomes toward lysosome-related organelles
  JOURNAL   Mol Biol Cell 18 (3), 768-780 (2007)
   PUBMED   17182842
  REMARK    Erratum:[Mol Biol Cell. 2017 Feb 1;28(3):500.. PMID: 28137951]
REFERENCE   5  (bases 1 to 1782)
  AUTHORS   Starcevic,M. and Dell'Angelica,E.C.
  TITLE     Identification of snapin and three novel proteins (BLOS1, BLOS2,
            and BLOS3/reduced pigmentation) as subunits of biogenesis of
            lysosome-related organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 279 (27), 28393-28401 (2004)
   PUBMED   15102850
REFERENCE   6  (bases 1 to 1782)
  AUTHORS   Ciciotte,S.L., Gwynn,B., Moriyama,K., Huizing,M., Gahl,W.A.,
            Bonifacino,J.S. and Peters,L.L.
  TITLE     Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a
            novel protein that is part of the pallidin-muted complex (BLOC-1)
  JOURNAL   Blood 101 (11), 4402-4407 (2003)
   PUBMED   12576321
REFERENCE   7  (bases 1 to 1782)
  AUTHORS   Zhang,Q., Li,W., Novak,E.K., Karim,A., Mishra,V.S., Kingsmore,S.F.,
            Roe,B.A., Suzuki,T. and Swank,R.T.
  TITLE     The gene for the muted (mu) mouse, a model for Hermansky-Pudlak
            syndrome, defines a novel protein which regulates vesicle
            trafficking
  JOURNAL   Hum Mol Genet 11 (6), 697-706 (2002)
   PUBMED   11912185
REFERENCE   8  (bases 1 to 1782)
  AUTHORS   Lyon,M.F. and Meredith,R.
  TITLE     Muted, a new mutant affecting coat colour and otoliths of the
            mouse, and its position in linkage group XIV
  JOURNAL   Genet Res 14 (2), 163-166 (1969)
   PUBMED   5367369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225255.4, XM_001063623.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166529.1, CK602089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1782
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /note="biogenesis of lysosomal organelles complex 1
                     subunit 5"
                     /db_xref="GeneID:306868"
                     /db_xref="RGD:1306846"
     exon            1..188
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..640
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /note="BLOC-1 subunit 5; protein Muted homolog; biogenesis
                     of lysosomal organelles complex-1, subunit 5, muted"
                     /codon_start=1
                     /product="biogenesis of lysosome-related organelles
                     complex 1 subunit 5"
                     /protein_id="NP_001100817.1"
                     /db_xref="GeneID:306868"
                     /db_xref="RGD:1306846"
                     /translation="MSGGGTETPVACEAAQGGGGKKRDSLGTAGAAHLIIKDLGEIHS
                     RLLDHRPVTQGEIRYFVKEFEEKRGLRELRVLENLKNMIQETNERMLPKCRETMQGGL
                     EETLQRLQAATDSIHRLQQREQERKKVINDHLTASEKQRMLQWEEFLRGQPQRRAEVD
                     AEHRKAMERLREQYAAMEKDLAKFSTF"
     exon            189..271
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /inference="alignment:Splign:2.1.0"
     exon            272..401
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /inference="alignment:Splign:2.1.0"
     exon            402..460
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /inference="alignment:Splign:2.1.0"
     exon            461..1782
                     /gene="Bloc1s5"
                     /gene_synonym="Muted"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgtcggt ctcccttaag agtctctggg ttcgcgcctg cgtcgcggag gccgcgggtg
       61 ggcggagctg ttcgggatga gtggcggagg gacagagacc ccggtagcat gcgaggccgc
      121 ccagggcggc ggcggcaaga agcgagactc gctggggact gcgggtgcgg cgcacctcat
      181 tatcaaggat cttggagaaa ttcattcaag actgctggat cacagaccag ttacccaagg
      241 tgaaatccgt tactttgtaa aagaatttga agaaaaacgt ggtcttcgag aattgcgcgt
      301 tcttgagaac ttgaagaata tgatccagga aacaaatgag cgcatgcttc ccaagtgcag
      361 agagaccatg cagggtggcc tggaggagac cctgcagaga ttgcaagctg ctactgactc
      421 catccataga ctccagcaga gagaacagga gcggaaaaag gtgattaatg accacttgac
      481 agctagtgag aagcagcgta tgctccagtg ggaggagttc ctgagaggac agccgcagcg
      541 cagagccgaa gtggatgccg agcacagaaa agccatggag aggctcagag agcaatatgc
      601 agcaatggag aaggacctag ccaagttttc caccttttaa gaatttgatc ttaaagagac
      661 agatgaatgg gaacacacct catcccccca aatcctccca ccaaccatgt agcctctcct
      721 tcaagcttcg caatacactc aggggcactc ttaggtctga agagaggcac tgctggagcc
      781 agatacatgc ccagtggaag acgagtgctt gtgtacttag ctgtggtcgt ctgaggaaga
      841 ggagggcacg tgggatgcat tcactgctaa acagattggc ctcttcgggg attagcttag
      901 agggttctga gagtagattt ctgcaagggt ccacttcatt gtgccaaggg taaatggttt
      961 gacattgtgg attaaatggc agatatgaca gctgcctgtc acagcatcct gtgacagaga
     1021 tgccacagta ggcgttgaac agcttgcttg gagacaccag gttttgcagt gcaacacaat
     1081 gccatgtgtt tcaatgggtg acaagacata cttgattggt agccttgtag cacttaatat
     1141 tttcgttttc taagctatgc ttaggagaaa taacaagtat tttgactttt tcctctcgaa
     1201 ggaccatcat cttgcccaca gaacttacct tgctttcctg tccatttcac tctgggcaag
     1261 cgctccaagg aatagatagc atctacgcat gtttcagttg cacagtcaac agaatctgcc
     1321 aagaagtcac tcccaggccg tgtaagatgg gctctgggtg ggtcaaacat gctggcccac
     1381 acagtgggtg atctgagtca gagataaatc ctctttgtgt tagcatctga cctccagcag
     1441 gtgtgtccgg atggaacagg actgtccagc accactgtga tctttccgtg cctgcactag
     1501 tctaaggaag gactgcggca aatgccattt gctgtaaact aaacagaaat tcctgcaatc
     1561 gttgaggaga tgcatagcca gtggatttga ggtgtggacg ggtctttcta gtattttctg
     1621 ttcttaagta aagaagggca aggcagaaaa ttcctacctg ccattttctc tcagtgttct
     1681 tactgcagaa aattgacaat gtgtgcctgt gtgaatgtat ggccgactgt gaaagcttca
     1741 ttcttggctc atgttgaaac gtgattaaag ctaatagaag ag
//
