LOCUS       NM_001401248            1552 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus biogenesis of lysosomal organelles complex-1,
            subunit 3 (Bloc1s3), mRNA.
ACCESSION   NM_001401248 XM_006228499
VERSION     NM_001401248.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Lee,H.H., Nemecek,D., Schindler,C., Smith,W.J., Ghirlando,R.,
            Steven,A.C., Bonifacino,J.S. and Hurley,J.H.
  TITLE     Assembly and architecture of biogenesis of lysosome-related
            organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 287 (8), 5882-5890 (2012)
   PUBMED   22203680
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Setty,S.R., Tenza,D., Truschel,S.T., Chou,E., Sviderskaya,E.V.,
            Theos,A.C., Lamoreux,M.L., Di Pietro,S.M., Starcevic,M.,
            Bennett,D.C., Dell'Angelica,E.C., Raposo,G. and Marks,M.S.
  TITLE     BLOC-1 is required for cargo-specific sorting from vacuolar early
            endosomes toward lysosome-related organelles
  JOURNAL   Mol Biol Cell 18 (3), 768-780 (2007)
   PUBMED   17182842
  REMARK    Erratum:[Mol Biol Cell. 2017 Feb 1;28(3):500. PMID: 28137951]
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Di Pietro,S.M., Falcon-Perez,J.M., Tenza,D., Setty,S.R.,
            Marks,M.S., Raposo,G. and Dell'Angelica,E.C.
  TITLE     BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate
            protein trafficking on endosomes
  JOURNAL   Mol Biol Cell 17 (9), 4027-4038 (2006)
   PUBMED   16837549
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Morgan,N.V., Pasha,S., Johnson,C.A., Ainsworth,J.R., Eady,R.A.,
            Dawood,B., McKeown,C., Trembath,R.C., Wilde,J., Watson,S.P. and
            Maher,E.R.
  TITLE     A germline mutation in BLOC1S3/reduced pigmentation causes a novel
            variant of Hermansky-Pudlak syndrome (HPS8)
  JOURNAL   Am J Hum Genet 78 (1), 160-166 (2006)
   PUBMED   16385460
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Ahmed,F., Lundin,L.G. and Shire,J.G.
  TITLE     Lysosomal mutations increase susceptibility to anaesthetics
  JOURNAL   Experientia 45 (11-12), 1133-1135 (1989)
   PUBMED   2513223
REFERENCE   7  (bases 1 to 1552)
  AUTHORS   Ahmed,F. and Shire,J.G.
  TITLE     Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL
            mice
  JOURNAL   J Hered 76 (4), 311-312 (1985)
   PUBMED   4031470
REFERENCE   8  (bases 1 to 1552)
  AUTHORS   Orn,A., Hakansson,E.M., Gidlund,M., Ramstedt,U., Axberg,I.,
            Wigzell,H. and Lundin,L.G.
  TITLE     Pigment mutations in the mouse which also affect lysosomal
            functions lead to suppressed natural killer cell activity
  JOURNAL   Scand J Immunol 15 (3), 305-310 (1982)
   PUBMED   7089489
REFERENCE   9  (bases 1 to 1552)
  AUTHORS   Daniel,W.L., Harrison,B.W. and Nelson,K.
  TITLE     Genetic regulation of murine hepatic arylsulfatase B activity
            during development
  JOURNAL   J Hered 73 (1), 24-28 (1982)
   PUBMED   7069188
REFERENCE   10 (bases 1 to 1552)
  AUTHORS   Gibb,S., Hakansson,E.M., Lundin,L.G. and Shire,J.G.
  TITLE     Reduced pigmentation (rp), a new coat colour gene with effects on
            kidney lysosomal glycosidases in the mouse
  JOURNAL   Genet Res 37 (1), 95-103 (1981)
   PUBMED   7203014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 4, 2022 this sequence version replaced XM_006228499.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.1490.1,
                                           SRR26643298.1783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000001.1  88286170-88286238   c
            70-1552             JAXUCZ010000001.1  88283864-88285346   c
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1552
                     /gene="Bloc1s3"
                     /note="biogenesis of lysosomal organelles complex-1,
                     subunit 3"
                     /db_xref="GeneID:680476"
                     /db_xref="RGD:1591724"
     exon            1..69
                     /gene="Bloc1s3"
                     /inference="alignment:Splign:2.1.0"
     exon            70..1552
                     /gene="Bloc1s3"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..666
                     /gene="Bloc1s3"
                     /note="biogenesis of lysosome-related organelles
                     complex-1, subunit 3"
                     /codon_start=1
                     /product="biogenesis of lysosome-related organelles
                     complex 1 subunit 3"
                     /protein_id="NP_001388177.1"
                     /db_xref="GeneID:680476"
                     /db_xref="RGD:1591724"
                     /translation="MASSQGRRRRPGTVVPGEAAETDSELSASSSEEELYLGPSGPTR
                     GRPTGLRVAGEAAETDSEPEPEPRVAPGDLPPLVVQRDAVEAWGTEETPVLAPARSLL
                     QLRLAESQTRLDHDVAAAVSGVYRRAGRDVAALAGRLAAAQAIGLAAAHSVRLARGDL
                     CALAERLDIVAGCRLLPDIRGVPGIEPEQDPGPRA"
ORIGIN      
        1 gctacgcgaa gagaacgcct cacttccgcc aggcggcgga tccctcgggc tcggagcttc
       61 ggagaccggc tccgtgccat ggcgtcgtcc caaggtcggc ggagaaggcc gggaacagtg
      121 gtgcccgggg aagcggcgga gaccgactcg gagctgtctg catcatcatc cgaggaggag
      181 ctatacctgg gtccctcggg cccgacacgc ggccgcccca ctgggttgcg ggtggccggg
      241 gaggcggcgg agaccgactc cgagcctgag ccggagccca gggtcgcgcc gggagacctg
      301 ccccccctcg tggtgcaacg ggatgcagtg gaggcgtggg gcaccgagga gacccctgtc
      361 ctagcgcctg cgcgctctct gctgcagctc aggttggctg agagccagac gcgcctggac
      421 cacgacgtag cggctgcggt gagcggcgtg taccgccgtg cgggtcgcga tgtggccgcc
      481 ctggccggga ggctggcagc tgcccaggcc atcgggctgg cggccgccca cagcgtgcgc
      541 ctggcgcgcg gagacctctg cgcgcttgcg gagcgcctgg atattgtggc tggttgtcgc
      601 ctgctgccgg acatacgagg ggtgccgggc atcgagcccg agcaggaccc gggaccgaga
      661 gcctaggctg ttactctgtg tcccccccac ctgactctgc ctcttggtgg acattagtac
      721 cacctgtggc atctgactct gtctttgttc ttggatcacc gaggcctcca attcgtacta
      781 acgtttggtt aacgccaacc gaagcatctt cgttggtttg gcccgattaa attcttagca
      841 caattctggg atccccaacc caagactcgg cccaggttct gtggctatca agtggtttag
      901 cccccacccc ttcattttgg tcctatttcc taaattgagc ttctctccta ggcaaggctg
      961 gggtttgctt ccttttcttg aacctctcta gtctaggctt tttttggggg gggggcgtcc
     1021 ctctagtttc catccctaaa tgatgatcac ccctgatccg aggatacttt cattttacac
     1081 acccctctta cacacagacc actgtggcca gatgcagacc aacctaggcc tgggtagtga
     1141 ccctaactct caggcgtttg ggtctggggc agcgccccct cgtgttttga tcgttatagg
     1201 agatgactcc acagatacaa atttaccact cactttgtct gtttctggat ggtaaaagga
     1261 cttggatttc tgacctctat gggcaccaag gataatagtt tctttgggtc ttggtttttt
     1321 actcttttgg ccactccctt tgtctccgtc ttaatgagga ttctctgacc gtatgtggaa
     1381 gggacttggg tggtggggtg agccgttagc tcagtgagtg gtattgtgca tgcctagtgt
     1441 gggcagccct gggttcaagt cctagtacca cccttctcca aaagaaacaa agaaactagc
     1501 acatccttag atatctctgt cccctttaaa aacgtaccct cttacttctc ac
//
