LOCUS       NM_001105941             548 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus biogenesis of lysosomal organelles complex-1,
            subunit 1 (Bloc1s1), mRNA.
ACCESSION   NM_001105941 XM_001068887 XM_213833
VERSION     NM_001105941.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 548)
  AUTHORS   Thapa,D., Zhang,M., Manning,J.R., Guimaraes,D.A., Stoner,M.W.,
            Lai,Y.C., Shiva,S. and Scott,I.
  TITLE     Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory
            capacity under hyperglycemic conditions
  JOURNAL   Physiol Rep 7 (8), e14054 (2019)
   PUBMED   31033247
  REMARK    GeneRIF: Loss of GCN5L1 activity under hyperglycemic conditions
            impairs cardiac energy metabolism.
REFERENCE   2  (bases 1 to 548)
  AUTHORS   Thapa,D., Zhang,M., Manning,J.R., Guimaraes,D.A., Stoner,M.W.,
            O'Doherty,R.M., Shiva,S. and Scott,I.
  TITLE     Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced
            fatty acid oxidation in the heart
  JOURNAL   Am J Physiol Heart Circ Physiol 313 (2), H265-H274 (2017)
   PUBMED   28526709
  REMARK    GeneRIF: Acetylation of cardiac mitochondrial fatty acid oxidation
            enzymes by GCN5L1 significantly upregulates their activity in
            diet-induced obese mice.
REFERENCE   3  (bases 1 to 548)
  AUTHORS   Pu,J., Schindler,C., Jia,R., Jarnik,M., Backlund,P. and
            Bonifacino,J.S.
  TITLE     BORC, a multisubunit complex that regulates lysosome positioning
  JOURNAL   Dev Cell 33 (2), 176-188 (2015)
   PUBMED   25898167
REFERENCE   4  (bases 1 to 548)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   5  (bases 1 to 548)
  AUTHORS   Scott,I., Webster,B.R., Li,J.H. and Sack,M.N.
  TITLE     Identification of a molecular component of the mitochondrial
            acetyltransferase programme: a novel role for GCN5L1
  JOURNAL   Biochem J 443 (3), 655-661 (2012)
   PUBMED   22309213
REFERENCE   6  (bases 1 to 548)
  AUTHORS   Larimore,J., Tornieri,K., Ryder,P.V., Gokhale,A., Zlatic,S.A.,
            Craige,B., Lee,J.D., Talbot,K., Pare,J.F., Smith,Y. and Faundez,V.
  TITLE     The schizophrenia susceptibility factor dysbindin and its
            associated complex sort cargoes from cell bodies to the synapse
  JOURNAL   Mol Biol Cell 22 (24), 4854-4867 (2011)
   PUBMED   21998198
REFERENCE   7  (bases 1 to 548)
  AUTHORS   Di Pietro,S.M., Falcon-Perez,J.M., Tenza,D., Setty,S.R.,
            Marks,M.S., Raposo,G. and Dell'Angelica,E.C.
  TITLE     BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate
            protein trafficking on endosomes
  JOURNAL   Mol Biol Cell 17 (9), 4027-4038 (2006)
   PUBMED   16837549
REFERENCE   8  (bases 1 to 548)
  AUTHORS   Wong,K., Zhang,J., Awasthi,S., Sharma,A., Rogers,L., Matlock,E.F.,
            Van Lint,C., Karpova,T., McNally,J. and Harrod,R.
  TITLE     Nerve growth factor receptor signaling induces histone
            acetyltransferase domain-dependent nuclear translocation of
            p300/CREB-binding protein-associated factor and hGCN5
            acetyltransferases
  JOURNAL   J Biol Chem 279 (53), 55667-55674 (2004)
   PUBMED   15496412
  REMARK    GeneRIF: NGF receptor signaling induces histone acetyltransferase
            domain-dependent nuclear translocation of PCAF and hGCN5
            acetyltransferases
REFERENCE   9  (bases 1 to 548)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   10 (bases 1 to 548)
  AUTHORS   Starcevic,M. and Dell'Angelica,E.C.
  TITLE     Identification of snapin and three novel proteins (BLOS1, BLOS2,
            and BLOS3/reduced pigmentation) as subunits of biogenesis of
            lysosome-related organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 279 (27), 28393-28401 (2004)
   PUBMED   15102850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF979060.1 and CB613801.1.
            
            On Dec 24, 2009 this sequence version replaced NM_001105941.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB613801.1, FQ217708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CF979060.1         19-22
            5-548               CB613801.1         11-554
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..548
                     /gene="Bloc1s1"
                     /note="biogenesis of lysosomal organelles complex-1,
                     subunit 1"
                     /db_xref="GeneID:288785"
                     /db_xref="RGD:1307564"
     exon            1..148
                     /gene="Bloc1s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..465
                     /gene="Bloc1s1"
                     /note="BLOC-1 subunit 1; protein acetyltransferase
                     BLOC1S1"
                     /codon_start=1
                     /product="biogenesis of lysosome-related organelles
                     complex 1 subunit 1"
                     /protein_id="NP_001099411.2"
                     /db_xref="GeneID:288785"
                     /db_xref="RGD:1307564"
                     /translation="MLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNV
                     GVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIE
                     LDMRTIATALEYVYKGQLQSAPS"
     exon            149..221
                     /gene="Bloc1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..354
                     /gene="Bloc1s1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..548
                     /gene="Bloc1s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttcggagc aagcgagcca aggcaaggtc cggctcccgc agctttaggg aggggcccgc
       61 ggtgcccgca ccgagccaga ctcgaccatg ctgtcccgcc tgctcaaaga acaccaggca
      121 aagcagaacg aacggaagga gctgcaggag aagaggaggc gagaggctat cactgcagcc
      181 acctgcctga ccgaagcgtt ggtggatcac ctcaacgtgg gtgtggccca ggcctacatg
      241 aaccagagaa agctggacca tgaggtgaag accctgcagg tccaggctgc ccagtttgcc
      301 aagcagaccg gccagtggat tggcatggtg gaaaacttca accaggcact taaggaaatc
      361 ggggatgtgg agaactgggc tcggagcatc gaactggaca tgcgcaccat tgccacagcg
      421 ctggagtacg tctacaaagg gcagctgcag tctgcaccgt cctagactaa aacccacccc
      481 tctcacctca ccctcctgga caggagggag actggcaagc catgaataaa aactcaagct
      541 tccattct
//
