LOCUS       NM_001025767            1765 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus B-cell linker (Blnk), mRNA.
ACCESSION   NM_001025767 XM_574669
VERSION     NM_001025767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1765)
  AUTHORS   Cheng,Y., Li,F., Zhang,W.S., Zou,G.Y. and Shen,Y.X.
  TITLE     Silencing BLNK protects against interleukin-1beta-induced
            chondrocyte injury through the NF-kappaB signaling pathway
  JOURNAL   Cytokine 148, 155686 (2021)
   PUBMED   34521030
  REMARK    GeneRIF: Silencing BLNK protects against interleukin-1beta-induced
            chondrocyte injury through the NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 1765)
  AUTHORS   Wilm,B., James,R.G., Schultheiss,T.M. and Hogan,B.L.
  TITLE     The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus
            intermediate mesoderm cell fate
  JOURNAL   Dev Biol 271 (1), 176-189 (2004)
   PUBMED   15196959
REFERENCE   3  (bases 1 to 1765)
  AUTHORS   Minegishi,Y., Rohrer,J., Coustan-Smith,E., Lederman,H.M., Pappu,R.,
            Campana,D., Chan,A.C. and Conley,M.E.
  TITLE     An essential role for BLNK in human B cell development
  JOURNAL   Science 286 (5446), 1954-1957 (1999)
   PUBMED   10583958
REFERENCE   4  (bases 1 to 1765)
  AUTHORS   Fu,C., Turck,C.W., Kurosaki,T. and Chan,A.C.
  TITLE     BLNK: a central linker protein in B cell activation
  JOURNAL   Immunity 9 (1), 93-103 (1998)
   PUBMED   9697839
REFERENCE   5  (bases 1 to 1765)
  AUTHORS   Fu,C. and Chan,A.C.
  TITLE     Identification of two tyrosine phosphoproteins, pp70 and pp68,
            which interact with phospholipase Cgamma, Grb2, and Vav after B
            cell antigen receptor activation
  JOURNAL   J Biol Chem 272 (43), 27362-27368 (1997)
   PUBMED   9341187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098790.1.
            
            On Jul 22, 2005 this sequence version replaced XM_574669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098790.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132286,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1765
                     /gene="Blnk"
                     /note="B-cell linker"
                     /db_xref="GeneID:499356"
                     /db_xref="RGD:1561933"
     exon            1..154
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1481
                     /gene="Blnk"
                     /note="cytoplasmic adapter protein"
                     /codon_start=1
                     /product="B-cell linker protein"
                     /protein_id="NP_001020938.1"
                     /db_xref="GeneID:499356"
                     /db_xref="RGD:1561933"
                     /translation="MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMDKIKKLKVKGP
                     PSVPRRDYALDNPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEETGDDSYEPPPAE
                     QQTRVVHPALPFTRGEYVDNRSSQRHSPPFSKTLPSKPSWPSAKARLASTLPAPNSLQ
                     KPQVPPKPKDLLEDEADYVVPVEDNDENYIHPRESSPLPAEKAPTVNRSTKPNSSSKH
                     VSPPGTVAGRNSGVWDSKSSLPAAPSPLPRAGKKTATPLKTTPVPSLQNASNVCEEKP
                     VPAERHRGSSHRQDTVQSPVFPPTQKPVLQKPVPLPRFTEGGSPAADGPVPSFPFNST
                     FADQEAELHGKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVAFFNK
                     RVYNIPVRFIEATKQYALGKKKNGEEYFGSVVEIIKNHQHNPLVLIDSQNNTKDSTRL
                     KYAVKVS"
     exon            155..220
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            221..270
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            271..311
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            312..468
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            469..632
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            633..714
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            715..786
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            787..856
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            857..884
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            885..927
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1012
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1044
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1121
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1205
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1361
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1740
                     /gene="Blnk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcatga gcccttgagg ccagagtctt accatgctgc tccccaggaa gcccaggagc
       61 tgctgacatc cctctggaca gcgactccac agcccctctc aagaaaaatg gacaaactga
      121 ataaaataac tgtccctgcc agtcagaagc tgagacagct tcagaagatg gtccacgata
      181 ttaagaacaa tgaaggtgga ataatggaca agataaagaa gctaaaagtc aaaggacctc
      241 caagtgttcc tcgaagggac tatgcattag acaaccccgc ggacgaagag gagcaatggt
      301 cagatgactt tgacagcgac tatgaaaatc cagatgaaca ttcggactcc gagatgtatg
      361 tgatgcccgc agaggagacg ggggacgatt cctatgagcc gcctcccgct gagcagcaga
      421 cacgggtggt ccatccagcc ctgcccttca cgaggggcga gtatgtagat aatcgatcca
      481 gccagcggca ctctccaccc ttcagcaaga cacttcctag taagcccagc tggccttcag
      541 cgaaagcaag gctggcctcc actctgccag cccccaactc tctacagaag cctcaagtcc
      601 cccccaagcc caaagacctc cttgaggatg aggctgatta tgtggtccct gtggaggata
      661 acgatgaaaa ctatatccat cccagagaaa gcagcccgct gcctgctgag aaagctccca
      721 cggtgaatag atcaaccaaa ccaaacagct cctcaaagca tgtgtcccct ccagggactg
      781 tcgcaggtcg aaacagtggg gtctgggact ccaagtcatc tttgcctgct gcaccatccc
      841 cactgccacg agctgggaag aaaacagcta caccacttaa gacgactccc gttccttccc
      901 tacagaacgc atcaaatgtt tgtgaagaaa agcctgttcc tgctgagcgc caccgagggt
      961 ctagtcacag acaagacact gtacagtcac cagtgtttcc tcccacccag aaacctgtcc
     1021 ttcaaaagcc tgtacccctg ccaaggttca cagaaggggg aagcccagct gcagacggac
     1081 cggtacctag cttcccattt aattctactt ttgcagacca ggaggctgaa ctgcacggta
     1141 agccctggta cgctggcgcc tgcgaccgca agtctgctga agaggccttg caccgatcca
     1201 acaaggatgg atcatttctt attcggaaaa gctccggcca cgattctaag cagccgtaca
     1261 cactagttgc gttctttaac aagcgtgtat ataatatccc tgtgcggttc atcgaagcaa
     1321 ccaaacaata tgctttggga aagaagaaaa atggcgaaga gtactttgga agcgttgtgg
     1381 agatcatcaa gaatcaccag cacaaccccc tggttcttat tgacagtcag aataacacaa
     1441 aagactccac gagactgaaa tacgccgtga aggtttcata acgaaagaga cggtcgacgc
     1501 cgctgtccca gacatttccc ccgtttcttc ttttgagaaa acttcgtgtt ctggctgtga
     1561 gtcatcagcg atgagggaga gaagatgaat gaagcccctg agacttcatg aatgaatgaa
     1621 tccactcctc cgtaagatgt tcacacgagc ttttctatgg cctgacttga tgaagtaatg
     1681 gctggggagg gtcggttatt ctgctactaa tattgtctaa ataaatgtat ttaaaagaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaaaa
//
