LOCUS       NM_001034163            2291 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus bleomycin hydrolase (Blmh), mRNA.
ACCESSION   NM_001034163 XM_213406
VERSION     NM_001034163.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Kamata,Y., Taniguchi,A., Yamamoto,M., Nomura,J., Ishihara,K.,
            Takahara,H., Hibino,T. and Takeda,A.
  TITLE     Neutral cysteine protease bleomycin hydrolase is essential for the
            breakdown of deiminated filaggrin into amino acids
  JOURNAL   J Biol Chem 284 (19), 12829-12836 (2009)
   PUBMED   19286660
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Kamata,Y., Itoh,Y., Kajiya,A., Karasawa,S., Sakatani,C.,
            Takekoshi,S., Osamura,R.Y. and Takeda,A.
  TITLE     Quantification of neutral cysteine protease bleomycin hydrolase and
            its localization in rat tissues
  JOURNAL   J Biochem 141 (1), 69-76 (2007)
   PUBMED   17158865
  REMARK    GeneRIF: Blmh was localized as granular staining in the distal and
            proximal tubular cells of the kidney, and it was also detected in
            hepatocytes of the liver, in the red pulpy region of the spleen and
            in neurons of the brain.
            Erratum:[J Biochem (Tokyo). 2007 Jun;141(6):929]
REFERENCE   6  (bases 1 to 2291)
  AUTHORS   Stoltze,L., Schirle,M., Schwarz,G., Schroter,C., Thompson,M.W.,
            Hersh,L.B., Kalbacher,H., Stevanovic,S., Rammensee,H.G. and
            Schild,H.
  TITLE     Two new proteases in the MHC class I processing pathway
  JOURNAL   Nat Immunol 1 (5), 413-418 (2000)
   PUBMED   11062501
REFERENCE   7  (bases 1 to 2291)
  AUTHORS   Schwartz,D.R., Homanics,G.E., Hoyt,D.G., Klein,E., Abernethy,J. and
            Lazo,J.S.
  TITLE     The neutral cysteine protease bleomycin hydrolase is essential for
            epidermal integrity and bleomycin resistance
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4680-4685 (1999)
   PUBMED   10200322
REFERENCE   8  (bases 1 to 2291)
  AUTHORS   Beninga,J., Rock,K.L. and Goldberg,A.L.
  TITLE     Interferon-gamma can stimulate post-proteasomal trimming of the N
            terminus of an antigenic peptide by inducing leucine aminopeptidase
  JOURNAL   J Biol Chem 273 (30), 18734-18742 (1998)
   PUBMED   9668046
REFERENCE   9  (bases 1 to 2291)
  AUTHORS   Takeda,A., Masuda,Y., Yamamoto,T., Hirabayashi,T., Nakamura,Y. and
            Nakaya,K.
  TITLE     Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a
            DNA-binding cysteine protease
  JOURNAL   J Biochem 120 (2), 353-359 (1996)
   PUBMED   8889821
REFERENCE   10 (bases 1 to 2291)
  AUTHORS   Takeda,A., Higuchi,D., Yamamoto,T., Nakamura,Y., Masuda,Y.,
            Hirabayashi,T. and Nakaya,K.
  TITLE     Purification and characterization of bleomycin hydrolase, which
            represents a new family of cysteine proteases, from rat skin
  JOURNAL   J Biochem 119 (1), 29-36 (1996)
   PUBMED   8907172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB774190.1, CK363809.1, CB772927.1, CB768995.1, CB583895.1 and
            JAXUCZ010000010.1.
            
            On Oct 16, 2005 this sequence version replaced XM_213406.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128701.1, SRR26360176.1725116.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CB774190.1         16-88
            74-787              CK363809.1         1-714
            788-820             CB772927.1         360-392
            821-1060            CB768995.1         15-254              c
            1061-1460           CB583895.1         197-596
            1461-2291           JAXUCZ010000010.1  62312519-62313349
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2291
                     /gene="Blmh"
                     /note="bleomycin hydrolase"
                     /db_xref="GeneID:287552"
                     /db_xref="RGD:1304668"
     exon            1..188
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1543
                     /gene="Blmh"
                     /EC_number="3.4.22.40"
                     /note="BH; BMH; BLM hydrolase"
                     /codon_start=1
                     /product="bleomycin hydrolase"
                     /protein_id="NP_001029335.1"
                     /db_xref="GeneID:287552"
                     /db_xref="RGD:1304668"
                     /translation="MNNAGLNSEKVAALIQKLNSDPQFVLAQNVGTTHDLLDICLKRA
                     TVQGAQHVFQHVVPQEGKPVTNQKSSGRCWIFSCLNVMRLPFMKKFNIEEFEFSQSYL
                     FFWDKVERCYFFLNAFVDTAQKKEPEDGRLVQYLLMNPTNDGGQWDMLVNIVEKYGVV
                     PKKCFPESHTTEATRRMNDILNHKMREFCIRLRNLVHSGATKGEISSTQDAMMEEIFR
                     VVCICLGNPPETFTWEYRDKDKNYHKVGPITPLQFYKEHVKPLFNMEDKICFVNDPRP
                     QHKYNKLYTVDYLSNMVGGRKTLYNNQPIDFLKKMVAASIRDGEAVWFGCDVGKHFNG
                     KLGLSDMNVYDHELVFGVSLKNMNKAERLAFGESLMTHAMTFTAVSEKDDQEGAFVKW
                     RVENSWGEDHGHKGYLCMTDEWFSEYVYEVVVDKKHVPEEVLAVLEQEPIVLPAWDPM
                     GALAE"
     exon            189..386
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            387..496
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            497..638
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            639..727
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            728..820
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            821..976
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1135
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1203
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1321
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1391
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..2291
                     /gene="Blmh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgtccctc cgcggacccc gtttctctcg gccaccattg agcgggtttc cttcttccgg
       61 cgctttgggt gcgagaacca ggtccggcca gctaggcagc gggttgtagt ataaccccgg
      121 agctcacctg aggaccctga aaactaacgt tttcccacga ggcagtttgg gcaccatgaa
      181 caacgcagga ctaaattcgg agaaggtagc tgctttgatc cagaaactaa attctgaccc
      241 tcagttcgta cttgcccaga atgtcgggac cacccacgat ctgctggaca tttgtctgaa
      301 gagggccaca gtccagggtg ctcagcatgt gttccagcac gttgtgcctc aggaaggcaa
      361 gccagtcacc aaccagaaga gctctggacg atgctggatc ttttcttgtt tgaatgttat
      421 gagacttcca ttcatgaaaa aatttaacat tgaagaattt gagtttagtc agtcttacct
      481 gtttttttgg gacaaggtcg aacgctgtta cttcttcttg aatgcttttg tggacacagc
      541 ccagaaaaaa gagcctgaag atggaagact ggtgcagtat ttgcttatga accctacaaa
      601 tgatggtgga cagtgggata tgcttgtcaa tattgttgaa aaatatggtg ttgtccctaa
      661 gaaatgcttc cctgaatcgc atacgacaga ggccaccaga agaatgaacg atattctgaa
      721 tcacaagatg agagaattct gtatacggct tcggaacctg gtacacagtg gagcaaccaa
      781 aggagagatc tcatctacac aagatgccat gatggaggag atattcagag tagtgtgcat
      841 atgtttgggt aacccaccag agaccttcac ctgggagtat cgagacaaag ataaaaacta
      901 ccacaaggtc ggccccataa cacccttgca gttttacaag gaacacgtga agccactctt
      961 caacatggaa gataagattt gttttgtgaa tgacccacgg ccccagcaca agtacaataa
     1021 attgtacaca gtagactact tgagcaatat ggttggaggg agaaaaacgc tgtataacaa
     1081 ccagcccatt gacttcttga aaaagatggt tgctgcctcc atcagagatg gagaggctgt
     1141 gtggtttggc tgtgatgttg ggaagcactt caatggcaag ctgggcctca gtgacatgaa
     1201 tgtctatgat cacgagttag tgttcggtgt ctccttgaag aacatgaaca aagctgagag
     1261 gttggctttt ggtgagtcac tcatgaccca cgccatgacc ttcactgctg tctcagagaa
     1321 ggatgaccag gaaggtgcat ttgtgaaatg gagagtagag aattcatggg gtgaagacca
     1381 cggccacaaa ggttacctgt gcatgaccga tgagtggttc tctgagtatg tctacgaggt
     1441 ggtggtggac aagaagcatg tcccagaaga ggtgctggct gtgttagagc aggagcctat
     1501 tgtcctgccg gcatgggacc ccatgggggc tttggctgaa tgagtgagtg gaccgcctcc
     1561 agctccttcc tcttcccatg ggatcggatg tagctgccaa ggacagatcc agggactgaa
     1621 accaaagtta catgggtggc tgttcccaca ggatacagtc agactcttgg gtttccagtc
     1681 tcttccagga acctctttga gaaaaatgct ttctgctgaa acaaaatatt cataaaggaa
     1741 aaaaataaag gggaaggatt ggggcatcct gtctgctctc ctcatctctg acggctcagg
     1801 acctcatagc attttaattg gatgtagttg tccacggtca tggtctttgt gtttgtggta
     1861 agacagtaag atgagcggct gaggtgtgtg gagaacaaac agtcctgggc tccttgttcc
     1921 tacagtagat tagggagggt tagctaggat ttgaactctc aacgctgcat gctgccgcac
     1981 aggtcactgt ccttcctacc tggcagtcgc tgaattcaac ttccacaagg ttgtctcatg
     2041 tgactaatag ctcgagaagg gaaggctgat cggctctgac atgattcctt cctgttctga
     2101 actgtggggc tcacctgggc caggttaaac ctcgtcaggg gctcaactgt catcactagg
     2161 gcaccccatt gaatgcttta acgtctgtct ctgtgttggg ggttgggtgg ggagaaaaag
     2221 tgatgctcat tctttctgat aactcgatgg tgctgagaag cttttgaata aaagactttg
     2281 ctaaatgaga a
//
