LOCUS       NM_001025751            2290 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus BLK proto-oncogene, Src family tyrosine kinase
            (Blk), mRNA.
ACCESSION   NM_001025751 XM_344419
VERSION     NM_001025751.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C,
            Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S,
            Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z,
            Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C,
            Mao Z and Ge B.
  TITLE     Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
  JOURNAL   Nature 563 (7729), 131-136 (2018)
   PUBMED   30356214
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski
            WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS,
            Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN and
            Doria A.
  TITLE     Mutations at the BLK locus linked to maturity onset diabetes of the
            young and beta-cell dysfunction
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14460-14465 (2009)
   PUBMED   19667185
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Ito I, Kawasaki A, Ito S, Hayashi T, Goto D, Matsumoto I, Tsutsumi
            A, Hom G, Graham RR, Takasaki Y, Hashimoto H, Ohashi J, Behrens TW,
            Sumida T and Tsuchiya N.
  TITLE     Replication of the association between the C8orf13-BLK region and
            systemic lupus erythematosus in a Japanese population
  JOURNAL   Arthritis Rheum 60 (2), 553-558 (2009)
   PUBMED   19180478
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Canatan H.
  TITLE     The effect of cardiac ischemic preconditioning on rat left
            ventricular gene expression profile
  JOURNAL   Cell Biochem Funct 26 (2), 179-184 (2008)
   PUBMED   17562528
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   Azolov,V.V.
  TITLE     [Restoration of the function of bilateral hand grip at the expense
            of the fingers of the same hand]
  JOURNAL   Ortop Travmatol Protez (4), 60-65 (1977)
   PUBMED   876631
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098683.1.
            
            On Jul 22, 2005 this sequence version replaced XM_344419.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132278,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..2290
                     /gene="Blk"
                     /note="BLK proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:364403"
                     /db_xref="RGD:1308859"
     exon            1..351
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            352..457
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1852
                     /gene="Blk"
                     /EC_number="2.7.10.2"
                     /note="B lymphoid tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Blk"
                     /protein_id="NP_001020922.1"
                     /db_xref="GeneID:364403"
                     /db_xref="RGD:1308859"
                     /translation="MGLLSSKRQISEKSKSWSPVKARAQGKVPPPLPPLVVFNHLPPP
                     SPNQHPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLKSTGDWWLARSLVTGREGYV
                     PSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKD
                     VTSQGEMVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSEKGDGLCQKLTLPCVNPA
                     PKNPWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFL
                     GEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDM
                     SAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFP
                     IKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPC
                     PETCPPELYHDVITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP"
     exon            458..509
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            510..603
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            604..702
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            703..806
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            807..953
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1106
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1286
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1363
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1514
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1646
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..2290
                     /gene="Blk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccagcatg gctgaacgtc aggtgcccac ggaacttcct caagaggatc tctggggctg
       61 aggagccaga attctccaga aggcttggct ggagggtgga gctcacgttg aactgcttct
      121 tggggctttt gatggaagtc tgatcacaac gggggcacac acacctctga atgctgttag
      181 caggaagcca caagccactg aagctgactg agatgagaag aatccatctg gggatgggat
      241 tggtttgtcg taactgggtc cagagcttct ggttgctgct agaagattct tcaaccacat
      301 gcaccctggg atctgaacag ctatgttgaa aggctactga agccctgcaa ggatggggct
      361 actgagcagc aagaggcaga tcagcgagaa gagcaagagc tggagccctg tgaaggcccg
      421 cgcccagggc aaggtacccc cgcccctgcc acccctggtt gtcttcaacc acctccctcc
      481 tccatctcct aaccagcacc cagatgaaga ggagcgtttt gtggtggccc tgtttgacta
      541 tgccgctgtg aatgacaggg acctgcaagt gctaaaggga gagaagctcc aagtcttgaa
      601 gagcactgga gactggtggt tggccaggtc actcgtcaca ggaagagaag gctatgtgcc
      661 cagcaacttt gtggccccag tagagaccct ggaagtagaa aaatggttct tcaggaccat
      721 tagccggaag gatgctgaga ggcagttgct ggctccaatg aacaaagccg gctcctttct
      781 catcagagag agtgagagca ataaaggtgc cttttcccta tctgtgaaag acgtcaccag
      841 ccagggggag atggtcaagc actataagat ccgctcactg gacaatggag gctattacat
      901 ctcgccccgg atcaccttcc ccaccctcca ggccctggtg cagcactatt ctgagaaagg
      961 ggacggtttg tgtcagaagt tgaccctgcc ctgtgtgaac ccagccccga agaatccctg
     1021 ggcccaagac gaatgggaaa tccccaggca gtccctcaag ttggtccgga aacttgggtc
     1081 tgggcagttt ggtgaagtct ggatgggtta ttacaaaaat aacatgaagg tggcaatcaa
     1141 gaccctgaag gagggaacca tgtctccgga agctttcctg ggtgaggcca acgtgatgaa
     1201 aaccctgcag catgagaggc tggtccgtct ctacgccgtg gtcaccagag agcccatcta
     1261 cattgtcacg gaatacatgg ccagaggatg cttgctggat tttctgaaga ccgatgaagg
     1321 tagcagattg tcccttccaa ggctgattga catgtcagcc caggttgcag aagggatggc
     1381 ttacatagag cgcatgaatt ccatccaccg tgacctgcgg gcagccaaca tcctggtgtc
     1441 tgagaccttg tgctgcaaaa tcgctgactt cggcttggcc aggatcatcg acagtgaata
     1501 tactgcccaa gagggggcca agttccccat caagtggact gccccagaag ccatccactt
     1561 cggggtgttt accatcaagg ctgatgtgtg gtcctttgga gtcttgctga tggagattgt
     1621 cacatatggg cgtgttccct acccaggaat gagcaaccct gaggtcatcc gtagcctgga
     1681 gcatggctac cgaatgccat gcccagagac atgtccgcct gagttgtacc atgacgtcat
     1741 cactgagtgc tggcgaggcc gacctgagga gcggcctacc tttgagttcc tgcagtcagt
     1801 gctggaggac ttctacacag ccacggaggg ccaatatgag ctgcagcctt agcagcaaat
     1861 aggctcttca gtgttccctg cctgagtctc cttcctgctg gactcttgac tttgagttaa
     1921 tatgttccca tttaactagc tcttctttca gactaggtag gctgcagagt cggggtggaa
     1981 tggcgggcct gcttctcaaa tgagggagcc aggagacaag ggtggcttcg tggtggggca
     2041 tggactctca aggtacaacc ttggtccact cttgccttgg cccacccttc cctggctgtg
     2101 tgcctttggg caagttactt agctgctctg tgccctccat tccttgaatg taacacaaag
     2161 aaggattggg ttagaactta cctccggggg ttggggattt agctcagtgg tagagcgctt
     2221 gcctagcaag cgcaaggccc tgggttcggt ccccagcttc ggggaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa
//
