LOCUS       NM_023987               2636 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus baculoviral IAP repeat-containing 3 (Birc3),
            mRNA.
ACCESSION   NM_023987
VERSION     NM_023987.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Jiang XJ, Chen ZW, Zhao JF, Liao CX, Cai QH and Lin J.
  TITLE     cIAP2 via NF-kappaB signalling affects cell proliferation and
            invasion in hepatocellular carcinoma
  JOURNAL   Life Sci 266, 118867 (2021)
   PUBMED   33310033
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Tang D, Liu H, Zhao Y, Qian D, Luo S, Patz EF Jr, Su L, Shen S,
            ChristianI DC, Gao W and Wei Q.
  TITLE     Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome
            pathway are associated with non-small cell lung cancer survival
  JOURNAL   Am J Cancer Res 10 (8), 2582-2595 (2020)
   PUBMED   32905523
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Chen Z, Xu G, Wu D, Wu S, Gong L, Li Z, Luo G, Hu J, Chen J, Huang
            X, Chen C, Jiang Z and Li X.
  TITLE     Lobaplatin induces pyroptosis through regulating cIAP1/2,
            Ripoptosome and ROS in nasopharyngeal carcinoma
  JOURNAL   Biochem Pharmacol 177, 114023 (2020)
   PUBMED   32413426
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Tomicic MT, Steigerwald C, Rasenberger B, Brozovic A and Christmann
            M.
  TITLE     Functional mismatch repair and inactive p53 drive sensitization of
            colorectal cancer cells to irinotecan via the IAP antagonist BV6
  JOURNAL   Arch Toxicol 93 (8), 2265-2277 (2019)
   PUBMED   31289894
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Zhang W, An F, Xia M, Zhan Q, Tian W and Jiao Y.
  TITLE     Increased HMGB1 expression correlates with higher expression of
            c-IAP2 and pERK in colorectal cancer
  JOURNAL   Medicine (Baltimore) 98 (3), e14069 (2019)
   PUBMED   30653121
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Jung B, Kim MO, Yun SJ and Lee EH.
  TITLE     Down-regulation of the expression of rat inhibitor-of-apoptosis
            protein-1 and -3 during transforming growth factor-beta1-mediated
            apoptosis in rat brain microglia
  JOURNAL   Neuroreport 14 (6), 857-860 (2003)
   PUBMED   12858047
  REMARK    GeneRIF: decrease in IAP-1 expression by TGF-beta1 might provide an
            important regulatory function in TGF-beta1-mediated microglial
            death and in attenuation of excessive microglial activation in
            pathological conditions.
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ,
            Taki W, Simon RP and Henshall DC.
  TITLE     Formation of a tumour necrosis factor receptor 1 molecular
            scaffolding complex and activation of apoptosis signal-regulating
            kinase 1 during seizure-induced neuronal death
  JOURNAL   Eur J Neurosci 17 (10), 2065-2076 (2003)
   PUBMED   12786973
REFERENCE   8  (bases 1 to 2636)
  AUTHORS   Holcik M, Lefebvre CA, Hicks K and Korneluk RG.
  TITLE     Cloning and characterization of the rat homologues of the Inhibitor
            of Apoptosis protein 1, 2, and 3 genes
  JOURNAL   BMC Genomics 3, 5 (2002)
   PUBMED   11860601
REFERENCE   9  (bases 1 to 2636)
  AUTHORS   Sugiyama,T., Asaka,M., Nakamura,T., Nakamura,S., Yonezumi,S. and
            Seto,M.
  TITLE     API2-MALT1 chimeric transcript is a predictive marker for the
            responsiveness of H. pylori eradication treatment in low-grade
            gastric MALT lymphoma
  JOURNAL   Gastroenterology 120 (7), 1884-1885 (2001)
   PUBMED   11398794
REFERENCE   10 (bases 1 to 2636)
  AUTHORS   Yang Y, Fang S, Jensen JP, Weissman AM and Ashwell JD.
  TITLE     Ubiquitin protein ligase activity of IAPs and their degradation in
            proteasomes in response to apoptotic stimuli
  JOURNAL   Science 288 (5467), 874-877 (2000)
   PUBMED   10797013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083555.1 and CA505609.1.
            
            On Sep 28, 2011 this sequence version replaced NM_023987.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083555.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132288,
                                           SAMD00132291 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2312              BC083555.1         1-2312
            2313-2636           CA505609.1         1-324               c
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2636
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /note="baculoviral IAP repeat-containing 3"
                     /db_xref="GeneID:78971"
                     /db_xref="RGD:621282"
     exon            1..55
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..140
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2041
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /EC_number="2.3.2.27"
                     /note="inhibitor of apoptosis protein 1"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 3"
                     /protein_id="NP_076477.3"
                     /db_xref="GeneID:78971"
                     /db_xref="RGD:621282"
                     /translation="MAKQWGISLVVKLTKSHEQNYLPGERLLPSPPCRLTMNMVQGSA
                     FLAKLMKSADTFELKYDFSCELYRLSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKC
                     FSCGLMLDNWKQGDSPIEKHRKLYPSCSFVQTLNPANSLEASPQPPLPSTATSTMPSG
                     FAASESTGYFSGSYSSFPSDPVNFRANQDCPAFSTSPYHFAMNTEKARLLTYQTWPLS
                     FLSPAELAKAGFYYTGPGDRVACFACGGKLSNWDRKDDPLSEHRRHFPSCPFLKDVGQ
                     FTSQYTVSNLSMQTHAARVRTFSTWPSSALVHPQELASAGFYYTGHSDDVKCFCCDGG
                     LRCWESGDDPWVEHAKWFPRCEYLIRIKGQEFVGQVQAGYPHLLEQLLSTSDSPEDET
                     GEAAIVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSD
                     LVIGLLDAEDEMREEQTEQEAEEEESDDLTLIRKNKMVLLQHLTPVTPILDCLLSARV
                     ITEQEYDAVKQKPHTLQARTLIDTVLAKGNTAATSFRNSLQEIDPGLYRDIFVRQNIR
                     SLPTDDIAALPMEEQLRKLQEERTCKVCMDREVSLVFIPCGHLVVCKECAPSLRKCPI
                     CRGTIKGTVRTFLS"
     exon            141..1085
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1185
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1264
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1313
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1553
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1805
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1847
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2619
                     /gene="Birc3"
                     /gene_synonym="Birc2; IAP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacatatctg cctttttctt ataaaaagaa ggaaaagggg agggggaagc cgatggcaat
       61 ggacaaggac agtgagcggc cgaggtagaa ggtggtcagc aaagttccgt aggagagaac
      121 gaagatggca aagcaatggg gtatcagcct agtggtaaaa ctgaccaaaa gtcatgaaca
      181 aaactacctc cccggagaaa ggctgcttcc ttcccctccc tgtcgtctca ccatgaacat
      241 ggttcaaggc agcgccttcc tggccaagct gatgaagagt gccgacacct ttgagttgaa
      301 gtacgacttt tcatgtgagc tgtaccgctt gtccacatat tcaactttcc ctgctggagt
      361 ccctgtctca gagaggagtc tggctcgtgc tggcttttac tacacaggtg tcaatgacaa
      421 ggtcaagtgc ttctcctgtg gcctgatgct ggacaactgg aaacaagggg acagtcccat
      481 cgagaagcac agaaagctgt atcccagctg cagctttgtg cagaccctga atccagccaa
      541 cagtctggaa gctagccctc agcctcctct tccttccaca gcgacaagca ccatgccctc
      601 cggctttgca gcttccgaga gcactggcta cttcagtggc tcctactcaa gctttccctc
      661 agaccctgtg aacttccgcg caaatcaaga ctgccctgct ttcagcacaa gtccctacca
      721 ctttgcaatg aacacggaga aggccagatt actcacctat caaacgtggc cgttgtcttt
      781 tctgtcccca gcagagctgg ccaaagcagg attctactac acagggcctg gagatagagt
      841 ggcctgcttt gcgtgtggtg ggaaactgag caactgggat cgtaaggatg atcctctgtc
      901 agagcacagg agacatttcc ccagctgccc attcttaaaa gatgtgggtc agttcacttc
      961 acaatacact gtctctaacc tgagcatgca gacccacgca gcacgtgtta gaacgttctc
     1021 tacctggcct tctagcgctc tcgttcatcc tcaggaactt gcaagtgcgg gcttttatta
     1081 cacgggacac agtgatgacg tcaagtgctt ttgctgtgat ggtgggctaa gatgctggga
     1141 atctggagac gacccctggg tggaacacgc caagtggttt ccaaggtgtg agtacttgat
     1201 cagaatcaaa ggccaagagt tcgttggcca agttcaagct ggttaccctc atctacttga
     1261 gcagctatta tctacgtcag actccccaga ggatgagact ggagaggcag caattgtgca
     1321 tctgggccct ggagagaatt gggaagatgc agtgatgatg aacacacctg tggttaaagc
     1381 agccttggac atgggcttca gtaggagcct ggtgagacag acggttcagc gacagatcct
     1441 ggccactggt gagaactaca ggacggtcag tgacctcgtg ataggcctac tggatgcaga
     1501 agatgagatg agagaggagc agacggagca ggaggccgag gaggaggagt cagatgatct
     1561 aacattaatc cggaagaaca aaatggtgct tcttcaacat ttgacgcctg tgacaccaat
     1621 cctggattgc ctcctaagtg ccagggtcat taccgaacag gagtacgatg ccgtaaaaca
     1681 gaaaccacac accttgcagg caaggacact gatcgatact gtattagcga aaggaaacac
     1741 cgcagcgacc tcattcagaa actccctgca ggaaatcgac cctgggttgt acagagatat
     1801 atttgtgcga cagaacatta ggagtcttcc cacagatgac attgcagctc taccgatgga
     1861 agaacagttg cggaaactcc aggaagagag aacgtgtaaa gtgtgtatgg accgagaggt
     1921 gtccctcgtt ttcattccct gtggccatct ggtcgtgtgc aaagaatgtg ccccctctct
     1981 gaggaagtgt cccatctgca gagggactat caagggcaca gtgcgcacat ttctctcctg
     2041 aacaggactg gactgatggt ccacggttgt gaccccagcc aggaggagca gaagttcaat
     2101 gtcactccca gctccataag gaacttgagg ccggcctgga tgacatgaga cactgcctct
     2161 aaatagtgta aaaatgaaaa acatggggaa aaaaaacctt ttgtctaaac tcaaagaatg
     2221 gattacttac ataataattt taattggttt ccttaaaagt gctatttatt cccaactcag
     2281 agaactgttt tcagtaaagt attttcatac tatctgcatc taaagcatgt ctgtttgtat
     2341 attcagatgc catgagagag ggtttcattc ttattcccga aacgcaggta ttacctggag
     2401 tcctgaaatt ctcagagaag atttacaatg ttggcattta tgattcagaa actagaatct
     2461 tctcaagttg ctttaagaac tgggagcaca gatttccatg tgttttatgt atagaaattc
     2521 ccgttattta ttggatgaca ttttagggat atggaacttt tataaagaat tcgtgaggaa
     2581 aaattaataa agcaataaaa ttaaactttt ttaaaatgaa aaaaaaaaaa aaaaaa
//
