LOCUS       NM_021752               2892 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus baculoviral IAP repeat-containing 2 (Birc2),
            mRNA.
ACCESSION   NM_021752
VERSION     NM_021752.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Meng,L., Qi,Y., DU,K. and Zhang,X.
  TITLE     LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting
            miRNA-29c and Participates in Neuroprotection During Cerebral
            Ischemia/Reperfusion Injury in Rats
  JOURNAL   Turk Neurosurg 33 (1), 39-45 (2023)
   PUBMED   35416269
  REMARK    GeneRIF: LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by
            Targeting miRNA-29c and Participates in Neuroprotection During
            Cerebral Ischemia/Reperfusion Injury in Rats.
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   Chen,Z., Xu,G., Wu,D., Wu,S., Gong,L., Li,Z., Luo,G., Hu,J.,
            Chen,J., Huang,X., Chen,C., Jiang,Z. and Li,X.
  TITLE     Lobaplatin induces pyroptosis through regulating cIAP1/2,
            Ripoptosome and ROS in nasopharyngeal carcinoma
  JOURNAL   Biochem Pharmacol 177, 114023 (2020)
   PUBMED   32413426
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Jiang,L. and Xiao,J.
  TITLE     2-phenylethynesulfonamide inhibits growth of oral squamous cell
            carcinoma cells by blocking the function of heat shock protein 70
  JOURNAL   Biosci Rep 40 (3) (2020)
   PUBMED   32110810
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Tomicic,M.T., Steigerwald,C., Rasenberger,B., Brozovic,A. and
            Christmann,M.
  TITLE     Functional mismatch repair and inactive p53 drive sensitization of
            colorectal cancer cells to irinotecan via the IAP antagonist BV6
  JOURNAL   Arch Toxicol 93 (8), 2265-2277 (2019)
   PUBMED   31289894
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Dong,Z., Nishiyama,J., Yi,X., Venkatachalam,M.A., Denton,M., Gu,S.,
            Li,S. and Qiang,M.
  TITLE     Gene promoter of apoptosis inhibitory protein IAP2: identification
            of enhancer elements and activation by severe hypoxia
  JOURNAL   Biochem J 364 (Pt 2), 413-421 (2002)
   PUBMED   12023884
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Li,X., Yang,Y. and Ashwell,J.D.
  TITLE     TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
  JOURNAL   Nature 416 (6878), 345-347 (2002)
   PUBMED   11907583
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Manderscheid,M., Pereda-Fernandez,C. and Pfeilschifter,J.
  TITLE     Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1)
            mRNA in renal mesangial cells
  JOURNAL   Kidney Int 61 (3), 797-803 (2002)
   PUBMED   11849428
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Holcik,M., Lefebvre,C.A., Hicks,K. and Korneluk,R.G.
  TITLE     Cloning and characterization of the rat homologues of the Inhibitor
            of Apoptosis protein 1, 2, and 3 genes
  JOURNAL   BMC Genomics 3, 5 (2002)
   PUBMED   11860601
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Yang,Y., Fang,S., Jensen,J.P., Weissman,A.M. and Ashwell,J.D.
  TITLE     Ubiquitin protein ligase activity of IAPs and their degradation in
            proteasomes in response to apoptotic stimuli
  JOURNAL   Science 288 (5467), 874-877 (2000)
   PUBMED   10797013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_021752.4.
            
            On Nov 27, 2020 this sequence version replaced NM_021752.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062055.1, AF190020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1553              JAXUCZ010000008.1  13269988-13271540   c
            1554-1632           JAXUCZ010000008.1  13263504-13263582   c
            1633-1681           JAXUCZ010000008.1  13262210-13262258   c
            1682-1921           JAXUCZ010000008.1  13257293-13257532   c
            1922-2176           JAXUCZ010000008.1  13254881-13255135   c
            2177-2218           JAXUCZ010000008.1  13254450-13254491   c
            2219-2892           JAXUCZ010000008.1  13253697-13254370   c
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2892
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /note="baculoviral IAP repeat-containing 2"
                     /db_xref="GeneID:60371"
                     /db_xref="RGD:620690"
     exon            1..1553
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..2412
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /EC_number="2.3.2.27"
                     /note="inhibitor of apoptosis protein; apoptosis inhibitor
                     2"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 2"
                     /protein_id="NP_068520.2"
                     /db_xref="GeneID:60371"
                     /db_xref="RGD:620690"
                     /translation="MENSTVLSNWTKENKEKMKYDFSCELYRMSTYSAFPRGVPVSER
                     SLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQFYPSCSFVQTLLSGGLQS
                     AAKNTSPAKSRFAHSLPLEQGGIHSSLPSNPLNSRAVEDFSLRMNPCSYAMSTEEARF
                     LSYSMWPLSFLSPAELAKAGFYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPH
                     CPFLENTSETQRFSVSNLSMQTHSARMRTFLYWPSSVLVQPEQLASAGFYYVDHNDDV
                     KCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLST
                     SDTSEEENADPPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATG
                     ENYRTVSDIVSALLNAEDERREEEKERQSEETASGDLSLIRKNRMALFQQLTCVIPIL
                     DDLLEASVLTKEEHDIIRQKTQIPLQARELIDTILVKGNAAASVFKNSLKEVDSTLYE
                     HLFVEKTMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDREVSIVFIPCGHLVVCREC
                     APSLRKCPICRGTIKGTVRTFLS"
     exon            1554..1632
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1681
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1921
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2176
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2218
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2892
                     /gene="Birc2"
                     /gene_synonym="Api2; rIAP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaattaag gtggtgatat atgagattta tataacaatg agagagtaat agtttatgct
       61 ttaagcactg tttatttata acaaatcctg tagtcttagt agagctgtgc tgacttccct
      121 ggaagttatg cagttgatgt aacccacttt agagagtcct gtgataatga tgagctgtat
      181 gacattagtt ctgaggaaat acaggatgca gacttcaggt cctttccttt gctaggaaaa
      241 gaagtagttc agacatcaga tttaagtcct taaagggaaa agagcccgca tatatacagt
      301 cagcagttgc cctataacta ataacgagaa gtaggttctg ggtctatagc tctcgggtta
      361 cccagaagag ttcatgtgat ttcccagaga gtcccgagca gtgtcttgtc atatgagaca
      421 gatttgtcct gtgagtgtga actcatcagt tcagtcagaa gaccgtgaat gtgtccagtt
      481 agctgtctgc tgtctcattc ccgtctatgg tagagatctt gtgtgaagta gtgaggagct
      541 tcatatggaa gtttaagctg ccagaaatac tattactatt cctgcacaga actctcccag
      601 agacttgtcc agggtgcctt accccagtaa actaacggta taatggagaa tagcacagtc
      661 ttgtcaaatt ggacaaaaga aaacaaagaa aaaatgaagt atgacttttc atgtgaactc
      721 tacagaatgt ccacatactc agcttttccc aggggagttc ctgtctcaga gaggagtctg
      781 gctcgtgctg gcttttacta cacaggtgtc aatgacaagg tcaagtgctt ctgctgtggc
      841 ctgatgctgg acaactggaa acaaggggac agtcccactg agaagcacag acagttctat
      901 cccagctgca gctttgtgca gactttgctt tcaggcggtc tgcagtctgc agctaagaac
      961 acgtctcctg cgaaaagtag atttgcacac tcgctacctc tggaacaagg tggcattcat
     1021 tccagcctgc cctcaaaccc tctcaattct agagcagtgg aagacttctc gttgaggatg
     1081 aatccctgca gctatgccat gagtacagaa gaggccaggt ttctttctta cagtatgtgg
     1141 ccattaagtt ttctgtcccc agcagagctg gccaaagcag gcttctacta cacagggcct
     1201 ggagacaggg tggcctgttt tgcctgtggt gggaaactga gcaactggga accgaacgat
     1261 gatcctctgt cagagcacag gagacatttt ccccactgtc catttctgga aaatacttca
     1321 gaaacgcaga ggtttagtgt atccaatctc agtatgcaga cacactctgc tcggatgagg
     1381 acgtttctgt actggccatc gagtgttctt gttcagcctg agcagcttgc aagtgctgga
     1441 ttttattatg tggatcacaa tgatgatgtc aaatgctttt gttgtgatgg tggcttgaga
     1501 tgttgggaac ccggagatga cccctggata gaacatgcca aatggtttcc aaggtgtgag
     1561 ttcttgatac ggatgaaggg tcaggagttt gttgatgaga ttcaagctag atatcctcat
     1621 cttcttgagc agctgttgtc cacttcagac acctcagaag aagaaaatgc tgaccctcca
     1681 gttgtgcatc tgggccctgg agagaattgg gaagatgcag tgatgatgaa cacacctgtg
     1741 gttaaagcag ccttggatat gggcttcagt aggagcctgg tgagacagac ggttcagcga
     1801 cagatcctgg ccactggtga gaactacagg acggtcagtg atattgtctc agcacttctg
     1861 aatgctgaag atgagagaag agaagaggag aaggagagac agagtgaaga gacggcatca
     1921 ggtgacttgt cattgattcg gaagaataga atggccctct tccaacagtt gacgtgtgtc
     1981 attcctatcc tggatgatct tcttgaggcc agtgtactta caaaggagga acatgatatt
     2041 atcagacaga aaacacagat acccttacaa gcaagagagc tcatcgacac catcttagtc
     2101 aagggaaatg ctgcagccag cgtcttcaaa aactctctga aggaagtcga ctctacgcta
     2161 tatgaacact tatttgtgga gaagacgatg aagtatattc ccacagaaga cgtttcaggc
     2221 ttgtcattgg aagaacagct gcggagatta caagaagaaa gaacgtgtaa agtgtgtatg
     2281 gacagagagg tctctatcgt tttcattcct tgtggtcatc tggtagtctg ccgggaatgt
     2341 gccccttccc tgagaaagtg ccccatctgc agggggacaa ttaaagggac tgtgcgtacg
     2401 tttctctcat gaatgaagga agctgtctga acaaagaatt actgattcag ctacgcagca
     2461 gaacatatgt gctctactct ttcaagatta ataatcttgc tttatgtcat attgtatatt
     2521 taatcttagt ctgttgcagg ggagggtcta tgctgatgag ctacaggagt gtgtatgtcc
     2581 cagagcagga gtggggatgc ttgctgtgtg tcctcaggac ttcctggatt tgggatttct
     2641 gaaaactttg gattcaggtg atgtggaact cagaaatcct gaaaccagtg gtcctggcac
     2701 tcagcagtta gccctgtgct tcttggtgct tttcccttct ggaaaataag tatttttctg
     2761 ttactagtaa ataatatttt ctgtttatga gaaacatact gaagtttttt ttttaaaggc
     2821 ttgcatcatc agtgtgtgta ggaatgtatg caggcagaac actgtgtaca taataaatct
     2881 tttaaaaatg tt
//
