LOCUS       NM_053959               2453 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus bridging integrator 1 (Bin1), mRNA.
ACCESSION   NM_053959 XM_346509
VERSION     NM_053959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Malki,I., Cantrelle,F.X., Sottejeau,Y., Lippens,G., Lambert,J.C.
            and Landrieu,I.
  TITLE     Regulation of the interaction between the neuronal BIN1 isoform 1
            and Tau proteins - role of the SH3 domain
  JOURNAL   FEBS J 284 (19), 3218-3229 (2017)
   PUBMED   28755476
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Calafate,S., Flavin,W., Verstreken,P. and Moechars,D.
  TITLE     Loss of Bin1 Promotes the Propagation of Tau Pathology
  JOURNAL   Cell Rep 17 (4), 931-940 (2016)
   PUBMED   27760323
  REMARK    GeneRIF: lower BIN1 levels promote the propagation of Tau pathology
            by efficiently increasing aggregate internalization by endocytosis
            and endosomal trafficking.
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Miyagawa,T., Ebinuma,I., Morohashi,Y., Hori,Y., Young Chang,M.,
            Hattori,H., Maehara,T., Yokoshima,S., Fukuyama,T., Tsuji,S.,
            Iwatsubo,T., Prendergast,G.C. and Tomita,T.
  TITLE     BIN1 regulates BACE1 intracellular trafficking and amyloid-beta
            production
  JOURNAL   Hum Mol Genet 25 (14), 2948-2958 (2016)
   PUBMED   27179792
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   D'Alessandro,M., Hnia,K., Gache,V., Koch,C., Gavriilidis,C.,
            Rodriguez,D., Nicot,A.S., Romero,N.B., Schwab,Y., Gomes,E.,
            Labouesse,M. and Laporte,J.
  TITLE     Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking
            the Nuclear Envelope to the Actin and Microtubule Cytoskeleton
  JOURNAL   Dev Cell 35 (2), 186-198 (2015)
   PUBMED   26506308
REFERENCE   6  (bases 1 to 2453)
  AUTHORS   Micheva,K.D., Kay,B.K. and McPherson,P.S.
  TITLE     Synaptojanin forms two separate complexes in the nerve terminal.
            Interactions with endophilin and amphiphysin
  JOURNAL   J Biol Chem 272 (43), 27239-27245 (1997)
   PUBMED   9341169
REFERENCE   7  (bases 1 to 2453)
  AUTHORS   Wigge,P., Kohler,K., Vallis,Y., Doyle,C.A., Owen,D., Hunt,S.P. and
            McMahon,H.T.
  TITLE     Amphiphysin heterodimers: potential role in clathrin-mediated
            endocytosis
  JOURNAL   Mol Biol Cell 8 (10), 2003-2015 (1997)
   PUBMED   9348539
REFERENCE   8  (bases 1 to 2453)
  AUTHORS   McMahon,H.T., Wigge,P. and Smith,C.
  TITLE     Clathrin interacts specifically with amphiphysin and is displaced
            by dynamin
  JOURNAL   FEBS Lett 413 (2), 319-322 (1997)
   PUBMED   9280305
REFERENCE   9  (bases 1 to 2453)
  AUTHORS   Butler,M.H., David,C., Ochoa,G.C., Freyberg,Z., Daniell,L.,
            Grabs,D., Cremona,O. and De Camilli,P.
  TITLE     Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs
            family, is concentrated in the cortical cytomatrix of axon initial
            segments and nodes of ranvier in brain and around T tubules in
            skeletal muscle
  JOURNAL   J Cell Biol 137 (6), 1355-1367 (1997)
   PUBMED   9182667
REFERENCE   10 (bases 1 to 2453)
  AUTHORS   Sakamuro,D., Elliott,K.J., Wechsler-Reya,R. and Prendergast,G.C.
  TITLE     BIN1 is a novel MYC-interacting protein with features of a tumour
            suppressor
  JOURNAL   Nat Genet 14 (1), 69-77 (1996)
   PUBMED   8782822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 16, 2022 this sequence version replaced NM_053959.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13380.1, SRR26360176.1094682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000018.1  24283951-24284212
            263-343             JAXUCZ010000018.1  24311889-24311969
            344-398             JAXUCZ010000018.1  24318027-24318081
            399-493             JAXUCZ010000018.1  24318217-24318311
            494-589             JAXUCZ010000018.1  24318718-24318813
            590-697             JAXUCZ010000018.1  24319781-24319888
            698-790             JAXUCZ010000018.1  24320500-24320592
            791-876             JAXUCZ010000018.1  24325412-24325497
            877-952             JAXUCZ010000018.1  24325642-24325717
            953-1035            JAXUCZ010000018.1  24327286-24327368
            1036-1183           JAXUCZ010000018.1  24330299-24330446
            1184-1312           JAXUCZ010000018.1  24331645-24331773
            1313-1420           JAXUCZ010000018.1  24334631-24334738
            1421-1444           JAXUCZ010000018.1  24335147-24335170
            1445-1552           JAXUCZ010000018.1  24336250-24336357
            1553-1624           JAXUCZ010000018.1  24337148-24337219
            1625-1735           JAXUCZ010000018.1  24337465-24337575
            1736-1837           JAXUCZ010000018.1  24337803-24337904
            1838-2453           JAXUCZ010000018.1  24340843-24341458
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2453
                     /gene="Bin1"
                     /note="bridging integrator 1"
                     /db_xref="GeneID:117028"
                     /db_xref="RGD:621786"
     exon            1..262
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1945
                     /gene="Bin1"
                     /note="amphiphysin II; amphiphysin-like protein;
                     amphiphysin IIamph2; Amph2"
                     /codon_start=1
                     /product="myc box-dependent-interacting protein 1"
                     /protein_id="NP_446411.1"
                     /db_xref="GeneID:117028"
                     /db_xref="RGD:621786"
                     /translation="MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQF
                     EQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANK
                     IAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESL
                     QTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEE
                     MNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGS
                     NTFTVKAQPSDSAPEKGNKSPSPPPDGSPAATPEIRVNHEPEPASGASPGATIPKSPS
                     QLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTTPSQFEAPGPFSEQASLL
                     DLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGVLPSGEPSSAEGSFAVAWPSQ
                     TAEPGPAQPAEASEVVGGTQEPGETAASEATSSSLPAVVVETFSATVNGAVEGSTTTG
                     RLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDW
                     NQHKELEKCRGVFPENFTERVQ"
     exon            263..343
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..398
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..493
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..589
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..697
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..790
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..876
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..952
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1035
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1183
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1312
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1420
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1444
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1552
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1624
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1735
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1837
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2453
                     /gene="Bin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgctctc cccgcgcacg ctccgtctcc gtcagtcccc tgagctgttc tagtgcgcgg
       61 cgtggagcca ggcagggctc aggctggtgg agcgaccggg gctggaggct gggagtgagg
      121 cgctcacggc ctccccgcgc cattatccgc gctcgctacg ggcgaggccg gcgccaggat
      181 ggcagagatg gggagcaagg gggtgacggc ggggaagatc gcaagcaatg ttcagaagaa
      241 gctgactcga gctcaggaga aggtcctgca gaaactgggg aaggcggatg aaacgaagga
      301 tgagcagttc gaacagtgcg tccagaattt caataagcag ctgacagagg gcacccggct
      361 gcagaaggat cttcggacct acctggcttc tgttaaagcc atgcacgaag cctccaagaa
      421 gctgagtgag tgtctccagg aggtgtatga gcctgagtgg cctggcaggg atgaagcgaa
      481 caagatagca gagaacaatg acctgctatg gatggactat caccagaagc tggtggacca
      541 ggctctgctg accatggata cctacctggg ccagttccct gatatcaagt cacgcattgc
      601 caagcggggg cggaagctgg tggactacga cagcgcccgg caccactatg agtctcttca
      661 aaccgccaaa aagaaggatg aagccaaaat tgccaagcct gtctcgctgc ttgagaaagc
      721 cgccccccag tggtgccaag gcaaactaca ggctcatctt gtagctcaaa ctaacctgct
      781 ccgaaatcag gcagaagagg agctcatcaa agcccagaag gtgttcgagg agatgaatgt
      841 ggacctgcag gaggagctgc catccctgtg gaacagccgt gtgggtttct atgtcaacac
      901 gttccagagc atcgcgggtc tggaggaaaa cttccataaa gagatgagta agctcaatca
      961 gaacctcaat gatgtcctgg tcagcctaga gaagcaacac gggagcaaca ccttcacagt
     1021 caaggcccag cccagtgaca gcgcccctga aaaagggaac aagagccctt cacctcctcc
     1081 agatggttcc cctgctgcta cccctgagat cagagtgaac catgagccag agccggccag
     1141 tggggcatcg cctggggcta ccatccccaa gtccccatct cagctccgga aaggcccacc
     1201 ggtccctccg cctcccaaac acaccccatc caaggagatg aagcaggagc agattctcag
     1261 cctttttgat gacgcatttg tccctgagat cagcgtgacc accccctccc agtttgaggc
     1321 ccctgggcct ttctcagagc aggccagtct actagacctg gacttcgagc cccttccacc
     1381 agtggcaagc cctgtgaagg cacccacacc ctctggtcag tcaatcccat gggacctctg
     1441 ggagcccaca gagagtcaag ctggcgtcct gccttccggg gagcccagtt ctgctgaggg
     1501 cagctttgct gtggcctggc ccagccagac agccgagcca gggcctgccc aaccagcaga
     1561 ggcctccgag gtggtgggtg gaacccagga gccaggggag acagcagcca gtgaagcgac
     1621 ctccagctct ctcccggctg tggtggtgga gaccttctca gcaactgtga atggcgccgt
     1681 ggagggcagc actacgactg gacgcttgga tctgcccccg ggattcatgt tcaaggtgca
     1741 agcccagcat gattacacgg ccactgacac tgacgagctg caactcaaag ctggcgatgt
     1801 ggtactggtg atccccttcc agaacccaga ggagcaggat gaaggctggc tcatgggtgt
     1861 gaaggagagc gactggaatc agcacaagga actggagaaa tgccgcggcg tcttcccgga
     1921 gaatttcaca gagcgggtgc agtgacggga gagcctctgc agccttccgg tgtgtgaaga
     1981 acctttcccc aaaagatgtg tgcttttctt ttctttgttt ttcttcctct tcttttctgt
     2041 tttttgtttt gttttgaaac tcttgaaaag tgtcgggaaa ttggggagcg gaaacctaag
     2101 ccaagaggtg tacccccaaa gatgaggtgg ttttccaaaa agccgtccga cccagttcag
     2161 tggacttctc cagtattccc gaagctgctg tgtccccctc ctagttgagt tcccgatgcc
     2221 cgcatgttca gggcgggccg ggggtgcaga gccaccgccg cacttgcctg acgcttggcc
     2281 gcgccaccgg acagggcttg ggtcctcttc tggcagctgc cctgggcagg gcctgcactg
     2341 tggcccagcc tggtccgctc tgcagaccaa ccgtgtgctg tttgaaaata agccctagtg
     2401 ttcaaaatgc agcgaaacaa acaaaaatga aaaaccggac aaaaccacca gaa
//
