LOCUS       NM_053704                956 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus BCL2-interacting killer (Bik), mRNA.
ACCESSION   NM_053704
VERSION     NM_053704.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 956)
  AUTHORS   Wu,H., Li,Y., Wang,X., Zhang,Z. and Huang,Y.
  TITLE     Long non-coding RNA TUG1 knockdown prevents neurons from death to
            alleviate acute spinal cord injury via the microRNA-338/BIK axis
  JOURNAL   Bioengineered 12 (1), 5566-5582 (2021)
   PUBMED   34517787
  REMARK    GeneRIF: Long non-coding RNA TUG1 knockdown prevents neurons from
            death to alleviate acute spinal cord injury via the
            microRNA-338/BIK axis.
REFERENCE   2  (bases 1 to 956)
  AUTHORS   Dalal,S., Zha,Q., Singh,M. and Singh,K.
  TITLE     Osteopontin-stimulated apoptosis in cardiac myocytes involves
            oxidative stress and mitochondrial death pathway: role of a
            pro-apoptotic protein BIK
  JOURNAL   Mol Cell Biochem 418 (1-2), 1-11 (2016)
   PUBMED   27262843
  REMARK    GeneRIF: OPN induces oxidative stress via the involvement of
            mitochondria and NOX-4. It may affect mitochondrial morphology and
            integrity, at least in part, via the involvement of BIK.
REFERENCE   3  (bases 1 to 956)
  AUTHORS   Manohar,S., Jamesdaniel,S. and Salvi,R.
  TITLE     Cisplatin inhibits hippocampal cell proliferation and alters the
            expression of apoptotic genes
  JOURNAL   Neurotox Res 25 (4), 369-380 (2014)
   PUBMED   24277158
REFERENCE   4  (bases 1 to 956)
  AUTHORS   Du,H., Wolf,J., Schafer,B., Moldoveanu,T., Chipuk,J.E. and
            Kuwana,T.
  TITLE     BH3 domains other than Bim and Bid can directly activate Bax/Bak
  JOURNAL   J Biol Chem 286 (1), 491-501 (2011)
   PUBMED   21041309
REFERENCE   5  (bases 1 to 956)
  AUTHORS   Isaian,A., Bogdanova,N.V., Houshmand,M., Movahadi,M.,
            Aghamohammadi,A., Rezaei,N., Atarod,L., Sadeghi-Shabestari,M.,
            Tonekaboni,S.H., Chavoshzadeh,Z., Hassani,S.M., Mirfakhrai,R.,
            Cheraghi,T., Kalantari,N., Ataei,M., Dork-Bousset,T. and
            Sanati,M.H.
  TITLE     BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian
            patients with ataxia telangiectasia
  JOURNAL   J Clin Immunol 30 (1), 132-137 (2010)
   PUBMED   19898928
  REMARK    Erratum:[J Clin Immunol. 2010 Jul;30(4):620. Agamohammadi, Asghar
            [corrected to Aghamohammadi, Asghar]]
REFERENCE   6  (bases 1 to 956)
  AUTHORS   Li,Y.M., Wen,Y., Zhou,B.P., Kuo,H.P., Ding,Q. and Hung,M.C.
  TITLE     Enhancement of Bik antitumor effect by Bik mutants
  JOURNAL   Cancer Res 63 (22), 7630-7633 (2003)
   PUBMED   14633680
REFERENCE   7  (bases 1 to 956)
  AUTHORS   Itoh,T., Itoh,A. and Pleasure,D.
  TITLE     Bcl-2-related protein family gene expression during
            oligodendroglial differentiation
  JOURNAL   J Neurochem 85 (6), 1500-1512 (2003)
   PUBMED   12787069
REFERENCE   8  (bases 1 to 956)
  AUTHORS   Leo,C.P., Hsu,S.Y., Chun,S.Y., Bae,H.W. and Hsueh,A.J.
  TITLE     Characterization of the antiapoptotic Bcl-2 family member myeloid
            cell leukemia-1 (Mcl-1) and the stimulation of its message by
            gonadotropins in the rat ovary
  JOURNAL   Endocrinology 140 (12), 5469-5477 (1999)
   PUBMED   10579309
REFERENCE   9  (bases 1 to 956)
  AUTHORS   Hegde,R., Srinivasula,S.M., Ahmad,M., Fernandes-Alnemri,T. and
            Alnemri,E.S.
  TITLE     Blk, a BH3-containing mouse protein that interacts with Bcl-2 and
            Bcl-xL, is a potent death agonist
  JOURNAL   J Biol Chem 273 (14), 7783-7786 (1998)
   PUBMED   9525867
REFERENCE   10 (bases 1 to 956)
  AUTHORS   Hsu,S.Y., Kaipia,A., McGee,E., Lomeli,M. and Hsueh,A.J.
  TITLE     Bok is a pro-apoptotic Bcl-2 protein with restricted expression in
            reproductive tissues and heterodimerizes with selective
            anti-apoptotic Bcl-2 family members
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12401-12406 (1997)
   PUBMED   9356461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF372501.1, FQ225338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000007.1  116552303-116552401
            100-271             JAXUCZ010000007.1  116568196-116568367
            272-370             JAXUCZ010000007.1  116569848-116569946
            371-488             JAXUCZ010000007.1  116570317-116570434
            489-956             JAXUCZ010000007.1  116570850-116571317
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..956
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /note="BCL2-interacting killer"
                     /db_xref="GeneID:114496"
                     /db_xref="RGD:621547"
     exon            1..99
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            100..271
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..581
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /note="BCL2-interacting killer (apoptosis-inducing)"
                     /codon_start=1
                     /product="bcl-2-interacting killer"
                     /protein_id="NP_446156.1"
                     /db_xref="GeneID:114496"
                     /db_xref="RGD:621547"
                     /translation="MSEARLMARDIIKTLLHDQVPQPAVVSGAPSMKEPVGVEDVSPV
                     RDLDFMRCLESRNQVALRLACIGDEMDRCLRSPRLVQLPGIAMHRLAATYSQTGVRGI
                     FRSLIGSLTNLRENIWSWRVFTPGAWVSPDQDPGQLFPMVLLVFLLLGGAWHLQLQ"
     exon            272..370
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            371..488
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /inference="alignment:Splign:2.1.0"
     exon            489..956
                     /gene="Bik"
                     /gene_synonym="Biklk; Blk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taacccgcct ccagccagcg cccccaactc agccacccga gtctgggccg agaggtgttc
       61 gggcagctcg cccgccgcta cgccagctta gccgggcaga agacatgtca gaggcgagac
      121 taatggccag agacattatc aagactcttc tacacgacca ggtcccccaa cctgcagtgg
      181 tctctggggc tcccagcatg aaggagcctg tgggggttga ggacgtcagt cctgtgagag
      241 acttggattt catgaggtgc ctggagagca gaaaccaggt ggccctgagg ctagcctgca
      301 tcggcgatga gatggaccgg tgtcttcgga gcccccgtct ggtccagctg cctgggattg
      361 ctatgcacag acttgctgcc acctacagcc agacgggtgt cagaggtatt ttcagaagct
      421 tgattggaag cctcaccaac ctcagggaaa atatctggtc ctggagagtc ttcactcctg
      481 gcgcctgggt gtcacctgac caggaccctg ggcagctgtt tcccatggtg ctgctggtct
      541 tcttgctgct gggtggggcc tggcatttgc agcttcagtg aggtgcagct ggggcagggc
      601 tggcccctgt cccccaaccc ctagaggtgc cggcacccta accgtggtgt tttctgactg
      661 tccctttttt ttttttatat ttaactcagg atagtgctga gatttcatac aggttttctg
      721 ggtttttgta aggtaaatga attcactata cctcaggagc gttactggct aaatatccct
      781 gaggcctggc tggcccttct ctcttgaccc ctgccacctt cctctctgca ggctggtcct
      841 gtggccacca gtggggggag tgccggccac acccctgtct gtgaagcctt gaggcacgga
      901 atctactgga ctagattcct ttggggtgga gagttcaata aagggttgtt tccagg
//
