LOCUS       NM_001033674            6324 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant
            1, mRNA.
ACCESSION   NM_001033674
VERSION     NM_001033674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6324)
  AUTHORS   Matsuto,M., Kano,F. and Murata,M.
  TITLE     Reconstitution of the targeting of Rab6A to the Golgi apparatus in
            semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on
            Golgi membranes and a concerted role of Rab6A/BICD2 interactions in
            Golgi-to-ER retrograde transport
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2592-2609 (2015)
   PUBMED   25962623
REFERENCE   2  (bases 1 to 6324)
  AUTHORS   Schroeder,C.M., Ostrem,J.M., Hertz,N.T. and Vale,R.D.
  TITLE     A Ras-like domain in the light intermediate chain bridges the
            dynein motor to a cargo-binding region
  JOURNAL   Elife 3, e03351 (2014)
   PUBMED   25272277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6324)
  AUTHORS   Jaarsma,D., van den Berg,R., Wulf,P.S., van Erp,S., Keijzer,N.,
            Schlager,M.A., de Graaff,E., De Zeeuw,C.I., Pasterkamp,R.J.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     A role for Bicaudal-D2 in radial cerebellar granule cell migration
  JOURNAL   Nat Commun 5, 3411 (2014)
   PUBMED   24614806
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6324)
  AUTHORS   Neveling,K., Martinez-Carrera,L.A., Holker,I., Heister,A.,
            Verrips,A., Hosseini-Barkooie,S.M., Gilissen,C., Vermeer,S.,
            Pennings,M., Meijer,R., te Riele,M., Frijns,C.J., Suchowersky,O.,
            MacLaren,L., Rudnik-Schoneborn,S., Sinke,R.J., Zerres,K.,
            Lowry,R.B., Lemmink,H.H., Garbes,L., Veltman,J.A., Schelhaas,H.J.,
            Scheffer,H. and Wirth,B.
  TITLE     Mutations in BICD2, which encodes a golgin and important motor
            adaptor, cause congenital autosomal-dominant spinal muscular
            atrophy
  JOURNAL   Am J Hum Genet 92 (6), 946-954 (2013)
   PUBMED   23664116
REFERENCE   5  (bases 1 to 6324)
  AUTHORS   Splinter,D., Razafsky,D.S., Schlager,M.A., Serra-Marques,A.,
            Grigoriev,I., Demmers,J., Keijzer,N., Jiang,K., Poser,I.,
            Hyman,A.A., Hoogenraad,C.C., King,S.J. and Akhmanova,A.
  TITLE     BICD2, dynactin, and LIS1 cooperate in regulating dynein
            recruitment to cellular structures
  JOURNAL   Mol Biol Cell 23 (21), 4226-4241 (2012)
   PUBMED   22956769
REFERENCE   6  (bases 1 to 6324)
  AUTHORS   Splinter,D., Tanenbaum,M.E., Lindqvist,A., Jaarsma,D., Flotho,A.,
            Yu,K.L., Grigoriev,I., Engelsma,D., Haasdijk,E.D., Keijzer,N.,
            Demmers,J., Fornerod,M., Melchior,F., Hoogenraad,C.C., Medema,R.H.
            and Akhmanova,A.
  TITLE     Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore
            complexes and regulate centrosome and nuclear positioning during
            mitotic entry
  JOURNAL   PLoS Biol 8 (4), e1000350 (2010)
   PUBMED   20386726
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6324)
  AUTHORS   Loschi,M., Leishman,C.C., Berardone,N. and Boccaccio,G.L.
  TITLE     Dynein and kinesin regulate stress-granule and P-body dynamics
  JOURNAL   J Cell Sci 122 (Pt 21), 3973-3982 (2009)
   PUBMED   19825938
REFERENCE   8  (bases 1 to 6324)
  AUTHORS   Fumoto,K., Hoogenraad,C.C. and Kikuchi,A.
  TITLE     GSK-3beta-regulated interaction of BICD with dynein is involved in
            microtubule anchorage at centrosome
  JOURNAL   EMBO J 25 (24), 5670-5682 (2006)
   PUBMED   17139249
REFERENCE   9  (bases 1 to 6324)
  AUTHORS   Matanis,T., Akhmanova,A., Wulf,P., Del Nery,E., Weide,T.,
            Stepanova,T., Galjart,N., Grosveld,F., Goud,B., De Zeeuw,C.I.,
            Barnekow,A. and Hoogenraad,C.C.
  TITLE     Bicaudal-D regulates COPI-independent Golgi-ER transport by
            recruiting the dynein-dynactin motor complex
  JOURNAL   Nat Cell Biol 4 (12), 986-992 (2002)
   PUBMED   12447383
  REMARK    Erratum:[Nat Cell Biol. 2003 Jan;5(1):84.]
REFERENCE   10 (bases 1 to 6324)
  AUTHORS   Hoogenraad,C.C., Akhmanova,A., Howell,S.A., Dortland,B.R., De
            Zeeuw,C.I., Willemsen,R., Visser,P., Grosveld,F. and Galjart,N.
  TITLE     Mammalian Golgi-associated Bicaudal-D2 functions in the
            dynein-dynactin pathway by interacting with these complexes
  JOURNAL   EMBO J 20 (15), 4041-4054 (2001)
   PUBMED   11483508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000017.1.
            
            On Mar 26, 2015 this sequence version replaced NM_001033674.1.
            
            Summary: This gene encodes a dynein-dynactin adaptor protein. In
            mouse, the protein primarily localizes to the Golgi complex as well
            as to microtubule plus ends through dynactin. Overexpression
            studies suggest that the N-terminus mediates the dynein-dynactin
            interaction, while the C-terminus is responsible for Golgi
            targeting. Knockout of this gene in mouse results in a defect in
            cerebellar granule cell migration. In human, mutations in this gene
            are associated with spinal muscular dystrophy. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2015].
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100660.1, SRR26643298.68719.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               JAXUCZ010000017.1  15510976-15511305   c
            331-543             JAXUCZ010000017.1  15485113-15485325   c
            544-696             JAXUCZ010000017.1  15479344-15479496   c
            697-1158            JAXUCZ010000017.1  15474815-15475276   c
            1159-2184           JAXUCZ010000017.1  15473158-15474183   c
            2185-2336           JAXUCZ010000017.1  15472375-15472526   c
            2337-6324           JAXUCZ010000017.1  15466193-15470180   c
FEATURES             Location/Qualifiers
     source          1..6324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..6324
                     /gene="Bicd2"
                     /note="BICD cargo adaptor 2"
                     /db_xref="GeneID:306809"
                     /db_xref="RGD:735093"
     exon            1..330
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2646
                     /gene="Bicd2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bicaudal D protein; bicaudal D homolog 2"
                     /codon_start=1
                     /product="protein bicaudal D homolog 2 isoform 1"
                     /protein_id="NP_001028846.1"
                     /db_xref="GeneID:306809"
                     /db_xref="RGD:735093"
                     /translation="MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAA
                     EYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREES
                     LIQESASKEQYYVRKVLELQTELKQLRNVLINTQSENERLTSVAQELKEINQNVEIQR
                     GRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEE
                     TEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHL
                     QVSLDGLKFSDDAVTAEPNNDAEALVNGFEHSGLVKASLDNKTSTPRKDGLAPPSPSL
                     VSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVSRL
                     TENLSALRRLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILSCKYHVAVAEAGE
                     LREQLKALHSTHEAREAQLAEEKGRYEAEVQALTEKVSLLEKASHQDQELLAQLEKEL
                     RKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKA
                     GRTSPEGRGRRSPVLLPKGLLSTEIGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIY
                     NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTK
                     REQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFS
                     SLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELD
                     HEQTRRGRNKATSKAKPATPSVSHTCACASERAEGTGLANQVFCSEKHSIYCD"
     exon            331..543
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..696
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1158
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..2184
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2336
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..6324
                     /gene="Bicd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgtcgg ggctgggcgg cggcggcggc ggctaagagg gcccggcttg tgggagccaa
       61 ggtgggagcg ggcctcggcg cgcggccacc atgtccgcgc cgtcggagga ggaggagtat
      121 gcgcgtctgg tgatggaggc gcagccggag tggctgcgcg ccgaggtgaa gcgactgtcc
      181 cacgagctgg ccgaaaccac gcgtgagaag atccaggcgg ccgagtatgg actggcggtg
      241 cttgaggaga agcaccagct caagctgcag ttcgaggagc tcgaggtgga ctatgaggcc
      301 atccgcagcg agatggagca gctcaaagag gcatttggcc aggcacacac aaaccacaag
      361 aaggtggctg ctgatggaga gagccgggag gagagcctga tccaggagtc cgcctctaag
      421 gagcagtact atgtgcggaa ggtgctggag ctgcagacag agctgaaaca gctgcgcaat
      481 gtccttatca acactcagtc tgagaatgag cgcctcacgt ctgtggccca ggagctgaaa
      541 gagatcaacc agaatgtgga gattcagcgt ggtcgcctgc gagatgacat caaggagtac
      601 aagttccggg aggcccgtct acttcaggac tactctgagc tggaggagga gaacattagc
      661 ctgcagaaac aagtgtctgt gctcaggcag aaccaggtgg aatttgaggg cctcaagcat
      721 gaaatcaagc gtctggagga ggagacagag taccttaaca gccagctgga ggatgccatc
      781 cggcttaagg agatctctga acggcagttg gaggaagcgc tggagacgtt gaagacagag
      841 cgagagcaga agaacaacct acgtaaggag ttgtcgcact acatgagcat caacgattcc
      901 ttctatacca gccacctgca ggtatcctta gatggcctca agttcagtga tgatgctgtc
      961 actgctgagc ccaacaacga cgccgaagcc ctggtcaatg gctttgagca cagcggcttg
     1021 gtcaaagcgt cgttggacaa caagacatcc acacccagaa aggatggcct ggctccgccc
     1081 tcccccagcc ttgtttccga cctgctcagt gagctccaca tatctgagat ccagaagctg
     1141 aagcagcagc tggtgcagat ggagcgggag aaggtgggtc tgctggcgac attacaggac
     1201 acacagaagc agctagagca ggctcgggga accctctctg agcaacatga gaaggtgagt
     1261 cgtctcacag agaaccttag tgccctccgg cgcctgcagg ctggcaagga gcgacagact
     1321 tccctggata acgaaaagga ccgagatagc catgaagacg gtgactacta tgaggttgac
     1381 atcaatgggc ctgagatcct gtcctgcaag taccatgtag ctgtggccga ggctggcgag
     1441 ctccgggagc agctcaaggc cctgcacagc acacatgaag ctcgggaagc ccagcttgca
     1501 gaagaaaagg gccgctatga ggctgaggtc caggctctca ctgagaaggt gtcactgctg
     1561 gagaaggcta gccaccagga ccaagagctg ctggcccagc tggaaaagga gctgaggaag
     1621 gtgagtgacg tggctggtga gacccagggc agcctgaatg tggctcagga tgagttggtg
     1681 accttcagcg aggagctggc caatctctac caccatgtgt gcatgtgcaa caacgagaca
     1741 cccaaccgtg tcatgctgga ctattaccgt gaggggcagg gcaaggctgg ccgcaccagc
     1801 ccagaaggcc gcgggcgccg ctcgcctgtc cttttgccca aggggctgtt gtcgacagag
     1861 atcggccgag cagatggtgg gactggggac aacagccctt cacccagctc ttcactgcca
     1921 tcaccattga gtgacccccg ccgggaacct atgaacatct acaacctgat cgccatcatc
     1981 cgagaccaga tcaagcacct gcaggcagcc gtagatcgta caaccgagct gtcccggcag
     2041 cggattgcct cacaggagct gggccctgct gtggataagg acaaggaagc actcatggag
     2101 gagatcctca agctgaagtc actgctgagt accaagaggg aacagatcac cacacttcgt
     2161 actgtgctca aggctaacaa gcagacggca gaggtggccc tcgccaacct gaagagcaag
     2221 tatgagaatg agaaggccat ggtgaccgag accatgatga agctgcggaa cgagctgaag
     2281 gccctcaagg aggacgcagc caccttctcc tccctgcgtg ccatgttcgc caccaggtgt
     2341 gatgagtaca tcacgcagct ggatgagatg cagcggcagc tggcggctgc cgaggatgag
     2401 aagaagactc ttaattccct gctgcgcatg gccatccagc agaagctggc actcacccag
     2461 cggctggagc tgctggagct ggaccatgag cagacccgca ggggccgtaa caaggccacc
     2521 tccaaggcca agccagccac accgagcgta agtcacacct gcgcctgtgc cagcgagagg
     2581 gcggagggca ccgggctggc caaccaggtg ttctgcagcg agaagcacag catttactgt
     2641 gattagggcc gtggggcgcc gcataccgct aacgtccgct tcacctcaac taacccagct
     2701 gcagcagcgg gacagcagtg ctaggccagt cttaacgtga ctaacgcaca gagggcggca
     2761 ttctgggcga gcggcagcat tggggtacgt ctgtcaccag gacactttga gctttgtgct
     2821 gcttttcact ccacagcacc ccccgggata tcccatgtca gttgctgtct tgggatgctg
     2881 gtatcaaagg taggggtgga tctgcacagc tttgtggaag acagtggggt gaaaatgttt
     2941 tccagggcct ccaggcactg ttaggcgaac ccaagggtga gttcttccct gggcactcac
     3001 aggggcagaa cctgagttga aacttgcatg ttcttcgcat gtgtctgctg tcagcacttg
     3061 aaagcagttc tgtgaggctc tggcctgcat cacaggacta gcctaggtta gctctctgtg
     3121 gttggcgtag tttcatgaag actttcttgt agtttgtgca gcatctcact gcaaaccaca
     3181 ttcaggacag aaatgcagaa cttcttcccc agacccagag ggcatggacc ctgaaagcct
     3241 gccttctgca gtgagcccca cacctcagac acaataaccg tagcccagga agacagagct
     3301 gggctgctct agggtctcat ctctgagctc tgcatgctgc tctgccctga gaggagacag
     3361 attggcaggg cctgaggtcc taggtttcct ttttgatgag aaagtgttcc aagtgcctgg
     3421 tcagaccctg gcccttggta cagaacctgc tctttggtcc tttgagatcc tcagcttgtg
     3481 cttgggtcct tacccagaag ttgtcagacc caaagaagca atgttctgag aactgttagt
     3541 gctctgtcag actgtacggc acagtagagc ccagctgtgt gcggcggctt tctgtggcct
     3601 ggagcggtgt tcagcaccgg caggtaagag ttttgcagtt cagtgtagta tggggatgct
     3661 gcagaaggaa gaaaggccac cgaggctctc ctcttcagat gctgtggcag tgcagagctg
     3721 tggcaccagg cgtttgcgtt agtgagctgt aaagcaggac tctgctcagt atttctctcc
     3781 cagcccccac tgggcatcca gtcctaagac tcccatctcc catgacagct gcttggctgc
     3841 ctccctgcgg aaaggcatct ttcatggtgt ggaacaatcg ctacccaata tggggccctg
     3901 tagtctctga gacagttttc tctttcttcc ctctggtgcc tggggtgtcc cagtgtgccc
     3961 agagtctagg caccaaccac agggtctaca ctggggatag aacagaccac atgtgtccct
     4021 tgcatgtccg tcctgggaat ggctgcccgc atgcccaccc accttctgcc tttctttctc
     4081 ttcgggccag aacgcagctt ctcttacacc gtatggggct ttgtgggcac ttggagcccc
     4141 acccctaaca tacttgcagc aggccttctg ccaactaacg tgatcgctca ctcacaccca
     4201 gaacaggagc tttagcagtc aagtgagcag ggagtggcac tcgactcatt tctaatgctg
     4261 tcttgttttc tcctgttttc agctgtagag tagctgcccg gaggacgtgg ccaccaggcc
     4321 ctgtcacact gcagcccctc cccctcccct cctgtggccc atgcagagga aggaagggca
     4381 gcctaaagtc cacttagaaa tgtttggata tgccactgta attctttcaa aatagcatcc
     4441 cccaagtttt taatgggagg aaaaaaaaag ctttactctt gagaatgctg caagctgctg
     4501 cttggaaagg tctctggccg aagaacctgc ttccttcctt ccgcagcctt ggccaggctc
     4561 taggagctgg aatgcctgct gggggtcctt attacacatg ctccttttaa tccgatcaac
     4621 ctgtgcactt ttgatatttt gatattatat ttgcttcctt aattccttgc atagagacgg
     4681 tctccagtgc cgtggtctgt gcgcgtggtc ctgtagctgt ccgtcctagc tctggtgtgt
     4741 tgacctgcgt cagcacaagg tagagctgag ctccatggtg tgtagctaga ctgcgggtga
     4801 ggctccgacc cggcaaggag ccggctagtg tgtccacgct gtggttcagc agcctttaga
     4861 ggacagggca ttgtggttca tgtttgaaat tacagatttt aaatgccatg ttcattaaga
     4921 aatccagggt attccaattc tggggttttt tcatattgta ttattattat tattattctt
     4981 aggaatagtt caatgtaaca agaagaaaac ttgacctttg ctctggttaa aacagtaata
     5041 ggcacttgaa agcataaatt attgaatgag tagtattacc tacaaattcc agagttttct
     5101 gggttttagg acattgtgaa gcatgactga ctaacagaat tttatacaac tgcaccagtg
     5161 aaattccaaa ttggaattgt tttgttattc tggttgtcgt gccaaattgt ggtacactta
     5221 gaaaattcta cagccgtcga tttttaggtg ttctatttca acaccttttt gttagtaacc
     5281 attgccagta gtgccttcat cagttcaggg aggtgtccca gccaagtaag gtctctagga
     5341 tgggcagcgg agagctagtt gggaatgctg aaggccagtg tggaccagga ggtacctgcc
     5401 tcacttcgta cttgggcatc ttcattgagg gagcgagaac agtgattgtg caaaattctg
     5461 ttagtcagtg atacttcaca tgcaaattca ggggcttaga aacaaaaaca aacacaaacc
     5521 tggactgtgc tttgggaacc aaatggactt cctgggacag gctaagcaag ctatacagac
     5581 atggcgtttg tgaagagctg agggcgtcag gagagccggc acagtcggca tgtgagtagg
     5641 ggaagagggt tagccatagt attctttgca aatgtgaaag tcagacatta tatcttctct
     5701 tgcttggtgt aactaatcac tgttaatttc aggaaacaga agtcagtaaa actccttagt
     5761 aagcccttgc taagtgaggt tcagggtgtg gtcaaattgg tactagtgga ggaaaagaag
     5821 ttgtcctccg gcctaaaaag ggacaaatta caataatata aattgttaga aattgaagaa
     5881 ttctgtttcc tggaatgagc atttcttatt cctacttgtt gggactcttt gccttctgtt
     5941 acagtgttga ttcacataaa acattgttac atttaagata acatcatctg tacggggtat
     6001 ttatttgcaa cgatgtctaa gtactgtatt ttttctgtgt gttaccttag tgtcagaatg
     6061 ttggtcttta ttttaaaagt catatgcatg ttctcctgcc aaggtacctt tacacagacc
     6121 cgaaacagta acgaacagat gccttcggtt tctgagacaa tgaggccaag tgaggagaag
     6181 gcataggaag gtgagactaa ccgagactta ggtggcggtt gatggcggac cgtctccaca
     6241 gccagcacac ataggaaaag tgggcctggg taaagagtca cattggtagg accaataaag
     6301 aataataaaa acaactgaag caca
//
