LOCUS       NM_001415073            5533 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus BicC family RNA binding protein 1 (Bicc1), mRNA.
ACCESSION   NM_001415073 XM_039098829
VERSION     NM_001415073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5533)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   2  (bases 1 to 5533)
  AUTHORS   Ota,K.T., Andres,W., Lewis,D.A., Stockmeier,C.A. and Duman,R.S.
  TITLE     BICC1 expression is elevated in depressed subjects and contributes
            to depressive behavior in rodents
  JOURNAL   Neuropsychopharmacology 40 (3), 711-718 (2015)
   PUBMED   25178406
  REMARK    GeneRIF: findings identify a role for increased levels of BICC1 in
            the pathophysiology of depressive behavior
REFERENCE   3  (bases 1 to 5533)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 5533)
  AUTHORS   Kraus,M.R., Clauin,S., Pfister,Y., Di Maio,M., Ulinski,T.,
            Constam,D., Bellanne-Chantelot,C. and Grapin-Botton,A.
  TITLE     Two mutations in human BICC1 resulting in Wnt pathway hyperactivity
            associated with cystic renal dysplasia
  JOURNAL   Hum Mutat 33 (1), 86-90 (2012)
   PUBMED   21922595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 21, 2022 this sequence version replaced XM_039098829.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.78327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               JAXUCZ010000020.1  17448765-17449162
            399-445             JAXUCZ010000020.1  17529746-17529792
            446-515             JAXUCZ010000020.1  17581200-17581269
            516-595             JAXUCZ010000020.1  17646878-17646957
            596-754             JAXUCZ010000020.1  17648902-17649060
            755-808             JAXUCZ010000020.1  17650004-17650057
            809-1003            JAXUCZ010000020.1  17650527-17650721
            1004-1255           JAXUCZ010000020.1  17651333-17651584
            1256-1387           JAXUCZ010000020.1  17654102-17654233
            1388-1574           JAXUCZ010000020.1  17657377-17657563
            1575-1739           JAXUCZ010000020.1  17659560-17659724
            1740-1936           JAXUCZ010000020.1  17660496-17660692
            1937-2069           JAXUCZ010000020.1  17660838-17660970
            2070-2226           JAXUCZ010000020.1  17661919-17662075
            2227-2392           JAXUCZ010000020.1  17663797-17663962
            2393-2432           JAXUCZ010000020.1  17666466-17666505
            2433-2587           JAXUCZ010000020.1  17667073-17667227
            2588-2744           JAXUCZ010000020.1  17673152-17673308
            2745-2905           JAXUCZ010000020.1  17676213-17676373
            2906-3005           JAXUCZ010000020.1  17677610-17677709
            3006-5533           JAXUCZ010000020.1  17683358-17685885
FEATURES             Location/Qualifiers
     source          1..5533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..5533
                     /gene="Bicc1"
                     /note="BicC family RNA binding protein 1"
                     /db_xref="GeneID:361832"
                     /db_xref="RGD:1307459"
     exon            1..398
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..3145
                     /gene="Bicc1"
                     /note="bicaudal C homolog 1"
                     /codon_start=1
                     /product="protein bicaudal C homolog 1"
                     /protein_id="NP_001402002.1"
                     /db_xref="GeneID:361832"
                     /db_xref="RGD:1307459"
                     /translation="MAAQGEPGYLAAAQSDPGSNSERSTDSPVAGSEDDLVAAAPLLH
                     SPEWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKS
                     KKDPHIKVSGKKEAVKEAKEMIMAVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKV
                     MEDTGCHIHFPDSNRNNQVEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGI
                     LQPVPDPNTPSIQHISQTYSVSVSFKQRSRMYGATVIVRGSQNNTNAVKEGTAMLLEH
                     LAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNVKHIMQRTGAQIHFPDPSNPQKKSTV
                     YLQGTIESVCLARQYLMGCLPLVLMFDMKEDIDVDPQVITQLMEQLDVFISIKPKPKQ
                     PSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLSPASCPAGLACPSLDILASA
                     GLGLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSSSSGTPSPTTLWASSIPNT
                     ASATGFSTIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEG
                     KNISASINGHVQPPNMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSVEGC
                     NDAFVEVGMPRSPSHSGNAGDLKQMLGPSKVSCAKRQTVELLQGTKNSHLHSTDRLLS
                     DTELSATESPLADKKAPGSERAAERAAAAQQNSERARLASQPPYVHMQAFDYEQKKLL
                     ATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTAYEGSS
                     LSLSRSSSREHLASGSESDNWRDRNGIGPMGHSEFSAPIGSPKRKQNKSREHYLSSSN
                     YMDCISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQD
                     LKELGITTFGARRKMLLAISELSKNRRKLFEPPNTPTTCTSFLEGGVSGRLPRQYHSD
                     IASVSGRW"
     exon            399..445
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..515
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..595
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..754
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..808
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1003
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1255
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1387
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1574
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1739
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1936
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2069
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2226
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2392
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2432
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2587
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2744
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2905
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3005
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..5533
                     /gene="Bicc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgctcgg agcgggcgct gcgggcgggc gggggccggg gcgcagcgga tcggcgcggc
       61 ggggcggggg gcggcgcccg aggcggtgat gcgcagggct tcccgcggcc acggaggcgg
      121 cgggggcacg agctagcgct gcggcgcgcc gagccacatc ggcctgggcc ggggcggcgg
      181 cagcccgagc gccgctcgca ccatggccgc gcagggcgag ccgggctacc tggcggcggc
      241 gcagtcggac ccgggctcca acagcgagcg cagcaccgac tcgccggtgg ccggctccga
      301 ggacgatctg gtggccgcgg cgcccctcct gcacagcccc gagtggagcg aggagcgctt
      361 ccgcgtggac aggaagaaac tcgaggccat gctccaagct gcagctgaag gaaaaggcag
      421 aagtggggaa gacttttttc aaaagatcat ggaggagaca aacacgcaga ttgcatggcc
      481 gtccaaactg aagatcgggg ccaaatccaa gaaagatccc cacatcaagg tttctgggaa
      541 gaaagaggct gtgaaggaag ccaaagaaat gatcatggct gtcttagaca cgaaaagcaa
      601 ccgggtcacg ctgaagatgg atgtctcgca cacagagcac tcccacgtca tcggcaaggg
      661 tggtaacaac attaaaaagg tgatggaaga cacgggctgc cacatccact tcccagactc
      721 caacaggaac aaccaggtgg aaaagagtaa ccaggtgtct atagcaggac agccagcagg
      781 agtagaatcg gcccgagcga ggattcggga gctgcttcct ttggtgctga tgtttgagtt
      841 accgatcgcc gggattctcc agccggtccc agatcccaac accccctcca tccagcacat
      901 ctcacagacg tacagcgttt ccgtgtcatt taagcagagg tctcgaatgt atggtgctac
      961 cgtcatagtg cgagggtctc agaataacac taatgctgtg aaggaaggga cagccatgct
     1021 attggaacac ctcgcaggaa gcttggcatc cgccatcccc gtgagcacac aactggatat
     1081 agcagcccaa caccacctct tcatgatggg ccggaacggg agcaacgtca aacacatcat
     1141 gcagaggaca ggggcacaga tccactttcc cgaccccagc aatccacaga agaaatccac
     1201 cgtctacctc cagggcacca ttgagtccgt ctgcctggca aggcagtacc tcatggggtg
     1261 tcttcctctg gtgttgatgt ttgatatgaa ggaggacatc gacgtggacc cacaggtcat
     1321 cacacagctc atggagcagc tagacgtctt tatcagtatt aaaccgaagc ccaaacagcc
     1381 cagcaagtct gtgattgtga aaagtgttga gcgaaatgcc ttaaatatgt atgaagcaag
     1441 gaagtgtctc ctcggacttg aaagcagtgg ggtttccata gcaaccagtc tatccccagc
     1501 atcgtgccct gccggcctgg catgtcccag cctggatatc ttagcttcgg caggccttgg
     1561 actcactgga ctaggtctat tggggcccac cacattgtcc ctcaacacat caaccacccc
     1621 aaactcactc ctgaacgccc tcaacagttc cgtcagtcct ttgcaaagtt caagttctgg
     1681 gaccccaagc ccgacgacgt tgtgggcctc ctcaatcccc aacactgcaa gtgccacagg
     1741 tttttctacc ataccacacc ttatgatccc atctactgcc caggccacat taaccaatat
     1801 cctgctgtct ggagtgccca catatgggca tacagccccg tctcccccac ctggcttgac
     1861 tcctgttgac gtccacatca acagcatgca gacagaaggc aaaaacatct ctgcttctat
     1921 aaatggacac gtgcagcctc cgaacatgaa atacggtccg ctttccactt catcgcttgg
     1981 ggaaaaagtg ctgagttcta atcacggcga tccatccatg cagacagctg ggcccgaaca
     2041 ggcttctcct aaatcaaact cagtggaagg ctgcaatgat gcctttgttg aagtgggcat
     2101 gcctcgaagt ccttcccatt ccggaaacgc tggtgacttg aagcagatgc tgggtccctc
     2161 caaggtctcc tgtgccaagc ggcagaccgt tgagctactg cagggcacga agaactcgca
     2221 cctccacagc actgacagat tactctcaga caccgaactg agtgcaacag aaagtcctct
     2281 tgctgacaag aaggccccag ggagcgagcg tgcggctgag agggcagcgg ctgcccagca
     2341 gaactcggaa agggcccgcc tggcctcgca gccaccatat gtccacatgc aggcctttga
     2401 ctatgagcag aagaagctac tagccaccaa agcgatgtta aagaagccag tggtgactga
     2461 ggtcagaacg cctacgaaca catggagtgg cctggggttc tcgaagtcca tgccggcaga
     2521 aaccatcaag gaactgagga gagcgaacca tgtgtcttat aagcccacaa tgacaaccgc
     2581 ctatgagggc tcctcattgt ccctctcaag gtccagcagt cgtgagcacc tggcgagcgg
     2641 aagcgagtca gacaactgga gagaccgaaa cggaatcggc cccatgggtc acagtgaatt
     2701 ctcggcaccg atcggcagcc ccaagcgcaa gcagaacaaa tcaagagagc actatctaag
     2761 cagcagcaac tacatggact gcatttcctc gctgacagga agcaatggct gcaacctgaa
     2821 cagttgtttc aaaggctcgg acctccccga gcttttcagc aaactgggcc tcggcaaata
     2881 cacagatgtc ttccagcagc aggagatcga tctccagaca ttcctcaccc tcacagacca
     2941 ggatctgaag gagctgggaa tcacaacctt tggtgcccgg aggaaaatgc tgctggcaat
     3001 ttcagagcta agtaaaaacc gaagaaaact ctttgaaccg ccaaacacgc caaccacgtg
     3061 cacctccttc ctggaaggtg gagtcagtgg gaggctgccc cgccagtatc attcagacat
     3121 cgccagcgtc agtggccgct ggtagcggta ccttctggac acgcacctgc tatcagcaaa
     3181 ggtggacgcg atctgtggac agtcttcact gcgctcgtcc gtccttggca ctccgggcgt
     3241 ctgctatcag gaccaaagtg tggaattcgc acccgtactt cacggcaaaa taagaagaca
     3301 agagaaaggg tctcgtggtc tcatgttgcc gtaaaagcac caaaggggaa atgctttttc
     3361 aaaccggcaa ttggacagaa tttgcaaaat gagggtaggg ctttgtttct ttgtatttac
     3421 ctatattaca tatgcactga tttttttttt cttggtacct aaaatgaagg agaattttga
     3481 catctgggat gccagaaaac gtagaattta ttttgttggt tcgaactgtc ttggtatttg
     3541 gggatttgaa aaaaaaataa tcaaagtata atttttctgc tttaaaatga tgactgaggt
     3601 cttccagcac tttacatgat ctagttgttc ctcctgtgga atctgtctct catctccgtg
     3661 tttccggtat tggtatagtt tttttttttt ttcctggctc cttcacatgt ttatttgaaa
     3721 tggtactgga ccttaattag ttcccatgcc gagttttctg tgctgttggg aaatgtgggc
     3781 cacttggctc tggaccaaag tcaattcatt tgtgtcaaca tcttaggaac ctttggccat
     3841 gacaggccag gtacgataga cagaccgaat ggactttaca atactaactc tttgtggttg
     3901 gcatagttag ctgctgtctt gtattgctaa attccaatgg ttgtctgaag gccaagaggc
     3961 tggtctttta gtatactgcc actaaaggac atttatttat atcaaacttt tatttttaga
     4021 tattataagc ctacagtaga caaactgatg agattgatat tttctagaga tttatggtag
     4081 agattgagct gcattcataa ctggagccct aggttgtcac tttatttaag aagacaagca
     4141 accatttgac gagacagcac tgctgccatt atgaagagaa gaggccccgc ctccttaccc
     4201 agtagctccg ccccctgtgg gtcagggggc tttccctaaa agtgcctttg tctgctcaga
     4261 agtcaacttg gatcagttgg aaacataagg gtctagggga cagcttatcc aagagctgaa
     4321 ttctgaaggg ggagaaaaaa aaaaggcttt ctaaatggct agatttattg ttacaatctt
     4381 atactgtgaa agtctaagag attagtggac actatttcct gtctttgcag atgatacaaa
     4441 ggttttcagt ccaatgagga aaaccactca agtgcctctc ttcagagcta cattcttacc
     4501 aaatgtatac agttttttag ggaggggagg ggaggggatt tttcccatag ggcatgttgt
     4561 cagttacctt tagtgattgt gtttctgtcc atatgttaat gctttctgtg tgatataaac
     4621 ccctccctcc tgttcttggt agagaggagt tggaggtgta tgctgggtgc ctatacaaat
     4681 tcgaggtacg aaatacttgc ctgatgttct cttcggaggc taattctggt caccaaagaa
     4741 ctgaagggat attttttaca catagaaaaa attttcactt tgcaaacgtt ggctacctgg
     4801 aagcttagcc gatgacaacg aacttaccac ggcggtaata tctacctggc ttcaatctca
     4861 gcctaactgc ataaggatac agaattgaat cactccctgc acaagcatgg tgtggccatc
     4921 ccgtgcccat atgctcagat gaccacccga ggctcaacac atagccaact gaccaaattt
     4981 ggccagtttt ccaaatttgg ttgtttcttt aattaaaaaa ggaaaaaagt cattgggagc
     5041 ttattgtgga ctctgtcatg catttgctaa aaggaaggaa aggaatcaaa tatttagtaa
     5101 taagccggct taggttgtat acatagtgct ttgatttcac accaaaggga aaactgttca
     5161 ctccaactca attaaatggg gaggctaaga aataattaaa aacactggaa ggtttttctc
     5221 cctttctttt aatggagtga agggaatata acaccagggc ctacagagtt gttggtgttc
     5281 tttgtcacgc atggaatatt tgggttgttg gaagtaatgt tagcttttag ccaacctggc
     5341 ttttctcatg attggtgatc tgtaaatatg gaacggacct ggattgtatt tcatgggggt
     5401 gggggggtcc ttgtcctttt tatcactttt taaaaacccg tgagatggga tcaacattga
     5461 aagtggggat ttttttttct aaagcaatca ttacatgaga aataaattta tataacccct
     5521 ttgtatcgct ttc
//
