LOCUS       NP_001402002             980 aa            linear   ROD 01-APR-2024
DEFINITION  protein bicaudal C homolog 1 [Rattus norvegicus].
ACCESSION   NP_001402002 XP_038954757
VERSION     NP_001402002.1
DBSOURCE    REFSEQ: accession NM_001415073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 980)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   2  (residues 1 to 980)
  AUTHORS   Ota,K.T., Andres,W., Lewis,D.A., Stockmeier,C.A. and Duman,R.S.
  TITLE     BICC1 expression is elevated in depressed subjects and contributes
            to depressive behavior in rodents
  JOURNAL   Neuropsychopharmacology 40 (3), 711-718 (2015)
   PUBMED   25178406
  REMARK    GeneRIF: findings identify a role for increased levels of BICC1 in
            the pathophysiology of depressive behavior
REFERENCE   3  (residues 1 to 980)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 980)
  AUTHORS   Kraus,M.R., Clauin,S., Pfister,Y., Di Maio,M., Ulinski,T.,
            Constam,D., Bellanne-Chantelot,C. and Grapin-Botton,A.
  TITLE     Two mutations in human BICC1 resulting in Wnt pathway hyperactivity
            associated with cystic renal dysplasia
  JOURNAL   Hum Mutat 33 (1), 86-90 (2012)
   PUBMED   21922595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 21, 2022 this sequence version replaced XP_038954757.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.78327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     Protein         1..980
                     /product="protein bicaudal C homolog 1"
                     /note="bicaudal C homolog 1"
                     /calculated_mol_wt=105318
     Region          48..128
                     /region_name="KH-I_BICC1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in protein bicaudal C homolog 1 (BICC1) and similar
                     proteins; cd22420"
                     /db_xref="CDD:411848"
     Site            order(64,71..75,78..79,82..83,89..92)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411848"
     Region          133..202
                     /region_name="KH-I_BICC1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in protein bicaudal C homolog 1 (BICC1) and similar
                     proteins; cd22421"
                     /db_xref="CDD:411849"
     Site            order(144,146..148,150..154,157..158,161..162,167..170)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411849"
     Region          286..351
                     /region_name="KH-I_BICC1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in protein bicaudal C homolog 1 (BICC1) and similar
                     proteins; cd22422"
                     /db_xref="CDD:411850"
     Site            order(296,298..300,302..306,309..310,313..314,319..322)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411850"
     Region          876..939
                     /region_name="SAM_BICC1"
                     /note="SAM domain of BICC1 (bicaudal) subfamily; cd09520"
                     /db_xref="CDD:188919"
     CDS             1..980
                     /gene="Bicc1"
                     /coded_by="NM_001415073.1:203..3145"
                     /db_xref="GeneID:361832"
                     /db_xref="RGD:1307459"
ORIGIN      
        1 maaqgepgyl aaaqsdpgsn serstdspva gseddlvaaa pllhspewse erfrvdrkkl
       61 eamlqaaaeg kgrsgedffq kimeetntqi awpsklkiga kskkdphikv sgkkeavkea
      121 kemimavldt ksnrvtlkmd vshtehshvi gkggnnikkv medtgchihf pdsnrnnqve
      181 ksnqvsiagq pagvesarar irellplvlm felpiagilq pvpdpntpsi qhisqtysvs
      241 vsfkqrsrmy gatvivrgsq nntnavkegt amllehlags lasaipvstq ldiaaqhhlf
      301 mmgrngsnvk himqrtgaqi hfpdpsnpqk kstvylqgti esvclarqyl mgclplvlmf
      361 dmkedidvdp qvitqlmeql dvfisikpkp kqpsksvivk svernalnmy earkcllgle
      421 ssgvsiatsl spascpagla cpsldilasa glgltglgll gpttlslnts ttpnsllnal
      481 nssvsplqss ssgtpspttl wassipntas atgfstiphl mipstaqatl tnillsgvpt
      541 yghtapsppp gltpvdvhin smqtegknis asinghvqpp nmkygplsts slgekvlssn
      601 hgdpsmqtag peqaspksns vegcndafve vgmprspshs gnagdlkqml gpskvscakr
      661 qtvellqgtk nshlhstdrl lsdtelsate spladkkapg seraaeraaa aqqnserarl
      721 asqppyvhmq afdyeqkkll atkamlkkpv vtevrtptnt wsglgfsksm paetikelrr
      781 anhvsykptm ttayegssls lsrsssrehl asgsesdnwr drngigpmgh sefsapigsp
      841 krkqnksreh ylsssnymdc issltgsngc nlnscfkgsd lpelfsklgl gkytdvfqqq
      901 eidlqtfltl tdqdlkelgi ttfgarrkml laiselsknr rklfeppntp ttctsflegg
      961 vsgrlprqyh sdiasvsgrw
//
