LOCUS       NM_001014256            1995 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus betaine-homocysteine S-methyltransferase 2
            (Bhmt2), mRNA.
ACCESSION   NM_001014256 XM_345307
VERSION     NM_001014256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Li,D., Liu,H.X., Fang,Y.Y., Huo,J.N., Wu,Q.J., Wang,T.R.,
            Zhou,Y.M., Wang,X.X. and Ma,X.X.
  TITLE     Hyperhomocysteinemia in polycystic ovary syndrome: decreased
            betaine-homocysteine methyltransferase and cystathionine
            beta-synthase-mediated homocysteine metabolism
  JOURNAL   Reprod Biomed Online 37 (2), 234-241 (2018)
   PUBMED   29804940
  REMARK    GeneRIF: These findings indicate that decreased liver Bhmt and
            Cbs-mediated homocysteine metabolism might have a role in
            hyperhomocysteinemia in polycystic ovary syndrome and provides
            further evidence for a potential role of decreased liver function
            in PCOS.
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Li,M., Li,J., Wei,C., Lu,Q., Tang,X., Erickson,S.W., MacLeod,S.L.
            and Hobbs,C.A.
  TITLE     A Three-Way Interaction among Maternal and Fetal Variants
            Contributing to Congenital Heart Defects
  JOURNAL   Ann Hum Genet 80 (1), 20-31 (2016)
   PUBMED   26612412
REFERENCE   4  (bases 1 to 1995)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1995)
  AUTHORS   Szegedi,S.S., Castro,C.C., Koutmos,M. and Garrow,T.A.
  TITLE     Betaine-homocysteine S-methyltransferase-2 is an
            S-methylmethionine-homocysteine methyltransferase
  JOURNAL   J Biol Chem 283 (14), 8939-8945 (2008)
   PUBMED   18230605
REFERENCE   6  (bases 1 to 1995)
  AUTHORS   Olivier,E., Soury,E., Risler,J.L., Smih,F., Schneider,K.,
            Lochner,K., Jouzeau,J.Y., Fey,G.H. and Salier,J.P.
  TITLE     A novel set of hepatic mRNAs preferentially expressed during an
            acute inflammation in rat represents mostly intracellular proteins
  JOURNAL   Genomics 57 (3), 352-364 (1999)
   PUBMED   10329001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079366.1 and CK481317.1.
            
            On Oct 10, 2007 this sequence version replaced NM_001014256.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079366.1, Z83053.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BC079366.1         1-57
            58-189              CK481317.1         153-284
            190-1995            BC079366.1         190-1995
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1995
                     /gene="Bhmt2"
                     /note="betaine-homocysteine S-methyltransferase 2"
                     /db_xref="GeneID:365972"
                     /db_xref="RGD:1359418"
     exon            1..56
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1115
                     /gene="Bhmt2"
                     /EC_number="2.1.1.10"
                     /note="betaine-homocysteine methyltransferase 2; SMM-hcy
                     methyltransferase"
                     /codon_start=1
                     /product="S-methylmethionine--homocysteine
                     S-methyltransferase BHMT2"
                     /protein_id="NP_001014278.2"
                     /db_xref="GeneID:365972"
                     /db_xref="RGD:1359418"
                     /translation="MAPAGGPRVKKGILERLDSGEVVVGDGGFLFTLEKRGFVKAGLW
                     TPEAVVEYPSAVRQLHTEFLRAGADVLQTFTFSAAEDRMESKWEAVNAAACDLAQEVA
                     DGGAALVAGGICQTSLYKYHKDETRIKNIFRLQLGVFARKNVDFLIAEYFEHVEEAVW
                     AVEVLREVGAPVAVTMCIGPEGDMHGVTPGECAVRLSRAGANIIGVNCRFGPWTSLQT
                     MKLMKEGLRDAGLQAHLMVQCLGFHTPDCGKGGFVDLPEYPFGLEPRVATRWDIQKYA
                     REAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGIWGSGLDMHTKPWI
                     RARARREYWETLLPASGRPFCPSLSKPDA"
     exon            57..189
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..281
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..473
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..621
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..804
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1033
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1974
                     /gene="Bhmt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcttgca cagtggcggc gacatggcac cagccggagg cccacgagtc aagaagggta
       61 tcttggagcg tctggacagc ggggaggttg tggttgggga cggcggcttt ctcttcactc
      121 tggaaaagag aggctttgtg aaggcaggac tttggactcc agaagcagtg gtagagtatc
      181 caagtgcagt tcgtcagctt cacacagaat tcttgagagc gggagccgat gtcttgcaga
      241 cattcacctt ttcggctgct gaagacagaa tggaaagcaa gtgggaagct gtgaatgcag
      301 ctgcctgtga cctggcccag gaggtggctg atggaggggc tgctttggtg gcagggggca
      361 tctgccagac atcactgtac aagtaccaca aggatgaaac tagaattaaa aacattttcc
      421 gactacagct aggtgttttt gccaggaaaa atgtggactt cttgattgca gagtattttg
      481 agcatgtgga agaagccgtg tgggctgtgg aagtcttgag agaggtgggg gcacctgtgg
      541 ctgtgaccat gtgcatcggc ccagaggggg acatgcacgg cgtgacaccg ggagagtgtg
      601 cggtgagact gtctcgtgca ggggcgaaca tcattggggt aaactgccgg tttgggccct
      661 ggaccagctt acagaccatg aagctcatga aggagggcct cagggatgcc ggcctacaag
      721 ctcaccttat ggtccagtgc ttgggtttcc acacaccgga ctgtggcaag ggagggtttg
      781 tggaccttcc tgaatatcct ttcggcctgg agccaagagt tgccaccaga tgggatattc
      841 aaaaatacgc cagagaggcc tacaacctgg gggtcaggta cattggcggc tgctgcggat
      901 ttgagcccta ccacatcagg gccattgcag aggagctcgc cccagaaagg ggatttttgc
      961 caccagcttc agaaaaacat ggcatctggg gaagtggttt ggacatgcac accaaaccct
     1021 ggatcagagc aagggctaga cgggaatact gggaaactct gttgccagct tcgggaagac
     1081 ctttctgtcc ttccctatca aagccagatg cttgagaagc catgaaagag acctctgaag
     1141 tgacagaaag gaggaaacag cctcaagccc catctggaat cttcctggct gctgtcctca
     1201 gcccgttctt ctggctgttg agcatcgatg agctgtcgtc ccttccaatt gagtgacata
     1261 tcactcctga gtatgcccac tagatgcggt ggagatgcag aggcatccgg accccacgcc
     1321 ccaccccctc ccctcacaca cttactctct gcctagtaat gccacagagc ttccatcccc
     1381 atccaaaggt catcaggcat ggctatcagt tggctctcag ggtggatttg acattctcag
     1441 atgattagaa gttggcaaga agcaaccttg gtgaataact ctggtgtcta aactctgtac
     1501 ttgagttaca gtctcagtag aggagacgcc aaagctgttg cgagtgacgg caggattatt
     1561 gaacagtcat gatgcttggc tttcaaaggc gattatcgct ttaaggtctt agaattagta
     1621 agtgcatctt tataaccagg catagctaga tcataaacta ctgatggcca aggaccatag
     1681 aacgtgcttc ttaccttcct ctctagttag cattacgaca aacataatca ccaacgctca
     1741 gggaaacact tgctgattca agtaaaatgc atgaaccttg gaagaccttt ctagaagtca
     1801 gagatcaagt tcatcttgtt ctagcacttt ccacattcat gtttggtttg tatgctgcgc
     1861 cctacttttg ttttttgcta caatgtaaca aattagtgag taaccattag tgaaattgcg
     1921 aataattttc cttttctaaa ttttgatttc tttggaacat tgatttaaaa aaaaaaaaaa
     1981 aaaaaaaaaa aaaaa
//
