LOCUS       NM_133303               3140 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus basic helix-loop-helix family, member e41
            (Bhlhe41), mRNA.
ACCESSION   NM_133303 XM_039108889 XM_346728
VERSION     NM_133303.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Liang,Y., Zhang,P., Li,S., Li,H., Song,S. and Lu,B.
  TITLE     MicroRNA-873 acts as a tumor suppressor in esophageal cancer by
            inhibiting differentiated embryonic chondrocyte expressed gene 2
  JOURNAL   Biomed Pharmacother 105, 582-589 (2018)
   PUBMED   29890466
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Zhao,Q., Zheng,G., Yang,K., Ao,Y.R., Su,X.L., Li,Y. and Lv,X.Q.
  TITLE     The clock gene PER1 plays an important role in regulating the clock
            gene network in human oral squamous cell carcinoma cells
  JOURNAL   Oncotarget 7 (43), 70290-70302 (2016)
   PUBMED   27602964
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Takagi,K., Asano,K., Haneishi,A., Ono,M., Komatsu,Y., Yamamoto,T.,
            Tanaka,T., Ueno,H., Ogawa,W., Tomita,K., Noguchi,T. and Yamada,K.
  TITLE     Insulin stimulates the expression of the SHARP-1 gene via multiple
            signaling pathways
  JOURNAL   Horm Metab Res 46 (6), 397-403 (2014)
   PUBMED   24446161
  REMARK    GeneRIF: Insulin induces the SHARP-1 gene expression at the
            transcription level.
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Goriki,A., Hatanaka,F., Myung,J., Kim,J.K., Yoritaka,T., Tanoue,S.,
            Abe,T., Kiyonari,H., Fujimoto,K., Kato,Y., Todo,T., Matsubara,A.,
            Forger,D. and Takumi,T.
  TITLE     A novel protein, CHRONO, functions as a core component of the
            mammalian circadian clock
  JOURNAL   PLoS Biol 12 (4), e1001839 (2014)
   PUBMED   24736997
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Wu,T., Ni,Y., Zhuge,F., Sun,L., Xu,B., Kato,H. and Fu,Z.
  TITLE     Significant dissociation of expression patterns of the basic
            helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney
  JOURNAL   J Exp Biol 214 (Pt 8), 1257-1263 (2011)
   PUBMED   21430201
  REMARK    GeneRIF: Results describe significant dissociation of expression
            patterns with arrhythmic expression of Dec1 and rhythmic expression
            of Dec2 in rat kidney under a normal light-dark (LD) cycle.
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Butler,M.P., Honma,S., Fukumoto,T., Kawamoto,T., Fujimoto,K.,
            Noshiro,M., Kato,Y. and Honma,K.
  TITLE     Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei
            of Clock mutant mice
  JOURNAL   J Biol Rhythms 19 (2), 126-134 (2004)
   PUBMED   15038852
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Kawamoto,T., Noshiro,M., Sato,F., Maemura,K., Takeda,N., Nagai,R.,
            Iwata,T., Fujimoto,K., Furukawa,M., Miyazaki,K., Honma,S.,
            Honma,Ki. and Kato,Y.
  TITLE     A novel autofeedback loop of Dec1 transcription involved in
            circadian rhythm regulation
  JOURNAL   Biochem Biophys Res Commun 313 (1), 117-124 (2004)
   PUBMED   14672706
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Azmi,S., Sun,H., Ozog,A. and Taneja,R.
  TITLE     mSharp-1/DEC2, a basic helix-loop-helix protein functions as a
            transcriptional repressor of E box activity and Stra13 expression
  JOURNAL   J Biol Chem 278 (22), 20098-20109 (2003)
   PUBMED   12657651
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Honma,S., Kawamoto,T., Takagi,Y., Fujimoto,K., Sato,F., Noshiro,M.,
            Kato,Y. and Honma,K.
  TITLE     Dec1 and Dec2 are regulators of the mammalian molecular clock
  JOURNAL   Nature 419 (6909), 841-844 (2002)
   PUBMED   12397359
  REMARK    GeneRIF: Dec1 and Dec2 are regulators of the mammalian molecular
            clock, and form a fifth clock-gene family [dec1 & dec2]
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Rossner,M.J., Dorr,J., Gass,P., Schwab,M.H. and Nave,K.A.
  TITLE     SHARPs: mammalian enhancer-of-split- and hairy-related proteins
            coupled to neuronal stimulation
  JOURNAL   Mol Cell Neurosci 10 (3-4), 460-475 (1997)
   PUBMED   9532582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Jan 5, 2022 this sequence version replaced
            XM_039108889.1, NM_133303.1.
            
            Summary: This gene encodes a basic helix-loop-helix protein
            expressed in various tissues. The encoded protein can interact with
            Arntl or compete for E-box binding sites in the promoter of Per1
            and repress Clock/Arntl's transactivation of Per1. This gene is
            believed to be involved in the control of circadian rhythm and cell
            differentiation. Defects in this gene are associated with the short
            sleep phenotype. [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.17835.1,
                                           SRR26643290.18354.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               JAXUCZ010000004.1  180569027-180569355 c
            330-393             JAXUCZ010000004.1  180568826-180568889 c
            394-501             JAXUCZ010000004.1  180568412-180568519 c
            502-613             JAXUCZ010000004.1  180567921-180568032 c
            614-3140            JAXUCZ010000004.1  180565003-180567529 c
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3140
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /note="basic helix-loop-helix family, member e41"
                     /db_xref="GeneID:117095"
                     /db_xref="RGD:70900"
     exon            1..329
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1500
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /note="basic helix-loop-helix domain containing, class B3;
                     enhancer-of-split and hairy-related protein 1"
                     /codon_start=1
                     /product="class E basic helix-loop-helix protein 41"
                     /protein_id="NP_579837.2"
                     /db_xref="GeneID:117095"
                     /db_xref="RGD:70900"
                     /translation="MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDT
                     YKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTAL
                     TEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCA
                     QLVSHLHAVATQLLTPQVTPGRGPGRAPCSAGAAAASGSERVARCVPVIQRTQPGTEP
                     EHDTDTDSGYGGEAEQGRAAVKQEPPGDPSPAPKRLKLEARGALLGPEPALLGSLVAL
                     GGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIP
                     AAAAAAAAAAFPCLSSVLSPPPEKAGSAAGAPFLAHEVAPPGSLRPQHAHSRTHLPHA
                     VNPESSQEDATQPAKDAP"
     exon            330..393
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..501
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..613
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..3140
                     /gene="Bhlhe41"
                     /gene_synonym="Bhlhb3; Dec2; SHARP-1; Sharp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaacactgc ccggagtgag agcaaactac cagcgcagtg cgtgtgtgcg cgcgggtgtg
       61 cgcgcgcggg tgtgcgagag ggcgagcgag cgagcacggg gcggaggggc ggccaactgc
      121 ttcacacttt caatactgca ctgaagaggg agagcgagac agcctggaga cgcacacaac
      181 cccccaaaat ctctccagac gaccgtccca cggatcacag gacagaaccc tccaaatcga
      241 aacggaggaa acggacagcc attgaacatg gacgaaggaa tccctcattt gcaagagaga
      301 cagttactgg aacataggga ttttatagga ctggactatt cctctttgta tatgtgtaaa
      361 cccaaaagga gcttgaagcg agacgacacc aaggatacct acaaattacc gcacagatta
      421 atagaaaaga agagacgaga ccgaattaat gaatgtattg ctcagctgaa agacttactg
      481 cctgaacatc tgaaattgac aacactgggg catctggaga aagcagtagt cttggaatta
      541 actttgaagc acttaaaagc tttaacagcc ttaacggagc agcagcatca gaagataatt
      601 gctttacaga atggggagcg ctctctgaaa tcgccggtcc aggccgactt ggatgcgttc
      661 cactcggggt ttcaaacctg cgccaaagaa gtcttgcaat acctcgcgcg ctttgagagc
      721 tggacgccca gggaaccgcg ctgcgcacag ctcgtcagcc acctgcacgc tgtggctacc
      781 cagcttctga cgccacaggt gaccccaggc aggggccctg ggcgcgcgcc ctgcagcgct
      841 ggggctgcag ccgcctccgg ttccgagcgc gtcgcccgct gcgtgccggt catccagcgg
      901 actcagcccg gcacggagcc cgagcacgac acggacaccg acagcggcta tggaggcgag
      961 gcggagcagg gccgcgccgc cgtcaagcag gagccacccg gggacccgtc gcctgcgccc
     1021 aagaggctga agctggaggc gcgcggcgcg ctcctgggcc cggagcccgc gctgctcggc
     1081 tctctcgtgg cgttgggcgg gggtgcgccc ttcgcgcagc ccgccgccgc gcccttctgc
     1141 ctgcccttct acctgctgtc gccgtccgcc gccgcctacg tacagccctg gctagacaag
     1201 agtggcctgg acaagtatct gtaccccgcg gcggccgcgc ccttcccgct gctgtatccc
     1261 ggcatccccg cagcagccgc cgctgccgcc gccgccgctt tcccttgctt gtcgtccgtg
     1321 ctatcgccac ccccggagaa ggcaggttcg gccgctggtg ccccattcct ggcgcacgag
     1381 gtggcgcccc cggggtcgct gcgcccccag cacgcgcata gccgcaccca cctgccgcac
     1441 gccgtgaacc cagagagctc tcaggaagat gccacgcagc cggccaagga cgccccctga
     1501 acccagcatt ccttccagaa cagggcaggg ggctcctgag gagtcgccag gtttccaagt
     1561 tcaaacatcc cctaaggcgt accagggagg aagagtaaga gatgctctgc tcgacaggct
     1621 taggacaaaa acaggtgttt tgtgtatgtt tggagttcct gttttgcccc tttctcaccc
     1681 ttctgccacc ccaccctcta ccctttgaca ctcccttccc catccctgct gtcacagagc
     1741 ctccctgaga aatactggtt atcttaaatt accctccctt acatttagtt cacgtcctct
     1801 gtttccaaac atagaccctg gttcaggagt ctgttgggtg ggagagccac acggaaccag
     1861 ttagagtgcc tggtatcagg gctccttgac ccaggcctgg aacagtagct gtgtcccctg
     1921 tctgtcccct taggaggtga cccacaactg agggtctctg aaagttacat tgacgtgtca
     1981 gtattttgta ttcttcagct ttttggaagg tacctctttt tcaaagaagt gaggatgcca
     2041 ttgccctgtt gtgaggtggc tggagtggtg tctttatacc ttgcacctgt tgggagaaac
     2101 tgagagttgg ggccatcttc aggcactgtg tcagtgtggg agctggaaga gggagtttgg
     2161 agcccgtggc gcctttctcg cactttattg acaaattgac ctcaacccct ttgtcccatg
     2221 tctcaactca cagatatatg tcataggtta tatatttgtg tttctgatcc ctcgttattt
     2281 tatccatcat ggtcccaaat ttttgtaatg ttactggggt ttggggtggg gtggggtgtt
     2341 aaagtgctct gggctggaaa aagacaagcc caaacctatt gattgtcgaa ttcttagatg
     2401 acagaagtgg agagaggggc ttgtggtccc ttgtgatggg aagtgctgtg aacatgtaga
     2461 aggccctgcc aggcctcgct ctctcaagtc tgtatgtatt tttcgggaga ccaaaccaga
     2521 caccagataa tcaggaagaa agctttttaa aataaggcaa aaaccgagac cttgtctaga
     2581 tatttttagt ttgttgccaa ggtagcactg agaaatctca cttgaatgtt acataaggag
     2641 tgattcacaa tagtctagag tgaagaaagt tatctgggtc tgtgagtgtt cgggtccgtt
     2701 tgctgctgct gttgctactg tttgcctcaa acgctgtgtt taaacaacgt taaacttctt
     2761 agcctaccaa ggcggccgta tgtacatagc tgttaatact cccaactaat gtctgacatg
     2821 ctatttttgt agggagaaga tacctgctag tgatattttg agttaaaata tcttttgggg
     2881 cggacttggt gaaatgtttg cactttggtc acaatgcttc tactgcttgg tgcaagctta
     2941 cgctgtctta aattattaaa caaataaaaa atactatctg caagaaaaac cagctggttt
     3001 agacaagttt agtatgtaaa gataagctag aaactatctt tatattctag tattttcagc
     3061 actccatatt acctaaatat tgccacacta ttttgtgatt taaaagttct tactaaggaa
     3121 taaaatcttt atatatgata
//
