LOCUS       NM_053328               2376 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus basic helix-loop-helix family, member e40
            (Bhlhe40), mRNA.
ACCESSION   NM_053328
VERSION     NM_053328.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Sun,L., Gao,G., Wang,X., Zhang,X. and Li,Y.
  TITLE     Protective effect of basic helix-loop-helix family member e40 on
            cerebral ischemia/reperfusion injury: Inhibition of apoptosis via
            repressing the transcription of pleckstrin homology-like domain
            family A, member 1
  JOURNAL   Adv Clin Exp Med 32 (6), 655-666 (2023)
   PUBMED   36881362
  REMARK    GeneRIF: Protective effect of basic helix-loop-helix family member
            e40 on cerebral ischemia/reperfusion injury: Inhibition of
            apoptosis via repressing the transcription of pleckstrin
            homology-like domain family A, member 1.
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Nakashima,A., Kawamoto,T., Noshiro,M., Ueno,T., Doi,S., Honda,K.,
            Maruhashi,T., Noma,K., Honma,S., Masaki,T., Higashi,Y. and Kato,Y.
  TITLE     Dec1 and CLOCK Regulate Na+/K+-ATPase beta1 Subunit Expression and
            Blood Pressure
  JOURNAL   Hypertension 72 (3), 746-754 (2018)
   PUBMED   30012868
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Tian,J., Wu,J., Chen,X., Guo,T., Chen,Z.J., Goldstein,J.L. and
            Brown,M.S.
  TITLE     BHLHE40, a third transcription factor required for insulin
            induction of SREBP-1c mRNA in rodent liver
  JOURNAL   Elife 7, e36826 (2018)
   PUBMED   29952285
  REMARK    GeneRIF: BHLHE40 is required for insulin induction of SREBP-1c mRNA
            in rodent liver.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Marczak,M.M. and Yan,B.
  TITLE     Circadian rhythmicity: A functional connection between
            differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer
            partner (SHP)
  JOURNAL   Arch Biochem Biophys 631, 11-18 (2017)
   PUBMED   28797635
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Kanai,Y., Asano,K., Komatsu,Y., Takagi,K., Ono,M., Tanaka,T.,
            Tomita,K., Haneishi,A., Tsukada,A. and Yamada,K.
  TITLE     Induction of the SHARP-2 mRNA level by insulin is mediated by
            multiple signaling pathways
  JOURNAL   Biosci Biotechnol Biochem 81 (2), 256-261 (2017)
   PUBMED   27792527
  REMARK    GeneRIF: insulin induces the expression of the rat SHARP-2 gene at
            the transcription level via both a PI 3-K/aPKClambda- and a PI
            3-K/mTOR- pathways
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Mizutani,T., Noguchi,T. and
            Miyamoto,K.
  TITLE     Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via
            a phosphoinositide 3-kinase pathway
  JOURNAL   J Biol Chem 278 (33), 30719-30724 (2003)
   PUBMED   12796501
  REMARK    GeneRIF: insulin induces the transcription of the rat SHARP-2 gene
            via a phosphoinositide 3-kinase pathway.
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Li,Y., Xie,M., Song,X., Gragen,S., Sachdeva,K., Wan,Y. and Yan,B.
  TITLE     DEC1 negatively regulates the expression of DEC2 through binding to
            the E-box in the proximal promoter
  JOURNAL   J Biol Chem 278 (19), 16899-16907 (2003)
   PUBMED   12624110
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   St-Pierre,B., Flock,G., Zacksenhaus,E. and Egan,S.E.
  TITLE     Stra13 homodimers repress transcription through class B E-box
            elements
  JOURNAL   J Biol Chem 277 (48), 46544-46551 (2002)
   PUBMED   12297495
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Honma,S., Kawamoto,T., Takagi,Y., Fujimoto,K., Sato,F., Noshiro,M.,
            Kato,Y. and Honma,K.
  TITLE     Dec1 and Dec2 are regulators of the mammalian molecular clock
  JOURNAL   Nature 419 (6909), 841-844 (2002)
   PUBMED   12397359
  REMARK    GeneRIF: Dec1 and Dec2 are regulators of the mammalian molecular
            clock, and form a fifth clock-gene family [dec1 & dec2]
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Rossner,M.J., Dorr,J., Gass,P., Schwab,M.H. and Nave,K.A.
  TITLE     SHARPs: mammalian enhancer-of-split- and hairy-related proteins
            coupled to neuronal stimulation
  JOURNAL   Mol Cell Neurosci 10 (3-4), 460-475 (1997)
   PUBMED   9532582
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053328.1.
            
            Summary: This gene encodes a basic helix-loop-helix protein
            expressed in various tissues. The encoded protein can interact with
            Arntl or compete for E-box binding sites in the promoter of Per1
            and repress Clock/Arntl's transactivation of Per1. This gene is
            believed to be involved in the control of circadian rhythm and cell
            differentiation. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF009330.1, SRR26643298.24443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               JAXUCZ010000004.1  143174450-143174848
            400-469             JAXUCZ010000004.1  143175017-143175086
            470-577             JAXUCZ010000004.1  143175365-143175472
            578-701             JAXUCZ010000004.1  143176377-143176500
            702-2376            JAXUCZ010000004.1  143178476-143180150
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..2376
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /note="basic helix-loop-helix family, member e40"
                     /db_xref="GeneID:79431"
                     /db_xref="RGD:68439"
     exon            1..399
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1555
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /note="basic helix-loop-helix domain containing, class B2;
                     enhancer-of-split and hairy-related protein 2; class B
                     basic helix-loop-helix protein 2; stimulated by retinoic
                     acid 14"
                     /codon_start=1
                     /product="class E basic helix-loop-helix protein 40"
                     /protein_id="NP_445780.2"
                     /db_xref="GeneID:79431"
                     /db_xref="RGD:68439"
                     /translation="MERIPSAQPPPTCLPKTPGLEHGDLSGMDFAHMYQVYKSRRGIK
                     RSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLK
                     HVKALTNLIDQQQQKIMALQSGLQAGDLSGRNIEAGQEMFCSGFQTCAREVLQYLAKH
                     ENTRDLKSSQLVTHLHRVVSELLQGSASRKPLDSAPKPVDFKEKPSFLAKGSEGPGKN
                     CVPVIQRTFAPSGGEQSGSDTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFTVGERVS
                     TIKQESEEPPTKKSRMQLSDEEGHFVGSDLMGSPFLGPHPHQPPFCLPFYLIPPSATA
                     YLPMLEKCWYPTSVPLLYPGLNTSAAALSSFMNPDKIPTPLLLPQRLPSPLAHSSLDS
                     SALLQALKQIPPLNLETKD"
     exon            400..469
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /inference="alignment:Splign:2.1.0"
     exon            470..577
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /inference="alignment:Splign:2.1.0"
     exon            578..701
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /inference="alignment:Splign:2.1.0"
     exon            702..2376
                     /gene="Bhlhe40"
                     /gene_synonym="Bhlhb2; Dec1; SHARP-2; Sharp2; Stra13;
                     Stra14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccctcccg cctctccacc cgccccactt ctcattcact tggctcgcac ggcgcagaca
       61 gcgcagcgag cacacaccgc cagtctgtgt gcagagcggg agccagaagc cgtgggggac
      121 acccggtcat gcacgccccc aactgaagcg acacctcaaa gccgcagctc ctggcagccc
      181 agcgcattgc aagaagctca ggctagctca taggaacata ccccttgaga ccctcggatc
      241 ctcccttcca gggcagtcct ctctcagact ctctgctaag tgcagacagg agcgcacagt
      301 ggcccctgct cgccgcatca tggagcggat ccccagcgcg caaccacctc ctacctgcct
      361 gcccaaaacg ccagggctgg agcacggaga cctgtcaggg atggattttg cccacatgta
      421 ccaagtgtac aagtccaggc ggggaataaa acggagcgag gacagcaagg aaacttacaa
      481 attgccgcac cggttgattg agaaaaagag acgtgaccgg attaacgagt gcattgccca
      541 gctgaaggat ctcctacccg aacatctcaa acttactact ttgggtcact tggagaaagc
      601 agtggttctc gagctgacgc tgaagcacgt gaaagcattg acaaacctaa ttgatcagca
      661 gcagcagaaa atcatggccc tgcagagcgg tttacaagct ggtgatctgt cgggaagaaa
      721 tattgaggca ggacaagaaa tgttctgctc cggtttccag acctgtgccc gggaggtact
      781 tcagtacctg gccaagcatg aaaacactag ggacctgaag tcttcccagc ttgtcactca
      841 tctccaccgt gtggtctctg aactcctgca gggtagtgct tccaggaaac cattggactc
      901 agctcccaaa cccgtggact tcaaagagaa gcccagcttc ctagccaagg gatcagaagg
      961 ccctgggaaa aactgtgtgc cagtcatcca gaggactttt gctccctcgg gcggggagca
     1021 gagtggtagt gacacggaca cagacagtgg ctacggaggc gaattggaga agggtgactt
     1081 gcgcagtgag caaccctact tcaagagcga tcacggacgc aggttcaccg tgggagaacg
     1141 cgtcagcaca attaagcaag aatctgaaga gccccccacc aaaaagagcc gaatgcagct
     1201 ctcagatgag gaaggccact tcgtgggcag tgacctgatg ggttccccat ttcttgggcc
     1261 tcacccacat cagcctccct tttgcctgcc cttctatctc atcccaccat cggccactgc
     1321 ctatctgcct atgctggaga aatgctggta tccgacctct gtgccactgt tatacccagg
     1381 cctcaacacc tcagcagcag ccctctccag cttcatgaac ccagacaaga tcccaactcc
     1441 cttgctcctg ccccagagac tcccttctcc cttggcacat tcgtcccttg actcttcagc
     1501 cttgctccag gccctgaagc agatccctcc tttaaactta gaaaccaaag actaaactct
     1561 tgagggcgaa tctcctgctg ctttgctttt cctttcccca ctaattccaa gaccacaaaa
     1621 ggtttctgtg agtgcagaga gatcggccca ccatgcagac ccacagagaa gattcagaat
     1681 gtgtgtgaga gtgagtgtgt gagtgcgcgt gcgtgtgctt gtatgtgtgt ttatagatgt
     1741 aggacattaa gttccttctg acacagggaa gatgtgagaa ggatggcctg acatcagatg
     1801 acaagaggtc tatagcacat ctctgggctt ttccctaccc agagaagagc cccctttgat
     1861 acaaatcagt tggattttca tatgcttcaa aggcttgatc tgtgagtcac tccagtttgg
     1921 gacataggtc tgtctgtggc tttgagaaaa ggtactttca aaagagggct ttccagagca
     1981 cagctcacag ccagctgtta ggaccccacc cttctccttt attgtggagg tgactcacag
     2041 cagactgaca gtggtcagac tgagctttct gctaaggtgg tgaggtagcc aacactggca
     2101 tgtctcggta gtggtttggg caaatttccg caggtctctt cccccaaccc tgcctctgat
     2161 gaataaagac aatgagtaca gttccttaat tcaggctttt gtgactagct tactacggaa
     2221 ccgaaaatgg tcccctttgt acaagccgag ctgttatgga atcacggtga accagaccca
     2281 ggtctgtggc acctgttttt tttttttttt tttttttagc tctcatttct acggcatgct
     2341 ttccaaggaa ccaaaggagg gtctcagaga tgcccc
//
