LOCUS       NM_017087               2446 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus biglycan (Bgn), mRNA.
ACCESSION   NM_017087 XM_001057996
VERSION     NM_017087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Liu,Z., Liu,S., Guo,J., Sun,L., Wang,S., Wang,Y., Qiu,W. and Lv,J.
  TITLE     Identification and Analysis of Key Genes Driving Gastric Cancer
            Through Bioinformatics
  JOURNAL   Genet Test Mol Biomarkers 25 (1), 1-11 (2021)
   PUBMED   33470887
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Liu,Q., Gibson,M.P., Sun,H. and Qin,C.
  TITLE     Dentin sialophosphoprotein (DSPP) plays an essential role in the
            postnatal development and maintenance of mouse mandibular condylar
            cartilage
  JOURNAL   J Histochem Cytochem 61 (10), 749-758 (2013)
   PUBMED   23900597
  REMARK    Erratum:[J Histochem Cytochem. 2014 Oct;62(10):759.]
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Lechner,B.E., Lim,J.H., Mercado,M.L. and Fallon,J.R.
  TITLE     Developmental regulation of biglycan expression in muscle and
            tendon
  JOURNAL   Muscle Nerve 34 (3), 347-355 (2006)
   PUBMED   16810681
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Schaefer,L., Beck,K.F., Raslik,I., Walpen,S., Mihalik,D.,
            Micegova,M., Macakova,K., Schonherr,E., Seidler,D.G., Varga,G.,
            Schaefer,R.M., Kresse,H. and Pfeilschifter,J.
  TITLE     Biglycan, a nitric oxide-regulated gene, affects adhesion, growth,
            and survival of mesangial cells
  JOURNAL   J Biol Chem 278 (28), 26227-26237 (2003)
   PUBMED   12719420
  REMARK    GeneRIF: biglycan has a role in signaling; nitric oxide modulates
            the course of renal glomerular disease through regulation of
            biglycan expression
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Ayada,Y., Kusachi,S., Murakami,T., Hirohata,S., Takemoto,S.,
            Komatsubara,I., Hayashi,J., Iwabu,A., Ninomiya,Y. and Tsuji,T.
  TITLE     Increased expression of biglycan mRNA in pressure-overloaded rat
            heart
  JOURNAL   Clin Exp Hypertens 23 (8), 633-643 (2001)
   PUBMED   11728008
  REMARK    GeneRIF: Increased expression of biglycan mRNA in
            pressure-overloaded rat heart.
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Dreher,K.L., Asundi,V., Matzura,D. and Cowan,K.
  TITLE     Vascular smooth muscle biglycan represents a highly conserved
            proteoglycan within the arterial wall
  JOURNAL   Eur J Cell Biol 53 (2), 296-304 (1990)
   PUBMED   2081545
REFERENCE   10 (bases 1 to 2446)
  AUTHORS   Bianco,P., Fisher,L.W., Young,M.F., Termine,J.D. and Robey,P.G.
  TITLE     Expression and localization of the two small proteoglycans biglycan
            and decorin in developing human skeletal and non-skeletal tissues
  JOURNAL   J Histochem Cytochem 38 (11), 1549-1563 (1990)
   PUBMED   2212616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U17834.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001057996.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U17834.1, AY724513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..2446
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /note="biglycan"
                     /db_xref="GeneID:25181"
                     /db_xref="RGD:2207"
     exon            1..111
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..363
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1232
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /note="PG-S1; bone/cartilage proteoglycan I; Small
                     proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage
                     proteclycan 1 precursor)"
                     /codon_start=1
                     /product="biglycan precursor"
                     /protein_id="NP_058783.1"
                     /db_xref="GeneID:25181"
                     /db_xref="RGD:2207"
                     /translation="MRPLWLLTLLLALSQALPFEQKGFWDFTLDDGLLMMNDEEASGS
                     DTTSGVPDLDSLTPTFSAMCPFGCHCHLRVVQCSDLGLKTVPKEISPDTTLLDLQNND
                     ISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPS
                     SLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISE
                     AKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSF
                     LPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHSNNITKVGINDFCPMGFGVKRAYYN
                     GISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK"
     exon            364..476
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..690
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..801
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..895
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1034
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..2433
                     /gene="Bgn"
                     /gene_synonym="BSPG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggagtga gcagctgctc ccggttggcc ctgacggaca gacaaaccga cagcctgaca
       61 tcctagtcca ccaactaacc agcctgtacc tggctgcttc cccctcccca ggaacattga
      121 ccatgcgtcc cctgtggcta ctcaccttgc tgctggctct gagccaggcc ttgccctttg
      181 agcagaaggg cttctgggac ttcaccttgg atgatgggct gctcatgatg aatgatgagg
      241 aggcttcagg ctcagacacc acttcaggtg tccctgacct ggactctctc acacctacct
      301 tcagtgccat gtgtcctttt ggctgccact gccacctgcg ggttgttcag tgctctgact
      361 tgggtctgaa gactgtgccc aaggagatct cacctgatac cacactgcta gacctgcaga
      421 acaatgacat ctctgaactc cgcaaggatg acttcaaagg cctccagcac ctctatgctc
      481 tggtcctggt aaacaataag atctccaaga tccatgagaa ggcctttagc cctctgcgga
      541 agctgcagaa actctacatc tccaagaacc acctggtgga gattcctccc aacctgccca
      601 gctccctggt agagctacga atccatgaca accgtatccg caaagtgccc aagggcgtgt
      661 tcagtgggct ccggaacatg aactgcattg agatgggtgg gaatcccctg gagaacagtg
      721 gctttgaacc cggagccttt gatggcctga agctcaacta cctgcgcatc tcagaggcca
      781 agctcactgg catccccaaa gatctccctg agaccctgaa tgaacttcac ttggaccaca
      841 acaaaatcca ggctatcgag ttggaggatc tacttcgcta ctccaagctg tacaggctgg
      901 gcttaggaca caatcagatc cgaatgattg agaatgggag cctgagtttt ctgcctaccc
      961 tgagggaact tcacttggac aacaacaagc tgtcccgggt gcctgctggc ctcccagatc
     1021 tcaaactcct ccaggttgtc tatctgcact ccaacaacat caccaaggtg ggcatcaacg
     1081 atttctgccc catgggcttt ggagtcaaga gggcctacta taatggcatc agcctcttca
     1141 acaaccctgt gccctactgg gaagtgcagc ctgccacctt ccgctgcgtc actgaccgcc
     1201 tggccatcca atttggaaat tataagaagt agaagcagtg gtagccacca tggctcgttg
     1261 gtgagagtct ctgaggaaca tagccagttg ttccacaggg gaaggggaac aaagaagcaa
     1321 cacctttgtt ccccaatatt aactcactgc ccaccacagc ttcctctggc tcctaagcat
     1381 gcacatatgc acatggcctg gcctctccca ttcccctcag cctttgagat ttaacactca
     1441 cccaccatgt ccactcagag actccctata aatctttttt cttgctcatc ctgaaactca
     1501 gatgtttgtg ggaagaatgg acagagcaca tggccacagt tactgttcca tccgggcatg
     1561 tattcctcct cttccttacc catgtctgac ttctagctct cctgggctct gctgctgccc
     1621 ttatcctctg gtgatctctc ttcaacaagt tcactacctg tccatccaag ccgccacctg
     1681 gctctactaa ctcctggatc cttccctctc tccaactctg ttatgcttcc tggcactttt
     1741 cttccttctg gggttataga tctgtccctg ccatctctgg acctggttca tatctttctg
     1801 tctttgtctc tttctgtatt tctttgccta tatctctgtc tgtctctatt tctgtttctg
     1861 tctctctgtc tttatatctg cctctctctc tctctctctc tctctctctc tctctctctc
     1921 tctctcacac acacacacac acacacacaa acacacaaac acaaacacac acacacacac
     1981 acacacacac acacacacac acacacacac acacacaccg tcttctccag gctgctttct
     2041 gtttcacagg tctctggcca gtccctgcac aaacaaatat agggaaacta ttttcctgac
     2101 tgccctacct ggcacttgat ctcccatccc tggaggaagc tggaagctgg aggcccagaa
     2161 tcctatccat attgtccagg aaagggtcca tactctgtta tcaagatgag gatcaggaag
     2221 cttcctagcc cctggagagg ctcagcaggc caccagaggc ccccaccccg aaccagtttg
     2281 cattggcccc tgccctctcc ccaagatggc taggtcccct ccctcacccc tgggtccctg
     2341 ctgtggcagg aggtggtggt cagttgtacc cagcaggagg gagtgctgct tatgaggtca
     2401 gttgtctctc aattaaagaa acactgtgca ataaaaaaaa aaaaaa
//
