LOCUS       NM_013414                487 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus bone gamma-carboxyglutamate protein (Bglap),
            mRNA.
ACCESSION   NM_013414
VERSION     NM_013414.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Pinheiro,G.V.V.D.S., Sabino-Silva,R., Araujo,M.R., Gomes,S.P.,
            Oliveira,S.W., Aguiar,E.M.G., Cardoso-Sousa,L., Gonzaga,C.C. and
            Claudino,M.
  TITLE     Experimental Acute Sepsis Reduced Number of Osteocalcin
            Immunolabeled Cells in Periodontal Ligament
  JOURNAL   Braz Dent J 31 (2), 143-151 (2020)
   PUBMED   32556013
  REMARK    GeneRIF: acute sepsis induction resulted in reduced number of
            osteocalcin labelled cells in periodontal ligament region.
            Moreover, no significant histological differences were observed in
            the periodontium of rats under acute sepsis
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Sadek,N.B., Gamal,S.M., Aboulhoda,B.E., Rashed,L.A., Shawky,H.M.
            and Gamal El-Din,M.M.
  TITLE     The Potential Role of Undercarboxylated Osteocalcin Upregulation in
            Microvascular Insufficiency in a Rat Model of Diabetic
            Cardiomyopathy
  JOURNAL   J Cardiovasc Pharmacol Ther 25 (1), 86-97 (2020)
   PUBMED   31533469
  REMARK    GeneRIF: The Potential Role of Undercarboxylated Osteocalcin
            Upregulation in Microvascular Insufficiency in a Rat Model of
            Diabetic Cardiomyopathy.
REFERENCE   3  (bases 1 to 487)
  AUTHORS   Gao,J., Bai,T., Ren,L., Ding,Y., Zhong,X., Wang,H., Guo,Y., Li,J.,
            Liu,Y. and Zhang,Y.
  TITLE     The PLC/PKC/Ras/MEK/Kv channel pathway is involved in
            uncarboxylated osteocalcin-regulated insulin secretion in rats
  JOURNAL   Peptides 86, 72-79 (2016)
   PUBMED   27746193
  REMARK    GeneRIF: Uncarboxylated osteocalcin potentiates insulin secretion,
            inhibits Kv channels and increases [Ca(2+)]i.
REFERENCE   4  (bases 1 to 487)
  AUTHORS   Gamal,S.M., Sadek,N.B., Rashed,L.A., Shawky,H.M. and Gamal
            El-Din,M.M.
  TITLE     Effect of gamma-carboxylase inhibition on serum osteocalcin may be
            partially protective against developing diabetic cardiomyopathy in
            type 2 diabetic rats
  JOURNAL   Diab Vasc Dis Res 13 (6), 405-417 (2016)
   PUBMED   27488359
  REMARK    GeneRIF: gamma-Carboxylase inhibition prevents osteocalcin
            carboxylation and protects against diabetic cardiomyopathy,
            possibly through direct action on upregulated G protein-coupled
            receptor family C group 6 member A and indirectly via adiponectin.
REFERENCE   5  (bases 1 to 487)
  AUTHORS   Lambert,L.J., Challa,A.K., Niu,A., Zhou,L., Tucholski,J.,
            Johnson,M.S., Nagy,T.R., Eberhardt,A.W., Estep,P.N., Kesterson,R.A.
            and Grams,J.M.
  TITLE     Increased trabecular bone and improved biomechanics in an
            osteocalcin-null rat model created by CRISPR/Cas9 technology
  JOURNAL   Dis Model Mech 9 (10), 1169-1179 (2016)
   PUBMED   27483347
  REMARK    GeneRIF: This rat model of complete loss of osteocalcin provides a
            platform for further understanding the role of osteocalcin in
            disease.
REFERENCE   6  (bases 1 to 487)
  AUTHORS   Thomas,S., Movsowitz,C., Epstein,S., Jowell,P. and Ismail,F.
  TITLE     The response of circulating parameters of bone mineral metabolism
            to ethanol- and EDTA-induced hypocalcemia in the rat
  JOURNAL   Bone Miner 8 (1), 1-6 (1990)
   PUBMED   2106357
REFERENCE   7  (bases 1 to 487)
  AUTHORS   Theofan,G., Haberstroh,L.M. and Price,P.A.
  TITLE     Molecular structure of the rat bone Gla protein gene and
            identification of putative regulatory elements
  JOURNAL   DNA 8 (3), 213-221 (1989)
   PUBMED   2785907
REFERENCE   8  (bases 1 to 487)
  AUTHORS   Lian,J., Stewart,C., Puchacz,E., Mackowiak,S., Shalhoub,V.,
            Collart,D., Zambetti,G. and Stein,G.
  TITLE     Structure of the rat osteocalcin gene and regulation of vitamin
            D-dependent expression
  JOURNAL   Proc Natl Acad Sci U S A 86 (4), 1143-1147 (1989)
   PUBMED   2784002
REFERENCE   9  (bases 1 to 487)
  AUTHORS   Wientroub,S., Price,P.A. and Reddi,A.H.
  TITLE     The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and
            24,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic
            acid-containing protein in serum and bone in vitamin D-deficient
            rats
  JOURNAL   Calcif Tissue Int 40 (3), 166-172 (1987)
   PUBMED   3105848
REFERENCE   10 (bases 1 to 487)
  AUTHORS   Celeste,A.J., Rosen,V., Buecker,J.L., Kriz,R., Wang,E.A. and
            Wozney,J.M.
  TITLE     Isolation of the human gene for bone gla protein utilizing mouse
            and rat cDNA clones
  JOURNAL   EMBO J 5 (8), 1885-1890 (1986)
   PUBMED   3019668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M25490.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11777.1, X04141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680429, SAMN06680433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..487
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="bone gamma-carboxyglutamate protein"
                     /db_xref="GeneID:25295"
                     /db_xref="RGD:2206"
     exon            1..113
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..349
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /note="gamma-carboxyglutamic acid-containing protein; bone
                     Gla-protein; osteocalcin; bone gamma-carboxyglutamate
                     protein 2; bone gamma-carboxyglutamate (gla) protein
                     (osteocalcin); bone gamma-carboxyglutamic acid (Gla)
                     protein (osteocalcin)"
                     /codon_start=1
                     /product="osteocalcin preproprotein"
                     /protein_id="NP_038200.1"
                     /db_xref="GeneID:25295"
                     /db_xref="RGD:2206"
                     /translation="MRTLSLLTLLALTAFCLSDLAGAKPSDSESDKAFMSKQEGSKVV
                     NRLRRYLNNGLGAPAPYPDPLEPHREVCELNPNCDELADHIGFQDAYKRIYGTTV"
     exon            114..146
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
     exon            147..216
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
     exon            217..487
                     /gene="Bglap"
                     /gene_synonym="Bglap2; Bgp; Bgpr; Bgpra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacagaca agtcccacac agcaactcgg tgcagaccta gcagacacca tgaggaccct
       61 ctctctgctc actctgctgg ccctgactgc attctgcctc tctgacctgg caggtgcaaa
      121 gcccagcgac tctgagtctg acaaagcctt catgtccaag caggagggca gtaaggtggt
      181 gaatagactc cggcgctacc tcaacaatgg acttggagcc ccagccccct acccagatcc
      241 cctggagcct cacagggagg tgtgtgagct caaccccaat tgtgacgagc tagcggacca
      301 cattggcttc caggacgcct acaagcgcat ctatggcacc accgtttagg gcatgtgttg
      361 ccctggagcc caacggcagc ttcagctttg gctactctcc aggactcgac cctccctgtt
      421 ccctctctct gcctcgaaag tatggacggc acagctgctc caaaataaag tccagatgag
      481 gaacggt
//
