LOCUS       NM_001277434            1549 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus beaded filament structural protein 2 (Bfsp2),
            mRNA.
ACCESSION   NM_001277434 XM_003750577 XM_003754451
VERSION     NM_001277434.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Oka,M., Kudo,H., Sugama,N., Asami,Y. and Takehana,M.
  TITLE     The function of filensin and phakinin in lens transparency
  JOURNAL   Mol Vis 14, 815-822 (2008)
   PUBMED   18449355
  REMARK    GeneRIF: The degradation of filensin and phakinin in normal and
            cataractous rat lenses, was examined.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Fleschner,C.R.
  TITLE     Lens membrane fraction associated intermediate filaments of
            different aged rats
  JOURNAL   Curr Eye Res 24 (4), 296-304 (2002)
   PUBMED   12324869
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Conley,Y.P., Erturk,D., Keverline,A., Mah,T.S., Keravala,A.,
            Barnes,L.R., Bruchis,A., Hess,J.F., FitzGerald,P.G., Weeks,D.E.,
            Ferrell,R.E. and Gorin,M.B.
  TITLE     A juvenile-onset, progressive cataract locus on chromosome 3q21-q22
            is associated with a missense mutation in the beaded filament
            structural protein-2
  JOURNAL   Am J Hum Genet 66 (4), 1426-1431 (2000)
   PUBMED   10729115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 8, 2021 this sequence version replaced NM_001277434.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.21111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680453, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               JAXUCZ010000008.1  112941690-112942246 c
            558-640             JAXUCZ010000008.1  112916067-112916149 c
            641-797             JAXUCZ010000008.1  112913290-112913446 c
            798-959             JAXUCZ010000008.1  112911994-112912155 c
            960-1091            JAXUCZ010000008.1  112893357-112893488 c
            1092-1312           JAXUCZ010000008.1  112886616-112886836 c
            1313-1549           JAXUCZ010000008.1  112885087-112885323 c
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1549
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /note="beaded filament structural protein 2"
                     /db_xref="GeneID:501046"
                     /db_xref="RGD:1591927"
     exon            1..557
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1316
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /note="beaded filament structural protein 2, phakinin; 49
                     kDa cytoskeletal protein; lens intermediate filament-like
                     light; lens fiber cell beaded filament protein CP 47; lens
                     fiber cell beaded filament protein CP 49"
                     /codon_start=1
                     /product="phakinin"
                     /protein_id="NP_001264363.1"
                     /db_xref="GeneID:501046"
                     /db_xref="RGD:1591927"
                     /translation="MSERRVAMDLPSGSNASMPLQRHRVSSLRGTRSPSSLDSPPASR
                     TSAVGSLVRAPGVYVGVAPSGGIGGLGARVTRRALGISSVFLQGLRSSGLATAPAPGP
                     ERNHATAEDLGGCLVEYMTKVHALEQVSQELETQLRAHLESKAKRSGGWDALRASWAS
                     SYQQVGEAVLENARLMLQMETIQAGADDFKERYENEQPFRKAAEEEVSSLYKVIDEAN
                     LTKTDLEHQIESLKEELGSLSRSYEEDVKVLYKQLAGSELEQTDVPMGTGLDDVLETI
                     RVQWERDVEKNRAEAGAVLQAKQQTEVVHVSQTQEEKLAAALSVELHDTSRQVQSLQA
                     ETESLRALKRGLENTLHDAKHWHDMELQNLGAVVGRLEAELAEIHSETEQQQQERAHL
                     LACKGQLQKDVASYHALLDREESN"
     exon            558..640
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
     exon            641..797
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
     exon            798..959
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1091
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1312
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1549
                     /gene="Bfsp2"
                     /gene_synonym="CP47; CP49; LIFL-L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggggcgg caaccaaaag ccactggacc gtgtgaacct gccatgcacc acagaggcag
       61 tgagaatgag cgagaggaga gtagcaatgg acttgccctc aggatccaac gccagcatgc
      121 ccctgcaaag gcacagggtg tcatccctta ggggaacacg atctccttcc tccctggata
      181 gccccccagc atccaggacc agtgctgtag gtagcctcgt ccgtgcccct ggggtctatg
      241 taggagtagc acccagtggt ggcataggtg gcctcggtgc ccgagtgacc cgccgggccc
      301 tgggcatcag cagtgtcttc ctgcagggcc tgcggagctc aggccttgcc actgcacctg
      361 ctccaggccc agaaaggaat cacgccactg ctgaggacct ggggggctgc ctagtggagt
      421 atatgaccaa ggtgcacgct ctggaacaag tcagccagga gctggagaca caactacggg
      481 ctcacttgga gagcaaggcc aagcgctccg gaggctggga tgccctccgt gcctcctggg
      541 ccagcagcta ccagcaggtg ggagaggccg tcttggaaaa tgcccgactc atgctgcaga
      601 tggagaccat ccaggccggt gcggatgact ttaaagagag atatgagaac gagcagccat
      661 tcaggaaggc ggcggaagag gaagtcagct ccctgtacaa agtcatcgat gaagctaatt
      721 tgacgaagac ggatctggag catcaaatcg aaagcctgaa agaagaactg ggctctctgt
      781 caagaagcta tgaagaggat gtgaaggttc tgtacaaaca gctggcgggg tctgagctgg
      841 agcaaacaga tgttcccatg ggcactggtc tggatgatgt ccttgagacg atccgagttc
      901 agtgggagag agatgtggaa aagaaccgag cagaagcagg agctgtgctc caagctaagc
      961 agcagacaga ggtagtccat gtatcccaga cccaagaaga aaagctggcc gctgccctca
     1021 gtgtagagtt acacgacact tcacgccaag tccagagtct ccaggctgag acagaatctt
     1081 tacgggctct gaaacgaggc ctggaaaaca ccttgcacga tgccaagcac tggcatgata
     1141 tggaactgca gaacctgggt gccgtggtgg gcaggctgga ggcagagctg gcagagatcc
     1201 actcagagac agagcagcaa cagcaggagc gggcacacct gctggcgtgc aagggccagc
     1261 tacagaagga tgtggcatcc taccacgccc tgctggacag agaggagagc aactaacggg
     1321 aaaaacaaaa acgacttcct cttttcacaa agaaactcta ccttcctcag cagcccactg
     1381 gtgatgatgt ttaaagacct tcagttgctg ctggagtccc ttagctgact cagagggagc
     1441 tggaaggctt cctgggagtg gcgagggccc ttctgccctc aattatgtag tctgtagctt
     1501 caacagccaa ggcctctctg aataaatact ttgcgtgcgg ctctcagtc
//
