LOCUS       NM_031555               2132 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus beaded filament structural protein 1 (Bfsp1),
            mRNA.
ACCESSION   NM_031555 XM_001053697 XM_342529
VERSION     NM_031555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Oka,M., Kudo,H., Sugama,N., Asami,Y. and Takehana,M.
  TITLE     The function of filensin and phakinin in lens transparency
  JOURNAL   Mol Vis 14, 815-822 (2008)
   PUBMED   18449355
  REMARK    GeneRIF: The degradation of filensin and phakinin in normal and
            cataractous rat lenses, was examined.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Wyatt,K., Gao,C., Tsai,J.Y., Fariss,R.N., Ray,S. and Wistow,G.
  TITLE     A role for lengsin, a recruited enzyme, in terminal differentiation
            in the vertebrate lens
  JOURNAL   J Biol Chem 283 (10), 6607-6615 (2008)
   PUBMED   18178558
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Yoon,K.H., Blankenship,T., Shibata,B. and Fitzgerald,P.G.
  TITLE     Resisting the effects of aging: a function for the fiber cell
            beaded filament
  JOURNAL   Invest Ophthalmol Vis Sci 49 (3), 1030-1036 (2008)
   PUBMED   18326727
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Sandilands,A., Wang,X., Hutcheson,A.M., James,J., Prescott,A.R.,
            Wegener,A., Pekny,M., Gong,X. and Quinlan,R.A.
  TITLE     Bfsp2 mutation found in mouse 129 strains causes the loss of CP49'
            and induces vimentin-dependent changes in the lens fibre cell
            cytoskeleton
  JOURNAL   Exp Eye Res 78 (4), 875-889 (2004)
   PUBMED   15037121
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   DePianto,D.J., Blankenship,T.N., Hess,J.F. and FitzGerald,P.G.
  TITLE     Analysis of non-crystallin lens fiber cell gene expression in c-Maf
            -/- mice
  JOURNAL   Mol Vis 9, 288-294 (2003)
   PUBMED   12835653
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Masaki,S. and Watanabe,T.
  TITLE     cDNA sequence analysis of CP94: rat lens fiber cell beaded-filament
            structural protein shows homology to cytokeratins
  JOURNAL   Biochem Biophys Res Commun 186 (1), 190-198 (1992)
   PUBMED   1378722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB003104.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_001053697.1, XM_342529.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB003104.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2132              AB003104.1         2-2133
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2132
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /note="beaded filament structural protein 1"
                     /db_xref="GeneID:25394"
                     /db_xref="RGD:2205"
     exon            1..368
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2007
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /note="lens fiber cell beaded-filament structural protein
                     CP 94; CP97 115-kDa; beaded filament structural protein 1,
                     filensin"
                     /codon_start=1
                     /product="filensin"
                     /protein_id="NP_113743.1"
                     /db_xref="GeneID:25394"
                     /db_xref="RGD:2205"
                     /translation="MYRRSYVFQARQERYERAQPAGPTAQPGGTAPGLAALQALGERV
                     AAQVQRARALQQRHAGLRRQLYAFQRLGEQPGPEEALARHVEANLQRARDLAAEHARL
                     ERQEAEAQRALDEFRSKYENECECQLVLKEMLERLNKEADEALLRNLHLQLEAQFLQA
                     DISVAKDRYKKNLLEIQTYITILQQIIQTAPQVSLVTGGMREEKLLTEREVAALRNQL
                     DEGREAVTHLQAQKAELQAQTTALEQAIKHAHECYDDEIQLYNGQIENLRKEIEEAER
                     SLERSSYDCRQLAVAQQTLRNELDRYHRIIEIEGNRLSSVFIETPISLITPSHGASLS
                     LGSNVKDLTRAVQDITAAKPRQKALPKSLPKRKEIIAQDKVDETLEDAPLKTLQEPKA
                     VQGELTGDGDSQLGAGGGHEVSPTQEGGPEDVPDGSQISKAFGKLCKVVKERVSGHKE
                     PVPEPPADLFTKGRHILVTGESSFVDPEFYSSSIPARGGVVVSIEEDSMHHDGHVEPS
                     PGQPMPPVENGQGVPQGREGAHSNHQQVTDKNGIRAKEPKDLEEKDDDSRKDDEAGRR
                     PCPVIIPGPDGPSTTHSQTSGSNQGGPEGPGSKSSSLLAKSPSKALSFKKVEVVESIE
                     KISTESIQTYEETSVIVETVIGKTKGNKKPGEKSSSNAKA"
     exon            369..429
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     exon            430..525
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     exon            526..618
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     exon            619..726
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     exon            727..947
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1033
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..2132
                     /gene="Bfsp1"
                     /gene_synonym="115-kDa; CP94; CP95; CP97"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccgggag ccatgtaccg ccgcagctac gtcttccagg cccgccagga gcgctacgag
       61 cgcgcccagc ccgcgggccc taccgcccaa cccggaggaa ccgcgcccgg cctggcggcg
      121 ctgcaggcac tgggcgagcg cgtggccgcc caggtccagc gggcccgcgc gctccagcag
      181 cgccacgccg gcctgaggcg gcagctctac gccttccagc gcctgggcga gcagcccggg
      241 cccgaggagg cgcttgcccg ccacgtcgag gccaatctgc agcgcgcccg ggacctggca
      301 gccgagcacg cgcggctgga gaggcaggag gccgaggcgc agcgcgcgct cgacgagttc
      361 cgcagcaaat acgaaaatga gtgtgaatgt caattggtgc taaaggaaat gctggaacgg
      421 ctgaacaagg aagctgatga agccttattg cgtaacctgc accttcagtt ggaagcccag
      481 tttctgcagg cagatatcag tgtggccaag gacaggtaca aaaagaatct tctggaaatt
      541 cagacctaca tcaccatcct gcagcagatc atacagactg ctcctcaagt gtccctggtc
      601 acgggtggga tgagggagga gaagctgctc acagaacggg aagtagctgc cctgaggaac
      661 cagctggatg agggccggga ggcagtcacc cacctgcagg cacagaaagc tgagctgcag
      721 gcccagacaa cagccctgga acaagctatt aagcatgctc atgagtgcta cgatgacgag
      781 atccagcttt ataatgggca gatcgaaaac ctccggaagg agatagagga ggctgagcgg
      841 tctctggaga ggtcgtccta tgactgcagg cagctggctg tggcccagca gaccctgagg
      901 aacgagctag accggtatca tcggatcatt gagattgaag gcaacaggtt gagctccgtt
      961 ttcatagaga ctcccatctc tttgatcacc ccaagccatg gggcctctct cagccttgga
     1021 tccaatgtga aagatcttac cagggctgtg caggatatta cagcagctaa acccagacag
     1081 aaggccctcc ccaagagcct tccaaaaaga aaggagatta tagctcaaga taaagtggac
     1141 gaaactctgg aagatgcacc attaaaaact ctacaagagc caaaggcagt gcagggggag
     1201 cttacaggag atggagactc tcagctggga gcagggggcg gacatgaagt aagtccaaca
     1261 caagaaggcg gtcctgagga cgtgccagat gggagccaga taagcaaagc ctttgggaaa
     1321 ctttgcaaag tagtcaaaga gagagtgagc ggccacaaag agcctgtgcc agagccaccc
     1381 gcggacctct tcaccaaagg acggcatata ctggtcacag gggaatctag ttttgttgac
     1441 cccgagttct actcctcctc catcccagct agaggtgggg tggtggtttc cattgaggaa
     1501 gactctatgc atcatgatgg ccatgtggag ccctctcctg gacagcccat gccacctgtg
     1561 gagaatggtc agggggttcc ccagggcagg gaaggtgccc actcaaacca tcaacaggtt
     1621 acagacaaga atgggataag agccaaggaa ccgaaagatc tggaggaaaa agatgatgac
     1681 agcaggaagg acgatgaggc gggcaggaga ccctgtcctg tgatcatacc tggtcctgat
     1741 ggaccatcta cgacccattc acaaacgtct gggtccaatc agggtggacc agaggggcct
     1801 gggagtaaga gcagtagcct gctggccaag agcccttcga aggctttgtc ttttaagaag
     1861 gtagaggtgg tggaatccat tgagaagatt tcgacagaga gtattcagac gtatgaagaa
     1921 acttctgtaa ttgtggagac ggtgattggg aagacaaagg gtaacaagaa accgggagag
     1981 aagagctcct caaatgccaa ggcttgaagg aagagagtgt ctggggccag taggggaagt
     2041 gctttgagat agcttcctgt ttggattaga tcatagttga cctgtctggc ggacgacctt
     2101 cattaaactg ctttattttt gcttgcacca tc
//
