LOCUS       NM_001013125            2786 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus bifunctional apoptosis regulator (Bfar),
            transcript variant 1, mRNA.
ACCESSION   NM_001013125 XM_222538
VERSION     NM_001013125.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2786)
  AUTHORS   Rong,J., Chen,L., Toth,J.I., Tcherpakov,M., Petroski,M.D. and
            Reed,J.C.
  TITLE     Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum
            (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein
            stability and function in ER Stress
  JOURNAL   J Biol Chem 286 (2), 1453-1463 (2011)
   PUBMED   21068390
REFERENCE   2  (bases 1 to 2786)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 2786)
  AUTHORS   Zhang,H., Xu,Q., Krajewski,S., Krajewska,M., Xie,Z., Fuess,S.,
            Kitada,S., Pawlowski,K., Godzik,A. and Reed,J.C.
  TITLE     BAR: An apoptosis regulator at the intersection of caspases and
            Bcl-2 family proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2597-2602 (2000)
   PUBMED   10716992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1, FM033098.1 and BC087103.1.
            
            On Aug 10, 2016 this sequence version replaced NM_001013125.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087103.1, SRR26360176.2397861.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000010.1  2059241-2059260
            21-657              FM033098.1         1-637
            658-2786            BC087103.1         640-2768
FEATURES             Location/Qualifiers
     source          1..2786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..2786
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /note="bifunctional apoptosis regulator"
                     /db_xref="GeneID:304709"
                     /db_xref="RGD:1304791"
     exon            1..92
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     exon            93..427
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1517
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="bifunctional apoptosis regulator"
                     /protein_id="NP_001013143.1"
                     /db_xref="GeneID:304709"
                     /db_xref="RGD:1304791"
                     /translation="MEEPQKNDLSMRGQEEDHPVRSSGPQISVSEFSCHCCYDTLVNP
                     TTLNCGHSFCRHCLALWWMSSKKTECPECREKWEGFPKVNILLRDAIEKLFPDAIKMR
                     VEDIQQNNDVVQSLAAFQKYGNDQNPLAPSTGRVNQQRGGGFFSGVLTALTGVAVILL
                     VYHWRSRESEHGLLVHKAVDKWTTEEVVLWLEQLGPWASLYRDRFLSERVNGRLLLTL
                     TEEEFSRAPYTIENSSHRRVILMELERVRALGVKPPQNLWEYKAVNPGRSLFLLYALK
                     SSPRLGLLYLYLFDYTDSFLPFIHTICPLQEDSFGEDIFTKLLDLREPTWKQWREFLI
                     KYSFLPYQLIAEFAWDWLEVHYWTSRFLIVNAMLLSVLELFSFWRIWSRSELKTVPQR
                     MWSHFWKVSTQGLFMAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKEIRRLETQVF
                     "
     exon            428..632
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     exon            633..802
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     exon            803..947
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1121
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1324
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2763
                     /gene="Bfar"
                     /gene_synonym="RGD1305537"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccggaa acgaagcctg ccgcttgtcc tctacttccg cggggtcctg gcgggtggca
       61 gtgacggagt gggtcccagg actagtggcg agactacgat gcactatagc agtatcccga
      121 gtttgaaagt gtctatatgt atggatccct gaatttgctg agagatggag gagcctcaga
      181 aaaatgacct gagcatgaga gggcaggaag aagatcatcc tgtcagaagc agtggccctc
      241 agatttctgt gagtgagttc tcctgccact gctgttacga caccctggtt aaccccacca
      301 ccttgaactg tggccacagc ttctgccggc actgcttagc attatggtgg atgtcttcaa
      361 agaaaacaga gtgtccagaa tgcagagaaa aatgggaagg ttttcccaaa gtcaacattc
      421 tcctcaggga cgccattgaa aagttatttc ctgatgccat taaaatgcga gttgaagaca
      481 ttcagcagaa taatgatgta gtccaaagtc ttgcagcctt tcagaaatat gggaatgatc
      541 aaaatccctt agctcccagc acagggagag tgaatcagca gagaggaggg ggattcttct
      601 ccggcgtact cacagcttta actggtgtgg cagtcatcct gcttgtgtat cactggcgca
      661 gcagagagtc tgagcatggc ctcctggtgc acaaggctgt agacaaatgg acgacagaag
      721 aagttgtcct ctggttagaa cagctaggcc cttgggcctc actgtacaga gacaggttct
      781 tatctgaaag agtaaatgga aggttacttt taactttgac agaagaagaa ttttccaggg
      841 caccttacac catagaaaac agtagccaca gaagagtcat cctcatggag ctggagcgcg
      901 tgagagccct gggtgtgaag ccaccacaga atctctggga atacaaggct gtcaacccag
      961 gcaggtccct gttcttgctc tacgccctca agagctcacc aagacttggc ttgctatacc
     1021 tgtacttgtt tgactacaca gactcctttc tacccttcat ccacaccatc tgccctttgc
     1081 aggaagacag ctttggcgag gacatcttca ccaagcttct ggacctgagg gagcccacgt
     1141 ggaagcagtg gagagaattc cttatcaagt actcctttct cccgtatcag ctgattgcag
     1201 agtttgcctg ggactggctg gaggtccact actggacatc gcgcttcctc atcgtcaatg
     1261 ccatgctgct gtctgttctg gagttgttct ctttttggag gatctggtca agaagcgaac
     1321 tgaagacagt gccccagagg atgtggagcc acttttggaa agtatcgacg caggggcttt
     1381 tcatggccat gttctggccg ctcattcctc agtttgtctg caactgttta ttttactggg
     1441 ctctgtactt caacccaatt attaacattg atctggtggt caaggaaatc cgacggctgg
     1501 aaacccaagt gttctgatca gcagcaaggc cctgagagag cccgcaaatc tacctgacat
     1561 ccaagttgtg acattcaaag agacaaggga cttatttcta cccctggtaa agcaaggtgc
     1621 tgcttctgtg tgtcaaggct tcaaccaggt cccttgtcct ttgactctgg caccatgcta
     1681 ggtaactgct atccaggtga ggcaagactc tgtggtcaac acccagccag tcttcttaca
     1741 gggcttgaga ggctcaggct attttggcca acagaagtgg gagtcttgga catgatttgg
     1801 ggtggcatgc tgtcaaaagg ctaatacagg ctgtgtgtga tagtacacac cttgaatctg
     1861 accacttgga aaacagagac aggtggattt tttttagttc aagaccagac tggtctacag
     1921 agtgagttcc aagacagctg ggctacacag agaaaccctg tctccaaaac aatcaaatca
     1981 aaacaaaagg aagaaaagat aaaaggaagg ttatgatggt cagtggcctt aacctcactg
     2041 actgacaggc tcccagacca ggcttactgg gccagttctg tcacgtgagt cacatttagg
     2101 aaaacaaggg taggtttttg tcataagcat agataattgc acatagaaaa taaagagaaa
     2161 gagaaaactt gaggctgaga gacagtgatg gctagctgtg ttgtttcctg ttgtgatcat
     2221 tggaaactga gttctccttt ctgtgagcag ggtgtccaat ggaatgcccg tgaggctgtc
     2281 ttcttaggtg actgagagca ctacttggtg ttttgtttaa atgtggaata gactgttcaa
     2341 ggaagcattt tgtaaggtac cctcatactg tataatggat aatctttatt gtcctgttct
     2401 ttagtataaa agcatgtata actatgccaa gtgctaccat catgaatatg gagtaagctg
     2461 gtgtgtgctg gtgtagatgt agtatatagc agatgtagag tgcgagctca tcagccttgg
     2521 cctacctaaa acagcatcca aagtgtgaga gtgtgggggg aggtaagtat ataggtgtgt
     2581 gaggggggtg gtgagtgtat aggtgtgtga gagagaaaga gacagagaca gaaagagaga
     2641 gacagagact tagtaattca ttaacccttt gtatctcaga gtgaagattt cacttaaact
     2701 ttgcattgaa agtttgaaaa attacttgaa ataaataaat taaagatttt tatataaata
     2761 caaaaaaaaa aaaaaaaaaa aaaaaa
//
