LOCUS       NM_001396105            2095 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus bestrophin 2 (Best2), mRNA.
ACCESSION   NM_001396105 NM_001108895 XM_006255283
VERSION     NM_001396105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Broegger,T., Jacobsen,J.C., Secher Dam,V., Boedtkjer,D.M.,
            Kold-Petersen,H., Pedersen,F.S., Aalkjaer,C. and Matchkov,V.V.
  TITLE     Bestrophin is important for the rhythmic but not the tonic
            contraction in rat mesenteric small arteries
  JOURNAL   Cardiovasc Res 91 (4), 685-693 (2011)
   PUBMED   21498420
  REMARK    GeneRIF: mRNA levels for bestrophin-1 and -2 were also
            significantly reduced by bestrophin-3 down-regulation
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Pifferi,S., Pascarella,G., Boccaccio,A., Mazzatenta,A.,
            Gustincich,S., Menini,A. and Zucchelli,S.
  TITLE     Bestrophin-2 is a candidate calcium-activated chloride channel
            involved in olfactory transduction
  JOURNAL   Proc Natl Acad Sci U S A 103 (34), 12929-12934 (2006)
   PUBMED   16912113
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Qu,Z., Chien,L.T., Cui,Y. and Hartzell,H.C.
  TITLE     The anion-selective pore of the bestrophins, a family of chloride
            channels associated with retinal degeneration
  JOURNAL   J Neurosci 26 (20), 5411-5419 (2006)
   PUBMED   16707793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Sep 30, 2021 this sequence version replaced
            NM_001108895.1, XM_006255283.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN13663594,
                              SAMN13663608 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               JAXUCZ010000019.1  40047191-40047537
            348-442             JAXUCZ010000019.1  40047635-40047729
            443-676             JAXUCZ010000019.1  40048942-40049175
            677-831             JAXUCZ010000019.1  40049254-40049408
            832-909             JAXUCZ010000019.1  40049719-40049796
            910-1062            JAXUCZ010000019.1  40050680-40050832
            1063-1143           JAXUCZ010000019.1  40050917-40050997
            1144-1298           JAXUCZ010000019.1  40051122-40051276
            1299-2095           JAXUCZ010000019.1  40052420-40053216
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2095
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /note="bestrophin 2"
                     /db_xref="GeneID:364973"
                     /db_xref="RGD:1305377"
     exon            1..347
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1722
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /note="vitelliform macular dystrophy 2-like protein 1"
                     /codon_start=1
                     /product="bestrophin-2"
                     /protein_id="NP_001383034.1"
                     /db_xref="GeneID:364973"
                     /db_xref="RGD:1305377"
                     /translation="MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYM
                     ALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPL
                     PDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEA
                     GFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFR
                     SKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCIPIF
                     TLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEK
                     DLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDVVDGPLGEAHGD
                     FLQRLLPAGAGTVGPLGRRLSLLRRKNSCVSEASTAASCSCAGAADGGGVECGCGDPL
                     LDPSLREPELEPPACPEPPAPIPGPTPEPFTAVSIPGPRAPAPPWLPSPIGEEEESPA
                     "
     exon            348..442
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..676
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..831
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..909
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1062
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1143
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1298
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..2095
                     /gene="Best2"
                     /gene_synonym="Vmd2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaccgctc tagggcaact aatcgccagg gtcctgagac agggtcctga gatatcacct
       61 ggtgctctgt ctgccgggca cctccacctt caactgaaat ttccaggatc agcccctccc
      121 agctttttcc cttggctcac aggcccggac tcaggctaac cccttctcca ctggccacac
      181 tggccaggtg caacgatgac cgtcacctac acagcccgag tggcgaatgc ccgcttcggt
      241 ggcttctcgc agctgctgct gttgtggcgc ggaagcatct acaagctcct gtggcgagag
      301 ctgctgtgtt tcctgggact ctacatggca ctaagcgccg cctatcgctt cttactggca
      361 gaagagcaga agcgctactt cgagaagctt gtcatatact gcgaccagta cgccagcctc
      421 atccccgtct cgtttgtact tggcttctac gtgactctgg tggtgcatcg ctggtggaac
      481 cagtacctat gcatgcccct gccagacgca cttatgtgca tagtggccgg caccgtgcat
      541 gggcgcgacg atcggggccg cctctaccgg cgcacgctca tgcgctacgc agggctctcc
      601 gcggtgctga tccttcgttc tgttagcaca gcagtcttca aacggtttcc caccatagac
      661 cacgtggtcg aggctggatt tatgacccga gaggagcgca agaagttcga gaacttgaac
      721 tcgtcctaca acaagtactg ggtgccctgc gtgtggttct ccagcttggc agcgcaggcg
      781 cgacgagagg ggcgtatccg tgataacagt gcccttaaat tgctgctaga ggagctgaat
      841 gtgttccgga gcaagtgcgg gatgctgttt cactacgact ggattagcat acccctcgtc
      901 tacacccagg tagtcactat cgcagtgtac agctacttct tggcttgcct catcggccgt
      961 cagttcctag accctgcaca gggctacaaa gaccacaccc tggacctatg cattccgatc
     1021 ttcaccttgc tgcagttctt cttctacgct ggctggctta aggtagcaga gcagcttatt
     1081 aaccctttcg gagaggacga cgacgacttc gagaccaact ttcttattga ccgcaacttc
     1141 caggtgtcca tgctagcggt agatgagatg tatgacgact tggccatgtt ggaaaaagat
     1201 ctatactggg atgcagcgga agctcgagcg ccctacaccg cggccaccgc tttcctgctt
     1261 cagcaaccct ccttccaggg ttccaccttt gatatagcgc tggctaaaga ggacatgcag
     1321 ttccagcggc tggacgttgt ggatggccct ctgggagagg ctcacgggga ctttctgcag
     1381 cgcctcctgc cggcgggggc gggtactgtg ggtccgctgg ggcggcgcct gtcactcttg
     1441 cggcgaaaga acagctgcgt gtccgaggcc tccaccgcag ccagctgcag ctgtgcaggc
     1501 gcggcggatg gtggaggcgt tgagtgcggt tgtggcgatc cattgctcga ccccagcctg
     1561 cgggaacctg agctggagcc tcccgcatgt cctgagccgc ctgcccctat cccgggccca
     1621 actcctgaac cttttaccgc tgtgtcgatt cccgggcctc gggctcctgc gccaccctgg
     1681 ctacccagcc ctattggaga ggaggaagag agtccggcct gagactctgg gaccagggcc
     1741 cctacggaca cctaatcctg caccgggcat gctggcgacc accggggcct gcacaagcta
     1801 actaggccta cagaaagccg acctgttcat tttgaccaac cgtgtctccc actaggactg
     1861 gtggtgttag gggtccattt tctcccagct gctgttgctt ctccccgccc cgacccccga
     1921 ccccactccc tagcatcttt aagaggattt gcttcccaaa caccaccgcc tgacttgtgg
     1981 cctctgtggc tcttctgact ggtgccttgt gttcttccct tccagtggaa ttgtgattgc
     2041 ttatctcatg acttgtgagg atgaaaacaa aaataaacga aactatgtct ttaaa
//
