LOCUS       NM_001011940            2035 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus bestrophin 1 (Best1), mRNA.
ACCESSION   NM_001011940 XM_219573
VERSION     NM_001011940.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Martinez-Magana,C.J., Munoz-Castillo,P.A. and Murbartian,J.
  TITLE     Spinal bestrophin-1 and anoctamin-1 channels have a pronociceptive
            role in the tactile allodynia induced by REM sleep deprivation in
            rats
  JOURNAL   Brain Res 1834, 148915 (2024)
   PUBMED   38582414
  REMARK    GeneRIF: Spinal bestrophin-1 and anoctamin-1 channels have a
            pronociceptive role in the tactile allodynia induced by REM sleep
            deprivation in rats.
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Garcia,G., Martinez-Magana,C.J., Oviedo,N., Granados-Soto,V. and
            Murbartian,J.
  TITLE     Bestrophin-1 Participates in Neuropathic Pain Induced by Spinal
            Nerve Transection but not Spinal Nerve Ligation
  JOURNAL   J Pain 24 (4), 689-705 (2023)
   PUBMED   36521670
  REMARK    GeneRIF: Bestrophin-1 Participates in Neuropathic Pain Induced by
            Spinal Nerve Transection but not Spinal Nerve Ligation.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Pineda-Farias,J.B., Barragan-Iglesias,P., Loeza-Alcocer,E.,
            Torres-Lopez,J.E., Rocha-Gonzalez,H.I., Perez-Severiano,F.,
            Delgado-Lezama,R. and Granados-Soto,V.
  TITLE     Role of anoctamin-1 and bestrophin-1 in spinal nerve
            ligation-induced neuropathic pain in rats
  JOURNAL   Mol Pain 11, 41 (2015)
   PUBMED   26130088
  REMARK    GeneRIF: There is functional anoctamin-1 and bestrophin-1
            expression in rats at sites related to nociceptive processing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Broegger,T., Jacobsen,J.C., Secher Dam,V., Boedtkjer,D.M.,
            Kold-Petersen,H., Pedersen,F.S., Aalkjaer,C. and Matchkov,V.V.
  TITLE     Bestrophin is important for the rhythmic but not the tonic
            contraction in rat mesenteric small arteries
  JOURNAL   Cardiovasc Res 91 (4), 685-693 (2011)
   PUBMED   21498420
  REMARK    GeneRIF: mRNA levels for bestrophin-1 and -2 were also
            significantly reduced by bestrophin-3 down-regulation
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   Barro Soria,R., Spitzner,M., Schreiber,R. and Kunzelmann,K.
  TITLE     Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia
  JOURNAL   J Biol Chem 284 (43), 29405-29412 (2009)
   PUBMED   17003041
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Marmorstein,L.Y., Wu,J., McLaughlin,P., Yocom,J., Karl,M.O.,
            Neussert,R., Wimmers,S., Stanton,J.B., Gregg,R.G., Strauss,O.,
            Peachey,N.S. and Marmorstein,A.D.
  TITLE     The light peak of the electroretinogram is dependent on
            voltage-gated calcium channels and antagonized by bestrophin
            (best-1)
  JOURNAL   J Gen Physiol 127 (5), 577-589 (2006)
   PUBMED   16636205
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Rosenthal,R., Bakall,B., Kinnick,T., Peachey,N., Wimmers,S.,
            Wadelius,C., Marmorstein,A. and Strauss,O.
  TITLE     Expression of bestrophin-1, the product of the VMD2 gene, modulates
            voltage-dependent Ca2+ channels in retinal pigment epithelial cells
  JOURNAL   FASEB J 20 (1), 178-180 (2006)
   PUBMED   16282372
  REMARK    GeneRIF: The presence of bestrophin-1 influences kinetics and
            voltage-dependence of voltage-dependent Ca2+ channels; these
            effects might open new ways to understand the mechanisms leading to
            retinal degeneration in Best's disease.
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Marmorstein,A.D., Marmorstein,L.Y., Rayborn,M., Wang,X.,
            Hollyfield,J.G. and Petrukhin,K.
  TITLE     Bestrophin, the product of the Best vitelliform macular dystrophy
            gene (VMD2), localizes to the basolateral plasma membrane of the
            retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 97 (23), 12758-12763 (2000)
   PUBMED   11050159
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Petrukhin,K., Koisti,M.J., Bakall,B., Li,W., Xie,G., Marknell,T.,
            Sandgren,O., Forsman,K., Holmgren,G., Andreasson,S., Vujic,M.,
            Bergen,A.A., McGarty-Dugan,V., Figueroa,D., Austin,C.P.,
            Metzker,M.L., Caskey,C.T. and Wadelius,C.
  TITLE     Identification of the gene responsible for Best macular dystrophy
  JOURNAL   Nat Genet 19 (3), 241-247 (1998)
   PUBMED   9662395
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079048.1.
            
            On Feb 11, 2005 this sequence version replaced XM_219573.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2035
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /note="bestrophin 1"
                     /db_xref="GeneID:293735"
                     /db_xref="RGD:1311656"
     exon            1..116
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            117..304
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1805
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /note="vitelliform macular dystrophy 2 homolog;
                     vitelliform macular dystrophy (Best disease, bestrophin)"
                     /codon_start=1
                     /product="bestrophin-1"
                     /protein_id="NP_001011940.1"
                     /db_xref="GeneID:293735"
                     /db_xref="RGD:1311656"
                     /translation="MTITYTNEVANARLGSFSCLLLRWRGSIYKLLYGEFLVFIFLYY
                     CIRGLYRMVLSNHQQQQFEKLALYCNSYIQFIPISFVLGFYVTLVVSRWWNQYENLPW
                     PDRLMMQVSSFVEGKDEQGRLLRRTLIRYAILGQVLILRSISTSVYKRFPSLQHLMQA
                     GFMTPGEYKQLQRLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLR
                     TQCGHLYAYDWINIPLVYTQVVTVAVYSFFLACLIGRQFLNPLKNYPGHEMDLVVPVF
                     TILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHHDVPPLER
                     DLYWNEAAPQPPYTAASAGSHRQSFMGSTFNMSLKKKDSEEESDTYDKKENDYGSTIG
                     RFLGLQSNDYHPPKTDLKTKLLWSKKDPFLEDQSKNDKQKDQKNDVWKPKDLFRAIPK
                     FKRPSYRQAPQPLGSHLPMVFPPQQSAPSVRYSDTGGGPSAQYQEACHMKKKTVEFNL
                     NIPECPTEHEQPHLDQMHTILKEPGESYPVSDKADTNPVSYK"
     exon            305..399
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..633
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..788
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..866
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1019
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1100
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1252
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1608
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1768
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2008
                     /gene="Best1"
                     /gene_synonym="Vmd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacatgac tctgtaccag ggggcaggag agcatgtgct cttctaccat caaagtcttc
       61 tctgcacacc cctcattcct cagacctccc ttcaacccca acagaaaccc taacaggacc
      121 caagcccacc gactgctact cagtgccaag ccatgactat cacctacaca aacgaagtgg
      181 ccaatgcccg ccttggttcc ttctcgtgcc tcctcctgcg ctggcgaggc agcatctaca
      241 agctgctgta cggagaattc cttgtcttca tattcctcta ctattgcatc cgtggactct
      301 acagaatggt tctctcgaat catcagcagc agcagtttga gaagttggct ctgtactgca
      361 acagctacat tcagttcatc cctatatcct tcgttctggg tttctatgtt acattggtgg
      421 tgagccgatg gtggaaccag tacgagaact tgccgtggcc cgaccgcctc atgatgcagg
      481 tatctagctt cgtggagggc aaggacgagc aaggccggtt gctgcggcgc acgctcatcc
      541 gctacgccat cctgggccaa gtgctcatcc tgcgcagcat cagcacctcg gtctacaagc
      601 gctttcccag tcttcaacac ctgatgcaag caggctttat gactcctggg gaatataagc
      661 agttgcagag gttgggccta ccacacaaca cattctgggt accctgggtg tggtttgcca
      721 acctgtcaat gaaagcctat cttggaggtc gaatcaggga cactgtcctg ctccagagcc
      781 tgatgaatga ggtgtgcacc ttgcgtactc agtgtggaca cctatatgcc tatgactgga
      841 tcaatatccc attggtgtac acacaggtgg tgacagtggc ggtttacagc tttttccttg
      901 catgcttgat cgggaggcag tttctgaacc cactcaagaa ctacccaggc cacgagatgg
      961 atctggttgt gcctgtcttc acaatcctgc agttcttatt ctacatgggc tggctcaagg
     1021 tggcagaaca gctcatcaac ccctttggag aggatgatga tgattttgag accaactgga
     1081 tcattgacag aaacctgcag gtgtccctgt tgtctgtgga tgggatgcac cacgacgtgc
     1141 ctcccctgga gcgagacctg tactggaatg aggcggcgcc tcagccgccc tacacagctg
     1201 cttctgccgg gtctcaccga caatccttca tgggctccac cttcaacatg agtctgaaga
     1261 aaaaagactc agaggaggag agtgacactt atgacaagaa agagaatgat tacggcagca
     1321 ccattggacg cttcttagga ctgcaatcca atgactacca tcctcccaag acagacttaa
     1381 agaccaaact gttgtggtct aagaaggacc ccttcctcga ggaccagtct aagaatgaca
     1441 agcagaaaga ccagaaaaat gatgtctgga aaccaaagga cctcttcaga gctataccaa
     1501 agtttaagag gccaagttac cgccaggccc cacagccact tggcagccac cttcccatgg
     1561 tcttccctcc tcagcagtca gcaccctcag tgcgttactc agacacaggt ggtgggcctt
     1621 ccgcacagta ccaagaggcc tgtcacatga agaagaaaac agtggagttt aacttgaaca
     1681 ttccagagtg ccctacggaa catgaacaac cccatttgga ccagatgcac acgatcctga
     1741 aggagcctgg agaatcctat cctgtcagtg ataaagctga caccaatcct gtttcctata
     1801 agtgatgctt cacagcttgg ttctcacctg catggatgcc agcagggcac tgacccagtc
     1861 agaggcacac agcagcgaca ctcaagaata tgttcccatg gcagtctggc aggtaactca
     1921 gaaccaggac tgcttagtcc tgtctgaaca cacctgtctt tcactatctt tccccaaact
     1981 agcgagttta ataaatattc tttcaggcaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
