LOCUS       NM_001034117            2118 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus beclin 1 (Becn1), transcript variant 2, mRNA.
ACCESSION   NM_001034117
VERSION     NM_001034117.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Zhan,Y., Li,L., Guo,C., Zhang,Y., Zhao,L., Tao,Z., Zhang,H. and
            Chen,S.
  TITLE     MicroRNA-141-3p reduces pulmonary hypoxia/reoxygenation injury
            through suppression of Beclin-1-dependent autophagy
  JOURNAL   Aging (Albany NY) 16 (2), 1352-1373 (2024)
   PUBMED   38261732
  REMARK    GeneRIF: MicroRNA-141-3p reduces pulmonary hypoxia/reoxygenation
            injury through suppression of Beclin-1-dependent autophagy.
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Luo,H., Huang,D., Tang,X., Liu,Y., Luo,Q., Liu,C., Huang,H.,
            Chen,W. and Qi,Z.
  TITLE     Beclin-1 exerts protective effects against cerebral
            ischemia-reperfusion injury by promoting DNA damage repair through
            a non-autophagy-dependent regulatory mechanism
  JOURNAL   Int J Mol Med 49 (5) (2022)
   PUBMED   35266018
  REMARK    GeneRIF: Beclin1 exerts protective effects against cerebral
            ischemiareperfusion injury by promoting DNA damage repair through a
            nonautophagydependent regulatory mechanism.
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Kang,H., Chen,J. and Cao,S.
  TITLE     Propofol Regulates the Expression of BecliN-1 through miR-30b and
            Protects against Lung Ischemia-Reperfusion Injury
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 348-355 (2022)
   PUBMED   35818233
  REMARK    GeneRIF: Propofol Regulates the Expression of BecliN-1 through
            miR-30b and Protects against Lung Ischemia-Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Chen,Y.H., Chiu,W.C., Xiao,Q., Chen,Y.L., Shirakawa,H. and
            Yang,S.C.
  TITLE     Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular
            Beclin-1 Elevation in Rats after Chronic Ethanol Administration
  JOURNAL   Int J Mol Sci 22 (22), 12547 (2021)
   PUBMED   34830430
  REMARK    GeneRIF: Synbiotics Alleviate Hepatic Damage, Intestinal Injury and
            Muscular Beclin-1 Elevation in Rats after Chronic Ethanol
            Administration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Tanida,I., Ueno,T. and Kominami,E.
  TITLE     LC3 conjugation system in mammalian autophagy
  JOURNAL   Int J Biochem Cell Biol 36 (12), 2503-2518 (2004)
   PUBMED   15325588
  REMARK    Review article
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Yue,Z., Jin,S., Yang,C., Levine,A.J. and Heintz,N.
  TITLE     Beclin 1, an autophagy gene essential for early embryonic
            development, is a haploinsufficient tumor suppressor
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15077-15082 (2003)
   PUBMED   14657337
REFERENCE   8  (bases 1 to 2118)
  AUTHORS   Yue,Z., Horton,A., Bravin,M., DeJager,P.L., Selimi,F. and Heintz,N.
  TITLE     A novel protein complex linking the delta 2 glutamate receptor and
            autophagy: implications for neurodegeneration in lurcher mice
  JOURNAL   Neuron 35 (5), 921-933 (2002)
   PUBMED   12372286
REFERENCE   9  (bases 1 to 2118)
  AUTHORS   Kihara,A., Kabeya,Y., Ohsumi,Y. and Yoshimori,T.
  TITLE     Beclin-phosphatidylinositol 3-kinase complex functions at the
            trans-Golgi network
  JOURNAL   EMBO Rep 2 (4), 330-335 (2001)
   PUBMED   11306555
REFERENCE   10 (bases 1 to 2118)
  AUTHORS   Liang,X.H., Kleeman,L.K., Jiang,H.H., Gordon,G., Goldman,J.E.,
            Berry,G., Herman,B. and Levine,B.
  TITLE     Protection against fatal Sindbis virus encephalitis by beclin, a
            novel Bcl-2-interacting protein
  JOURNAL   J Virol 72 (11), 8586-8596 (1998)
   PUBMED   9765397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK600131.1 and BC074011.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074011.1, SRR8487227.17539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               CK600131.1         1-113
            114-2118            BC074011.1         1-2005
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2118
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /note="beclin 1"
                     /db_xref="GeneID:114558"
                     /db_xref="RGD:620190"
     exon            1..200
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            201..329
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1549
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /note="coiled-coil myosin-like BCL2-interacting protein;
                     beclin 1 (coiled-coil, myosin-like BCL2-interacting
                     protein); beclin 1, autophagy related"
                     /codon_start=1
                     /product="beclin-1"
                     /protein_id="NP_001029289.1"
                     /db_xref="GeneID:114558"
                     /db_xref="RGD:620190"
                     /translation="MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAP
                     LLTTAQAKPGESQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEAS
                     DGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNY
                     KRCLEMLEQMNEGDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAE
                     RLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATFHIWH
                     SGQFGTINNFRLGRLPSAPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNH
                     SYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPY
                     RMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK"
     exon            330..397
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..456
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..547
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..684
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..879
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1026
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1176
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1237
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1380
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..2086
                     /gene="Becn1"
                     /gene_synonym="Beclin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggatctgga ccaggggtcc ttgcgtcagc tctcgtcaag gcgtcacttc tgggcccggg
       61 cggaagtctt cagctagccg accgggaagt agctgaagac cgggcgatgg gaactctgga
      121 ggtctcgctc tggggcggac ccgaggccac cgttcccccg cggtagagcg agcctaggtg
      181 gcgggctccg gggtcctgag gaatggaggg gtctaaggcg tccagcagca ccatgcaggt
      241 gagcttcgtg tgccagcgct gtagccagcc tctgaaactg gacacgagct tcaagatcct
      301 ggaccgagtg accattcagg aactcacagc tccattactt accacagccc aggcgaaacc
      361 aggagagagc caggaggaag aggctaactc aggagaggag ccatttattg aaactcgcca
      421 ggatggtgtc tctcgaagat tcatcccccc agccaggatg atgtctacag aaagtgctaa
      481 tagcttcact ctgatcgggg aggcatctga tggtggcacc atggagaacc tcagccggag
      541 actcaaggtc actggagacc tttttgacat catgtctggc cagacagatg tggatcaccc
      601 actgtgtgag gaatgcacag atactctttt agaccagctg gacactcagc tcaatgttac
      661 tgaaaacgag tgtcagaact acaaacgctg tttggagatg ttggagcaaa tgaatgaggg
      721 cgacagtgaa cagctacaga gggagctgaa ggagttggcc ttggaggagg agaggctgat
      781 ccaggagctg gaagatgtgg aaaaaaaccg aaaggtggtg gcagaaaacc tggagaaggt
      841 ccaggctgag gcggagagac tggaccagga ggaagctcag taccagcgag aatatagtga
      901 atttaaaagg cagcagctgg agctggatga tgagctcaag agtgtagaga accagatgcg
      961 ctatgcccag atgcagctgg acaagctcaa gaaaaccaat gtcttcaatg cgaccttcca
     1021 tatctggcac agcggacaat ttggcacgat caataatttc agactgggtc gcttgcccag
     1081 tgctcctgtg gaatggaatg aaatcaatgc tgcctggggc cagacagtgt tgttgctcca
     1141 tgctttggcc aataagatgg gtctgaaatt tcagaggtac cgacttgttc cctatggaaa
     1201 tcactcgtat ctggagtccc tgacagacaa atctaaggag ttgccgttgt actgttctgg
     1261 gggtttgcgg tttttctggg acaacaagtt tgaccatgca atggtagctt ttctggactg
     1321 tgtgcagcag ttcaaagaag aggtggaaaa aggagagact cgattttgtc ttccgtacag
     1381 gatggacgtg gagaaaggca agattgaaga cactggaggc agtggcggct cctattccat
     1441 caaaacccag tttaactctg aggagcagtg gacaaaggcg ctcaagttca tgctgacgaa
     1501 tctcaagtgg ggtcttgctt gggtgtcctc acagttctat aacaagtgac ttgctcctta
     1561 ggggatattt gcctttaagg ttttacattt tgtttggttt ggaaagatgc tttaaattaa
     1621 atttgggtaa tattaaacca catgtttaca ataccagaat ccacaaaagc tactttattt
     1681 tacaatatga cagttttcag agcacagcac gccatgtata gcaaagagcc ctgccgtagt
     1741 ttggctcaac cccatgctgt cctttccctc ttccctggaa acaactaatt taaatttgct
     1801 ttgttttctt ttttaagttg aattgacatt aatgtgtttt cactggattt tatctctctc
     1861 aacttcctgt acttgaaaca gaaaagtttt gagatgagat gcttgtggca cacagttggg
     1921 taatgtgggg aagggacaag aggtaaaggt ttaactctgt cctcacttct agtattgaac
     1981 gcttactgtg ctaactattg gaattacaaa atgctgtttg atactgtttg agatgtggaa
     2041 ggatttaatt atttgtaata aaggatttgc tatggtctat taattaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaa
//
