LOCUS       NM_001270630            4018 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus brain-derived neurotrophic factor (Bdnf),
            transcript variant 1, mRNA.
ACCESSION   NM_001270630
VERSION     NM_001270630.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4018)
  AUTHORS   Balanya-Segura,M., Polishchuk,A., Just-Borras,L., Cilleros-Mane,V.,
            Silvera,C., Ardevol,A., Tomas,M., Lanuza,M.A., Hurtado,E. and
            Tomas,J.
  TITLE     Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic
            Pathways in Ageing Neuromuscular Synapses
  JOURNAL   Int J Mol Sci 25 (15), 8018 (2024)
   PUBMED   39125587
  REMARK    GeneRIF: Molecular Adaptations of BDNF/NT-4 Neurotrophic and
            Muscarinic Pathways in Ageing Neuromuscular Synapses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4018)
  AUTHORS   Harada,H., Mori,M., Murata,Y., Kohno,Y., Terada,K., Ohe,K. and
            Enjoji,M.
  TITLE     Divergent effects of chronic continuous and intermittent social
            defeat stress on emotional behaviors: Impact on phosphorylated CREB
            and BDNF protein levels in the rat hippocampus
  JOURNAL   Neurosci Lett 835, 137851 (2024)
   PUBMED   38838971
  REMARK    GeneRIF: Divergent effects of chronic continuous and intermittent
            social defeat stress on emotional behaviors: Impact on
            phosphorylated CREB and BDNF protein levels in the rat hippocampus.
REFERENCE   3  (bases 1 to 4018)
  AUTHORS   Hamze,M., Brier,C., Buhler,E., Zhang,J., Medina,I. and Porcher,C.
  TITLE     Regulation of Neuronal Chloride Homeostasis by Pro- and Mature
            Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride
            Cotransporters in Rat Cortical Neurons
  JOURNAL   Int J Mol Sci 25 (11), 6253 (2024)
   PUBMED   38892438
  REMARK    GeneRIF: Regulation of Neuronal Chloride Homeostasis by Pro- and
            Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2
            Cation-Chloride Cotransporters in Rat Cortical Neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4018)
  AUTHORS   Avarlaid,A., Falkenberg,K., Lehe,K., Mudo,G., Belluardo,N., Di
            Liberto,V., Frinchi,M., Tuvikene,J. and Timmusk,T.
  TITLE     An upstream enhancer and MEF2 transcription factors fine-tune the
            regulation of the Bdnf gene in cortical and hippocampal neurons
  JOURNAL   J Biol Chem 300 (6), 107411 (2024)
   PUBMED   38796067
  REMARK    GeneRIF: An upstream enhancer and MEF2 transcription factors
            fine-tune the regulation of the Bdnf gene in cortical and
            hippocampal neurons.
REFERENCE   5  (bases 1 to 4018)
  AUTHORS   Campbell,T.S., Donoghue,K. and Roth,T.L.
  TITLE     Unlocking the epigenome: Stress and exercise induced Bdnf
            regulation in the prefrontal cortex
  JOURNAL   Neurotoxicol Teratol 103, 107353 (2024)
   PUBMED   38648864
  REMARK    GeneRIF: Unlocking the epigenome: Stress and exercise induced Bdnf
            regulation in the prefrontal cortex.
REFERENCE   6  (bases 1 to 4018)
  AUTHORS   Ernfors,P., Van De Water,T., Loring,J. and Jaenisch,R.
  TITLE     Complementary roles of BDNF and NT-3 in vestibular and auditory
            development
  JOURNAL   Neuron 14 (6), 1153-1164 (1995)
   PUBMED   7605630
  REMARK    Erratum:[Neuron 1995 Sep;15(3):739]
REFERENCE   7  (bases 1 to 4018)
  AUTHORS   Ohara,O., Gahara,Y., Teraoka,H. and Kitamura,T.
  TITLE     A rat brain-derived neurotrophic factor-encoding gene generates
            multiple transcripts through alternative use of 5' exons and
            polyadenylation sites
  JOURNAL   Gene 121 (2), 383-386 (1992)
   PUBMED   1446835
REFERENCE   8  (bases 1 to 4018)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   9  (bases 1 to 4018)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   10 (bases 1 to 4018)
  AUTHORS   Yancopoulos,G.D., Maisonpierre,P.C., Ip,N.Y., Aldrich,T.H.,
            Belluscio,L., Boulton,T.G., Cobb,M.H., Squinto,S.P. and Furth,M.E.
  TITLE     Neurotrophic factors, their receptors, and the signal transduction
            pathways they activate
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 371-379 (1990)
   PUBMED   1966766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EF125680.1 and CN544668.1.
            
            Transcript Variant: This variant (1, also known as VI) encodes the
            longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF125680.1, BC087634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3961              EF125680.1         1-3961
            3962-4018           CN544668.1         1-57                c
FEATURES             Location/Qualifiers
     source          1..4018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q34"
     gene            1..4018
                     /gene="Bdnf"
                     /note="brain-derived neurotrophic factor"
                     /db_xref="GeneID:24225"
                     /db_xref="RGD:2202"
     exon            1..348
                     /gene="Bdnf"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1119
                     /gene="Bdnf"
                     /note="isoform 1 is encoded by transcript variant 1; brain
                     derived neurothrophic factor; proBDNF; neurotrophic factor
                     BDNF precursor form"
                     /codon_start=1
                     /product="neurotrophic factor BDNF precursor form isoform
                     1"
                     /protein_id="NP_001257559.1"
                     /db_xref="GeneID:24225"
                     /db_xref="RGD:2202"
                     /translation="MSDPSAWRWLSSGCPPLPPRRGAPAGWLSHGPHCARDSPAWRRK
                     PPGAARHLRLAGFDETGFPQLATAALGQTRKRTGPRAGRRDQERDNNVTPLPGIRELC
                     VDPEFHQVRRVMTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVN
                     GPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLE
                     PPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSG
                     GTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALT
                     MDSKKRIGWRFIRIDTSCVCTLTIKRGR"
     exon            349..4006
                     /gene="Bdnf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaatcgaag ctcaaccgaa gagctaaata atgtctgacc ccagtgcctg gcgctggctg
       61 agctctgggt gcccgccgct gccgccgcgc cggggcgcac ccgctggctg gctgtcgcac
      121 ggtccccatt gcgcccggga ctccccggct tggagaagga aaccgcctgg ggcggcgcgc
      181 cacctccgcc tggcaggctt tgatgagacc gggttccctc agctcgccac cgctgctttg
      241 gggcagacga gaaagcgcac ggggcccagg gcagggcgca gggaccagga gcgtgacaac
      301 aatgtgactc cactgccggg gatccgagag ctttgtgtgg accctgagtt ccaccaggtg
      361 agaagagtga tgaccatcct tttccttact atggttattt catacttcgg ttgcatgaag
      421 gctgcgccca tgaaagaagc aaacgtccac ggacaaggca acttggccta cccagctgtg
      481 cggacccatg ggactctgga gagcgtgaat gggcccaggg caggttcgag aggtctgacg
      541 acgacgtccc tggctgacac ttttgagcac gtgatcgaag agctgctgga tgaggaccag
      601 aaggttcggc ccaacgaaga aaaccataag gacgcggact tgtacacttc ccgggtgatg
      661 ctcagcagtc aagtgccttt ggagcctcct ctgctctttc tgctggagga atacaaaaat
      721 tacctggatg ccgcaaacat gtctatgagg gttcggcgcc actccgaccc cgcccgccgt
      781 ggggagctga gcgtgtgtga cagtattagc gagtgggtca cagcggcaga taaaaagact
      841 gcagtggaca tgtccggtgg gacggtcaca gtcctggaga aagtcccggt atcaaaaggc
      901 caactgaagc aatatttcta cgagaccaag tgtaatccca tgggttacac gaaggaaggc
      961 tgcaggggca tagacaaaag gcactggaac tcgcaatgcc gaactaccca atcgtatgtt
     1021 cgggccctta ctatggatag caaaaagaga attggctggc ggttcataag gatagacact
     1081 tcctgtgtat gtacactgac cattaaaagg ggaagatagt ggatttatgt tgtatagatt
     1141 atattgagac aaaaattatc tatttgtata tatacataac agggtaaatt attcagttaa
     1201 gaaaaagata attttatgaa ctgcatgtat aaatgaagtt tatacagtac agtggttcta
     1261 caatctattt attggacata tccatgacca gaaagaaaca gtcatttgcg cacaacttta
     1321 aaagtctgca ttacattcct cgataatgtt gtggtttgtt gccgttgcca agaattgaaa
     1381 acaaaaagtt aaaaaaaata ataaattgca tgctgcttta attgtgaatt gataataaac
     1441 tgtccctctt tcagaaaaca gacaaaaaaa caaaaaacaa aaaaaagcaa aaacaaaaat
     1501 ttgaaccaaa acattccgtt tacattttag acactaagta tcttcgttct tgttagtact
     1561 ctgttctact gctttcaact tctcatagcg ttggaattaa aactatgtca aggtgctgtt
     1621 gtcattgctt tactggctta ggggatgggg aacgggaggg gtagatttct gtttgttttg
     1681 tgttttattt cgtttgtttg tttgttttgt ttttttagtt ccacccggag tagggatgga
     1741 gaaaatttct tcactctcca ttctggttga taaagcgtta catttgtatg ttgtaaaaaa
     1801 tgtttgcaaa atccaatcag atgactggaa aacgaataaa aattaaggca actgaataaa
     1861 atgctcacac aacactgccc atgatgtatc tccctggtcc cccaggtcac tcttctggca
     1921 tgggtcaggg aaagctgctt ttattggaaa gaccagcatt tgtttaaagc acattctttc
     1981 cctccctcct cccattttgg tccctttctt ttttgttttg ttttaagaaa gaaaattaag
     2041 ttgcgcgctt tgaaatattt tatcactgct gtgaacagat gaacaatgtg tgtcatttca
     2101 tgacactcgt ggaaaacagt gatttttttt ttattttttg ccctaaggag aaacaagtaa
     2161 gaataaccga aaatgttctt tttttttaaa ggcataaaca gtggataagt tataatatgg
     2221 cctaacaatg tttgcagata aaagatattg catacagcca gatactagag cagggatcca
     2281 cactgccact gaaatgcgac tgaatggccc tgtggaggct aagtggagct gacatactat
     2341 ttcctggcag agcaggagga atttctgagt ggccatcctg aggtctagat ggaggtgggg
     2401 aatggtactt gagacattcc taaaggaagg ctcggaagca cccttcagag caggctctgg
     2461 aatgatgtgt caagtttctt aggccttctg ctttaagtgc ctacgttacc taacagtgct
     2521 caagaggttc tcaattggag aaccacactc aaatccattt atggcctcca tcccatttta
     2581 aataattatg gataaagttg gattaacctg gagcagcttt ggatccaaat atggcatagc
     2641 agtgatgcta tcagtgcagc atgatgggaa atgtttgctg tgaagagact taactttctt
     2701 tgcgcttaga cttcaggaag cctaggtttt atttatttat ttttttgaga cattttggtg
     2761 aaaggaaaaa agaaagaaga aaacaaacaa acaaaaccag aaaaagcacc aaaacttagg
     2821 cagaatgagc aatgtctgtc tgtaagggct agaatgacaa ggcataggaa ggtgctttca
     2881 ctgtgaaaga gacaagaaca caggaggaaa tactgcttaa gtgaagagca cagaaagctc
     2941 ctgatagttc tgtccattca gcacaagggt cccttctaca ctttacctct tggggttagg
     3001 agaagtcaag ctggaagcct gaatgaatgg ccccaatgag aactagtgtt aagcccattt
     3061 ccctagtgag gttttccgcc agcgcgaatg tgttagtggt tacctgactg ggctcctggg
     3121 catcagaaaa agaggcaaac aattgcttca tcttaggagt ggaaagggtg aaacaaagtg
     3181 gctgtccact gtgactcagg gagtgaagat accatcagca aatagtttct ttttgttcaa
     3241 ctgttccttt agaactagtc tgtcttctgg agtcccactg aatcccctgt ttttggaaga
     3301 cttcacgtag cctagattgt tttgtgccgt ttgacaacat taatctctgt catcattttt
     3361 aacctattaa ggaatgcttt gaatatctgc tatatgctaa ctttttgcag cttcattctg
     3421 agagacgtta gtcaaacaaa taaaaggagc cccatcacaa tctcacggta ttcgaagggc
     3481 caggtcgatt aggtggcttc ataggagacc ctccgcaact gtgtggtcag tggctggctc
     3541 tcatacccac taagatacat catagctcca tgtcggtggt ttatgttgac ctgagattga
     3601 tttgttaaaa tctctcctct gtttctgttc gttctgtttc cgtcctgttc tgttctgttc
     3661 tgttctgaaa gtcttgctgt ggtctctttt tggcagaagt gtttcatgca tggcagcagg
     3721 cctgatgctt tttatagtga ttcccattga aactgtaagt aaatgtctgt ggccttgttc
     3781 tctctatggt aaagatatta ttcaccatgt aaaacaagaa aaatatttat tgtattttag
     3841 tatatttata taattatgtt attgaaaaaa attggcatta aaacttaacc acatcagaag
     3901 cctattgtaa atacaggttc tatttaagtg taccaattaa catataatat atgttttaaa
     3961 tatagaattt ttaatgtttt taaatatatt ttcaaagtac ataaaaaaaa aaaaaaaa
//
