LOCUS       NM_001270713            4088 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus bradykinin receptor B2 (Bdkrb2), transcript
            variant 1, mRNA.
ACCESSION   NM_001270713
VERSION     NM_001270713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4088)
  AUTHORS   Shen,M., Yu,M., Qiu,C., Zhang,G., Li,J., Fang,W. and Wang,Q.
  TITLE     Myocardial angiogenesis induced by exercise training involves a
            regulatory mechanism mediated by kinin receptors
  JOURNAL   Clin Exp Hypertens 43 (5), 408-415 (2021)
   PUBMED   33687297
  REMARK    GeneRIF: Myocardial angiogenesis induced by exercise training
            involves a regulatory mechanism mediated by kinin receptors.
REFERENCE   2  (bases 1 to 4088)
  AUTHORS   Dagher,O.K., Jaffa,M.A., Habib,A., Ziyadeh,F.N. and Jaffa,A.A.
  TITLE     Heteromerization fingerprints between bradykinin B2 and thromboxane
            TP receptors in native cells
  JOURNAL   PLoS One 14 (5), e0216908 (2019)
   PUBMED   31086419
  REMARK    GeneRIF: This is the first study that provides evidence supporting
            the existence of bradykinin receptor B2 - thromboxane TP receptors
            heteromerization fingerprints in primary cultured vascular smooth
            muscle cell.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4088)
  AUTHORS   Ma,Z., Dong,Q., Lyu,B., Wang,J., Quan,Y. and Gong,S.
  TITLE     The expression of bradykinin and its receptors in spinal cord
            ischemia-reperfusion injury rat model
  JOURNAL   Life Sci 218, 340-345 (2019)
   PUBMED   30580020
  REMARK    GeneRIF: High bradykinin receptor B2 expression is associated with
            spinal cord ischemia-reperfusion injury.
REFERENCE   4  (bases 1 to 4088)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   5  (bases 1 to 4088)
  AUTHORS   Siltari,A., Korpela,R. and Vapaatalo,H.
  TITLE     Bradykinin -induced vasodilatation: Role of age, ACE1-inhibitory
            peptide, mas- and bradykinin receptors
  JOURNAL   Peptides 85, 46-55 (2016)
   PUBMED   27628189
  REMARK    GeneRIF: Mas receptor antagonist abolished relaxation while
            bradykinin receptor antagonist only slightly reduced it, suggesting
            that bradykinin-induced vasorelaxation is regulated also by other
            mechanisms than the classical BR1/BR2 pathway.
REFERENCE   6  (bases 1 to 4088)
  AUTHORS   Feletou,M., Lonchampt,M., Robineau,P., Jamonneau,I., Thurieau,C.,
            Fauchere,J.L., Villa,P., Ghezzi,P., Prost,J.F. and Canet,E.
  TITLE     Effects of the bradykinin B2 receptor antagonist S 16118
            (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different
            in vivo animal models of inflammation
  JOURNAL   J Pharmacol Exp Ther 273 (3), 1078-1084 (1995)
   PUBMED   7791078
REFERENCE   7  (bases 1 to 4088)
  AUTHORS   Pesquero,J.B., Lindsey,C.J., Zeh,K., Paiva,A.C., Ganten,D. and
            Bader,M.
  TITLE     Molecular structure and expression of rat bradykinin B2 receptor
            gene. Evidence for alternative splicing
  JOURNAL   J Biol Chem 269 (43), 26920-26925 (1994)
   PUBMED   7929432
REFERENCE   8  (bases 1 to 4088)
  AUTHORS   Wang,D.Z., Ma,J.X., Chao,L. and Chao,J.
  TITLE     Molecular cloning and sequence analysis of rat bradykinin B2
            receptor gene
  JOURNAL   Biochim Biophys Acta 1219 (1), 171-174 (1994)
   PUBMED   8086459
REFERENCE   9  (bases 1 to 4088)
  AUTHORS   McEachern,A.E., Shelton,E.R., Bhakta,S., Obernolte,R., Bach,C.,
            Zuppan,P., Fujisaki,J., Aldrich,R.W. and Jarnagin,K.
  TITLE     Expression cloning of a rat B2 bradykinin receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7724-7728 (1991)
   PUBMED   1715575
REFERENCE   10 (bases 1 to 4088)
  AUTHORS   Rajakulasingam,K., Polosa,R., Holgate,S.T. and Howarth,P.H.
  TITLE     Comparative nasal effects of bradykinin, kallidin and
            [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers
  JOURNAL   J Physiol 437, 577-587 (1991)
   PUBMED   1890650
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M59967.2 and JAXUCZ010000006.1.
            
            On Jan 6, 2017 this sequence version replaced NM_001270713.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M59967.2, SRR26643298.36952.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               M59967.2           7-318
            313-355             JAXUCZ010000006.1  130262691-130262733
            356-1773            M59967.2           356-1773
            1774-3454           JAXUCZ010000006.1  130264912-130266592
            3455-4088           M59967.2           3453-4086
FEATURES             Location/Qualifiers
     source          1..4088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..4088
                     /gene="Bdkrb2"
                     /gene_synonym="B2BKR; B2BRA"
                     /note="bradykinin receptor B2"
                     /db_xref="GeneID:25245"
                     /db_xref="RGD:2201"
     exon            1..34
                     /gene="Bdkrb2"
                     /gene_synonym="B2BKR; B2BRA"
                     /inference="alignment:Splign:2.1.0"
     exon            35..138
                     /gene="Bdkrb2"
                     /gene_synonym="B2BKR; B2BRA"
                     /inference="alignment:Splign:2.1.0"
     exon            139..355
                     /gene="Bdkrb2"
                     /gene_synonym="B2BKR; B2BRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1463
                     /gene="Bdkrb2"
                     /gene_synonym="B2BKR; B2BRA"
                     /note="isoform 1 is encoded by transcript variant 1; B2
                     bradykinin receptor; B2R; BK-2 receptor; bradykinin
                     receptor, beta 2"
                     /codon_start=1
                     /product="B2 bradykinin receptor isoform 1"
                     /protein_id="NP_001257642.1"
                     /db_xref="GeneID:25245"
                     /db_xref="RGD:2201"
                     /translation="MDTRSSLCPKTQAVVEVAMFWGPGCHLSTCIEMFNITTQALGSA
                     HNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIY
                     LGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSI
                     DRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTAC
                     VIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKAT
                     VLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCL
                     NPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQD
                     WAGNKQ"
     exon            356..4067
                     /gene="Bdkrb2"
                     /gene_synonym="B2BKR; B2BRA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctacaaca cagaaccggc tctctagaga aaaggacgat cctcactcgt ctttgtcctg
       61 agtacaaatg cactgttctt ggaagcgacc cgtgctcctg tccgtgcatg agcccatgcc
      121 caccacagcc tctctggggg gtccagaaac actaagcaac tgtccaaggc cataccgtga
      181 ccaggacttg accccaggag gactggtcca aagcctcgct gtgcctcctc ccgtgcaccc
      241 tctgctcacc tcctgtgctc tgctgcatgg acacaaggtc ctccctctgc ccgaagacac
      301 aggctgtcgt ggaagtggct atgttctggg gaccaggctg ccatctctcc acctgcattg
      361 aaatgttcaa catcaccacg caagccctgg ggtctgctca taacgggacc ttttcagagg
      421 tcaactgccc agacactgag tggtggagct ggctcaatgc catccaggcc cccttcctct
      481 gggtcctctt cctgctggcc gcactggaga acatctttgt cctcagcgtg ttctgtctgc
      541 acaaaaccaa ctgcactgtg gctgagatct acctgggcaa cctggcagcc gcggacctca
      601 tcctggcctg cggattaccc ttctgggcca tcaccatcgc caataacttc gactggctgt
      661 tcggagaggt gctgtgccgc gtggtgaata ccatgatcta catgaacctc tacagcagca
      721 tctgcttcct gatgcttgtg agtatcgacc gatacctggc gctggtgaag accatgtcca
      781 tgggccggat gcgcggggta cgctgggcca aactgtacag cctggtgatc tggagctgta
      841 cgctgcttct gagttcaccc atgttggtgt tcaggaccat gaaggactac agggaagagg
      901 gccacaacgt cacggcctgc gtcattgtct acccgtcccg ctcctgggag gtgttcacca
      961 acatgctgct gaacctggtg ggtttcctcc tacccctgag tatcatcacc ttctgcacgg
     1021 tgcgaatcat gcaggtgctg aggaacaacg agatgaagaa gttcaaggag gtccagacgg
     1081 agaagaaggc cactgtgctg gtgctggctg tcctggggct ctttgtgctg tgttggtttc
     1141 ctttccagat cagcaccttc ctggacacgc tgctgcggct tggcgtgctg tcgggatgct
     1201 ggaacgagcg tgccgtggat attgtcaccc agatcagttc ctacgtggcc tatagcaaca
     1261 gctgcctcaa cccgctggtg tacgtgattg tgggcaagcg cttccgaaag aagtcccgag
     1321 aggtgtacca ggcaatatgc cggaagggag gctgcatggg agagtccgtc cagatggaga
     1381 actccatggg gactctgagg acctctatct cggtggaccg gcagatccac aagctgcagg
     1441 attgggcggg gaacaagcag tgaacacaag ccatcgggca ggacgactgc cgagcgtgtg
     1501 aggactgctg ggacctgagc ttctcagcct gggttcagga aggagcttga agcatcctag
     1561 ggaatcaggc aggtgattcc agtcttgtct cacggcataa gcgtgctgtg ggggatgggg
     1621 accctggagc atagaggggt tgttattact ggctggtgct ctaaaatccc catgagtgga
     1681 gggggtcatg gggtagggat gggagtgaca aagcttcctt ccctttgggg gaaggacaga
     1741 tctcctgccg gttttggccc tgtggctaca tgcacagttg gcatggctgc ctcatttccc
     1801 agtttcaaga gtttaagatt tattggtctt ctgaaggctg aattctaagg agtctctggt
     1861 aagagcccag agactgggat tctgtggttc ctctcacccc tagacaaggt ggacggtaca
     1921 aaagaagaac cccaaagcat ttatggagca cttgcagagt acacagcatt gaacactgtg
     1981 ggcaggaggg aagacacaca tagtgtaatg tcttaaagga gccctgacgt tagtggagaa
     2041 agccaaggac ttgcagtctc cagaaggctg ctgatggcgt gccaaagcaa ggaactgtgg
     2101 gagaggggag agcacagggc ctaggggaac cggtaaccct gaacacggta gcctgatccc
     2161 tgcctctgct tcttctgctg taatgtgagg gtgtcctgtg ctttgaaaag tggggtgcta
     2221 tatggctgtg aggcgtcaga acacacatca ctgggtctgg acacacgtca catgcagacg
     2281 catcagaaca cacatcacat ggagatgcac cagaacgcac atcactgggt caggatacac
     2341 atcccgtgca gatgcaccag aacgcacatc actagatcaa gacacacatc acacggagac
     2401 acttggcaca gagaaagcca ctcaggctta ctctgcctgc aggtacaaga ggccctcact
     2461 ccctcctacc tttccctcct agtatcccac ccctatgcac acacaacaaa gcgtttggta
     2521 cttgggaagg gcgggagaaa gcaagtgttt gttttgcaat gagacaaaga aaaagatttc
     2581 tggtgggacc tgcccggaga atccacacct cacagcatgg ctgcaaattg gtagctgact
     2641 gggggagtct aagctgcttc ccagggctcc tggctcagtg accaagggat gccaattagt
     2701 ggtttatctg agagtgactc acaaagcagg gatgctacca aagagctgac ccatcatcca
     2761 aggtcactta actgagggcg tcaattccag gcccagctcc ctacatggct gcagggtgcc
     2821 tcgtgagtga tgtcaggggt gggtagggct gcctgggccc tggggaactc tgacaggaga
     2881 accaccccca ccttggggga gaggggaaca acacatctgc atattgagca ggtcttccac
     2941 cagagatagg atagccttcc ggatggtttc agggccagtg ggttccccat tagaacctat
     3001 tccaggggcc ttgggtgagc tcagtgtcag tggagacagt tgccccagca acgccataga
     3061 ctcgggtgac agacaccata ctcatagttc cagaatcttc catgggagtt tatttttcca
     3121 cgtgtccgta tcctgtgata aacttaacga caggggccac ttaagggaaa gagaagggtt
     3181 actttgtctc tcagtgtcaa aaaaaaaggc tatggtccag tgtagccggg gtctgtatgg
     3241 taaacagagc agtaaatgga gacccggctg gaaccagggc ggcatatgac cttcaaatgt
     3301 ctgcccctag tgacctttca cctactaggt cctacatctt aaagcttcca tcgcctttca
     3361 aaataggacc agcagtcagg aatgaaggga ggtgcctttc agactcaact ataacaattt
     3421 cactgccaat tggctggctt ctgaggctaa cactctgtca agcccctggg gacatctgag
     3481 ggacatatca aacaacctcc aacaccaagc cacgcaggag ctgaccgctc gatagccggg
     3541 ggctacggag actcaggaaa tgggcagagt tcactggtgt ttctggccag gctggagcca
     3601 agggagagcc tacatggcaa aaggcccgtg aatccccacc aatctgactc tgaatttcct
     3661 aagagagaag accccaggaa attctttttt ccaccccatc ctccacttgt agccaaaaga
     3721 aggaaacaga tggcatacgc tgagaatgga ctcagccaca cccatactgt gaaggcgaag
     3781 cagggcccca ccctcagagg agaagttggt gggctacggg cgtgagggac gcggcctggg
     3841 tccctcaggg tggctgaagg gtctgaaact gggtcactgc agggtctgca actaggtctg
     3901 caggagggaa gcccccttgt gcctttcgtc gacaccctga tgagaaacca tgtccattga
     3961 aggacggaga aagctctgta ccgtgcagag gaagtggccg acaagggagg agcactctgt
     4021 gtaagaacac acctcctctg tgcgctggaa taaacagatg aattttgaaa aaaaaaaaaa
     4081 aaaaaaaa
//
