LOCUS       NM_030851               1312 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus bradykinin receptor B1 (Bdkrb1), mRNA.
ACCESSION   NM_030851
VERSION     NM_030851.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1312)
  AUTHORS   Punapart,M., Seppa,K., Jagomae,T., Liiv,M., Reimets,R.,
            Kirillov,S., Kaasik,A., Moons,L., De Groef,L., Terasmaa,A.,
            Vasar,E. and Plaas,M.
  TITLE     The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is
            Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome
  JOURNAL   Genes (Basel) 12 (11), 1717 (2021)
   PUBMED   34828323
  REMARK    GeneRIF: The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is
            Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1312)
  AUTHORS   Shen,M., Yu,M., Qiu,C., Zhang,G., Li,J., Fang,W. and Wang,Q.
  TITLE     Myocardial angiogenesis induced by exercise training involves a
            regulatory mechanism mediated by kinin receptors
  JOURNAL   Clin Exp Hypertens 43 (5), 408-415 (2021)
   PUBMED   33687297
  REMARK    GeneRIF: Myocardial angiogenesis induced by exercise training
            involves a regulatory mechanism mediated by kinin receptors.
REFERENCE   3  (bases 1 to 1312)
  AUTHORS   Catalan,M., Aranguiz,P., Boza,P., Olmedo,I., Humeres,C., Vivar,R.,
            Anfossi,R., Ayala,P., Espinoza,C., Lavandero,S. and Diaz-Araya,G.
  TITLE     TGF-beta1 induced up-regulation of B1 kinin receptor promotes
            antifibrotic activity in rat cardiac myofibroblasts
  JOURNAL   Mol Biol Rep 46 (5), 5197-5207 (2019)
   PUBMED   31309451
  REMARK    GeneRIF: Findings show that B1R negatively regulates collagen
            synthesis in cardiac myofibroblasts involving differents signaling
            pathways.
REFERENCE   4  (bases 1 to 1312)
  AUTHORS   Ma,Z., Dong,Q., Lyu,B., Wang,J., Quan,Y. and Gong,S.
  TITLE     The expression of bradykinin and its receptors in spinal cord
            ischemia-reperfusion injury rat model
  JOURNAL   Life Sci 218, 340-345 (2019)
   PUBMED   30580020
  REMARK    GeneRIF: High bradykinin receptor B1 expression is associated with
            spinal cord ischemia-reperfusion injury.
REFERENCE   5  (bases 1 to 1312)
  AUTHORS   Hachana,S., Bhat,M., Senecal,J., Huppe-Gourgues,F., Couture,R. and
            Vaucher,E.
  TITLE     Expression, distribution and function of kinin B1 receptor in the
            rat diabetic retina
  JOURNAL   Br J Pharmacol 175 (6), 968-983 (2018)
   PUBMED   29285756
  REMARK    GeneRIF: Our results support the detrimental role of B1 receptors
            on endothelial and glial cells in acute and advanced phases of
            diabetes retinopathy
REFERENCE   6  (bases 1 to 1312)
  AUTHORS   Naicker,S., Naidoo,S., Ramsaroop,R., Moodley,D. and Bhoola,K.
  TITLE     Tissue kallikrein and kinins in renal disease
  JOURNAL   Immunopharmacology 44 (1-2), 183-192 (1999)
   PUBMED   10604543
REFERENCE   7  (bases 1 to 1312)
  AUTHORS   Jones,C., Phillips,E., Davis,C., Arbuckle,J., Yaqoob,M.,
            Burgess,G.M., Docherty,R.J., Webb,M., Bevan,S.J. and McIntyre,P.
  TITLE     Molecular characterisation of cloned bradykinin B1 receptors from
            rat and human
  JOURNAL   Eur J Pharmacol 374 (3), 423-433 (1999)
   PUBMED   10422787
REFERENCE   8  (bases 1 to 1312)
  AUTHORS   Ni,A., Chai,K.X., Chao,L. and Chao,J.
  TITLE     Molecular cloning and expression of rat bradykinin B1 receptor
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 177-185 (1998)
   PUBMED   9804950
REFERENCE   9  (bases 1 to 1312)
  AUTHORS   Bachvarov,D.R., Landry,M., Pelletier,I., Chevrette,M., Betard,C.,
            Houde,I., Bergeron,J., Lebel,M. and Marceau,F.
  TITLE     Characterization of two polymorphic sites in the human kinin B1
            receptor gene: altered frequency of an allele in patients with a
            history of end-stage renal failure
  JOURNAL   J Am Soc Nephrol 9 (4), 598-604 (1998)
   PUBMED   9555662
REFERENCE   10 (bases 1 to 1312)
  AUTHORS   Pesquero,J.B., Pesquero,J.L., Oliveira,S.M., Roscher,A.A.,
            Metzger,R., Ganten,D. and Bader,M.
  TITLE     Molecular cloning and functional characterization of a mouse
            bradykinin B1 receptor gene
  JOURNAL   Biochem Biophys Res Commun 220 (1), 219-225 (1996)
   PUBMED   8602848
  REMARK    Erratum:[Biochem Biophys Res Commun. 1996 Jul 5;224(1):281. doi:
            10.1006/bbrc.1996.1020.. PMID: 8694827]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ132230.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ132230.2, U66107.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680435, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1312
                     /gene="Bdkrb1"
                     /gene_synonym="b1bkr; Bdkrb; BKR"
                     /note="bradykinin receptor B1"
                     /db_xref="GeneID:81509"
                     /db_xref="RGD:620401"
     exon            1..88
                     /gene="Bdkrb1"
                     /gene_synonym="b1bkr; Bdkrb; BKR"
                     /inference="alignment:Splign:2.1.0"
     exon            89..1312
                     /gene="Bdkrb1"
                     /gene_synonym="b1bkr; Bdkrb; BKR"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1153
                     /gene="Bdkrb1"
                     /gene_synonym="b1bkr; Bdkrb; BKR"
                     /note="B1R; KB1; BK-1 receptor; kinin B1 receptor;
                     bradykinin receptor, beta 1; bradykinin B1 receptor"
                     /codon_start=1
                     /product="B1 bradykinin receptor"
                     /protein_id="NP_110478.1"
                     /db_xref="GeneID:81509"
                     /db_xref="RGD:620401"
                     /translation="MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVI
                     TICFFGLLGNLLVLSFFLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPF
                     WAENIGNRFNWPFGTDLCRVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRR
                     RRQAQATCLLIWVAGGLLSIPTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNV
                     LGFLLPVTAIIFFNYHILASLRGQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPY
                     HFFAFLDFLVQVRVIQDCSWKEITDLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVL
                     GTL"
ORIGIN      
        1 ggagctgccc caggacagaa acctcccaag acagcagtca ccatcaaaaa cacaggtgaa
       61 gctgtgagct ctttgctttt ctatccggac cacagctgga tttgacctcc tgtactgtgt
      121 caacgtcagg tcactgtgga tggcgtccga ggtcttgttg gagctccagc cctctaaccg
      181 aagcctgcag gcccctgcca acattacctc ctgcgagagt gccctagaag actgggacct
      241 gctgtatcgg gtgctgccag ggttcgtcat cactatctgc ttctttggcc tcttggggaa
      301 ccttttagtc ttgtccttct tccttttgcc ttggcgacag tggtggtggc agcaacgaca
      361 gaggcagcag cgcttaacca tagcggaaat ctacctggct aacttggcgg cttccgatct
      421 ggtgtttgtc ctgggcctgc ccttctgggc agagaacatc gggaaccgtt tcaactggcc
      481 cttcggaact gacctctgcc gggtggtcag cggggtcatc aaggccaacc tgtttgtcag
      541 catcttcctg gtggtggcta tcagtcagga ccgctacagg ctcctggtat accccatgac
      601 cagctggggg taccggcggc gacggcaagc ccaagctacg tgcctgctca tctgggtagc
      661 cgggggtctc ttgagcatcc ccacattcct tctacgctct gttaaagtcg tccccgatct
      721 gaacgtctct gcctgcatcc tgcttttccc ccacgaggct tggcactttg caaggatggt
      781 ggagttgaac gttttgggtt tcctcctccc cgtgactgct atcatcttct tcaactatca
      841 catcctggcc tccctgagag gacagaagga ggccagcagg actaggtgtg ggggtcccaa
      901 gggcagcaag acgacggggc tgatcctcac actggtagcc tccttcctgg tctgctggtg
      961 cccttaccac ttcttcgctt tcctggattt cctggtccag gtaagagtga tccaggactg
     1021 ctcctggaag gagatcacag acctgggcct gcagctcgcc aacttctttg cctttgtcaa
     1081 cagctgcttg aacccactga tttatgtctt cgcaggccgg ctccttaaga ccagggttct
     1141 ggggacttta taaatgatgc aaccgagaag cctcatgccc atgtggccca acaggaaggg
     1201 actcttccaa ttatcctgct ggaattcaaa cagcagggag ccaagaagcc tggcttcttg
     1261 accaaccatc tctggtatca taaagaccat ctggtcagct gacccacagc cc
//
