LOCUS       NM_001106473            1156 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus 3-hydroxybutyrate dehydrogenase 2 (Bdh2), mRNA.
ACCESSION   NM_001106473 XM_001075590 XM_215705
VERSION     NM_001106473.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Devireddy,L.R., Hart,D.O., Goetz,D.H. and Green,M.R.
  TITLE     A mammalian siderophore synthesized by an enzyme with a bacterial
            homolog involved in enterobactin production
  JOURNAL   Cell 141 (6), 1006-1017 (2010)
   PUBMED   20550936
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Guo,K., Lukacik,P., Papagrigoriou,E., Meier,M., Lee,W.H.,
            Adamski,J. and Oppermann,U.
  TITLE     Characterization of human DHRS6, an orphan short chain
            dehydrogenase/reductase enzyme: a novel, cytosolic type 2
            R-beta-hydroxybutyrate dehydrogenase
  JOURNAL   J Biol Chem 281 (15), 10291-10297 (2006)
   PUBMED   16380372
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215705.4, XM_001075590.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC095848.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760384, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1156
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /note="3-hydroxybutyrate dehydrogenase 2"
                     /db_xref="GeneID:295458"
                     /db_xref="RGD:1309898"
     exon            1..142
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            143..293
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..959
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /EC_number="1.1.1.30"
                     /EC_number="1.1.1.104"
                     /note="R-beta-hydroxybutyrate dehydrogenase;
                     dehydrogenase/reductase (SDR family) member 6;
                     3-hydroxybutyrate dehydrogenase, type 2; 4-oxo-L-proline
                     reductase; oxidoreductase UCPA; (R)-beta-hydroxybutyrate
                     dehydrogenase; short chain dehydrogenase/reductase family
                     15C member 1"
                     /codon_start=1
                     /product="dehydrogenase/reductase SDR family member 6"
                     /protein_id="NP_001099943.1"
                     /db_xref="GeneID:295458"
                     /db_xref="RGD:1309898"
                     /translation="MFLDCTAGSTMGRLEGKVIVLTAAAQGIGRASALAFAREGAKVI
                     ATDINEAKLQELENYPGIQTRVLDVTKKRQIDQFASEIEKIDVLFNVAGFVHHGTILD
                     CEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSIKGVENRCVYSAT
                     KAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARDDPKEALKAFLNRQKT
                     GRFASAEEVALLCVYLASDESAYVTGTPVVIDGGWSL"
     exon            294..372
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            373..469
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            470..578
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            579..639
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            640..753
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            754..812
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            813..905
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1156
                     /gene="Bdh2"
                     /gene_synonym="Dhrs6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggaatta gcaaaccaca gagaacggac ctgaactcca cctcccagca tgcattaatc
       61 agcatgtgac ttctcctgca caaagatccg aagtctgtct tctgaaggaa tctggaggac
      121 tgtgtggact cgctcttcta aaatctacca cctgcaaatt gatttcctac aacttgagcc
      181 attaaaggtg catgtttttg gattgcactg caggatccac catgggccgc ctggaaggga
      241 aagtcatcgt cctgacagct gccgctcaag ggatcggccg ggcttctgct ttagctttcg
      301 caagagaagg agccaaagtc atagccacag atatcaacga ggccaaactc caggagctgg
      361 aaaattaccc aggtattcaa actcgagtcc ttgatgtcac aaagaagaga caaattgatc
      421 agttcgcctc agaaattgag aagattgatg ttctctttaa cgttgctggt tttgtccacc
      481 acggaaccat cctggattgc gaggaaaaag actgggactt ctccatgaat ctcaacgtcc
      541 gcagcatgta cctgatgatc aaggcattcc tgcccaaaat gcttgctcag aaatctggca
      601 acattatcaa catgtcttcc gtggcctcca gcatcaaagg ggtggagaac agatgtgtgt
      661 acagtgcaac caaggcagct gtgatcggcc tcaccaagtc cgtggctgca gacttcatcc
      721 agcagggcat cagatgcaac tgtgtgtgcc caggaacggt tgacacccca tctctgcaag
      781 aaagaataca agccagagat gatcccaaag aggcactgaa agctttccta aacagacaga
      841 agaccggaag gtttgcatct gcagaagagg tcgccctgct ctgcgtatac ttggcctcag
      901 atgagtcagc ctatgtgact ggcacccctg tcgtcatcga tggcggttgg agtctgtgag
      961 tgcatggatc cctgctggaa gacaggccct ccctagccac agagaaaagc aaactggccg
     1021 ggtgagcatc tctcctgggt gacactcatg aaaacaagcc ctgtaagggt cgttcccaag
     1081 agcgactcgt taatagtctc tcgtctcttc tgaaaccatg gtaaataaat caaataaaat
     1141 gtattgattt tttggc
//
