LOCUS       NM_001007666            1685 bp    mRNA    linear   ROD 09-MAR-2025
DEFINITION  Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase
            complex chaperone (Bcs1l), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001007666 XM_217434
VERSION     NM_001007666.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Leveen,P., Kotarsky,H., Morgelin,M., Karikoski,R., Elmer,E. and
            Fellman,V.
  TITLE     The GRACILE mutation introduced into Bcs1l causes postnatal complex
            III deficiency: a viable mouse model for mitochondrial hepatopathy
  JOURNAL   Hepatology 53 (2), 437-447 (2011)
   PUBMED   21274865
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Tamai,S., Iida,H., Yokota,S., Sayano,T., Kiguchiya,S., Ishihara,N.,
            Hayashi,J., Mihara,K. and Oka,T.
  TITLE     Characterization of the mitochondrial protein LETM1, which
            maintains the mitochondrial tubular shapes and interacts with the
            AAA-ATPase BCS1L
  JOURNAL   J Cell Sci 121 (Pt 15), 2588-2600 (2008)
   PUBMED   18628306
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Visapaa,I., Fellman,V., Vesa,J., Dasvarma,A., Hutton,J.L.,
            Kumar,V., Payne,G.S., Makarow,M., Van Coster,R., Taylor,R.W.,
            Turnbull,D.M., Suomalainen,A. and Peltonen,L.
  TITLE     GRACILE syndrome, a lethal metabolic disorder with iron overload,
            is caused by a point mutation in BCS1L
  JOURNAL   Am J Hum Genet 71 (4), 863-876 (2002)
   PUBMED   12215968
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   de Lonlay,P., Valnot,I., Barrientos,A., Gorbatyuk,M., Tzagoloff,A.,
            Taanman,J.W., Benayoun,E., Chretien,D., Kadhom,N., Lombes,A., de
            Baulny,H.O., Niaudet,P., Munnich,A., Rustin,P. and Rotig,A.
  TITLE     A mutant mitochondrial respiratory chain assembly protein causes
            complex III deficiency in patients with tubulopathy, encephalopathy
            and liver failure
  JOURNAL   Nat Genet 29 (1), 57-60 (2001)
   PUBMED   11528392
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083660.1.
            
            On Nov 29, 2004 this sequence version replaced XM_217434.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083660.1, SRR8487226.14841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1685
                     /gene="Bcs1l"
                     /note="BCS1 homolog, ubiquinol-cytochrome c reductase
                     complex chaperone"
                     /db_xref="GeneID:301514"
                     /db_xref="RGD:1359658"
     exon            1..231
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            232..624
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1561
                     /gene="Bcs1l"
                     /EC_number="5.6.1.7"
                     /note="BC1 (ubiquinol-cytochrome c reductase)
                     synthesis-like"
                     /codon_start=1
                     /product="mitochondrial chaperone BCS1"
                     /protein_id="NP_001007667.1"
                     /db_xref="GeneID:301514"
                     /db_xref="RGD:1359658"
                     /translation="MPFTDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFR
                     RHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPG
                     NHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQ
                     QEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDR
                     GIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQ
                     SLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHI
                     DRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSQIS
                     PAQVQGYFMLYKNDPMGAIHNVESLR"
     exon            625..764
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            765..959
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1023
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1193
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1311
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1650
                     /gene="Bcs1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcctggga gcgcgggctg ggttgtgtag ggtgtccggg agtcagccgc tgtgtgtcag
       61 ggtcagtagc cggaggccag gagatcttcg tcagtggctg tccatgcaaa agtgttttgg
      121 aattctggat ctcggctctg agccttagcg gaggtcacgg ctgtcaattc accggtgtcc
      181 cggcgtgcca gacggaggac agagtggcgg tggaggagcg ttgcaggaga gttctgctgt
      241 tctccatctc taggttttga cagtgcctca gaacccgtga gcatctgtgt tttttccttt
      301 caagatgcca tttacagact ttgttctggc cctcaaagac aatccctact ttggggctgg
      361 atttgggctg gtaggtgtgg gtacagctct ggctatggcc cggaaaggag cccagttggg
      421 tctagtggca ttccgtcgcc attacatgat cacactggaa gtccctgcta gagacagaag
      481 ctatgcctgg ttgcttagct ggctgacccg gcacagcacc cgcactcagc acctcagtgt
      541 tgagacctca taccttcagc atgaaagtgg ccgaatctcc accaagtttg aattcatccc
      601 cagccctgga aaccacttca tttggtatca gggaaaatgg atccgggtag agcgaaatcg
      661 agaaatgcag atggtggact tgcaaacggg gactccttgg gaatctgtca ccttcacggc
      721 cctgggcact gatcgaaagg ttttcttcaa catcctggag gaagcgagag ccctggctct
      781 gcagcaggag gaagggaaga ctgtgatgta cacagctgtg ggttctgaat ggcgaacctt
      841 cggttatcca cgccggaggc ggccactgga ttctgtagtc ctacagcagg gtctggctga
      901 ccgaattgtt aaagatatcc gagaatttat tgataatccc aagtggtaca ttgacagagg
      961 catcccctac agacgtggct accttcttta tgggccccct ggttgtggaa agagcagttt
     1021 tataacagct ctggctggag aactggaaca cagcatctgc ctgctaagtc tcacagactc
     1081 tagcctctcg gacgaccggc tcaaccatct actaagcgta gcaccccagc agagcctggt
     1141 gctcctggaa gatgtagatg ctgcttttct cagtagagac ttggccgtgg agaaccctgt
     1201 aaagtaccaa ggattaggtc gcctcacctt cagcggactg cttaatgctt tggatggtgt
     1261 agcctctacc gaggctcgaa ttgtgttcat gaccactaac cacattgaca ggctggatcc
     1321 tgccctgata cgtcctgggc gagtagatct gaaggagtat gtgggctact gctcacactg
     1381 gcagctgacc cagatgttcc agaggttcta tccaggacaa gcgccttctt tggctgagaa
     1441 ttttgctgaa catgtcctta aagctacatc ccagattagt cctgcccagg tgcaaggcta
     1501 cttcatgctg tataaaaatg accccatggg ggccattcac aatgtcgaat ctctgaggtg
     1561 acccaccagg cctgtcacac gaatctggtt ggtgaccttc ttcttcccat tgctgtgttt
     1621 gtaattgaga ataaaacagg agttgccata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaa
//
