LOCUS       NM_001419609            7069 bp    mRNA    linear   ROD 19-FEB-2024
DEFINITION  Rattus norvegicus BCR activator of RhoGEF and GTPase (Bcr), mRNA.
ACCESSION   NM_001419609 XM_039099171
VERSION     NM_001419609.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7069)
  AUTHORS   Smith,K.R., Rajgor,D. and Hanley,J.G.
  TITLE     Differential regulation of the Rac1 GTPase-activating protein (GAP)
            BCR during oxygen/glucose deprivation in hippocampal and cortical
            neurons
  JOURNAL   J Biol Chem 292 (49), 20173-20183 (2017)
   PUBMED   29046349
  REMARK    GeneRIF: This work identifies BCR as a critical player in Rac1
            regulation during oxygen and glucose deprivation in hippocampal
            neurons.
REFERENCE   2  (bases 1 to 7069)
  AUTHORS   Gray,E.J., Petsalaki,E., James,D.A., Bagshaw,R.D., Stacey,M.M.,
            Rocks,O., Gingras,A.C. and Pawson,T.
  TITLE     Src homology 2 domain containing protein 5 (SH2D5) binds the
            breakpoint cluster region protein, BCR, and regulates levels of
            Rac1-GTP
  JOURNAL   J Biol Chem 289 (51), 35397-35408 (2014)
   PUBMED   25331951
  REMARK    GeneRIF: Data indicate that Src homology 2 domain containing
            protein 5 (SH2D5) controls neuronal morphology via breakpoint
            cluster region protein BCR and Rac1 GTP binding protein.
REFERENCE   3  (bases 1 to 7069)
  AUTHORS   Roberts,K.G., Pei,D., Campana,D., Payne-Turner,D., Li,Y., Cheng,C.,
            Sandlund,J.T., Jeha,S., Easton,J., Becksfort,J., Zhang,J.,
            Coustan-Smith,E., Raimondi,S.C., Leung,W.H., Relling,M.V.,
            Evans,W.E., Downing,J.R., Mullighan,C.G. and Pui,C.H.
  TITLE     Outcomes of children with BCR-ABL1-like acute lymphoblastic
            leukemia treated with risk-directed therapy based on the levels of
            minimal residual disease
  JOURNAL   J Clin Oncol 32 (27), 3012-3020 (2014)
   PUBMED   25049327
REFERENCE   4  (bases 1 to 7069)
  AUTHORS   Cai,J., Wu,G., Tan,X., Han,Y., Chen,C., Li,C., Wang,N., Zou,X.,
            Chen,X., Zhou,F., He,D., Zhou,L., Jose,P.A. and Zeng,C.
  TITLE     Transferred BCR/ABL DNA from K562 extracellular vesicles causes
            chronic myeloid leukemia in immunodeficient mice
  JOURNAL   PLoS One 9 (8), e105200 (2014)
   PUBMED   25133686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7069)
  AUTHORS   Dubash,A.D., Koetsier,J.L., Amargo,E.V., Najor,N.A., Harmon,R.M.
            and Green,K.J.
  TITLE     The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte
            differentiation via desmoglein-1
  JOURNAL   J Cell Biol 202 (4), 653-666 (2013)
   PUBMED   23940119
REFERENCE   6  (bases 1 to 7069)
  AUTHORS   Chuang,T.H., Xu,X., Kaartinen,V., Heisterkamp,N., Groffen,J. and
            Bokoch,G.M.
  TITLE     Abr and Bcr are multifunctional regulators of the Rho GTP-binding
            protein family
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10282-10286 (1995)
   PUBMED   7479768
REFERENCE   7  (bases 1 to 7069)
  AUTHORS   Karlic,H., Grill,R. and Schlogl,E.
  TITLE     Minor BCR (m-bcr) rearrangements may appear in major BCR
            (M-bcr)-positive CML cases
  JOURNAL   Hematol Pathol 6 (4), 203-207 (1992)
   PUBMED   1362728
REFERENCE   8  (bases 1 to 7069)
  AUTHORS   Diekmann,D., Brill,S., Garrett,M.D., Totty,N., Hsuan,J.,
            Monfries,C., Hall,C., Lim,L. and Hall,A.
  TITLE     Bcr encodes a GTPase-activating protein for p21rac
  JOURNAL   Nature 351 (6325), 400-402 (1991)
   PUBMED   1903516
REFERENCE   9  (bases 1 to 7069)
  AUTHORS   Grossman,A., Silver,R.T., Arlin,Z., Coleman,M., Camposano,E.,
            Gascon,P. and Benn,P.A.
  TITLE     Fine mapping of chromosome 22 breakpoints within the breakpoint
            cluster region (bcr) implies a role for bcr exon 3 in determining
            disease duration in chronic myeloid leukemia
  JOURNAL   Am J Hum Genet 45 (5), 729-738 (1989)
   PUBMED   2683759
REFERENCE   10 (bases 1 to 7069)
  AUTHORS   Shtivelman,E., Gale,R.P., Dreazen,O., Berrebi,A., Zaizov,R.,
            Kubonishi,I., Miyoshi,I. and Canaani,E.
  TITLE     bcr-abl RNA in patients with chronic myelogenous leukemia
  JOURNAL   Blood 69 (3), 971-973 (1987)
   PUBMED   3101769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000324.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001419609.2.
            
            On Apr 12, 2023 this sequence version replaced XM_039099171.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1730              JACYVU010000324.1  9319091-9320820     c
            1731-1903           JACYVU010000324.1  9254870-9255042     c
            1904-2008           JACYVU010000324.1  9248987-9249091     c
            2009-2194           JACYVU010000324.1  9247783-9247968     c
            2195-2302           JACYVU010000324.1  9243676-9243783     c
            2303-2363           JACYVU010000324.1  9241217-9241277     c
            2364-2416           JACYVU010000324.1  9237969-9238021     c
            2417-2557           JACYVU010000324.1  9235727-9235867     c
            2558-2679           JACYVU010000324.1  9228271-9228392     c
            2680-2848           JACYVU010000324.1  9227182-9227350     c
            2849-2968           JACYVU010000324.1  9225150-9225269     c
            2969-3044           JACYVU010000324.1  9224348-9224423     c
            3045-3149           JACYVU010000324.1  9222751-9222855     c
            3150-3224           JACYVU010000324.1  9222194-9222268     c
            3225-3322           JACYVU010000324.1  9215255-9215352     c
            3323-3454           JACYVU010000324.1  9212935-9213066     c
            3455-3514           JACYVU010000324.1  9203351-9203410     c
            3515-3624           JACYVU010000324.1  9202196-9202305     c
            3625-3764           JACYVU010000324.1  9200523-9200662     c
            3765-3899           JACYVU010000324.1  9198028-9198162     c
            3900-4005           JACYVU010000324.1  9197023-9197128     c
            4006-4168           JACYVU010000324.1  9196545-9196707     c
            4169-7069           JACYVU010000324.1  9193203-9196103     c
FEATURES             Location/Qualifiers
     source          1..7069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..7069
                     /gene="Bcr"
                     /note="BCR activator of RhoGEF and GTPase"
                     /db_xref="GeneID:309696"
                     /db_xref="RGD:1307993"
     exon            1..1730
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..4258
                     /gene="Bcr"
                     /EC_number="2.7.11.1"
                     /note="breakpoint cluster region homolog; BCR, RhoGEF and
                     GTPase activating protein"
                     /codon_start=1
                     /product="breakpoint cluster region protein"
                     /protein_id="NP_001406538.1"
                     /db_xref="GeneID:309696"
                     /db_xref="RGD:1307993"
                     /translation="MVDSVGFAEAWRAQFPDSEPPRMELRSVGDIEQELERCKASIRR
                     LEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQPPDGAAEPRASAPRLPPAPA
                     DGADPAPVEESEARPDGEGSPSKGRPATARRPAAAAPADRDDRGPPTSVAALRSNFEK
                     IRKGPAQPGSADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQQ
                     SAGQGLGEAPRPHYRGRSSESSCGLDGDYEDAELNPRFLKDNLINANGGNRPPWPPLE
                     YQPYQSIYVGGMMVEGEGKSPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDC
                     SSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQK
                     RHRQCQVVVSEATIVGVRKTGQIWPSDGDSTFQGEADSSFGTPPGYGCAADQAEEQRR
                     HQDGLPYIDDSPSSSPHLSSKGRGSPASGALEPTKASELDLEKGLEMRKWVLSGILAS
                     EETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPR
                     VQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRAR
                     SNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDALRISQN
                     FLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLK
                     KQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQ
                     REKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEW
                     RESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGFLHA
                     IVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLR
                     ILCYEKCYNKMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSV
                     KFTSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIY
                     RVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPN
                     FAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLAT
                     VFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQ
                     SILFSTEV"
     exon            1731..1903
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2008
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2194
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2302
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2363
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2416
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2557
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2679
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2848
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2968
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3044
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3149
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3224
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3322
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3454
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3514
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3624
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3764
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3899
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..4005
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4168
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..7069
                     /gene="Bcr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcagcgc tgagtgcggg ccggggcggg agtgcggcga gagctggccg tgctgagcgg
       61 agcgcctgcc cggaaggctg cggggcggcg cgggaaccgg aggcgaggag cccgcggggc
      121 tgcggccgtg ggcccgcggc ggccctgctc tgcggaggac cgctcccgcc gcctcgcgcg
      181 ccgcggagcc ccgcacacaa tagaggcgtg cgcaaccccg cgcccttccc ccgcccgcgc
      241 gcgcccctcg ccgccgccgc cgccgccgca gcggccgagc ctcccgcctc acctgcggcc
      301 ccggggggcg ggcattgttc gccgccgtag ccgcgggatc atgggaggcg ccggacgccc
      361 ggggcccggc accgtaagaa ccccgcgccg ccgctgagcc gggctccggc gcgcagctcc
      421 tcggcgcagg tgagccggcc gcgccatggt ggactcggtg ggcttcgccg aggcttggag
      481 agcgcagttc ccggactcgg agccgccgcg catggagctg cgctcggtgg gtgacatcga
      541 gcaggagctg gagcgctgca aggcctccat taggcgcttg gagcaggagg tgaaccagga
      601 gcgcttccgc atgatctacc tgcagacgct gctggccaag gagaagaaga gctacgatcg
      661 gcagcgctgg ggctttcgcc gggcagcgca gcccccggac ggcgccgccg agccccgagc
      721 gtccgccccg cgcctgccgc ccgcgcccgc cgacggcgca gacccggcgc ccgtcgagga
      781 gtcggaggcg cggccggacg gagaagggtc accgagtaag gggcgaccgg cgactgcccg
      841 caggccagcg gctgctgcgc cggcggaccg ggacgaccga gggcccccca ccagcgtggc
      901 ggcgctcaga tccaacttcg agaagatccg caagggacct gcccagcccg gctctgccga
      961 cgccgagaag cccttttacg tgaacgtcga gttccaccac gagcgcggcc tggtgaaggt
     1021 caacgacaaa gaggtgtccg accgaatcag ttctctgggc agccaggcca tgcaaatgga
     1081 gcgcaagaag tcccagcaga gcgccgggca gggcctgggg gaagcaccca gaccccatta
     1141 ccgtgggcgc tcctcggaga gcagctgcgg cctcgacggt gactatgagg atgcagagtt
     1201 gaatccccgt ttcctgaagg acaacctaat caatgccaat ggcggcaaca ggcccccttg
     1261 gccgcccctg gagtatcaac cctaccagag catctacgtc gggggtatga tggtggaagg
     1321 ggagggcaag agccctctcc tgcgaagcca gagcacttca gagcaggaga agcgcctcac
     1381 ctggccccgc aggtcctact cgcctcggag ttttgaggac agcggaggtg gctacactcc
     1441 ggactgcagc tccaatgaga acctcacctc cagtgaggag gacttttcct ctggccagtc
     1501 cagccgcgtg tcaccaagcc ccaccaccta ccgtatgttc cgggacaaga gtcgctcacc
     1561 ctcgcagaat tcacaacagt cctttgacag cagcagccct ccgacgccac agtgccagaa
     1621 gcggcaccgg cagtgccagg ttgtggtgtc tgaggctacc atagtaggtg ttcgcaagac
     1681 cgggcagatc tggcccagtg atggggacag cacctttcag ggggaagcag attcctcgtt
     1741 tggaacacca cctggatatg gctgtgctgc agaccaggct gaggaacagc gccggcacca
     1801 ggacgggctg ccctacatcg atgattcacc ttcctcctcg ccacacctca gcagcaaagg
     1861 caggggcagc ccagcctcag gcgccctgga gcccaccaaa gcgagtgagc tggatttgga
     1921 aaagggcttg gagatgagga agtgggtttt gtccggaatc ctggccagcg aggagacata
     1981 cctgagccat ctggaggccc tgctgctgcc catgaagcct ctgaaagccg ctgccaccac
     2041 gtctcagcct gtgctgacca gccagcagat tgagaccatt ttcttcaaag tgcctgagct
     2101 ctacgagatc cacaaggagt tctatgacgg gctctttccc cgcgtacaac agtggagcca
     2161 ccagcagcgc gtgggtgacc tcttccagaa gctggccagc cagctgggcg tgtaccgggc
     2221 ctttgtggat aactacggag tggccatgga aactgcagag aagtgctgtc aggccaacgc
     2281 tcagtttgca gaaatctctg agaacctgag ggccagaagc aacaaggacg tcaaggactc
     2341 aactaccaag aactctttgg aaactctgct ctacaaacct gtggaccggg tgacgaggag
     2401 cacactagtc cttcacgact tgctaaagca cactccatcc agccatcccg accattccct
     2461 gctgcaagat gccctccgca tctctcagaa cttcctgtcc agcatcaacg aggagatcac
     2521 gccccgccgg cagtccatga ccgtgaaaaa aggagagcac cggcagctgc tgaaggatag
     2581 cttcatggtg gagctggtgg agggggcccg caagctgcgt cacatcttcc tgttcactga
     2641 cctgctcctc tgcaccaagc tgaagaaaca aagtggaggc aaaacccagc aatatgactg
     2701 taaatggtac attccgctca cggacctcag cttccagatg gtggacgagt tggaggcact
     2761 acccaacatc cctctggtgc cagatgagga actggatgcc ttgaagatca aaatctccca
     2821 aatcaagagc gacatccaac gagagaagag agcaaacaag ggcagcaagg tcatggagag
     2881 gctgaggaag aagctgtcag agcaggaatc gctgctgctg ttgatgtccc ccagcatggc
     2941 cttcagggtg cacagtcgca atggcaagag ttatacattc cttatttcct ctgactatga
     3001 gcgagccgag tggagagaaa gcatccggga gcagcagaag aaatgtttca aaagtttctc
     3061 tctgacatct gtggagctac agatgctgac caactcgtgt gtaaaacttc agaccgttca
     3121 ccacattcca ctgaccatca acaaagaaga tgatgagtct cccggactct acggcttcct
     3181 gcatgccatc gtacattcag ccaccgggtt taagcagagc tcaaatctgt actgcaccct
     3241 ggaggtggat tcctttggct attttgtgaa caaagcgaag actcgagtct acagggatac
     3301 cactgagccg aactggaatg aggagtttga gatagagctc gaaggctccc agaccctgcg
     3361 gatactatgc tatgaaaagt gttacaacaa aatgaagatg gcgaaggagg atggcgagag
     3421 cgctgacaag ctcatgggga aaggacaggt ccagctggac ccccaaaccc tccaggacag
     3481 agactggcag cggactgtca tcgacatgaa tggaatcgaa gtgaaactct cggtcaagtt
     3541 cacgagcagg gagttcagcc tgaagagaat gccctcccgc aaacagacgg gggtcttcgg
     3601 tgtcaaaatc gctgtggtca caaagagaga gaggtccaag gtaccttaca ttgtacgcca
     3661 gtgtgtggag gagattgagc gccggggcat ggaggaagta ggcatctacc gagtgtccgg
     3721 agtggccacg gacatccagg ccctgaaggc agcctttgat gtcaataaca aggacgtgtc
     3781 cgtgatgatg agcgagatgg acgtgaacgc cattgctggc acgttgaagc tctacttccg
     3841 agagctgccc gagcccctct tcacggatga gttctaccct aacttcgcag aaggcattgc
     3901 tctttcagac cccgtcgcaa aggaaagctg catgctcaac ctgctgctgt ccctcccaga
     3961 agccaacctc ctgaccttcc tcttccttct ggaccacttg aaaagggtag ctgaaaagga
     4021 gacggtgaac aagatgtccc tgcacaacct cgccacggtc ttcggcccca cgctgcttcg
     4081 gccctcggag aaggagagca agctccctgc taaccccagc cagcccatca ccatgactga
     4141 cagctggtcc ctagaggtca tgtcccaggt ccaagtattg ctgtatttcc tgcagctgga
     4201 ggccatccct gcccctgaca gcaagagaca gagcatcctg ttttccactg aagtctaaaa
     4261 gcctggagtc agtcatctca ttaaagaggc ctacagaatg acccggaaac ctgtgacaag
     4321 agaacccacc cacggagttg ggaatgagac ccttcttgtg gtgtaaccta gccattccga
     4381 agctctgggc catctgccaa gagacaagta cccaaagcaa aagccaaggg ggcctacatg
     4441 cacccaggtg tggtccgcaa gccccaggct ggccccagac tgtacctttc cctcgctgcc
     4501 accagagggc accccaagcc agcccatctg caagccggac aagggaagag aggcggagaa
     4561 gagtggtttt tatgaatctt aatttatcag agttttaaaa aagaaaaaaa aatctctcct
     4621 ggatcatttg ttccaatgca tcctctctgg ggaataggga caccatcaga tcccttactg
     4681 ttgtgtcttg aataaacact gctgctgctt cctaatgcgg ggggcatggg gggggggggc
     4741 accatagcca tgtccctctg tgtaggtggg gacatcttca ctgtccctgc gtcaaaaaat
     4801 tccgctgtag gcctgacagg gtctgagacg ccaagtcagc actgtggtga cgtcttcggc
     4861 ccttgctatt cactttgtct tcccagaagg atgtctgtct gtgcagaagt aggtcaggtt
     4921 cgccaaggat gtctgtccgt gcagaagtag gtcaggttcg ccgtcgcttt caggagtgtg
     4981 ctccttcgca gcccagaagt gtctggggac cggacacagg aggggagacc ctggtcctca
     5041 cgcaccttac ggttccttct gtgggggagg gtggccgcgt ctactgatcc ttactgcctg
     5101 cctggtatcg gcgctccctt ctgtcttaaa aaggctgtga tttctctggc ctgcctctga
     5161 ctgctgtctc cgtcccttgc tgccccacgt aagaaagaga tcagtccctt tccttgctcc
     5221 cgacggagca gactctctcg gtcccctttc ttagccccat cgctgtcccg aagcagcagc
     5281 ctcctctagt ggcttgtttt aatactttga tcagaaatag cttttgatac ttgaatattt
     5341 ttaagtttta tacatagttt ctaatttttt tttcctaacg gattcagaca cctaataaga
     5401 tcctagaatg tacaccgtgg acgggccggg tccaggcgat atttctgtct tccttcgaga
     5461 gccggctgcc tttttgttcg gagtcattcc tgacatctct ggaacgtcag agatatggaa
     5521 ggacggttag gaaagtcagg cctggggata ggggcaaccg ccccaaagca ggctggaagc
     5581 taacacgcct gctgccctcc caccttccct ccctatagct gggtgggagc cagggtagtc
     5641 tcttactggc caccctactt agcaaaagag aaaggggaaa accactgatt gtttccaaga
     5701 aggaattcca caagtcctcc aatcgttttt tttaaaaggg tagaatcccg tcctccggag
     5761 acagttgccc ttgagctcag gaccagccgt gtcagcatag tgcttatcta ggtagctagg
     5821 actacccatt cggggctgtc ctacgagggc cttggggcag accaggagag acgagaaagg
     5881 ctggccctag acttgaatcc cgagctgtta ccgcaggaag gcattactta ggggtggagt
     5941 ctgcttgtca cgtgaggact cccgcacata ctccacggcc cctcccatgt ctggaaggtg
     6001 ggcgtgccca ccaatagcag gcatccacca accccagggc acatggggat ccttgagagg
     6061 cagagccctg agttcccctc ccgtctgctc tttttttttt tttttttttt tttttttttt
     6121 ttttccgggg ctggggatcg aacccgggac cttgtgcttc ctaggcaagt gctctaccac
     6181 tgagccaaat ccccaacccc tcccgtctgc tcttgaacct gcctaattaa tgtattgggc
     6241 aggaagcaaa agaccttaca gggtctctgt ctgcatacag tgtttaggtg gccctttctc
     6301 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc tctgcagagc
     6361 cacccattgg tctacccttg agcatttttc ggacccagtg ggctcctcta gtttggctgc
     6421 cccaccccag tccatgctgt ggctctgacc ctgtgagagg gtcactgctg agaaaagcca
     6481 ccgtcaaccc ccgctgtcat ttctgcaacc cacccccacc ccattgtctc tcgatttttg
     6541 tctgtcacct tgaactggaa agcaatatat taatcagtgt gccaacgtgc attccctggc
     6601 ccgtcccctg cctccgttca ctttatttat ataggtcatg tgttattttg atgatggaat
     6661 gaacattctc gcgctgtcct aagaagtgtt cctccgccgt cgccccacgg tggcagcgac
     6721 tggggctgcc tctcttaccc gactcacacc ttgcaggcct ctaaactggc aaagaaaaca
     6781 cgtggtgatg ttgtccagga gtagggacaa ctttcccctc tgcaaagaga gtgatggccc
     6841 caagtccttt gtgactgccc accaggcatg gcggccagac tctaaaggaa gtacttctta
     6901 ccttggaacc tggatcctgg gcacagtggg cttggctttc ctggtagtag cctagcctcc
     6961 acagtgggtg gatggtctct tagccgtgat cctgcttttg agttcagctg cctgtattac
     7021 tctgtgccgg aaggaccacg gacactttca ttaaagtctc ctgagacta
//
