LOCUS       NP_001178515            1757 aa            linear   ROD 22-OCT-2024
DEFINITION  BCL-6 corepressor isoform 1 [Rattus norvegicus].
ACCESSION   NP_001178515 XP_002730239
VERSION     NP_001178515.1
DBSOURCE    REFSEQ: accession NM_001191586.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1757)
  AUTHORS   He,Y. and Wang,X.
  TITLE     Identification of molecular features correlating with tumor
            immunity in gastric cancer by multi-omics data analysis
  JOURNAL   Ann Transl Med 8 (17), 1050 (2020)
   PUBMED   33145269
REFERENCE   2  (residues 1 to 1757)
  AUTHORS   Buchberger,E., Payrhuber,D., El Harchi,M., Zagrapan,B., Scheuba,K.,
            Zommer,A., Bugyik,E., Dome,B., Kral,J.B., Schrottmaier,W.C.,
            Schabbauer,G., Petzelbauer,P., Groger,M., Bilban,M. and Brostjan,C.
  TITLE     Inhibition of the transcriptional repressor complex Bcl-6/BCoR
            induces endothelial sprouting but does not promote tumor growth
  JOURNAL   Oncotarget 8 (1), 552-564 (2017)
   PUBMED   27880939
REFERENCE   3  (residues 1 to 1757)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1757)
  AUTHORS   Rokutan,H., Hosoda,F., Hama,N., Nakamura,H., Totoki,Y.,
            Furukawa,E., Arakawa,E., Ohashi,S., Urushidate,T., Satoh,H.,
            Shimizu,H., Igarashi,K., Yachida,S., Katai,H., Taniguchi,H.,
            Fukayama,M. and Shibata,T.
  TITLE     Comprehensive mutation profiling of mucinous gastric carcinoma
  JOURNAL   J Pathol 240 (2), 137-148 (2016)
   PUBMED   27313181
REFERENCE   5  (residues 1 to 1757)
  AUTHORS   Agardh,E., Lundstig,A., Perfilyev,A., Volkov,P., Freiburghaus,T.,
            Lindholm,E., Ronn,T., Agardh,C.D. and Ling,C.
  TITLE     Genome-wide analysis of DNA methylation in subjects with type 1
            diabetes identifies epigenetic modifications associated with
            proliferative diabetic retinopathy
  JOURNAL   BMC Med 13, 182 (2015)
   PUBMED   26248552
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1757)
  AUTHORS   Gearhart,M.D., Corcoran,C.M., Wamstad,J.A. and Bardwell,V.J.
  TITLE     Polycomb group and SCF ubiquitin ligases are found in a novel BCOR
            complex that is recruited to BCL6 targets
  JOURNAL   Mol Cell Biol 26 (18), 6880-6889 (2006)
   PUBMED   16943429
REFERENCE   7  (residues 1 to 1757)
  AUTHORS   Lee,J.A., Suh,D.C., Kang,J.E., Kim,M.H., Park,H., Lee,M.N.,
            Kim,J.M., Jeon,B.N., Roh,H.E., Yu,M.Y., Choi,K.Y., Kim,K.Y. and
            Hur,M.W.
  TITLE     Transcriptional activity of Sp1 is regulated by molecular
            interactions between the zinc finger DNA binding domain and the
            inhibitory domain with corepressors, and this interaction is
            modulated by MEK
  JOURNAL   J Biol Chem 280 (30), 28061-28071 (2005)
   PUBMED   15878880
REFERENCE   8  (residues 1 to 1757)
  AUTHORS   Ng,D., Thakker,N., Corcoran,C.M., Donnai,D., Perveen,R.,
            Schneider,A., Hadley,D.W., Tifft,C., Zhang,L., Wilkie,A.O., van der
            Smagt,J.J., Gorlin,R.J., Burgess,S.M., Bardwell,V.J., Black,G.C.
            and Biesecker,L.G.
  TITLE     Oculofaciocardiodental and Lenz microphthalmia syndromes result
            from distinct classes of mutations in BCOR
  JOURNAL   Nat Genet 36 (4), 411-416 (2004)
   PUBMED   15004558
REFERENCE   9  (residues 1 to 1757)
  AUTHORS   Srinivasan,R.S., de Erkenez,A.C. and Hemenway,C.S.
  TITLE     The mixed lineage leukemia fusion partner AF9 binds specific
            isoforms of the BCL-6 corepressor
  JOURNAL   Oncogene 22 (22), 3395-3406 (2003)
   PUBMED   12776190
REFERENCE   10 (residues 1 to 1757)
  AUTHORS   Huynh,K.D., Fischle,W., Verdin,E. and Bardwell,V.J.
  TITLE     BCoR, a novel corepressor involved in BCL-6 repression
  JOURNAL   Genes Dev 14 (14), 1810-1823 (2000)
   PUBMED   10898795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XP_002730239.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.761113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     Protein         1..1757
                     /product="BCL-6 corepressor isoform 1"
                     /note="Bcl6 interacting corepressor; BCL-6 corepressor"
                     /calculated_mol_wt=192462
     Region          <257..672
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          1203..1415
                     /region_name="BCOR"
                     /note="BCL-6 co-repressor, non-ankyrin-repeat region;
                     pfam15808"
                     /db_xref="CDD:434953"
     Region          <1463..1596
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          1465..1496
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(1466,1470..1471,1474..1476,1478..1479,1483,1486,
                     1496,1498,1500,1504..1505,1508..1510,1512..1513,1517,1520,
                     1529,1531,1533,1537..1538,1541..1543,1545..1546,1550,1553)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          1498..1529
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1531..1560
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1636..1749
                     /region_name="PUFD"
                     /note="BCORL-PCGF1-binding domain; pfam16553"
                     /db_xref="CDD:465171"
     Site            order(1638..1639,1641..1645,1647..1649,1651,1653,1662,
                     1664,1706..1708,1710..1711,1713..1714,1731,1742,1744,
                     1746..1748)
                     /site_type="other"
                     /note="RAWUL domain interface [polypeptide binding]"
                     /db_xref="CDD:271224"
     CDS             1..1757
                     /gene="Bcor"
                     /gene_synonym="RGD1562735"
                     /coded_by="NM_001191586.2:782..6055"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:317346"
                     /db_xref="RGD:1562735"
ORIGIN      
        1 mlsatplygn vhswmnserv rmcgtsedrk ipvndgdask arlelreenp lnhnvvdtsg
       61 ahridglaal smdrtglire glrvpgnivy sglcglgsek greatpssls glgfssernp
      121 emqfkpntpe tveasavsgk ppngfsaiyk tppgiqksav ataeslgldr pasdkqspln
      181 ingasylrlp wvnpymegat paiypfldsp nkyslnmyka llpqqsygla qplyspvcts
      241 gerflylppp hyvnphipss laspmrlstp sasaaipplv hcsdkslpwk mgvnpgnpvd
      301 shtyphiqns kqprvtsaka vnsglpgdaa lllppsprps trvhlptqpa aesysefhkh
      361 ypristspsv tltkpymtas sefptarlss gkypkaldgg dcapsmsghs rkttvqdrkd
      421 ggsppllekq tvtkdvtdkp ldlsskvvdv dtsktdhmkk maptvlvhsr atsglvlsgs
      481 eipketsppg ngcsiyrsei istapsswvv pgpspneenn gkslslknka ldwaipqqrs
      541 sscprmggtd avitnvsgsv sssgrpasas papnanadgt ktsrssvdtt psviqhvgqp
      601 pstpakhsgs tsskgakasn pepsfkasen glpptsifls pneafrsppi pyprsylpyp
      661 apegialspl slhgkgpvyp hpvllpngsl fpghlapkpg lpyglhtsrp efvtyqdalg
      721 lgmvhpmlip htpieitkee kperrsrshe raryedptlr srfseileas saklhpdvpt
      781 eknlkpnpsw nqgktgaksd klvyvdllre eteakadaga skaglvaena gqntdaakps
      841 adpviqqhre fislreelgr itdfhesftf kqapgqpvfs lgkdsvaags nkenlgvqva
      901 tpfletalgs egpavtfgkt qedpkpfcvg gappsmdvtp aytkdgtdea esndgkvlkp
      961 kpsklakria nsagyvgdrf kcvttelyad ssqlsreqra lqmeglqeds ilclpaayce
     1021 rammrfsele mkerevshpa tkdsevckfs padwerlkgn qekkpksval eeaiadqndt
     1081 ercdcstgnk hdlfeapedk dlpvekyfle rppvsepptd qgvvdmshsp tlrldrkrka
     1141 sgdsthtett veeltedplk akrrriskdd wperemtnss snhledphcn eltnlkvcie
     1201 ltglhpkkqr hllhlrerwe qqvsaaeskp grqsrkevtq avqpevtsqg nniteerpgr
     1261 kkaeakgnrg wseeslkscd neqglpvfsa sppmkslsst nasgkkqtqp sctpasrppa
     1321 kqqkikesqk tdvlcteede dcraasplqk ytdniekpsg krlcktkhli pqdsrrsvqi
     1381 tgeyyventd tkmtvrrfrk rpepstdydl sppakqepkp fdrlqqllpa tqatqlprsn
     1441 spqettqsrp mppearrliv nknagetllq raarlgyeev vlyclenkvc dvnhrdnagy
     1501 calheacarg wlnivrhlle ygadvncsaq dgtrplhdav endhleivrl llsygadptl
     1561 atysgrtimk mthselmekf ltdylndlqg rseedtsgaw efygssvcep ddesgydvla
     1621 nppgpedpde eedaysdmfe fefaessllp cyniqvsvaq gprnwlllsd vlkklkmssr
     1681 ifrcnfpnme ivsiaeaefy rqvstsllfs cpkdleafnp egkelldlve ftnelqtllg
     1741 ssvewlhpsd tghenyw
//
