LOCUS       NP_001121184             532 aa            linear   ROD 26-FEB-2024
DEFINITION  carotenoid-cleaving dioxygenase, mitochondrial [Rattus norvegicus].
ACCESSION   NP_001121184 XP_001070555 XP_236220
VERSION     NP_001121184.1
DBSOURCE    REFSEQ: accession NM_001127712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 532)
  AUTHORS   Widjaja-Adhi MA, Lobo GP, Golczak M and Von Lintig J.
  TITLE     A genetic dissection of intestinal fat-soluble vitamin and
            carotenoid absorption
  JOURNAL   Hum Mol Genet 24 (11), 3206-3219 (2015)
   PUBMED   25701869
REFERENCE   2  (residues 1 to 532)
  AUTHORS   Raghuvanshi S, Reed V, Blaner WS and Harrison EH.
  TITLE     Cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1)
            and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and
            intestine
  JOURNAL   Arch Biochem Biophys 572, 19-27 (2015)
   PUBMED   25575786
  REMARK    GeneRIF: Cellular localization of beta-carotene 15,15' oxygenase-1
            (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and
            intestine
REFERENCE   3  (residues 1 to 532)
  AUTHORS   Kim YS, Yeom SJ and Oh DK.
  TITLE     Production of beta-apo-10'-carotenal from beta-carotene by human
            beta-carotene-9',10'-oxygenase expressed in E. coli
  JOURNAL   Biotechnol Lett 33 (6), 1195-1200 (2011)
   PUBMED   21302131
REFERENCE   4  (residues 1 to 532)
  AUTHORS   Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss
            A, Palczewski K and von Lintig J.
  TITLE     A mitochondrial enzyme degrades carotenoids and protects against
            oxidative stress
  JOURNAL   FASEB J 25 (3), 948-959 (2011)
   PUBMED   21106934
REFERENCE   5  (residues 1 to 532)
  AUTHORS   Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE
            and von Lintig J.
  TITLE     Identification and characterization of a mammalian enzyme
            catalyzing the asymmetric oxidative cleavage of provitamin A
  JOURNAL   J Biol Chem 276 (17), 14110-14116 (2001)
   PUBMED   11278918
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC133725.1.
            
            On or before May 31, 2008 this sequence version replaced
            XP_001070555.1, XP_236220.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133725.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     Protein         1..532
                     /product="carotenoid-cleaving dioxygenase, mitochondrial"
                     /EC_number="1.14.99.-"
                     /note="carotenoid 9',10' monoxygenase II; beta-carotene
                     9', 10'-dioxygenase 2; beta,beta-carotene
                     9',10'-oxygenase; carotenoid 9',10' monooxygenase II"
                     /calculated_mol_wt=60060
     Region          11..531
                     /region_name="RPE65"
                     /note="Retinal pigment epithelial membrane protein;
                     pfam03055"
                     /db_xref="CDD:460788"
     CDS             1..532
                     /gene="Bco2"
                     /gene_synonym="Ab2-079; Bcdo2"
                     /coded_by="NM_001127712.1:101..1699"
                     /db_xref="GeneID:315644"
                     /db_xref="RGD:1309022"
ORIGIN      
        1 mlgpqqslpc iapllttvee tlstvsarvr ghipewlngy llrvgpgkfe fgkdrynhwf
       61 dgmallhqfk mekgtvtyks kflqsdtyka nsagdrivis efgtlalpdp cksiferfms
      121 rfepptmtdn tsvnfvqykg dyymstetnf mnkvdietle rtekvdwskf vavngatahp
      181 hydpdgtayn mgntygprgs cyniirvppk kkepgetihg aqvvcsiass ekmkpsyyhs
      241 fgmtknyivf veqplkmklw kiitskirgk sfadgiswep qyntrfhvvd khtgqplpgv
      301 yyskpfltyh qinafedqgc ividlccedd grsldiyqlq nlrkageeld qvykakaksf
      361 prrfvlpldi svgapegenl rplpyssasv vkqgdreiwc spenlhqedl eeeggiefpq
      421 inygrfsgkk ysffygcgfr hlvgdslikv dvvnktlrvw reegcypsep vfvpvpgade
      481 edsgailsvv itpnqgesnf llvldaknft elgraevpvr mpygfhgtfv pi
//
