LOCUS       NM_053648               1931 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus beta-carotene oxygenase 1 (Bco1), mRNA.
ACCESSION   NM_053648
VERSION     NM_053648.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Widjaja-Adhi,M.A., Lobo,G.P., Golczak,M. and Von Lintig,J.
  TITLE     A genetic dissection of intestinal fat-soluble vitamin and
            carotenoid absorption
  JOURNAL   Hum Mol Genet 24 (11), 3206-3219 (2015)
   PUBMED   25701869
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Raghuvanshi,S., Reed,V., Blaner,W.S. and Harrison,E.H.
  TITLE     Cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1)
            and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and
            intestine
  JOURNAL   Arch Biochem Biophys 572, 19-27 (2015)
   PUBMED   25575786
  REMARK    GeneRIF: cellular localization of beta-carotene 15,15' oxygenase-1
            (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and
            intestine
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Harrison,E.H.
  TITLE     Mechanisms involved in the intestinal absorption of dietary vitamin
            A and provitamin A carotenoids
  JOURNAL   Biochim Biophys Acta 1821 (1), 70-77 (2012)
   PUBMED   21718801
  REMARK    Review article
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Lobo,G.P., Amengual,J., Palczewski,G., Babino,D. and von Lintig,J.
  TITLE     Mammalian carotenoid-oxygenases: key players for carotenoid
            function and homeostasis
  JOURNAL   Biochim Biophys Acta 1821 (1), 78-87 (2012)
   PUBMED   21569862
  REMARK    Review article
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Mochizuki,H., Mochizuki,K., Suruga,K., Igarashi,M., Takase,S. and
            Goda,T.
  TITLE     Induction of the BCMO1 gene during the suckling-weaning transition
            in rats is associated with histone H3 K4 methylation and subsequent
            coactivator binding and histone H3 acetylation to the gene
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 58 (5), 319-326 (2012)
   PUBMED   23327966
  REMARK    GeneRIF: histone H3 K4 methylation and TRalpha-1 binding on the
            BCMO1 gene during the suckling-weaning transient period in rats
            predisposes to subsequent coactivator recruitment and histone H3
            acetylation
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Takitani,K., Miyazaki,H., Takaya,R. and Tamai,H.
  TITLE     Expression of beta-carotene 15,15'-monooxygenase gene and retinol
            status in type 2 diabetic Goto-Kakizaki rats
  JOURNAL   Biofactors 33 (1), 77-83 (2008)
   PUBMED   19276538
  REMARK    GeneRIF: BCM gene expression in the liver, intestine and testis of
            Goto-Kakizaki rats was increased compared with that in controls.
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Bachmann,H., Desbarats,A., Pattison,P., Sedgewick,M., Riss,G.,
            Wyss,A., Cardinault,N., Duszka,C., Goralczyk,R. and Grolier,P.
  TITLE     Feedback regulation of beta,beta-carotene 15,15'-monooxygenase by
            retinoic acid in rats and chickens
  JOURNAL   J Nutr 132 (12), 3616-3622 (2002)
   PUBMED   12468597
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Lindqvist,A. and Andersson,S.
  TITLE     Biochemical properties of purified recombinant human beta-carotene
            15,15'-monooxygenase
  JOURNAL   J Biol Chem 277 (26), 23942-23948 (2002)
   PUBMED   11960992
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Redmond,T.M., Gentleman,S., Duncan,T., Yu,S., Wiggert,B., Gantt,E.
            and Cunningham,F.X. Jr.
  TITLE     Identification, expression, and substrate specificity of a
            mammalian beta-carotene 15,15'-dioxygenase
  JOURNAL   J Biol Chem 276 (9), 6560-6565 (2001)
   PUBMED   11092891
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   Yan,W., Jang,G.F., Haeseleer,F., Esumi,N., Chang,J., Kerrigan,M.,
            Campochiaro,M., Campochiaro,P., Palczewski,K. and Zack,D.J.
  TITLE     Cloning and characterization of a human
            beta,beta-carotene-15,15'-dioxygenase that is highly expressed in
            the retinal pigment epithelium
  JOURNAL   Genomics 72 (2), 193-202 (2001)
   PUBMED   11401432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Feb 22, 2013 this sequence version replaced NM_053648.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219222.1, SRR26643288.61639.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000019.1  62058140-62058314
            176-304             JAXUCZ010000019.1  62060151-62060279
            305-434             JAXUCZ010000019.1  62066385-62066514
            435-582             JAXUCZ010000019.1  62069489-62069636
            583-730             JAXUCZ010000019.1  62071472-62071619
            731-954             JAXUCZ010000019.1  62074564-62074787
            955-1212            JAXUCZ010000019.1  62077827-62078084
            1213-1318           JAXUCZ010000019.1  62089040-62089145
            1319-1413           JAXUCZ010000019.1  62090828-62090922
            1414-1525           JAXUCZ010000019.1  62092212-62092323
            1526-1931           JAXUCZ010000019.1  62094274-62094679
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1931
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /note="beta-carotene oxygenase 1"
                     /db_xref="GeneID:114106"
                     /db_xref="RGD:70981"
     exon            1..175
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1812
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /EC_number="1.13.11.63"
                     /note="beta-carotene 15, 15'-dioxygenase;
                     beta,beta-carotene 15,15'-monooxygenase; beta-carotene
                     dioxygenase 1; beta-carotene 15, 15-dioxygenase;
                     beta-carotene 15,15'-monooxygenase 1"
                     /codon_start=1
                     /product="beta,beta-carotene 15,15'-dioxygenase"
                     /protein_id="NP_446100.2"
                     /db_xref="GeneID:114106"
                     /db_xref="RGD:70981"
                     /translation="MEIIFGRNKKEQLEPLRATVTGSIPAWLQGTLLRNGPGMHTVGD
                     SKYNHWFDGLALLHSFSIRDGEVFYRSKYLQSDTYNANIEANRIVVSEFGTMAYPDPC
                     KNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATTETNYIRKIDPQTLETLEKVDY
                     RKYVAVNLATSHPHYDEAGNVLNMGTSIADKGRTKYVMFKIPATAPGSKKKGKNPLKH
                     SEVFCSIPSRSLLSPSYYHSFGVTENYVVFLEQPFKLDILKMATAYMRGVSWASCMTF
                     CKEDKTYIHIIDQKTRKPVPTKFYTDPMVVFHHVNAYEEDGCVLFDVIAYEDNSLYQL
                     FYLANLNKDFEEKSRLTSVPTLRRFAVPLHVDKDAEVGSNLVKVSSTTATALKEKDDH
                     VYCQPEVLYEGLELPRINYAHNGKPYRYIFAAEVQWSPVPTKILKYDVLTKSSLKWSE
                     ESCWPAEPLFVPTPGAKDEDDGVILSAIISTDPQKLPFLLILDAKSFTELARASVDVD
                     MHLDLHGLFIPDAGWNAVKQTPAKTQEDENSDHPTGLTAPGLGHGENDFTAGHGGKSL
                     "
     exon            176..304
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..434
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..582
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..730
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..954
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1212
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1318
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1413
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1525
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1931
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcmo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacagatg gaggcatcaa ggagcagagg gcaggaagac aggacgcttt gagcacacgg
       61 ggctttgtgt ctattccact gacaacctcc tcactgccac ccaccggttc catggagata
      121 atatttggcc ggaataagaa agaacagctg gagccattac gggccacagt gacaggcagc
      181 attccagcat ggctgcaggg gaccctgctc cgaaacgggc ctgggatgca cacagtggga
      241 gacagcaagt acaaccattg gtttgatggc ctggcccttc tccacagttt ctccatcaga
      301 gatggggagg tcttctacag gagcaaatac ctgcagagcg acacctacaa cgccaacatc
      361 gaggccaata gaatcgtggt gtctgagttc ggaacaatgg cctacccaga cccctgcaaa
      421 aacatctttt ccaaagcttt ctcctacttg tcccacacca tccccgactt cacagacaac
      481 tgcctgatta acatcatgaa atgtggagaa gacttctatg ccaccacaga gaccaactac
      541 atcaggaaaa tcgaccccca gactctagag accttggaga aggttgatta ccggaagtat
      601 gtggctgtaa acctggctac ctcacaccct cattacgacg aggctggaaa tgtccttaac
      661 atgggtacct ccatcgcgga caaaggaagg acaaaatacg tgatgtttaa gatccccgcc
      721 acagcaccag gcagcaagaa gaaagggaag aaccccttga agcactcaga agttttctgc
      781 tccatcccgt cccgctcgct gctctccccc agttactacc acagctttgg agtcacggag
      841 aactatgtgg tgtttctgga gcagcctttt aagctggata tcctcaagat ggccaccgca
      901 tacatgaggg gtgtgagctg ggcttcctgt atgacattct gcaaggagga caagacttac
      961 attcatatca tcgaccagaa gaccagaaag cctgtgccaa ccaaattcta cacagacccc
     1021 atggtggtct tccaccatgt taatgcctat gaggaggacg gctgtgtgct gtttgatgtc
     1081 atcgcctatg aggacaacag tctctatcag ctcttctacc tggccaacct gaacaaggac
     1141 ttcgaggaga agtccaggct gacctcagtg cctaccctca ggaggtttgc tgtgcccctc
     1201 cacgtggaca aggatgcaga agtgggctcg aatttagtca aggtgtcatc tacaacagca
     1261 actgccctga aggagaagga cgaccatgtc tactgccagc ctgaggtcct ctacgaaggc
     1321 ctagagctcc ctcggataaa ttatgctcac aacgggaagc catatcgcta catctttgct
     1381 gctgaagtac aatggagtcc agtcccaacc aagatactaa aatatgacgt tctcaccaag
     1441 tcctccttaa agtggtccga ggagagctgc tggcctgcag agcctctgtt tgtccccaca
     1501 ccgggtgcga aggatgagga tgatggagtc atcttatcag ccatcatctc tacagatccc
     1561 caaaagctgc cctttttact tattctggat gcgaaaagtt ttacggaatt ggctcgcgcc
     1621 tctgttgatg tggacatgca cctggacctg catggtttat ttattccgga tgcaggctgg
     1681 aatgcagtga agcagactcc agccaaaacg caagaggatg aaaattcaga tcatcccaca
     1741 ggtctgacag caccaggatt gggccatggt gaaaatgact tcacggcagg tcatggcggc
     1801 aagagccttt aatcctagca ctcgaggcag aggcaagcag atctctgagt tcaaggccag
     1861 cctggtctac aacacaagtt ccaggacagc cagggataca cagagaaatc ctatcttgaa
     1921 aacaaagcaa a
//
