LOCUS       NM_001107084            3389 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus BCL6, transcription repressor (Bcl6), mRNA.
ACCESSION   NM_001107084 XM_001055978 XM_221333
VERSION     NM_001107084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Ni J, Wu QQ, Liao HH, Fan D and Tang QZ.
  TITLE     Bcl6 Suppresses Cardiac Fibroblast Activation and Function via
            Directly Binding to Smad4
  JOURNAL   Curr Med Sci 39 (4), 534-540 (2019)
   PUBMED   31346987
  REMARK    GeneRIF: The results showed that Bcl6 overexpression induced
            decreased proliferation and reduced activation of fibroblasts which
            were stimulated with TGFb1. It was found that activated smad2 and
            smad3 were not changed by overexpressing Bcl6, but smad4 was
            decreased.
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Gu Y, Luo M, Li Y, Su Z, Wang Y, Chen X, Zhang S, Sun W and Kong X.
  TITLE     Bcl6 knockdown aggravates hypoxia injury in cardiomyocytes via the
            P38 pathway
  JOURNAL   Cell Biol Int 43 (2), 108-116 (2019)
   PUBMED   29972264
  REMARK    GeneRIF: Bcl6 may participate in the maintenance of cardiomyocyte
            balance. Bcl6 deficiency disrupts this balance, causing
            inflammation, oxidative stress, and apoptosis in cardiomyocytes and
            aggregates in hypoxia-induced cardiomyocyte injury.
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Chen D, Zang YH, Qiu Y, Zhang F, Chen AD, Wang JJ, Chen Q, Li YH,
            Kang YM and Zhu GQ.
  TITLE     BCL6 Attenuates Proliferation and Oxidative Stress of Vascular
            Smooth Muscle Cells in Hypertension
  JOURNAL   Oxid Med Cell Longev 2019, 5018410 (2019)
   PUBMED   30805081
  REMARK    GeneRIF: BCL6 attenuates proliferation and oxidative stress of
            vascular smooth muscle cells in hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon
            ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent
            AL, Dinner AR and Bendelac A.
  TITLE     A negative feedback loop mediated by the Bcl6-cullin 3 complex
            limits Tfh cell differentiation
  JOURNAL   J Exp Med 211 (6), 1137-1151 (2014)
   PUBMED   24863065
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Tsuruoka N, Arima M, Yoshida N, Okada S, Sakamoto A, Hatano M,
            Satake H, Arguni E, Wang JY, Yang JH, Nishikura K, Sekiya S, Shozu
            M and Tokuhisa T.
  TITLE     ADAR1 protein induces adenosine-targeted DNA mutations in senescent
            Bcl6 gene-deficient cells
  JOURNAL   J Biol Chem 288 (2), 826-836 (2013)
   PUBMED   23209284
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Okabe S, Fukuda T, Ishibashi K, Kojima S, Okada S, Hatano M, Ebara
            M, Saisho H and Tokuhisa T.
  TITLE     BAZF, a novel Bcl6 homolog, functions as a transcriptional
            repressor
  JOURNAL   Mol Cell Biol 18 (7), 4235-4244 (1998)
   PUBMED   9632807
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Fukuda T, Yoshida T, Okada S, Hatano M, Miki T, Ishibashi K, Okabe
            S, Koseki H, Hirosawa S, Taniguchi M, Miyasaka N and Tokuhisa T.
  TITLE     Disruption of the Bcl6 gene results in an impaired germinal center
            formation
  JOURNAL   J Exp Med 186 (3), 439-448 (1997)
   PUBMED   9236196
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C,
            Nouri-Shirazi M, Orazi A, Chaganti RS, Rothman P, Stall AM,
            Pandolfi PP and Dalla-Favera R.
  TITLE     The BCL-6 proto-oncogene controls germinal-centre formation and
            Th2-type inflammation
  JOURNAL   Nat Genet 16 (2), 161-170 (1997)
   PUBMED   9171827
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Dent AL, Shaffer AL, Yu X, Allman D and Staudt LM.
  TITLE     Control of inflammation, cytokine expression, and germinal center
            formation by BCL-6
  JOURNAL   Science 276 (5312), 589-592 (1997)
   PUBMED   9110977
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Cattoretti G, Chang CC, Cechova K, Zhang J, Ye BH, Falini B, Louie
            DC, Offit K, Chaganti RS and Dalla-Favera R.
  TITLE     BCL-6 protein is expressed in germinal-center B cells
  JOURNAL   Blood 86 (1), 45-53 (1995)
   PUBMED   7795255
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055978.1, XM_221333.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3389
                     /gene="Bcl6"
                     /note="BCL6, transcription repressor"
                     /db_xref="GeneID:303836"
                     /db_xref="RGD:1309345"
     exon            1..141
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            142..180
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            181..352
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2315
                     /gene="Bcl6"
                     /note="B-cell leukemia/lymphoma 6; B-cell CLL/lymphoma 6"
                     /codon_start=1
                     /product="B-cell lymphoma 6 protein"
                     /protein_id="NP_001100554.1"
                     /db_xref="GeneID:303836"
                     /db_xref="RGD:1309345"
                     /translation="MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFR
                     AHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEISPEGFCILLDFMYTSRLNLREGNI
                     MAVMATAMYLQMEHVVDTCRKFIKASEAEMAPALKPPREEFLNSRMLMPHDVMAYRGR
                     EVVENNMPLRNTPGCESRAFAPPLYSGLSTPPASYPMYSHLPLSSFLFSDEELRDAPR
                     MPVANPFPKERALPCDSARPVPNEYSRPTMEVSPSLCHSNIYSPKEAVPEEARSDIHY
                     SVTEGPKPAAPSARHASYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQS
                     PQKSDCQPNSPTESSSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAK
                     PEGSEQAELGRLSPRAYPAPPACQPPMEPANLDLQSPTKLSASGEDSTIPQASRLNNI
                     VNRSLAGSPRSSSESHSPLYMHPPKCTSCGSQSPQHTEMCLHTAGPTFPEEMGETQSE
                     YSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHK
                     TVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLI
                     HTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKH
                     GAITNTKVQYRVSAADLPPELPKAC"
     exon            353..574
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            575..1549
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1734
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1902
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2033
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2171
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..3389
                     /gene="Bcl6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgccacgg agtcctcccc tgctgtggag caatggtaaa gcccgcagct caaattccga
       61 gaattgagct ctgttgattc ttagaactgg ggttcttaga agtggtgatg caagaagttt
      121 ctaggaaagg ccggacacca gttttaaagc aaaattttgg actgtgaagc aaggcattgg
      181 gcaaacacaa catggcctca ccggctgaca gctgtatcca gttcacccgc catgctagtg
      241 atgttcttct caaccttaac cgcctccgaa gtcgggacat cttgaccgac gttgtcatcg
      301 tggtgagccg tgagcagttt agagcccata agacagtgct catggcctgc agtggcctgt
      361 tctacagcat cttcactgac cagttgaaat gcaaccttag tgtaatcaat ctggatcctg
      421 agatcagccc tgaggggttt tgcatcctct tggacttcat gtacacatct aggctcaacc
      481 tgagggaagg caacatcatg gccgtgatgg ccacagccat gtacctgcag atggagcatg
      541 ttgtcgacac atgccggaag ttcatcaagg ccagtgaagc agaaatggcc cctgcactta
      601 agcctccccg tgaagagttc ctgaacagcc ggatgctgat gccccatgac gtcatggcct
      661 atcgaggtcg tgaggttgtg gagaacaata tgccactaag aaatactccc gggtgtgaga
      721 gtagagcttt tgcccctccc ctgtacagtg gcctgtcgac accaccagcc tcttatccga
      781 tgtatagcca tctcccgctc agcagtttcc tcttctccga cgaggaacta cgagatgccc
      841 cccgaatgcc tgtggctaac ccttttccca aggagcgcgc cctcccctgt gacagtgcca
      901 ggccagtccc taatgagtat agcaggccaa ccatggaggt gtcccccagc ttgtgccaca
      961 gcaatatcta ctcgcccaag gaggcagtcc cagaggaggc tcggagtgac atacactaca
     1021 gtgtgactga gggccccaag cctgctgccc cttctgctcg gcatgcctcg tacttcccct
     1081 gtgacaaagc cagcaaagaa gaagagagac cctcttcaga ggacgagatc gccctgcatt
     1141 tcgagccccc caatgcaccc ttgaaccgga agggtctggt tagtccccag agtccgcaga
     1201 aatccgactg ccagcccaac tcacccacag agtcctccag cagcaagaac gcctgcatcc
     1261 ttcaggcctc tggctctcct ccagccaaga gccccactga tccgaaagcc tgcaactgga
     1321 agaagtataa gttcatcgtt ctcaacagcc tcaatcagaa tgccaagcca gagggctctg
     1381 agcaggcaga gctgggccgc ctctccccac gagcctaccc tgcaccgccg gcctgccagc
     1441 cgcctatgga gcctgcgaac cttgatctcc agtctccaac caagctcagt gccagtgggg
     1501 aggactctac catcccccaa gccagccggc tcaataacat cgttaacagg tccctggcag
     1561 gctccccccg aagcagcagc gagagccact cgccactcta catgcacccc ccgaagtgca
     1621 catcctgcgg ctctcagtcc ccacagcata cagagatgtg tctccatact gccgggccca
     1681 cattcccgga ggagatggga gagacccagt cagagtattc ggattctagc tgtgagaatg
     1741 gggccttctt ctgcaatgaa tgtgactgcc gtttttctga ggaggcctca ctcaagaggc
     1801 acacgctgca gacgcacagt gacaaaccat acaaatgtga ccgctgccag gcctccttcc
     1861 gctacaaagg caacctcgcc agccacaaga cggtccacac aggtgaaaaa ccctaccgct
     1921 gtaacatttg tggagcgcag ttcaatcggc cagccaacct gaagacccac actcgaattc
     1981 actctggaga aaagccctac aaatgtgaaa cctgtggggc cagatttgtg caggtggctc
     2041 acctccgtgc ccacgtgctc atccacactg gagagaagcc gtacccctgt gaaatctgtg
     2101 gtacccgctt caggcacctt cagactctaa agagccatct gcgcatccac acaggagaga
     2161 aaccgtacca ttgtgagaag tgtaacctgc actttcgtca caaaagccaa ctgcgacttc
     2221 atttgcgtca gaaacatggc gccatcacca acaccaaggt gcaataccgt gtgtcggccg
     2281 ctgatttgcc tccggagctc cccaaagcct gctgaagcat ggagtgttga ctctttttct
     2341 ctccagcccc ttctcagaat ctacccaaag gatgctgtaa cactttacaa aggtcatccc
     2401 atgacgtagt gcctctctca tccactagag caaatcatag ttggggtggg ggtgggggtg
     2461 ggggtggggt ttgcgggacc gggagccaag gcagctctcc ttcccacact gccataaaac
     2521 attaagaaaa tactatcgct tcttctccta tgtgtaaggc aaaccacgtc agcaaaaatg
     2581 caaaatcatt ttcaatatca aaatagggga gaacgcagaa gttctgactt gacaggttgc
     2641 aacatgagga atgtaaatgt tctgtgggga cagagatctc ttttgtatgt aaatgtgcat
     2701 tgttttaaaa gacaagactt cagtatgttg tcaaagagag ggctttaatt ttttaaccaa
     2761 aggtgaagga atatatggca gagttgtaaa tatataaata tatatatata taatataaat
     2821 atataaacct aaaaagatat attgaaaata taaaactgtg ttaaaggctc gattttgtat
     2881 ctgcaggcag acacggatct gagaatcttt attgagaaag agcacttaag agactatttt
     2941 aagtattatg tctgtataag taagaaaata ttttgtctaa aatgcctccg tgtatttgta
     3001 tttttttgca agtgaaggtt tacaatttac aaagtgtgta ttaaaaacaa aaaagaacaa
     3061 aaaaaagctg cagaaggaga aatgtatact tttgttctgg ttttcacttt gtacatacct
     3121 gtaaacgtgt cctcacggtg cctttttaca cggaagtttt caatgatgga cgggtgtggg
     3181 ccatcccttt ttgaagtgta ggcagacaca gggacttgaa gttgtcacta actaaactct
     3241 ctttgggaat gtttgactcc tcccacattc tgcgtcatgc ttgttataat tactccggag
     3301 acagggtttg gctgtgtcta aactgcatta gtgcgttgta aaatatagct gtatctgtat
     3361 aaaatataag aataaaacat ggaaaagtc
//
