LOCUS       NM_001109422            1788 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus BCL3, transcription coactivator (Bcl3), mRNA.
ACCESSION   NM_001109422 XM_001057993
VERSION     NM_001109422.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Ma,J., Yin,H., Ran,Z., Luo,T., Jin,Z., Zheng,L. and Zhang,F.
  TITLE     Knockdown of BCL-3 Attenuates Inflammatory Response in
            Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment
  JOURNAL   Neuroscience 537, 105-115 (2024)
   PUBMED   38006962
  REMARK    GeneRIF: Knockdown of BCL-3 Attenuates Inflammatory Response in
            Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment.
REFERENCE   2  (bases 1 to 1788)
  AUTHORS   Mitsui,T., Ishida,M., Izawa,M., Kagami,Y. and Arita,J.
  TITLE     Inhibition of Bcl3 gene expression mediates the anti-proliferative
            action of estrogen in pituitary lactotrophs in primary culture
  JOURNAL   Mol Cell Endocrinol 345 (1-2), 68-78 (2011)
   PUBMED   21787835
  REMARK    GeneRIF: These results suggest that inhibition of Bcl3 expression
            is involved in the anti-proliferative action of estrogens in
            pituitary lactotrophs in culture.
REFERENCE   3  (bases 1 to 1788)
  AUTHORS   Langley,R.J., Mishra,N.C., Pena-Philippides,J.C., Hutt,J.A. and
            Sopori,M.L.
  TITLE     Granuloma formation induced by low-dose chronic silica inhalation
            is associated with an anti-apoptotic response in Lewis rats
  JOURNAL   J Toxicol Environ Health A 73 (10), 669-683 (2010)
   PUBMED   20391111
  REMARK    GeneRIF: Chronic silicotic lungs were TUNEL-negative and
            overexpressed Bcl-3 and NF-kappaB-p50.
REFERENCE   4  (bases 1 to 1788)
  AUTHORS   Bourteele,S., Oesterle,K., Weinzierl,A.O., Paxian,S., Riemann,M.,
            Schmid,R.M. and Planz,O.
  TITLE     Alteration of NF-kappaB activity leads to mitochondrial apoptosis
            after infection with pathological prion protein
  JOURNAL   Cell Microbiol 9 (9), 2202-2217 (2007)
   PUBMED   17573907
REFERENCE   5  (bases 1 to 1788)
  AUTHORS   Bauer,A., Villunger,A., Labi,V., Fischer,S.F., Strasser,A.,
            Wagner,H., Schmid,R.M. and Hacker,G.
  TITLE     The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and
            Puma control the death of activated T cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (29), 10979-10984 (2006)
   PUBMED   16832056
REFERENCE   6  (bases 1 to 1788)
  AUTHORS   Poljak,L., Carlson,L., Cunningham,K., Kosco-Vilbois,M.H. and
            Siebenlist,U.
  TITLE     Distinct activities of p52/NF-kappa B required for proper secondary
            lymphoid organ microarchitecture: functions enhanced by Bcl-3
  JOURNAL   J Immunol 163 (12), 6581-6588 (1999)
   PUBMED   10586052
REFERENCE   7  (bases 1 to 1788)
  AUTHORS   Bundy,D.L. and McKeithan,T.W.
  TITLE     Diverse effects of BCL3 phosphorylation on its modulation of
            NF-kappaB p52 homodimer binding to DNA
  JOURNAL   J Biol Chem 272 (52), 33132-33139 (1997)
   PUBMED   9407099
REFERENCE   8  (bases 1 to 1788)
  AUTHORS   Franzoso,G., Carlson,L., Scharton-Kersten,T., Shores,E.W.,
            Epstein,S., Grinberg,A., Tran,T., Shacter,E., Leonardi,A.,
            Anver,M., Love,P., Sher,A. and Siebenlist,U.
  TITLE     Critical roles for the Bcl-3 oncoprotein in T cell-mediated
            immunity, splenic microarchitecture, and germinal center reactions
  JOURNAL   Immunity 6 (4), 479-490 (1997)
   PUBMED   9133427
REFERENCE   9  (bases 1 to 1788)
  AUTHORS   Schwarz,E.M., Krimpenfort,P., Berns,A. and Verma,I.M.
  TITLE     Immunological defects in mice with a targeted disruption in Bcl-3
  JOURNAL   Genes Dev 11 (2), 187-197 (1997)
   PUBMED   9009202
REFERENCE   10 (bases 1 to 1788)
  AUTHORS   Zhang,Q., Didonato,J.A., Karin,M. and McKeithan,T.W.
  TITLE     BCL3 encodes a nuclear protein which can alter the subcellular
            location of NF-kappa B proteins
  JOURNAL   Mol Cell Biol 14 (6), 3915-3926 (1994)
   PUBMED   8196632
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001057993.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132263
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1788
                     /gene="Bcl3"
                     /note="BCL3, transcription coactivator"
                     /db_xref="GeneID:680611"
                     /db_xref="RGD:1589465"
     exon            1..279
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1385
                     /gene="Bcl3"
                     /note="B-cell leukemia/lymphoma 3; B-cell CLL/lymphoma 3"
                     /codon_start=1
                     /product="B-cell lymphoma 3 protein"
                     /protein_id="NP_001102892.1"
                     /db_xref="GeneID:680611"
                     /db_xref="RGD:1589465"
                     /translation="MPRCPAGAMDEGPVDLRTRPKGISGAALPLRKRPLRPASPEPAA
                     PRGPAGPLDALRSNCDVPAVPGPPHCVARPEALYYQGPLMPMYSTPTMAPPFPLLNLP
                     THPYSMICPVEHPLSADIAMATRVDEDGDTPLHIAVVQNNKTAVYRILSLFKLGNREV
                     DVHNNLRQTPLHLAVITTLPDIVRLLVTAGASPMALDRHGQTAVHLACEHRSPSCLQA
                     LLDSATPGSVDLEARNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLI
                     HAVENNSLNMVQLLLLHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKN
                     CHNDTPLMVARSRRVIDILRGKASRAASGSQPDPSPDQSATNSPESSSRLSSNGLQSS
                     PSSSPSLSPPKDAPSFPMTPQNYFLPATSAPAFLPFPGVLRGPGRPVAPSPAPGSS"
     exon            280..433
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            434..542
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..747
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            748..836
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            837..914
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1082
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1200
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1788
                     /gene="Bcl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagctcgcc gcacgccccg gcgtctccgg gcggcccgat gccccgatgc cccgcggggg
       61 ccatggacga ggggcccgtg gacctacgca cccggcccaa gggcatctca ggcgccgcgc
      121 tgccactccg caagcgcccg ctgcgtcccg cgtctccaga gcccgcagcc ccgcgaggtc
      181 ctgctggacc cctggacgcc ctgcgcagca actgcgacgt cccggctgtc cctggacccc
      241 ctcactgcgt ggccaggccg gaggctcttt actaccaggg acctctgatg cccatgtact
      301 ctaccccgac tatggccccg ccctttccgc tgctgaacct gcctactcac ccctactcca
      361 tgatttgccc cgtggagcac cccctttcag ctgacattgc catggccacc cgggtggatg
      421 aggacggaga cacgcctctc cacattgccg tggtccagaa taacaagacg gccgtctacc
      481 gaattctcag ccttttcaag cttgggaaca gggaagtcga tgtccacaac aacctgcgac
      541 agaccccgct ccacctggct gtgatcacca cattaccaga tatagtccgg ctcctggtga
      601 cagctggtgc cagccccatg gccctggatc gccacggtca gactgcagtc cacctggcat
      661 gcgagcaccg aagccccagc tgcctgcagg ccctgctaga cagcgcaacc ccgggctctg
      721 tggacctgga ggctcgcaat tatgaagggc tcactgccct gcacgtggcc gtgaacaccg
      781 ggtgccagga agctgttctg ctgctcctgg agcgtggcgc agacatcgat gcagtggata
      841 ttaagagcgg ccgctcccca ctcatccatg ctgtggagaa caacagcctg aacatggtgc
      901 aactgctcct gctgcacggc gccaacgtga acgctcagat gtactctggc agctcggctc
      961 tgcattccgc gtctggccgc gggcttctgc ctctggtgcg cacactggtg cgcagcgggg
     1021 ctgacagcgg cctcaagaac tgtcacaatg acacacccct catggtggcg cgcagccgca
     1081 gggtcattga tatcctaagg ggaaaggcct ctcgggctgc ttcagggtca cagcctgatc
     1141 catccccaga ccaaagtgcc accaactccc ctgagagcag cagccgtctc agctccaatg
     1201 gcctccagtc ctctccgagc tcctcaccct cgctgtctcc cccgaaggat gctccaagct
     1261 tccccatgac tccccaaaac tacttccttc ctgcaacatc tgcacctgcc ttcctgccct
     1321 tcccaggggt cctccgaggc cctggccggc ccgtagcccc ctccccagct ccaggaagca
     1381 gctgagacgg atgggggagc agacccggac tcatgaggaa gggcttccct gccctgtgga
     1441 gaccactctt ctggaaactg tgaggacctt gttctgcttc ccccgcccag tcttcgggac
     1501 caggttttgc accaaggcac atgcacatac tactgagcac agatactccc agttgcgccc
     1561 attgcccagg actctaagcc ccatttaatc tcaggcacga aggttccctc tctggaatcc
     1621 actagatatt cgattctttg agtggaggaa ccaaaggaca gcccctcctc tgccatcctc
     1681 taccccgacg gacccggagg aacagagggg attgggagga cattgatcac gatgtaaatt
     1741 attaggtttg ggtcagattt cttttgtaat aaactatttt tgtatcat
//
