LOCUS       NM_021850               3545 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus Bcl2-like 2 (Bcl2l2), mRNA.
ACCESSION   NM_021850
VERSION     NM_021850.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Zhang,L., Wang,D., Han,X., Guo,X., Cao,Y., Xia,Y. and Gao,D.
  TITLE     Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma
            cells
  JOURNAL   J Cell Mol Med 26 (17), 4686-4697 (2022)
   PUBMED   35894779
  REMARK    GeneRIF: Novel read-through fusion transcript Bcl2l2-Pabpn1 in
            glioblastoma cells.
REFERENCE   2  (bases 1 to 3545)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3545)
  AUTHORS   Li,Y., Li,X., Wang,L., Han,N. and Yin,G.
  TITLE     miR-375-3p contributes to hypoxia-induced apoptosis by targeting
            forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat
            cardiomyocyte h9c2 cells
  JOURNAL   Biotechnol Lett 43 (2), 353-367 (2021)
   PUBMED   33128129
  REMARK    GeneRIF: miR-375-3p contributes to hypoxia-induced apoptosis by
            targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2)
            in rat cardiomyocyte h9c2 cells.
REFERENCE   4  (bases 1 to 3545)
  AUTHORS   Adams,C.M., Kim,A.S., Mitra,R., Choi,J.K., Gong,J.Z. and
            Eischen,C.M.
  TITLE     BCL-W has a fundamental role in B cell survival and lymphomagenesis
  JOURNAL   J Clin Invest 127 (2), 635-650 (2017)
   PUBMED   28094768
REFERENCE   5  (bases 1 to 3545)
  AUTHORS   Cui,Y.H., Li,H.Y., Gao,Z.X., Liang,N., Ma,S.S., Meng,F.J., Li,Z.J.
            and Pan,H.W.
  TITLE     Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w
  JOURNAL   Invest Ophthalmol Vis Sci 57 (8), 3723-3730 (2016)
   PUBMED   27415790
REFERENCE   6  (bases 1 to 3545)
  AUTHORS   Hamner,S., Skoglosa,Y. and Lindholm,D.
  TITLE     Differential expression of bcl-w and bcl-x messenger RNA in the
            developing and adult rat nervous system
  JOURNAL   Neuroscience 91 (2), 673-684 (1999)
   PUBMED   10366024
REFERENCE   7  (bases 1 to 3545)
  AUTHORS   Print,C.G., Loveland,K.L., Gibson,L., Meehan,T., Stylianou,A.,
            Wreford,N., de Kretser,D., Metcalf,D., Kontgen,F., Adams,J.M. and
            Cory,S.
  TITLE     Apoptosis regulator bcl-w is essential for spermatogenesis but
            appears otherwise redundant
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12424-12431 (1998)
   PUBMED   9770502
REFERENCE   8  (bases 1 to 3545)
  AUTHORS   Hsu,S.Y., Lin,P. and Hsueh,A.J.
  TITLE     BOD (Bcl-2-related ovarian death gene) is an ovarian BH3
            domain-containing proapoptotic Bcl-2 protein capable of
            dimerization with diverse antiapoptotic Bcl-2 members
  JOURNAL   Mol Endocrinol 12 (9), 1432-1440 (1998)
   PUBMED   9731710
REFERENCE   9  (bases 1 to 3545)
  AUTHORS   Ross,A.J., Waymire,K.G., Moss,J.E., Parlow,A.F., Skinner,M.K.,
            Russell,L.D. and MacGregor,G.R.
  TITLE     Testicular degeneration in Bclw-deficient mice
  JOURNAL   Nat Genet 18 (3), 251-256 (1998)
   PUBMED   9500547
REFERENCE   10 (bases 1 to 3545)
  AUTHORS   Hsu,S.Y., Kaipia,A., McGee,E., Lomeli,M. and Hsueh,A.J.
  TITLE     Bok is a pro-apoptotic Bcl-2 protein with restricted expression in
            reproductive tissues and heterodimerizes with selective
            anti-apoptotic Bcl-2 family members
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12401-12406 (1997)
   PUBMED   9356461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074021.1.
            
            On Oct 17, 2004 this sequence version replaced NM_021850.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074021.1, AY185098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..3545
                     /gene="Bcl2l2"
                     /gene_synonym="BCL-W; BCL-WEL; BCL-WS; Bclw"
                     /note="Bcl2-like 2"
                     /db_xref="GeneID:60434"
                     /db_xref="RGD:620717"
     exon            1..102
                     /gene="Bcl2l2"
                     /gene_synonym="BCL-W; BCL-WEL; BCL-WS; Bclw"
                     /inference="alignment:Splign:2.1.0"
     exon            103..190
                     /gene="Bcl2l2"
                     /gene_synonym="BCL-W; BCL-WEL; BCL-WS; Bclw"
                     /inference="alignment:Splign:2.1.0"
     exon            191..630
                     /gene="Bcl2l2"
                     /gene_synonym="BCL-W; BCL-WEL; BCL-WS; Bclw"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..780
                     /gene="Bcl2l2"
                     /gene_synonym="BCL-W; BCL-WEL; BCL-WS; Bclw"
                     /codon_start=1
                     /product="bcl-2-like protein 2"
                     /protein_id="NP_068622.1"
                     /db_xref="GeneID:60434"
                     /db_xref="RGD:620717"
                     /translation="MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQ
                     AMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVF
                     GAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEAR
                     RLREGNWASVRTVLTGAVALGALVTVGAFFASK"
     exon            631..3521
                     /gene="Bcl2l2"
                     /gene_synonym="BCL-W; BCL-WEL; BCL-WS; Bclw"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcctttcc tccctctctc cctccctccc tccctccctc ccagctcctc caccaggaaa
       61 caaccggatt cccgatcccg accgaggcct tcttcctgac tcggctccac tctcgccggg
      121 aggatgaaag gcctcagctg ggggctccct gccatcagca ctgggtcgta agagctgcca
      181 tccaggctgg ccgcccggat ggcgacccca gcctcaaccc cagacacacg ggctctagtg
      241 gctgactttg taggctataa gctgaggcag aagggttatg tctgtggagc tggccctggg
      301 gaaggcccag cagccgaccc gctgcaccaa gccatgcggg cagctggaga cgagtttgag
      361 acccgcttcc ggcgcacctt ctctgacctg gccgctcagc tacacgtgac cccaggctca
      421 gcccagcaac gcttcaccca ggtttccgac gaacttttcc aagggggccc caactggggc
      481 cgtcttgtgg cattctttgt ctttggggct gccctgtgtg ctgagagtgt caacaaagaa
      541 atggagccat tggtgggaca agtgcaggat tggatggtga cctacctgga gacacgcttg
      601 gctgactgga tccacagcag tgggggctgg gcggagttca cagctctata cggggacggg
      661 gccctggagg aggcacggcg tctgcgggag gggaactggg catcagtgag gacagtgctg
      721 acgggggctg tggcactggg ggccctggta actgtagggg ccttttttgc tagcaagtga
      781 gaaagtctag ggtcaggtgg ggctaggtgt ggctaggggc caggagagct ggaacaatag
      841 agaatgccct tggaagaaac tggatggtca cggaacagag gaaggcagag gaaggtagtg
      901 tgtgtgggag ccaagcacgc caggcaggtg gcaggaagga ggacttggaa acactaagga
      961 atgtttcaag gccaggaacc cagagggtgg agtcatccca cggcttgcag ggaggtggga
     1021 ggaatcctgc ctatatcgtg ggcacacaaa ctacctggat cagggcttgt ggttccaagg
     1081 aaggtgagct cacttaaaag atcggtgtct ctactagatg aatgggattt agggaaccta
     1141 gaactcacct ccctttggaa tggaagcttg gtgactggat gaaatggctg tggctgtggg
     1201 ctgcatgggc acacctgtgc atgggcacac ctgtgcatgg gcacacctgt gcatgggcac
     1261 acctgtgcat gggcacatgc aggcatgctc atgtgcatgc tgggctgttt gttgactctg
     1321 atgatggggt acttagagaa aacattcctt cttgctgtgg caagaacaag ggccagttca
     1381 ctgcccttct cccctctgcc ccttccctag accttaggcc tccaggctgg aggaggaaca
     1441 ctgtatctag actagggctc tggcactgct gaaagttgac agggctttgg agagaagagt
     1501 tctgcagctg gccttgttct ttaccatccc ccttctgtgt gcatctgtgc accccggctg
     1561 acaaagggca aggctgtgga gcctgggtgg ataggagctt tggtacttgg gcttgcctat
     1621 caccttcccc tccaatggag gcaccttggt acctagagtg ttgcctgttt ctaggacctc
     1681 tttatccagc tgagactcta aattggggca ctaattttcc tttagaagat acggatatga
     1741 atgctgatct agaattcagt ttagttcctg agctgtctca gtgagactgc cgatgcctag
     1801 agaggaccat tcccactctg agtcccttgg gagtgatggg gacaggtact ccttgcctgg
     1861 cctattctgt gtggtgggtt ttggtgctgc tgtatcaggg gccaggtgta tgggttctag
     1921 agtacctgcc acgacttcaa cacgttttct tttgaagcca tccatgctct ttgcataggt
     1981 tgtgttgtca gtacttgagt ctctgaagat gtcggtcacg ttagaactca cagtccagtc
     2041 ctctagaaca aacccagacc atagcttttt ctttcgaggg aggaatcatt cactccaaac
     2101 gcatgccctg agccagacct cactgctgca ctttccaagg tgctaacatt gctgctcttt
     2161 gacgccaact tcgttcgcag tgctctagaa ccctacctac ctatcctgag cactgaccag
     2221 cttggctagg ccacagctga ctcgcctctt cacttggtcc tagaatgtgg catcgtatcg
     2281 tgcttgctag aatgtgggac caaattggcc tcaggtgttt agtccagact tttgcttctg
     2341 agagaaggtt gcactttttg atagtgtctg tgggggatgt gggaggctgc atgtgccagt
     2401 tggtgtattt tgagggtgat gatctaagaa actcagagct gtctctggca agcagttgga
     2461 gtgggaggct ctgacttgct caggacaaac taggccagtg gttttcaaac tgcttggcag
     2521 agccccgaag tgtcctaggg gttgcctcag gagtccttag ggagatgagg gagtggaggg
     2581 ctgggcagtt tgccctcaaa cagaacagct ccccttgtag ctgtcttatg tatcggggtt
     2641 cagggtaaga ttttatttgt ggtaagggct ttgctgctga aaaaagttag aaaaccactg
     2701 actagaccat cagctccatt tggagtctgt gctcctccga gttccgggaa gactctctgc
     2761 tctacccttc ccacgggacc cctacccaag ttagcattcc tgggggcctt tagcaaacag
     2821 gagcagtggg aaccagggtc gggttaccaa caccctctgc tgctgagcct ccagacaggt
     2881 gaaaggagag gccgttatgg gaagctaaag ggttggtctt ggtctggatt cccagaagct
     2941 tagcttagat gggaccacag tggggagttg tgacctgttc tgcccttcgt tttgagggcc
     3001 agtggaaacc cagagactct tctgtcaggg aaaaccaggg actgtctttc agagccatat
     3061 agttccttgg gatcagctct tggccaagag ggctgagtat ggctcccaac ttttaaatcc
     3121 atttcatttt tttaaatgag ggaaatagat ctaatttttc agatattaag taggtggaga
     3181 ggatgttctt gctctccaaa gcccaaaggg ataaataggg actttgctta ggccaaggca
     3241 agagcggaag tggggcaagt cagtcctgca gttgtcaatc ctactcccca cctcactagg
     3301 gcatacatat actattttac ttttttaaaa tcataaacgg caggagaaca gatttggtta
     3361 gtttagaaga agagaaaaag ctctataaat ataaatatat attcctgtat ttttatttaa
     3421 taatttataa atgccaagtt catttgactt ttatttttgt gtaatatgta atggtcgtat
     3481 taaaaataaa caaataaagc ccagaaattt aatgagaagt aaaaaaaaaa aaaaaaaaaa
     3541 aaaaa
//
